The Leisure & Cultural Services Department launched a one-stop online resources centre today for the public to view or participate in multi-faceted leisure and cultural activities from the comfort of their homes.

The online resources centre offers demonstrations of home exercises as well as videos of exercise demonstrations and Healthy Exercise for All Campaign interactive games.

The information portal carries knowledge on the plants and animals at the Zoological & Botanical Gardens, old and valuable trees at the department's major parks and colourful Hong Kong Flower Show archives.

The Museum of Art and the Heritage Museum are collaborating with the Google Arts & Culture Project to showcase exhibits in a digital format.

There are also virtual exhibitions that explore previous fascinating collections at the History Museum and the Science Museum.

While extensive content from intangible cultural heritage and modern arts integrating into life from Oi! is also included.

The Hong Kong Public Libraries offers vast e-resources allowing people to explore fun reading at home.

On the performing arts front, digital content covers concert archives from the Hong Kong Philharmonic Orchestra, Hong Kong Chinese Orchestra and Hong Kong Sinfonietta.

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

(University of Barcelona) The yellow-legged gull has a high ability to adapt to human activities and benefit from these as a food resource during all year. This is stated in a scientific article published in the journal Ecology and Evolution whose first author is the researcher Francisco Ramírez, from the Faculty of Biology and the Biodiversity Research Institute (IRBio) of the University of Barcelona.

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.

A small group of science teachers in Missouri is using the coronavirus as a teachable moment that's aligned to the Next Generation Science Standards.

Presleep activities (eg, television watching) have been implicated in the declining sleep duration of young people. However, previous research reported on selected presleep activities, raising the possibility that important activities in this period are not accounted for.

This is the first study in youth to construct the presleep period by using a use-of-time approach. Twin trajectories of higher screen time and lower nonscreen sedentary time/self-care were evident in late sleepers, with the opposite pattern occurring in early sleepers. (Read the full article)

Rehabilitation of people with cerebral palsy aims to achieve and maintain optimal performance in mobility and daily activities. Although insight into the developmental trajectories of activities from childhood into adulthood is important, little is known about long-term development.

The gross motor function of children with cerebral palsy determines the developmental trajectories of mobility performance but not of daily activities, where intellectual disability was shown to be the determining factor. (Read the full article)

The Student Activities Office at Penn State Wilkes-Barre typically offers a full slate of activities for students and will continue to do so throughout April — even though the way those activities are delivered may look a little different.

A new study finds that extracurricular activities have differing positive effects for rural boys compared to girls.

Authorities say the single victim of a shooting this week at a high school in North Las Vegas, Nev., was an 18-year-old student.

Fraudulent companies include shells owned by Manafort, Gates, and Cohen; others used to undermine democratic processes and launder drug money Attorney General Kathy Jennings announced Thursday that the she has filed actions in the state Court of Chancery to dissolve 15 Delaware business entities for involvement in criminal activities. State law allows the Attorney General […]

Any brand, in order to become stronger, has to constantly connect with its consumers. The entire theory of stimulus-response works on the principle of brands sending a stimulus for consumers to respond.

DOVER  – Lyme disease is the most common vector-borne disease in the United States with approximately 20,000 new cases reported each year. Delaware is among the top 10 states in the United States with the highest incidence rates. In 2018, the Division of Public Health (DPH) reported 520 confirmed and probable cases in the state. […]

While most state parks, nature and wildlife areas continue to stay open during the “Stay Home, Stay Safe” emergency order, many amenities are closed.

Job guarantee programme (MGNREGA) works are allowed with strict implementation of social distancing and face mask.

The Delhi government on Friday issued orders directing all the district magistrates and deputy commissioners of police to ensure smooth running of all economic activities permitted during the...

Banks to have a robust system of internal audit of all outsourced activities

For lovers of adrenaline sports and wildlife activities, Turkey presents a number of breathtaking options. Click through for the full list with a bonus in the end...

Istanbul presents unique experiences for those who want to escape from the intense week day into the weekend in the world’s only intercontinental city. Click through for the top five suggestions from Hürriyet Travel:

There are no signs North Korean leader Kim Jong-un received heart surgery when he disappeared from state media for three weeks, but he reduced public activity due to coronavirus concerns, South Korean lawmakers briefed by the spy agency said on Wednesday.Kim attended the completion of a fertiliser plant, North Korea’s official media said on Saturday, the first report of his appearing in public since April 11.His absence fuelled a flurry of speculation about his health and whereabouts, with a…

Tribune News Service Faridabad, January 24 Despite an overall lull in the real estate sector, illegal construction and encroachment in certain parts of the district appear to be going on in “full swing”. These include the hilly terrain of the Aravallis. However, the authorities have removed certain encroachments from the Surajkund area in the past. “Several construction activities have been noticed in the area, including the Surajkund road. As the non-forest area comes under the jurisdiction of the Municipal Corporation Faridabad (MCF), it has removed certain encroachments in the past,” said a source in the civic body. Admitting that illegal construction poses a threat to the green cover of the […]

Despite advances in oral health care, inequalities in oral health outcomes persist due to problems in access. With proper training, primary care providers can mitigate this inequality by providing oral health education, screening, and referral to advanced dental treatment. Diverging sets of oral health competencies and guidelines have been released or endorsed by multiple primary care disciplines. The aim of this study was to transform multiple sets of competencies into Entrustable Professional Activities (EPAs) for oral health integration into primary care training. A scoping review of the literature between January 2000 and December 2016 was conducted according to PRISMA methodology to identify all existing sets of competencies. The following primary care disciplines were included in the search: allopathic/osteopathic medical schools and residency programs in family medicine, internal medicine, and pediatrics; physician assistant programs; and nurse practitioner programs. Competencies were compared using the Health Resources and Services Administration Integration of Oral Health and Primary Care Practice competencies as the foundational set and translated into EPAs. The resulting EPAs were tested with a reactor panel. The scoping review produced 1,466 references, of which 114 were selected for full text review. Fourteen competencies were identified as being central to the integration of oral health into primary care. These were converted to seven EPAs for oral health integration into primary care and were mapped onto Accreditation Council for Graduate Medical Education residency competency domains as well to the Association of American Medical Colleges EPAs for graduating medical students. The resulting EPAs delineate the essential, observable work required of primary care providers to ensure that oral health is treated as a critical determinant of overall health.

Drug-induced liver injury (DILI) is a global medical problem. The risk of DILI is often related to expression and activities of drug-metabolizing enzymes, especially cytochrome P450s (P450s). However, changes on expression and activities of P450s after DILI have not been determined. The aim of this study is to fill this knowledge gap. Acetaminophen (APAP) was used as a model drug to induce DILI in C57BL/6J mice at different ages of days 10 (infant), 22 (child), and 60 (adult). DILI was assessed by levels of alanine aminotransferase and aspartate aminotransferase in plasma with a confirmation by H&E staining on liver tissue sections. The expression of selected P450s at mRNA and protein levels was measured by real-time polymerase chain reaction and liquid chromatography–tandem mass spectrometry, respectively. The activities of these P450s were determined by the formation of metabolites from probe drugs for each P450 using ultraperformance liquid chromatography–quadrupole time of flight mass spectrometry. DILI was induced at mild to severe levels in a dose-dependent manner in 200, 300, and 400 mg/kg APAP-treated groups at child and adult ages, but not at the infant age. Significantly decreased expression at mRNA and protein levels as well as enzymatic activities of CYP2E1, 3A11, 1A2, and 2C29 were found at child and adult ages. Adult male mice were more susceptible to APAP-induced liver injury than female mice with more decreased expression of P450s. These results suggest that altered levels of P450s in livers severely injured by drugs may affect the therapeutic efficacy of drugs, which are metabolized by P450s, more particularly for males.

Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure. These results support the utility of omadacycline as an effective antibiotic for the treatment of CABP caused by L. pneumophila.

Last year, more than 12,000 students in NSW received long suspensions of up to 20 days and a new report reveals this could be creating a pathway from school to prison.

Employee safety and business continuity are top priorities / Wide-ranging humanitarian and social engagement / Group sales increase by 6.0 percent (Fx & portfolio adj.) to 12.845 billion euros / EBITDA before special items up by 10.2 percent to 4.391 billion euros / All divisions report higher sales and earnings – strong demand at Consumer Health / Net income advances by 20.0 percent to 1.489 billion euros / Core earnings per share increase by 9.9 percent to 2.67 euros / Outlook for 2020: impact of COVID-19 not yet reliably quantifiable

Georgia-Pacific, a manufacturing company headquartered in Atlanta, has agreed to perform remedial work at an estimated cost of nearly $13 million to contain two former disposal areas within the Kalamazoo River Superfund site in Allegan and Kalamazoo Counties, Mich.

The findings reported in the Bureau of Justice Statistics’ (BJS) report, Sexual Victimization in Juvenile Facilities Reported by Youth, 2008-2009, bring into focus the dire circumstances that too many youth in juvenile correctional facilities have to endure.

Andres Echevarria, aka “B-Boy” and “King B-Boy,” pleaded guilty today to conspiracy to participate in a racketeering enterprise, in connection with his gang activities as a member of the Almighty Latin King and Queen Nation (Latin Kings).

Three alleged members and associates of the MS-13 gang have been indicted for various violent crimes stemming from a home invasion last year in the District of Columbia in which several persons were held at gunpoint.

Nelson Santos, aka “Nelly” and “King Nelly,” 27, of Silver Spring, Md., was sentenced today by U.S. District Judge Alexander Williams Jr. to 190 months in prison for conspiracy to participate in a racketeering enterprise and being a felon in possession of a firearm, in connection with his gang activities as a member of the Almighty Latin King and Queen Nation.

Erick Roman, aka “Erick Javier Sierra,” “Malian-T” and “King Malian-T,” 34, of Laurel, Md., was also ordered to serve five years of supervised release following his prison term.

Hawk Field Services LLC, a wholly-owned subsidiary of Houston-based Petrohawk Energy Corporation, pleaded guilty today in federal court in Little Rock, Ark., to charges stemming from the illegal take of endangered species in north-central Arkansas.

Professional duck hunter and guide Jeffrey B. Foiles was sentenced today by a federal judge in Springfield, Ill., to 13 months in prison.