activities Speaking Activities That Don't Suck By www.usingenglish.com Published On :: Mon, 05 Nov 2012 13:16:14 +0000 I have English Teacher X's obra prima to read next and have enjoyed the other ebooks - they include a lot of sensible and realistic advice - but I didn't enjoy Speaking Activities that Don't Suck as much. Full Article Asian Blog English Teacher X
activities The Challenging Job of an Electrical Commissioning Engineer (Activities and Real World Examples) By electrical-engineering-portal.com Published On :: Mon, 05 Aug 2024 05:43:17 +0000 This article aims to cover the activity of electrical commissioning. Such a task in its entirety would be immense. Commissioning can mean many things in different instances. This article aims to give a philosophical and high level conceptual overview of... Read more The post The Challenging Job of an Electrical Commissioning Engineer (Activities and Real World Examples) appeared first on EEP - Electrical Engineering Portal. Full Article Power Substation Premium Content Protection Testing and Commissioning abb accessible terminals alarms avr commissioning engineer commissioning engineers damaged equipment electrical commissioning energization fat generator ice breaker vessel injection testing inspecting and testing interlock lockout machine omicron injection tester premag system premag transformer project engineering project owner project planning system integrator test equipment testing ups
activities Resolution 55 - (Rev. Geneva, 2022) - Mainstreaming a gender perspective in ITU Telecommunication Standardization Sector activities By www.itu.int Published On :: Tue, 26 Apr 2022 20:30:25 GMT Resolution 55 - (Rev. Geneva, 2022) - Mainstreaming a gender perspective in ITU Telecommunication Standardization Sector activities Full Article
activities Resolution 92 - (Rev. Geneva, 2022) - Enhancing the standardization activities in the ITU Telecommunication Standardization Sector related to non-radio aspects of international mobile telecommunications By www.itu.int Published On :: Tue, 26 Apr 2022 21:47:10 GMT Resolution 92 - (Rev. Geneva, 2022) - Enhancing the standardization activities in the ITU Telecommunication Standardization Sector related to non-radio aspects of international mobile telecommunications Full Article
activities Short Answer- Build better k12 writers through social, engaging writing activities By www.ilearntechnology.com Published On :: Thu, 05 Sep 2024 22:07:38 +0000 I love technology built by teachers—it’s just different. You can feel the truth and passion behind it. It has features that you know were intentionally considered by someone who has been in the classroom. Short Answer is a fantastic writing tool that was obviously built by teachers solving real problems for real students. The best!... Full Article Analyze Anastasis Academy Character Education collaboration Create Evaluate Foreign Language Geography Government History Inquiry Language Arts Math Middle/High School Music PE Primary Elementary professional development Science Secondary Elementary Social Studies Teacher Resources Technology web tools Web2.0 Websites adaptive comparitive judgment ai algebra biology business calculus careers chemistry computer science earth science economics eithics english FCS formative assessment geometry neuroscience physics pre algebra psychology sel short answer social statistics trigonometry us history world history writing yass prize
activities Why Wildfires Started by Human Activities Can Be More Destructive and Harder To Contain By www.discovermagazine.com Published On :: Wed, 09 Oct 2024 14:00:00 GMT Heavy equipment working near dry brush sparked a destructive wildfire near Riverside, Calif., in September 2024. Full Article Environment
activities Looking for new activities? Google wants you to turn to its navigation app By www.latimes.com Published On :: Thu, 31 Oct 2024 14:00:11 GMT Google is adding more generative AI features to popular navigation apps such as Google Maps and Waze. Full Article
activities Nonspecific DNA binding by P1 ParA determines the distribution of plasmid partition and repressor activities [Microbiology] By www.jbc.org Published On :: 2020-12-11T00:06:21-08:00 The faithful segregation, or “partition,” of many low-copy number bacterial plasmids is driven by plasmid-encoded ATPases that are represented by the P1 plasmid ParA protein. ParA binds to the bacterial nucleoid via an ATP-dependent nonspecific DNA (nsDNA)-binding activity, which is essential for partition. ParA also has a site-specific DNA-binding activity to the par operator (parOP), which requires either ATP or ADP, and which is essential for it to act as a transcriptional repressor but is dispensable for partition. Here we examine how DNA binding by ParA contributes to the relative distribution of its plasmid partition and repressor activities, using a ParA with an alanine substitution at Arg351, a residue previously predicted to participate in site-specific DNA binding. In vivo, the parAR351A allele is compromised for partition, but its repressor activity is dramatically improved so that it behaves as a “super-repressor.” In vitro, ParAR351A binds and hydrolyzes ATP, and undergoes a specific conformational change required for nsDNA binding, but its nsDNA-binding activity is significantly damaged. This defect in turn significantly reduces the assembly and stability of partition complexes formed by the interaction of ParA with ParB, the centromere-binding protein, and DNA. In contrast, the R351A change shows only a mild defect in site-specific DNA binding. We conclude that the partition defect is due to altered nsDNA binding kinetics and affinity for the bacterial chromosome. Furthermore, the super-repressor phenotype is explained by an increased pool of non-nucleoid bound ParA that is competent to bind parOP and repress transcription. Full Article
activities Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase ϵ holoenzyme [DNA and Chromosomes] By www.jbc.org Published On :: 2020-12-11T00:06:21-08:00 In eukaryotic DNA replication, DNA polymerase ε (Polε) is responsible for leading strand synthesis, whereas DNA polymerases α and δ synthesize the lagging strand. The human Polε (hPolε) holoenzyme is comprised of the catalytic p261 subunit and the noncatalytic p59, p17, and p12 small subunits. So far, the contribution of the noncatalytic subunits to hPolε function is not well understood. Using pre-steady-state kinetic methods, we established a minimal kinetic mechanism for DNA polymerization and editing catalyzed by the hPolε holoenzyme. Compared with the 140-kDa N-terminal catalytic fragment of p261 (p261N), which we kinetically characterized in our earlier studies, the presence of the p261 C-terminal domain (p261C) and the three small subunits increased the DNA binding affinity and the base substitution fidelity. Although the small subunits enhanced correct nucleotide incorporation efficiency, there was a wide range of rate constants when incorporating a correct nucleotide over a single-base mismatch. Surprisingly, the 3'→5' exonuclease activity of the hPolε holoenzyme was significantly slower than that of p261N when editing both matched and mismatched DNA substrates. This suggests that the presence of p261C and the three small subunits regulates the 3'→5' exonuclease activity of the hPolε holoenzyme. Together, the 3'→5' exonuclease activity and the variable mismatch extension activity modulate the overall fidelity of the hPolε holoenzyme by up to 3 orders of magnitude. Thus, the presence of p261C and the three noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit and makes the hPolε holoenzyme an efficient and faithful replicative DNA polymerase. Full Article
activities Shifting Science Instruction to the Coronavirus: New Activities, Units By blogs.edweek.org Published On :: Tue, 21 Apr 2020 00:00:00 +0000 A small group of science teachers in Missouri is using the coronavirus as a teachable moment that's aligned to the Next Generation Science Standards. Full Article Missouri
activities DSB Highlights Activities for National Small Business Week/Month 2024 By news.delaware.gov Published On :: Fri, 26 Apr 2024 17:55:13 +0000 There are nearly 28-thousand small businesses in the State of Delaware. Each year, the month of May is set aside as a special time to celebrate small businesses, their courage, community efforts, and hard work. The Delaware Division of Small Business (DSB) is highlighting activities that do this taking place during National Small Business Month, and National Small Business Week (NSBW April 28 – May 4, 2024). Full Article Governor John Carney Office of the Governor Small Business economic development Economy entrepreneurs netde small business small business month
activities DPH Shares Activities As Part Of Falls Prevention Awareness Week By news.delaware.gov Published On :: Wed, 14 Sep 2022 14:05:51 +0000 DOVER, DE (Sept. 14, 2022) – Falls can result in broken bones, head injuries, and temporary or permanent disabilities, and the Delaware Coalition for Injury Prevention’s Falls Prevention Team says it takes community effort to prevent them. The Injury Prevention Coalition operates under the Division of Public Health’s (DPH) Office of Emergency Medical Services section. In recognition […] Full Article Division of Public Health News activities caution Delaware DPH falls falls prevention awareness week proclamation slips
activities dia student activities manual By english.al-akhbar.com Published On :: dia student activities manual Full Article
activities Health Tip: Find Activities You Enjoy By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Health Tip: Find Activities You EnjoyCategory: Health NewsCreated: 8/31/2018 12:00:00 AMLast Editorial Review: 8/31/2018 12:00:00 AM Full Article
activities Everyday Activities That Can Cut Your Odds for Dementia By www.medicinenet.com Published On :: Mon, 15 Aug 2022 00:00:00 PDT Title: Everyday Activities That Can Cut Your Odds for DementiaCategory: Health NewsCreated: 8/12/2022 12:00:00 AMLast Editorial Review: 8/15/2022 12:00:00 AM Full Article
activities Why you should be using a VPN to safeguard your stock trading activities By www.foxnews.com Published On :: Sat, 26 Oct 2024 08:00:36 -0400 Every stock trader should consider a virtual private network to safeguard their trading, according to tech guru Kurt "CyberGuy" Knutsson. Full Article 249e9ec5-64f0-546f-8978-cdd0f688fb70 fnc Fox News fox-news/tech fox-news/tech/topics/security fox-news/us/personal-freedoms/privacy fox-news/tech/topics/cybercrime fox-news/politics/finance fox-news/us fox-news/us/crime fox-news/tech article
activities Pakistan limits outdoor activities, market hours to curb air pollution-related illness By www.asiaone.com Published On :: Tue, 12 Nov 2024 10:21:25 +0800 LAHORE — Pakistan's Punjab province banned most outdoor activities and ordered shops, markets and malls in some areas to close early from Monday (Nov 11) to curb illnesses caused by intense air pollution. The province has closed educational institutions and public spaces like parks and zoos until Nov. 17 in places including Lahore, the world's most polluted city in terms of air quality, according to Swiss group IQAir's live ratings. The districts of Lahore, Multan, Faisalabad and Gujranwala have seen an unprecedented rise in patients with respiratory diseases, eye and throat irritation, and pink eye disease, the Punjab government said in an order issued late on Sunday. The new restrictions will also remain in force until Nov. 17. "The spread of conjunctivitis/ pink eye disease due to bacterial or viral infection, smoke, dust or chemical exposure is posing a serious and imminent threat to public health," the Punjab government said. Full Article
activities Shiv Sena (UBT) expels ex-Hingoli MP Wankhede for 'anti-party' activities By www.ibtimes.co.in Published On :: Sat, 09 Nov 2024 15:11:19 +0530 In an abrupt move, the Shiv Sena (UBT) has expelled its former Hingoli Lok Sabha MP Subhash Wankhede from the party for alleged 'anti-party' activities Full Article
activities Groupon cuts over 500 staff, plans to focus ‘only on mission-critical activities’ from now on By techcrunch.com Published On :: Mon, 08 Aug 2022 20:37:19 +0000 Chicago-based Groupon today laid off more than 500 of its employees — 15% of its 3,416-person headcount — according to posts from former employees on social media. The reduction impacted workers in teams including merchant development, sales, recruiting, engineering, product and marketing. Groupon confirmed the layoffs to TechCrunch after the publication of the story. “Our […] © 2024 TechCrunch. All rights reserved. For personal use only. Full Article Fintech Media & Entertainment coupons economy Groupon Layoffs marketplace offers downturn labor personnel moves laid off
activities Govt Warns Of "Unauthorized", "Ill-intentioned" Activities Of MSME Export Promotion Council By www.goodreturns.in Published On :: Sat, 17 Oct 2020 14:10:46 +0530 On Saturday, the Ministry of Micro, Small & Medium Enterprises (MSMEs) in a press note warned of "unauthorized and ill-intentioned" activities of the MSME Export Promotion Council and also clarified that the government is not associated with the council. "Ministry Full Article
activities Canada Orders TikTok to Terminate all Business Activities Citing National Security Concerns By www.gizbot.com Published On :: Thu, 07 Nov 2024 10:30:42 +0530 Canada has instructed TikTok to cease its operations within the nation, citing unspecified "national security risks" linked to the company and its parent, ByteDance. This decision mandates TikTok to terminate all business activities in Canada. However, the Canadian government has not Full Article
activities Royal Enfield Gears Up For The 2024 Motoverse Event In Goa: New Models & Thrilling Activities Assured By www.drivespark.com Published On :: Tue, 12 Nov 2024 19:45:09 +0530 Royal Enfield is gearing up to host the 2024 Motoverse event in Goa from the 22nd to the 24th of this month. This event will feature a showcase of new models, updates, and accessories from Royal Enfield. Enthusiasts can expect an Full Article
activities India Bike Week 2024: Exciting Activities & Ticket Details By www.drivespark.com Published On :: Tue, 12 Nov 2024 21:14:16 +0530 The India Bike Week is a highly anticipated event for motorcycle enthusiasts across the country. Traditionally held in Goa, this annual gathering takes place in early December. This year, it is scheduled for December 6th and 7th at Vagator, Goa. Ticket Full Article
activities Phenoxy-1,2-dioxetane-Based Activatable Chemiluminescent Probes: Tuning of Photophysical Properties for Tracing Enzymatic Activities in Living Cells By pubs.rsc.org Published On :: Analyst, 2024, Accepted ManuscriptDOI: 10.1039/D4AN01082E, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jagpreet Singh Sidhu, Gurjot Kaur, Atharva Rajesh Chavan, Mandeep Chahal, Rajeev TaliyanThe use of chemiluminophores for tracing enzymatic activities in live-cell imaging has gained significant attention, making them valuable tools for diagnostic applications. Among various chemiluminophores, the phenoxy-1,2-dioxetane scaffold exhibits significant...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Extreme weather for kids : lessons and activities all about hurricanes, tornadoes, blizzards, and more! / Matthew Cappucci ; illustrated by Stephanie Hathaway By darius.uleth.ca Published On :: Cappucci, Matthew, author Full Article
activities Tailoring of novel morpholine-sulphonamide linked thiazole moiety as dual targeting DHFR/DNA gyrase inhibitors: Synthesis, antimicrobial, antibiofilm activities and DFT with molecular modelling studies By pubs.rsc.org Published On :: New J. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D3NJ05774G, PaperMoaz M. Abdou, Essam Eliwa, Mohamed Abdel Reheim, Ahmed Abu-Rayyan, Shimaa M. Abd El-Gilil, Mohammed Abu-Elghait , Mohamed H. Sharaf, Mohamed Kalaba, Ahmed Halawa, Walid ElgammalHerein, the chemical synthesis of new thiazoles-based benzenesulfonamide-linked morpholine 4a,b–7 via late-stage thiazolation of the corresponding thiosemicarbazone 3 was reported. The skeletal formulas of the new compounds were confirmed by...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Deepavali weekend witnesses surge in tourist activities in Karnataka By www.thehindu.com Published On :: Sat, 22 Oct 2022 20:48:43 +0530 The demand has been so much that local tour operators are struggling to arrange for resources for those who are booking trips Full Article Bengaluru
activities Presenting Bengaluru’s weekend activities By www.thehindu.com Published On :: Fri, 03 Feb 2023 12:12:27 +0530 Full Article Leisure
activities Effect of ZnMgO2 nanoparticles used as a nanofertilizer: promoting the growth activities of rice seedlings By pubs.rsc.org Published On :: Environ. Sci.: Nano, 2024, 11,1571-1581DOI: 10.1039/D3EN00770G, PaperSajid Mehmood, Niteesh Kumar, Aadil Mansoori, Madan Mohan, Anirudh Kumar, Tanmay Kumar GhoraiNovel ZnMgO2 bimetallic nanoparticles were synthesized using Cinchona succirubra leaf extract and used as a nano fertilizer, promoting the growth activities of rice seedlings, α-amylase and antioxidant activity with average particle sizes of 24.8 nm.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Gujarat introduces stricter safety rules for boating activities By www.newkerala.com Published On :: Fri, 25 Oct 2024 20:10:03 +0530 Full Article
activities Minister promises IBM all support to expand activities in Kerala By www.thehindu.com Published On :: Tue, 14 Mar 2023 00:15:33 +0530 Full Article Kerala
activities Finance Ministry notifies new FDI limits for satellite-related activities under FEMA By www.thehindubusinessline.com Published On :: Wed, 17 Apr 2024 08:07:56 +0530 Finance Ministry’s new FDI limits for satellite activities, effective April 16, allow 100% FDI in the space sector with specific limits for different activities Full Article Science
activities Review meeting held to check Maoist activities along Telangana’s border with Chhattisgarh By www.thehindu.com Published On :: Tue, 12 Nov 2024 12:05:44 +0530 Full Article Telangana
activities Pakistan media accuses 8 Indian mission staffers of ‘anti-Pakistan activities’ By www.thehindu.com Published On :: Thu, 03 Nov 2016 16:05:08 +0530 The media leak claimed that the officials were working for either RAW or for Intelligence Bureau. Full Article World
activities The Structure of Firms' International Activities [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
activities Medicinal plant resin natural products: structural diversity and biological activities By pubs.rsc.org Published On :: Nat. Prod. Rep., 2024, 41,1471-1542DOI: 10.1039/D4NP00007B, Review ArticleMadhu Babu Sura, Yong-Xian ChengThis review explores medicinal plant resin natural products from six genera, encompassing 1115 structures and their biological activities, offering insights into the chemical and biological profiling of plant resins produced under various stress.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Siccanin-related drimane meroterpenoids: biological activities and synthesis By pubs.rsc.org Published On :: Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00025K, Review ArticleShengxin Sun, Xia Wang, Nvdan Hu, Shiqi Fu, Shengkun LiThis review describes the isolation, structural characteristics, bioactivities and divergent synthetic strategies of siccanin-related drimane meroterpenoids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Reactivities of tertiary phosphines towards allenic, acetylenic, and vinylic Michael acceptors By pubs.rsc.org Published On :: Chem. Sci., 2024, 15,18111-18126DOI: 10.1039/D4SC04852K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Feng An, Jan Brossette, Harish Jangra, Yin Wei, Min Shi, Hendrik Zipse, Armin R. OfialCombined experimental and quantum-chemical studies were used to characterise the philicity/fugality features of tertiary phosphines and Michael acceptors in phospha-Michael reactions, which are key steps in phosphine-catalysed organic reactions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities HC tells authorities to prevent anti-social activities by other methods before resorting to KAAPA By www.thehindu.com Published On :: Mon, 11 Nov 2024 19:34:32 +0530 Full Article Kochi
activities The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Above-normal pre-monsoon rain triggers agriculture activities in Raichur district of Karnataka By www.thehindu.com Published On :: Mon, 20 May 2024 16:18:31 +0530 The district received 26.5 mm of rain in 72 hours against the average of 1.9 mm Full Article Karnataka
activities Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35047-35063DOI: 10.1039/D4RA06412G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nasima Arshad, Yasir Mehmood, Hammad Ismail, Fouzia Perveen, Aneela Javed, Pervaiz Ali Channar, Aamer Saeed, Sadia Naseem, Fatima NaseerThis work reports synthesis, characterization, DNA, enzyme binding and cytotoxicity activity of three 4-((3-arylthiazolo[3,4-d]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4-d)isoxazole-based fused ring heterocyclic system.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities A facile synthesis of iron oxide nanoparticles as a nano-sensor to detect levofloxacin and ciprofloxacin in human blood and evaluation of their biological activities By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36093-36100DOI: 10.1039/D4RA05024J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Erum Hasan, Ziana Manzar, Nabeel Haroon, Ali Raza, Syed Nawazish Ali, Mehreen Lateef, Sabira BegumNew bioactive magnetic nanoparticles were synthesized and stabilized by 3-aminobenzoic acid (3-ABA) utilized in detection of levofloxacin and ciprofloxacin.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Effects of human activities and climate change on water quality and health risks of typical urban river in arid/semi-arid areas, a ten-year historical analysis By pubs.rsc.org Published On :: Environ. Sci.: Water Res. Technol., 2024, Accepted ManuscriptDOI: 10.1039/D4EW00689E, PaperXiang Zhu, Hanjie Zheng, Dezhi Zuo, Qingqing Pang, Lei Xie, Longmian Wang, Jin-Ying Xi, Lin-Feng Tian, Jing Wu, Wenjuan Jiang, Jiawei Sun, Hongyu Zhao, Jianhua JinWater resources are scarce in arid and semi-arid regions. Urban rivers, vital water sources, are susceptible to the influences of climate change and human activities. However, there have been few...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Oxygen redox activities governing high-voltage charging reversibility of Ni-rich layered cathodes By pubs.rsc.org Published On :: Energy Environ. Sci., 2024, Advance ArticleDOI: 10.1039/D4EE03832K, PaperGi-Hyeok Lee, Suwon Lee, Jiliang Zhang, Bernardine L. D. Rinkel, Matthew J. Crafton, Zengqing Zhuo, Youngju Choi, Jialu Li, Junghoon Yang, Jongwook W. Heo, Byungchun Park, Bryan D. McCloskey, Maxim Avdeev, Wanli Yang, Yong-Mook KangA schematic illustration indicative of the improved structural reversibility through stabilizing oxidized oxygen by Al doping.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activities Inter-{alpha}-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation [Glycobiology and Extracellular Matrices] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation. Full Article
activities Service activities shrink to all-time low; PMI hits near zero By www.financialexpress.com Published On :: 2020-05-06T10:48:04+05:30 India's service sector recorded largest contraction in business activity and new orders in April. Full Article Economy
activities NDMA issues guidelines for restarting industrial activities to avoid Vizag-type tragedy By www.financialexpress.com Published On :: 2020-05-10T11:39:00+05:30 In a communication to all states and union territories, the NDMA said due to several weeks of lockdown and the closure of industrial units, it is possible that some of the operators might not have followed the established standard operating procedures. Full Article Industry
activities No tourism activities despite reopening of Kaghan valley road By feedproxy.google.com Published On :: Sun, 10 May 2020 06:00:00 +0500 MANSEHRA: Though Kaghan-Naran section of Mansehra-Naran-Jalkhad road has been reopened to traffic following the suspension of five consecutive months, the tourism activities in the valley are yet to be resumed.The road, which was blocked due to heavy snowfall in Kaghan valley in December 2019, was... Full Article
activities “I did not announce ban lift on religious activities in Enugu” – Archbishop Ede By dailypost.ng Published On :: Sun, 10 May 2020 05:39:22 +0000 The Chairman of the Christian Council of Nigeria, Enugu State chapter, Archbishop Barr. Christopher Ede, has stated that he did not announce that ban on religious activities have been lifted in Enugu State, as is being erroneously peddled in the media. Reacting to a media report credited to him to the effect that Enugu State […] “I did not announce ban lift on religious activities in Enugu” – Archbishop Ede Full Article News Archbishop Ede Enugu religious gatherings