Zacros America Inc. has announced that it will move its Hedwin Division, along with 154 manufacturing jobs, from Baltimore to Newark, bolstering the state’s efforts to attract innovative companies and grow job opportunities in key sectors for today’s economy, including manufacturing.

Liam Payne, who rose to fame as a member of the boy band One Direction has died at the age of 31. The British singer fell to his death from the third-floor balcony of Hotel CasaSur Palermo in Buenos Aires, Argentina.

1. 9 Surprising Facts About Voyager 2’s Uranus Flyby  Moneycontrol
2. Potential For Life Found On Uranus' Moons, Scientists Reveal  NDTV
3. The anomalous state of Uranus’s magnetosphere during the Voyager 2 flyby  Nature.com
4. Voyager-2 visited Uranus in 1986. Something more happened when it arrived  India Today
5. Uranus and its moons may have ideal conditions for life—but Voyager 2 missed it due to one bad day  The Economic Times

Egypt became the ‘bread basket’ of Africa in 2018, attracting the largest number of foreign investments in food manufacturing. 

Having opened new production facilities in Rwanda and South Africa, Mara Phones is looking to alter Africa's mindset from being a 'consumer' to being a 'manufacturer'. 

Mexico suffered a second year of dwindling manufacturing, with the US's trade policy taking its toll. However, Mexico remains an attractive location for US companies and their suppliers.

Figures show 2018 was India’s best year for manufacturing FDI in seven years.

The UAE remained the Middle East's most popular destination for foreign manufacturing investments in 2018.

Over the past several weeks, there has been significant discussion about Verisign and its management of the .com top-level domain (TLD) registry. Much of this discussion has been distorted by factual inaccuracies, a misunderstanding of core technical concepts, and misinterpretations regarding pricing, competition, and market dynamics in the domain name industry. Billions of internet users […]

The post Setting the Record Straight – Myths vs. Facts about .com appeared first on Verisign Blog.

Wooden sticks found in an Australian cave appear to match the accounts of a 19th-century anthropologist, suggesting the GurnaiKurnai people practised the same ritual at the end of the last glacial period

We know that modern humans took one of two routes to first reach Australia, and now an ancient chunk of plant resin has tipped the evidence towards the northern option

Title: Neighborhood Factors Could Raise Your Child's Odds for Asthma
Category: Health News
Created: 7/25/2022 12:00:00 AM
Last Editorial Review: 7/25/2022 12:00:00 AM

Title: Brain Scans Show Risk Factor for Alzheimer's
Category: Health News
Created: 8/25/2011 11:01:00 AM
Last Editorial Review: 8/25/2011 12:00:00 AM

Title: Mental Decline a Risk Factor for Stroke, Study Suggests
Category: Health News
Created: 8/25/2014 12:36:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM

Title: Cheesecake Factory's Breakfast Burrito Tops Latest Xtreme Eating Awards
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: Can Breast Cancer Be a Risk Factor for Opioid Use Among Older Patients?
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Obesity in Youth Could Be Big Risk Factor for MS
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Title: Rheumatoid Factor (RF)
Category: Procedures and Tests
Created: 1/28/2002 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Background

Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function.

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

BACKGROUND AND PURPOSE:

Mechanical thrombectomy is a fundamental intervention for acute ischemic stroke treatment. While conventional techniques are effective, cyclic aspiration (CyA) shows potential for better recanalization rates. We aim to investigate factors affecting CyA and compare them with static aspiration (StA).

New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour.

It's the RPGCast trio bringing you another week of mild insanity. Kelley struggles because Japanese names are hard. Chris wants to take all the cats camping, but Anna Marie swiftly vetoes the idea. The dad jokes arrive in full force, and everyone's thinking about vacations.

The post RPG Cast – Episode 604: “Press 5 for More Rune Factory” appeared first on RPGamer.

Ryan slip 'n slides his health away. Robert lives on the side of danger and poor choices in video games. Meanwhile, Chris makes his own bathtub Geralt.

The post RPG Cast – Episode 725: “Not Every Idea in the Factory Is a Good One” appeared first on RPGamer.

REVERB features 17 audiovisual installations including new works by Es Devlin and Theaster Gates, plus Devon Turnbull's Listening Room.

The post The Vinyl Factory celebrates art and sound with immersive exhibition at 180 Studios appeared first on Fact Magazine.

Reverb features new works by Es Devlin and Theaster Gates, plus Devon Turnbull's Listening Room.

The post The Vinyl Factory: Reverb exhibition extended until 22 December appeared first on Fact Magazine.

A collective gasp echoed like a thunderclap in a valley in our Daily Beast newsroom late Wednesday afternoon at the news that singer Liam Payne, who became famous as a member of the group One Direction, died at age 31.

TMZ reports that Payne fell from a hotel balcony in Argentina, where he had reunited with bandmates at 1D-er Niall Horan’s concert. He had, according to the site, been behaving “erratically,” earlier in the day, and was spotted smashing a laptop in the hotel lobby and having to be carried back to his room. He had been in headlines on gossip blogs over tension with his ex-fiancée Maya Henry, who, TMZ says, alleged “he'd left her after asking her to get an abortion.”

In the shock of his death, fans couldn’t ignore the eerie nature that Payne had just connected with his One Direction bandmates. Dark questions emerge when a celebrity dies so young: What role did the often horrific toll of fame have on a person like Payne, who has been open about addiction and suicidal ideation? But there’s also an impulse to go back to the roots of a person’s talent, to revisit what it was that we all fell in love with—and was their passion—in the first place.

Read more at The Daily Beast.

I have zero archaeology experience or knowledge, but I bet archaeologists really love their jobs (for the most part). They get to analyse and discover cool artefacts and educate us on the histories of forgotten civilisations. That's dreamy stuff, that is. But I do wonder what it's like for archaeologists to discover and study something they shouldn't have; something with a disturbing secret - a curse, maybe. Bite-sized horror game The Children Of Clay explores this idea and I'd like more of it, please.

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To say that Factorio: Space Age throws out the rulebook is an understatement. It'd be more fitting to say it's somehow automated the whole process: an inserter plucked out the rulebook from my brain and deposited it in hot magma, while a new rulebook was churned out in a nearby machine and plopped into my brain from the other side - only for that to be immediately plucked out and incinerated as well. With each new planet and each new phase, Space Age reinvents itself. I'm battling hyperbole here, but ah hell, I admit defeat. Factorio: Space Age is a masterpiece, the final form of perhaps the most well-crafted building game I'll ever play.

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People report greater life satisfaction six months after starting Parkrun events, which could partly be due to the supportive environment

Manufacturing efficiency has always been a priority. As competition grows, optimizing every aspect of production becomes critical. Manufacturers turn to experts to make the right improvements and introduce systems that boost overall performance. One key area where many businesses seek help is through Manufacturing Execution Systems (MES). MES consultants play a pivotal role in achieving […]

The post The Role of MES Consultants in Streamlining Manufacturing Operations appeared first on Chart Attack.

From assembling delicate electronics to constructing safety-critical aerospace components, the margin for error has shrunk to almost nothing. To meet these rigorous standards, the manufacturing industry increasingly relies on robotic precision. Modern robotics, equipped with advanced sensors, grippers, and AI, allow manufacturers to complete intricate tasks with extraordinary accuracy. Technological Innovations Driving Robotic Precision Today’s […]

The post Robotic Precision in Manufacturing: Achieving High Accuracy for Complex Tasks appeared first on Chart Attack.

Rivian is teaming up with Volkswagen in a $5.8 billion joint venture for EV innovation on its R2 model, which the company says will eventually be manufactured in Georgia.

By comparing early markings used for business purposes to 'proto' cuneiform, we can say language transitioned from symbols to writing.

A new battery plant under construction in South Carolina will supply BMW factories.

The deal secured by the Hull facility is for the East Anglia TWO project off the Suffolk coast.

Une découverte biochimique intrigante pourrait permettre d’identifier rapidement les patients à haut risque.

The recent amendments brought by the Union Ministry of Ayush to the Drugs and Cosmetics Rules, 1945 are significant, as they introduce new regulatory requirements for the manufacturing and sale of traditional

Nick Guerin, CSP, director of environmental, health & safety at Tessy Plastics highlights how contract manufacturers are driving sustainability in the medical plastics industry.

This week, I’m rerunning some popular posts while we put the finishing touches on DCI’s new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors.

Click here to see the original post from June 2024.

ACRO’s Good Clinical Podcast is back with bonus episode! Host Sophia McLeod sat down with Tafoya Hubbard and Kristen Surdam to discuss ACRO’s new D&I Site Resource Grants Program.

The post Bonus Episode: Fast Facts on the ACRO D&I Grants Program first appeared on ACRO.

Hospitals have been forced to innovate with new ways of hydrating patients and giving them medications, after a key factory that produces IV fluid bags flooded during Hurricane Helene. (This story first aired on Morning Edition on Nov. 7, 2024.)

Pharmaceutical and biotech companies breathed a sigh of relief Monday when the Federal Circuit unanimously ruled in a precedential opinion that the mere sale of manufacturing services to create embodiments of a patented product is not a “commercial sale” of the invention that triggers the on-sale bar of 35 U.S.C. § 102(b) (pre-AIA).[1]  The en banc opinion...… Continue Reading

Growth Unlocked: Closing the Strategy-to-Execution Gap

Altimetrik defines future of the Enterprise Internet of Things