Between Mother's Day and the expected sunny weather, there's lots to celebrate this weekend! Whether you'll be enjoying nature or continuing to stay inside, here are some things you can do while maintaining social distancing.

Between Mother's Day and the expected sunny weather, there's lots to celebrate this weekend! Whether you'll be enjoying nature or continuing to stay inside, here are some things you can do while maintaining social distancing.

Between Mother's Day and the expected sunny weather, there's lots to celebrate this weekend! Whether you'll be enjoying nature or continuing to stay inside, here are some things you can do while maintaining social distancing.

As we continue to quarantine under Gov. Jay Inslee's "stay at home" order, there are still lots of fun activities you can do this weekend. So, stay in, read a book, start a movie marathon and order some takeout.

Spring is here. No time like the present to take up some gardening. Or just relax at home with a book ... or take The Seattle Times' Kitchen Pantry Challenge! Here are our ideas for things you can do this weekend.

Between Mother's Day and the expected sunny weather, there's lots to celebrate this weekend! Whether you'll be enjoying nature or continuing to stay inside, here are some things you can do while maintaining social distancing.

Between Mother's Day and the expected sunny weather, there's lots to celebrate this weekend! Whether you'll be enjoying nature or continuing to stay inside, here are some things you can do while maintaining social distancing.

What had long been expected became reality Tuesday when the Colorado High School Activities Association announced it was cancelling the remainder of the spring sports season.

These “cards” are really an excuse for kids to interview their moms and shower them with the ultimate gifts: attention to mom’s quirky uniqueness, gratitude, and offers of help! Here you go — click here! (Mother’s Day is SUNDAY!)

If you own a Xiaomi smartphone or have installed the Mi browser app on any of your other brand Android device, you should enable a newly introduced privacy setting immediately to prevent the company from spying on your online activities. The smartphone maker has begun rolling out an update to its Mi Browser/Mi Browser Pro (v12.1.4) and Mint Browser (v3.4.3) after concerns were raised over its

The goal for remote learning during the break “is to maintain the exciting and enriching aspects that Spring Recess provides,” Schools Chancellor Richard Carranza told teachers in a Monday night email.

The Pac-12 announced on Monday it is extending its suspension of all athletic activities until May 31 because of the COVID-19 pandemic.

Staying home this weekend? We've got some ideas. Take care of your plants, make your house cozier, help neighbors and start planning your next trip.

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.