A drilling project in the Taklamakan desert is aiming to reach more than 11,000 metres below Earth’s surface as China explores the deep earth for resources

Anthropologists have been arguing for 20 years about whether Sahelanthropus, a hominin that lived about 7 million years ago, was one of the first bipedal apes

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Kelley uses familiars to click her buttons. Josh scribbles in comic sans over your collector's edition with a sharpie. Which is good because Chris can't handle yet another collector's edition. They're all doing better than Ryan, though, who is suffering from Wizardry PTSD.

The post RPG Cast – Episode 731: “Dragon Quest: Start Your Own Taco Adventure” appeared first on RPGamer.

Disaster was averted at a Kentucky hospital when an ostensibly deceased organ donor began “thrashing” around in the operating theater, a preservationist tells NPR.

“He was moving around,” Natasha Miller recalled of the patient, whom NPR identified as Anthony Thomas “TJ” Hoover II. “He was crying visibly.”

The two surgeons assigned to the transplant naturally refused to go through with the procedure, which was reportedly scheduled to take place at Baptist Health Richmond Hospital in October 2021. But when her colleague called Kentucky Organ Donor Affiliates, which coordinated the harvest, Miller said the supervisor told them they “were going to do the case” and needed to “find another doctor.”

Read more at The Daily Beast.

Black Ops 6 is here, and fans have been itching to know what's included in Season 1 - and now we have an answer. Here's what's included, and when you can play

After a dismal start, the UN is hosting a "halftime summit" about its 15-year plan to meet a series of human-development targets by 2030. Delegates will try to focus on problems like extreme poverty and gender equality while watching for sparks between the representatives of Ukraine and Russia.

U.S.-based startup company Heliospect Genomics reportedly is offering wealthy couples embryo screening for IQ and other traits at $50,000 for 100 embryos.

It says these components will enable "the industry's highest DRAM bit density".

Samples from the asteroid Ryugu contain key ingredients in the biological cookbook.

Prince Turki bin Faisal al-Saud, former Saudi ambassador to the United States, has written an open letter to President-elect Donald Trump asking him to “finish what you started the last time you occupied the White House” with respect to Middle Eastern affairs.

The post Saudi Royals Ask Trump to ‘Finish What You Started’ in Middle East appeared first on Breitbart.

Earlier this year, Feral Interactive’s superb iOS version of Alien: Isolation (Free) was updated to change the game’s business model …

Continue reading "‘Alien: Isolation’ for Android Is Now a Free To Start Release Just Like iOS Letting Everyone Try Two Missions for Free"

Harvest Moon: Home Sweet Home has been a very interesting game to follow pre-release. I say this not only because …

Continue reading "‘Harvest Moon: Home Sweet Home’ iOS Review – A Great Start, but Needs More Work"

The grant program provides hardware startups with reimbursement for working with local manufacturers.

December 31, 2020 at 11.59 pm – across the world there was a collective sigh of relief that the ‘lost year’ is truly behind us. The end of a year, ...

The post Start 2021 Fresh With These 12 New Year Resolutions appeared first on Star Observer.

Signal users may be familiar with the problem of creating group chats just for a group call, but that’s about to become a thing of the past. You can now share a call link and let up to 50 people hop in, all in the span of a few seconds. The days of selecting contacts one by one are over.

Now, all you have to do is create a call link after going to the Calls tab and send it to whomever you want. The link is also reusable, which is convenient if you have fixed call times. Participants can raise their hands and send emojis. Hosts can set the room up so people must be approved before joining the conversation.

Based on Signal’s blog post, the new group call experience highly resembles Zoom. Those interested in privacy yet desire a conference call-like experience may find the new update helpful. Like Zoom, the desktop app offers more options.

Besides Zoom, these features will be familiar to frequent users of Microsoft Teams, Google Meet and some WhatsApp users. Raising hands is found on all three platforms as a non-verbal way to signal the speaker. WhatsApp does have a lower participant count of 32 people after an update in June. While there’s no raise hands function, doing certain gestures can send emojis for all to see. It’s worth noting that many apps with group call functionality are adopting similar features.

These new features are available on Android, iOS, Windows and macOS. If you don’t see them yet, we recommend updating your Signal app.

If it seems like the Christmas shopping season starts earlier every year, you're not wrong. In response to growing customer demand, stores of all stripes brought out their festive collections weeks before the unofficial start of the holiday shopping season.

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest

The post The Biotech Startup Contraction Continues… And That’s A Good Thing appeared first on LifeSciVC.

Tech startups are stepping up to meet the needs of 60 million people worldwide who use opioids, representing about 1 percent of the world’s adult population. In the United States, deaths involving synthetic opioids have risen 1,040 percent from 2013 to 2019. The COVID-19 pandemic and continued prevalence of fentanyl have since worsened the toll, with an estimated 81,083 fatal overdoses in 2023 alone.

Innovations include biometric monitoring systems that help doctors determine proper medication dosages, nerve stimulators that relieve withdrawal symptoms, wearable and ingestible systems that watch for signs of an overdose, and autonomous drug delivery systems that could prevent overdose deaths.

Helping Patients Get the Dosage They Need

For decades, opioid blockers and other medications that suppress cravings have been the primary treatment tool for opioid addiction. However, despite its clinical dominance, this approach remains underutilized. In the United States, only about 22 percent of the 2.5 million adults with opioid use disorder receive medication-assisted therapy such as methadone, Suboxone, and similar drugs.

Determining patients’ ideal dosage during the early stages of treatment is crucial for keeping them in recovery programs. The shift from heroin to potent synthetic opioids, like fentanyl, has complicated this process, as the typical recommended medication doses can be too low for those with a high fentanyl tolerance.

A North Carolina-based startup is developing a predictive algorithm to help clinicians tailor these protocols and track real-time progress with biometric data. OpiAID, which is currently working with 1,000 patients across three clinical sites, recently launched a research pilot with virtual treatment provider Bicycle Health. Patients taking Suboxone will wear a Samsung Galaxy Watch6 to measure their heart rate, body movements, and skin temperature. OpiAID CEO David Reeser says clinicians can derive unique stress indications from this data, particularly during withdrawal. (He declined to share specifics on how the algorithm works.)

“Identifying stress biometrically plays a role in how resilient someone will be,” Reeser adds. “For instance, poor heart rate variability during sleep could indicate that a patient may be more susceptible that day. In the presence of measurable amounts of withdrawal, the potential for relapse on illicit medications may be more likely.”

Nerve Stimulators Provide Opioid Withdrawal Relief

While OpiAID’s software solution relies on monitoring patients, electrical nerve stimulation devices take direct action. These behind-the-ear wearables distribute electrodes at nerve endings around the ear and send electrical pulses to block pain signals and relieve withdrawal symptoms like anxiety and nausea.

The U.S. Food and Drug Administration (FDA) has cleared several nerve stimulator devices, such as DyAnsys’ Drug Relief, which periodically administers low-level electrical pulses to the ear’s cranial nerves. Others include Spark Biomedical’s Sparrow system and NET Recovery’s NETNeuro device.

Masimo’s behind-the-ear Bridge device costs US $595 for treatment providers.Masimo

Similarly, Masimo’s Bridge relieves withdrawal symptoms by stimulating the brain and spinal cord via electrodes. The device is intended to help patients initiating, transitioning into, or tapering off medication-assisted treatment. In a clinical trial, Bridge reduced symptom severity by 85 percent in the first hour and 97 percent by the fifth day. A Masimo spokesperson said the company’s typical customers are treatment providers and correctional facilities, though it’s also seeing interest from emergency room physicians.

Devices Monitor Blood Oxygen to Prevent Overdose Deaths

In 2023, the FDA cleared Masimo’s Opioid Halo device to monitor blood oxygen levels and alert emergency contacts if it detects opioid-induced respiratory depression, the leading cause of overdose deaths. The product includes a pulse oximeter cable and disposable sensors connected to a mobile app.

Opioid Halo utilizes Masimo’s signal extraction technology, first developed in the 1990s, which improves upon conventional oxygen monitoring techniques by filtering out artifacts caused by blood movement. Masimo employs four signal-processing engines to distinguish the true signal from noise that can lead to false alarms; for example, they distinguish between arterial blood and low-oxygen venous blood.

Masimo’s Opioid Halo system is available over-the-counter without a prescription. Masimo

Opioid Halo is available over-the-counter for US $250. A spokesperson says sales have continued to show promise as more healthcare providers recommend it to high-risk patients.

An Ingestible Sensor to Watch Over Patients

Last year, in a first-in-human clinical study, doctors used an ingestible sensor to monitor vital signs from patients’ stomachs. Researchers analyzed the breathing patterns and heart rates of 10 sleep study patients at West Virginia University. Some participants had episodes of central sleep apnea, which can be a proxy for opioid-induced respiratory depression. The capsule transmitted this data wirelessly to external equipment linked to the cloud.

Celero’s Rescue-Rx capsule would reside in a user’s stomach for one week.Benjamin Pless/Celero Systems

“To our knowledge, this is the first time anyone has demonstrated the ability to accurately monitor human cardiac and respiratory signals from an ingestible device,” says Benjamin Pless, one of the study’s co-authors. “This was done using very low-power circuitry including a radio, microprocessor, and accelerometer along with software for distinguishing various physiological signals.”

Pless and colleagues from MIT and Harvard Medical School started Celero Systems to commercialize a modified version of that capsule, one that will also release an opioid antagonist after detecting respiratory depression. Pless, Celero’s CEO, says the team has successfully demonstrated the delivery of nalmefene, an opioid antagonist similar to Narcan, to rapidly reverse overdoses.

Celero’s next step is integrating the vitals-monitoring feature for human trials. The company’s final device, Rescue-Rx, is intended to stay in the stomach for one week before passing naturally. Pless says Rescue-Rx’s ingestible format will make the therapy cheaper and more accessible than wearable autoinjectors or implants.

Celero’s capsule can detect vital signs from within the stomach. www.youtube.com

Autonomous Delivery of Overdose Medication

Rescue-Rx isn’t the only autonomous drug-delivery project under development. A recent IEEE Transactions on Biomedical Circuits and Systems paper introduced a wrist-worn near-infrared spectroscopy sensor to detect low blood oxygen levels related to an overdose.

Purdue University biomedical engineering professor Hugh Lee and graduate student Juan Mesa, who both co-authored the study, say that while additional human experiments are necessary, the findings represent a valuable tool in counteracting the epidemic. “Our wearable device consistently detected low-oxygenation events, triggered alarms, and activated the circuitry designed to release the antidote through the implantable capsule,” they wrote in an email.

Lee and Purdue colleagues founded Rescue Biomedical to commercialize the A2D2 system, which includes a wristband and an implanted naloxone capsule that releases the drug if oxygen levels drop below 90 percent. Next, the team will evaluate the closed-loop system in mice.

This story was updated on 27 August 2024 to correct the name of Masimo’s Opioid Halo device.

While startups in highly regulated industries like healthcare and finance are almost certain to face heightened scrutiny, there are controllable factors that can offset these challenges.

The post The Startup Economy is Turbulent. Here’s How Founders Can Recognize and Avoid Common Pitfalls appeared first on MedCity News.

KOLKATA — A court in the eastern state of West Bengal began the trial on Monday (Nov 11) of a police volunteer accused of raping and murdering a doctor at a government hospital in August, a case that sparked outrage over the lack of safety for women in India. The woman's body was found in a classroom at the R.G. Kar Medical College and Hospital in the state capital Kolkata on Aug 9, the federal police said. They also said they had arrested a police volunteer, Sanjay Roy, for the crime.

The estranged DMK M.P. spoke about party's corrupt image & predicted its downfall; criticised ‘freebies'; praised Rahul Gandhi; was ‘very downbeat' about United Progressive Alliance's electoral prospects

Sep 2, 2015

"The seed industry in sub-Saharan Africa is informal in nature, with approximately 80% of farmers saving and replanting seeds from year to year. This gives them security of access. But improved varieties — including high-yielding and hybrid crops — will increase productivity and income. To get these seeds into the hands of farmers, a better marketing and distribution system is needed. Local small and medium-sized seed enterprises have a comparative advantage in reaching this underserved market due to their size and market reach."

SMASHD Labs Season 2 is a 10-week accelerator program based out of Los Angeles talent firm Atom Factory. We are inviting companies at the intersection of entertainment, technology, and culture to work alongside our team to accelerate their growth. Join us and our roster of world-class mentors for a masterclass in hustle.

Volvo Cars pioneers two-hour in-car delivery service with Swedish start-up urb-it

Imagine, if you will: an entire wargame, with strategic depth and intriguing possibilities . . . and the rules fit on one page.

If you're a long-time fan of Steve Jackson Games (or you saw the Daily Illuminator post from a couple of weeks ago), you know where we're going with this. One-Page Bulge – originally released in 1980 – did exactly what its title suggests, with Steve Jackson flexing his inimitable game-design skills to deliver a Battle of the Bulge wargame where the rules fit on one sheet of 8.5" × 11" double-sided paper.

This classic game is back with a new edition: One-Page Bulge Second Edition – in time for the 80th anniversary of the pivotal battle itself!

Thanks to Kickstarter (and fans like you), this updated version funded in 40 minutes! In honor of that success, we're providing a few more details about what makes it worth checking out.

One-Page Bulge Second Edition is being updated by Steve Jackson and wargame designer Dana Lombardy – two Hall of Fame designers working together to bring this classic game to a modern era. Find their behind-the-scenes insight about the new version on YouTube!

Some highlights of this edition include:

• New Random Event cards, with exciting events to represent unexpected battlefield surprises.
• A full-color mounted map.
• High-quality components, with two styles of counter sets to choose from (or get them both!).

The best annual livestream about the worst video game ever made is back for 2024! 

• Munchkin Gift Pack
• Knightmare Chess
• Munchkin Starfinder: I Want It All!
• The Awful Green Things From Outer Space
• GURPS Girl Genius Sourcebook & Roleplaying Game

For January, the most recent month for which data is available, the TCI came in at -1.71, a significant improvement over December’s -6.1 and November’s -7.94. That was preceded by October’s -11.25, its lowest level since the April 2020 all-time low, at -28.66. The September TCI reading came in at -2.35.

Have you always wanted to delight hobbit passerby with a beautiful springtime flower display but don't feel confident in your green thumb? Then you're in luck! Kili is here to show you just how easy it is to plant and grow bulbs! Watch the new episode and read her tips below.

Bulb planting tips:

• Plant bulbs in the autumn so that they have time to chill over winter.
• Choose a spot with partial to full sun
• Bulbs need soil that drains well (so they don't turn to mush after prolonged exposure to moisture), so amend clay soil with perlite or other substances to aid drainage
• As a general rule, dig a hole twice as deep as the bulb is tall.
• Plant bulbs in the autumn so that they have time to chill over winter.
• After the flowers have finished, don't prune them off! Allow the plant to continue its lifecycle. The leaves will continue to create and store energy that the bulb will use the following spring! The will die away on their own in mid-to-late summer.

Happy Hobbit has brought Middle-earth to its viewers' daily lives since 2012! Learn more hobbity recipes, crafts, and more by watching new episodes and/or perusing the 10+ years worth of videos on their YouTube channel. ???? New episodes debut every other Saturday, so be sure you are subscribed to Happy Hobbit so that you don't miss out!

Get even more slow-living hobbit content by following Happy Hobbit on Instagram, Facebook, Twitter, and TikTok! If watching the show has left you with an appetite for more, know that Kili (Kellie) has a podcast where Tolkien is often mentioned called Forests, Folklore & Fantasy

The US Department of Homeland Security is trialling chemical sensors that detect the first whiff of smoke in the air and alert fire crews while a potential blaze is still smouldering

The EU has agreed new rules that will see member states automatically exchange information on income earned by sellers on digital platforms from 2023.