The Court of Appeal ruled that the “Chief Justice was wrong to conclude that the Respondent’s right to freedom of expression under section 9 of the Constitution was violated by the pursuit of criminal proceedings in this case”, in relation to former police officer Barbi Bishop who was alleged to have posted an ‘All Lives […]

The court has dismissed an appeal by Jahmico Trott, who was convicted of offences including attempted murder. The ruling noted that “On 30 March 2021, following a retrial, Jahmico Trott [“the Appellant”] was convicted by a majority verdict [11-1] of a jury for the offences of: attempted murder; using a firearm to commit an indictable […]

The court has dismissed an appeal from Ray Charlton against his conviction for intrusion of privacy and sexual assault, with Charlton lodging an appeal claiming “involuntary intoxication”. The ruling noted, “This is an appeal against Magistrate Mr. Craig Attridge’s finding of guilt against the Appellant on Counts 1 and 3 of Information 19CR00139 which consists […]

The Women’s Resource Centre said they are “heartened by the guilty verdict in the Chavelle Dillon-Burgess case,” noting it “is a landmark case for Bermuda, and we recognise the efforts of the Bermuda Police Service in bringing Mr. Worrell before the courts and we wait with anticipation for his sentencing next month.” Their statement follows […]

Noting they find “it very difficult to respond to a decision that is so tragic, and in no way reduces the tragedy of the loss of Chavelle Dillon-Burgess,” the Centre Against Abuse said they ”are grateful for the verdict of guilty of murder.” Their statement follows after Kamal Worrell was found guilty of the murder of Chavelle […]

The Bermuda Tourism Authority’s second annual Art Month in October will showcase Bermuda’s vibrant arts scene through cultural events, exhibitions, and special hotel deals for art lovers. A spokesperson said, “The Bermuda Tourism Authority [BTA] is excited to announce the second annual Art Month, running throughout October. This celebration puts a spotlight on Bermuda’s vibrant […]

Due to demand from vendors, The Brooklyn Independent Comics Showcase (BICS) is going to a two day show in 2025

Being a relatively visible public Witch, I get plenty of requests for spells, which I politely decline to do. I tell people two things: One is that it's best to create one's own spells rather than have someone else cast them. The other is a caution against performing any magic that would interfere with the free will of another. The exception to that would be a binding of someone else, making them unable to do further harm.

If you believe someone has put a negative spell on you (usually called a hex), here are a few things you can do to protect yourself, and possibly reverse the spell.

First, purify your person. Take a shower, or better yet, soak for a while in hot water containing sea salt, bath salts, or Epsom salts. Allow the salt and water to neutralize any negativity within yourself; think of this as you soak. Let any contamination be washed away with the water spiraling down the drain, out of your house and out of your life. Drink lots of water to wash out your insides. Wash your hair, brush your teeth, put on clean clothes. You may also wish to drink mint tea or another tea that you find refreshing.

Second, purify your dwelling. Dust, sweep, vacuum, tidy up, polish. Air out the rooms. Wash the windows with a mild solution of vinegar and water. This allows purifying sunlight and moonlight to illuminate the room as well as making the glass more reflective to deflect unwanted energies.[1]

Circulate through the rooms where you live with sage or other purifying incense, making sure to fumigate everywhere -- stairways, closets, underneath stairways, basement, attic, garage if attached. If your dwelling is one that you can circumnavigate, you may wish to walk all around the outside of the building wafting this smoke.

Then mix salt and water and sprinkle it around the house. As with the incense, do this around the outside of the home, too, if you can. Be sure to cense and sprinkle all openings to the outside -- doors and windows, of course, but also skylights, electrical outlets, heating vents, chimneys, ventilator hoods, toilets, and sink, tub and shower drains. Also do this to mirrors.

While you're doing these things, speak the words, "With Earth and Water I purify this space," and "with Fire and Air I consecrate this space," because that's exactly what you're doing.[2]

Third, ward your space. If you're the witchy sort, trace a protective pentacle with the salt water on all doors, windows and mirrors. Rosemary grows in abundance where I live, so I like to use a sprig of it to sprinkle the salt water. Then I like to leave rosemary sprigs on all the window sills.

When you've done all these things, take a step back, be very quiet, look around, listen and note how different your space feels to you now.

You may also wish to perform these acts at other places where you spend a lot of time, such as work, if you can.

One last thing you may want to do, although it's not as easy and practical as the rest. You may wish to hang little mirrors in the windows or on the outside of the building to reflect away negativity. The mirrors aren't really necessary; they're just extra insurance, if you will. You should be fine just doing the other things I've recommended.

Now envision yourself within a bubble. Project this bubble around you and around your home. Nothing can pass through the membrane that has not been invited by you. Anything unwelcome bounces off the bubble. Build a strong image of this bubble in your mind. If you have a small object, maybe a clear quartz crystal or a piece of rosemary, that reminds you of this visualization, carry it in your pocket or keep it someplace handy. You can't be expected to hold this image in your consciousness all the time. But if you have this object, then at times when the image has faded and you feel you need to reinforce your working, take it out and look at it and touch it to reawaken your sense of your protective bubble.

As with all magic spells, you needn't stick with the formula offered here. If other ingredients call to you or other actions spring from you, trust your intuition and go with them.

These are my recommendations. For another approach, here's a Lemon UncrossingSpell (to break a curse). I have never tried this so I can offer no assurance of its efficacy.

[1] For a super-duper heavy cleansing of a home, say if you're just moving in after someone else has been living there, and if you have the time, get some dragon's blood incense and burn it on a piece of charcoal in a container left in the bathtub or shower. As soon as you light it, leave and let it fumigate the entire house. You don't want to breathe much of this stuff. Then return a few hours later and open all the windows to let out the dragon's blood fumes.

[2] Some additional things you can do to cleanse a new or dirty home: Walk throughout the rooms with noisemakers, rattles, a drum to frighten off unwanted spirits. Do this before censing and sprinkling. After censing and sprinkling, ring a little bell at the windows and mirrors.

REVIEW – One of the nice experiences when buying a new smartphone is choosing nice cases that are not only attractive but provide protection and create a good gripping surface. Let’s see how this Smartish Gripzilla iPhone 16 Pro Max case works for me. What is it? The Smartish Gripzilla iPhone 16 Pro Max case […]

Antec Inc., a global leader in high-performance computer components and accessories, is proud to announce the launch of the Antec CX600M Trio Mid-Tower Gaming Case. This latest addition to Antec's chassis lineup combines compact design with cutting-edge modern style, delivering a jaw dropping microATX case that's perfect for modern, high-performance PCs.

The post Antec Introduces the CX600M Trio PC Case appeared first on ThinkComputers.org.

This new pillarless case is the iCUE LINK 3500X RGB which comes in as a mid-tower with three pre-installed iCUE LINK RX120 fans and the iCUE LINK System Hub. Of course you have glass front and side panels to show off your system, support for 360mm radiators, and this case is compatible with back-connect motherboards like ASUS’s BTF and MSI’s Project Zero. Let’s take a look and see what this case is all about!

The post Corsair iCUE LINK 3500X RGB Case Review appeared first on ThinkComputers.org.

This research was undertaken by Stuart Fordyce as part of an MSc in Integrated Service Improvement (Health and Social Care) at the University of Edinburgh. It considers the impact of a rapidly ageing population on a Scottish local authority and its attempt to shift the focus to a more contemporary service provision. The aim is to explore what factors are inhibiting the effectiveness of enablement. Using a case study approach the research explored whether: (i) enablement is wholly effective in addressing the increase in current service demands; (ii) the approach adopted by the local authority is undermined as services are now over extended and are attempting to address competing objectives, and; (iii) the paradigmatic change across the sector in the future will materialise if organisations cannot create the capacity and infrastructure to enable change to occur

Today's architecture is no longer about creating the best space just for humans, though of course that has to be a factor. It's also about preserving and living in harmony with the natural world. But being harmonious with nature presents a unique set of challenges. The Hidden Garden House by RAD+ar (Research Artistic Design + Architecture) is a showcase of creative and innovative solutions for just such a challenge.[...]

If this keep up I'll have no choice but to start calling dogs "goggies."

A teen in Canada may be the first person to catch an H5 bird flu virus within the country. Health officials are now working to confirm the diagnosis.

Q: What will happen in Donald Trump’s New York state criminal case now that he is president-elect?

A: Trump is scheduled to be sentenced on Nov. 26, but the judge could decide that sentencing is no longer appropriate. If Trump does receive a sentence, it could be appealed, or the judgment could be deferred until 2029, when Trump would be out of office.

FULL QUESTION

What happens if Trump wins the election and then he gets sentenced at the end of the month?

The post Trump’s New York Case: What Happens Now? appeared first on FactCheck.org.

The Princeton microbiologist has also created a non-infectious version of the COVID-19 virus that researchers can study safely.

Lecture Series | Overcoming Bipolarity: New Approaches to the Cold War

Minerallac Company, an electrical construction hardware manufacturer, find Repeat Signage software a useful tool for keeping staff updated on events and information. Staff is their satellite office, 2000 miles away, now feel more connected since digital signage was utilised.

The TV presenter says the previous Tory administration was "reckless" to scale back climate policy.

Over the past year, Aya and Khalid have been filming their lives for a BBC documentary.

Nations across the continent are eager to promote themselves as destinations for the curious visitor.

Israel's parliament, the Knesset, has suspended lawmaker Ofer Cassif for six months due to comments he made about the IDF, the war in Gaza, and his support for South Africa accusing his country of genocide against Palestinians.

A federal judge in Manhattan has agreed to hear Sean "Diddy" Combs argue again to be let out of jail pending his May 5 trial date on sex-trafficking.

Sean Combs is trying to sell the private jet, which prosecutors have said makes him a flight risk.

Apple is about to make losing your luggage far less of a hassle. The Cupertino tech giant is readying the… Continue reading Apple is about to eliminate the stress of losing a suitcase

The post Apple is about to eliminate the stress of losing a suitcase appeared first on ReadWrite.

New York Judge Juan Merchan — who is overseeing President-elect Donald Trump’s business records case — agreed to freeze the case until Nov. 19. There was to be a hearing […]

The post Judge Juan Merchan Grants Request from Trump's Legal Team and DA in NY Hush Money Case appeared first on The Western Journal.

Late injection Johan Grobbelaar may find himself more than simply an “extra” on the Bok tour, writes Rob Houwing.

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domain arrangement which comprises a helicase core, an RecQ C-terminal domain, and an auxiliary element helicase and RNaseD C-terminal (HRDC) domain, the functions of which are poorly understood. In this study, we systematically characterized the roles of the HRDC domain in E. coli RecQ in various DNA transactions by single-molecule FRET. We found that RecQ repetitively unwinds the 3'-partial duplex and fork DNA with a moderate processivity and periodically patrols on the ssDNA in the 5'-partial duplex by translocation. The HRDC domain significantly suppresses RecQ activities in the above transactions. In sharp contrast, the HRDC domain is essential for the deep and long-time unfolding of the G4 DNA structure by RecQ. Based on the observations that the HRDC domain dynamically switches between RecA core- and ssDNA-binding modes after RecQ association with DNA, we proposed a model to explain the modulation mechanism of the HRDC domain. Our findings not only provide new insights into the activities of RecQ on different substrates but also highlight the novel functions of the HRDC domain in DNA metabolisms.

A. V. Silantyev
Trans. Moscow Math. Soc. 83 (), 75-149.
Abstract, references and article information

Programmed ribosomal frameshifting (PRF) is a mechanism used by arteriviruses like porcine reproductive and respiratory syndrome virus (PRRSV) to generate multiple proteins from overlapping reading frames within its RNA genome. PRRSV employs −1 PRF directed by RNA secondary and tertiary structures within its viral genome (canonical PRF), as well as a noncanonical −1 and −2 PRF that are stimulated by the interactions of PRRSV nonstructural protein 1β (nsp1β) and host protein poly(C)-binding protein (PCBP) 1 or 2 with the viral genome. Together, nsp1β and one of the PCBPs act as transactivators that bind a C-rich motif near the shift site to stimulate −1 and −2 PRF, thereby enabling the ribosome to generate two frameshift products that are implicated in viral immune evasion. How nsp1β and PCBP associate with the viral RNA genome remains unclear. Here, we describe the purification of the nsp1β:PCBP2:viral RNA complex on a scale sufficient for structural analysis using small-angle X-ray scattering and stochiometric analysis by analytical ultracentrifugation. The proteins associate with the RNA C-rich motif as a 1:1:1 complex. The monomeric form of nsp1β within the complex differs from previously reported homodimer identified by X-ray crystallography. Functional analysis of the complex via mutational analysis combined with RNA-binding assays and cell-based frameshifting reporter assays reveal a number of key residues within nsp1β and PCBP2 that are involved in complex formation and function. Our results suggest that nsp1β and PCBP2 both interact directly with viral RNA during formation of the complex to coordinate this unusual PRF mechanism.

The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also capable of inhibiting autophagic flux, demonstrating the ability of these compounds to engage with more than one target. In this study, we present two additional mechanisms by which tenovins are able to activate p53 and kill tumor cells in culture. These mechanisms are the inhibition of a key enzyme of the de novo pyrimidine synthesis pathway, dihydroorotate dehydrogenase (DHODH), and the blockage of uridine transport into cells. These findings hold a 3-fold significance: first, we demonstrate that tenovins, and perhaps other compounds that activate p53, may activate p53 by more than one mechanism; second, that work previously conducted with certain tenovins as SirT1 inhibitors should additionally be viewed through the lens of DHODH inhibition as this is a major contributor to the mechanism of action of the most widely used tenovins; and finally, that small changes in the structure of a small molecule can lead to a dramatic change in the target profile of the molecule even when the phenotypic readout remains static.

To date, the imaging and diagnosis of hepatocellular carcinoma (HCC) rely on CT/MRI, which have well-known limitations. Glypican-3 (GPC3) is a cell surface receptor highly expressed by HCC but not by normal or cirrhotic liver tissue. Here we report initial clinical results of GPC3-targeted PET imaging with [⁶⁸Ga]Ga-DOTA-RYZ-GPC3 (RAYZ-8009), a peptide-based GPC3 ligand in patients with known or suspected HCC. Methods: [⁶⁸Ga]Ga-RAYZ-8009 was obtained after labeling the peptide precursor with ⁶⁸Ga from a ⁶⁸Ge/⁶⁸Ga generator and heating at 90°C for 10 min followed by sterile filtration. After administration of [⁶⁸Ga]Ga-RAYZ-8009, a dynamic or static PET/CT scan was acquired between 45 min and 4 h after administration. Radiotracer uptake was measured by SUVs for the following tissues: suspected or actual HCC or hepatoblastoma lesions, non–tumor-bearing liver, renal cortex, blood pool in the left ventricle, and gastric fundus. Additionally, tumor–to–healthy-liver ratios (TLRs) were calculated. Results: Twenty-four patients (5 patients in the dynamic protocol; 19 patients in the static protocol) were scanned. No adverse events occurred. Two patients had no lesion detected and did not have HCC during follow-up. In total, 50 lesions were detected and analyzed. The mean SUV_max of these lesions was 19.6 (range, 2.7–95.3), and the mean SUV_mean was 10.1 (range, 1.0–49.2) at approximately 60 min after administration. Uptake in non–tumor-bearing liver and blood pool rapidly decreased over time and became negligible 45 min after administration (mean SUV_mean, <1.6), with a continuous decline to 4 h after administration (mean SUV_mean, 1.0). The opposite was observed for HCC lesions, for which SUVs and TLRs continuously increased for up to 4 h after administration. In individual lesion analysis, TLR was the highest between 60 and 120 min after administration. Uptake in the gastric fundus gradually increased for up to 45 min (to an SUV_max of 31.3) and decreased gradually afterward. Conclusion: [⁶⁸Ga]Ga-RAYZ-8009 is safe and allows for high-contrast imaging of GPC3-positive HCC, with rapid clearance from most normal organs. Thereby, [⁶⁸Ga]Ga-RAYZ-8009 is promising for HCC diagnosis and staging. Further research is warranted.

The Supreme Court appeared skeptical that companies should be required to include past events in their risk disclosure statements during oral arguments for Facebook Inc. vs. Amalgamated Bank on Wednesday.

A hologram of a sex worker who was murdered in Amsterdam more than a decade ago could help solve the cold case, investigators hope.

U.S. Defense Secretary Lloyd Austin has pledged to get to the bottom of reports of military personnel experiencing mysterious illnesses while overseas.

Nov. 6, 2024 — CoolIT Systems, a world leader in liquid cooling systems for artificial intelligence (AI) and high-performance computing (HPC), will showcase its latest AI cooling products at the Supercomputing […]

The post CoolIT Systems Showcases AI and HPC Liquid Cooling Solutions at SC24 appeared first on HPCwire.

Nov. 7, 2024 — Since 2011, CSCS has hosted a booth at the annual SC Conference, and this year makes no exception. CSCS invites attendees to discover the latest news […]

The post CSCS to Showcase Swiss HPC Innovations at SC24 in Atlanta appeared first on HPCwire.

SANTA CLARA, Calif. and MUNICH, Nov. 7, 2024 — Cerabyte, a pioneer of ceramic-based data storage solutions, today announced its participation at SuperComputing 2024 (SC24), taking place at the Georgia […]

The post Cerabyte Discusses Use Cases for Its Ceramic Data Storage Solution at SC24 appeared first on HPCwire.

BUFFALO, N.Y., Nov. 11, 2024 — Motivair Corporation, a leading global provider of advanced liquid cooling solutions, will be showcasing its cutting-edge MI300X Dynamic Cold Plates at the upcoming International […]

The post Motivair to Showcase MI300X Cold Plates at SC24 for AI Servers appeared first on HPCwire.

MANCHESTER, England, Nov. 12, 2024 — PEAK:AIO today announced it has achieved 400% growth in U.S. sales over the past year. This expansion, driven by its high-performance, energy-efficient solutions, solidifies PEAK:AIO’s […]

The post PEAK:AIO Showcases Expansive Growth and Energy-Efficient Solutions Ahead of SC24 appeared first on HPCwire.