COVID-19 is a brutal villain, infecting millions and taking more than 185,000 lives worldwide, just over 100 of which were Iowans at the time of this writing. In the face of this, Iowans are showing the strength of their character. Individual acts of courage have become everyday occurrences. Nowhere is this truer than in our state’s long-term care centers.

The threat facing those in long-term care is unprecedented. Because many who are infected remain asymptomatic, efforts to prevent the virus from being introduced into facilities has proved difficult. Once the virus is introduced, it is hard to impede its spread — and virtually impossible without enhanced testing capabilities and more personal protective equipment (PPE) than we have access to today.

Long-term care providers have taken unprecedented steps to protect their residents, including prohibiting non-essential visitors in early March. Unfortunately, even with these measures and following guidance from the Centers for Medicare and Medicaid Services, the Centers for Disease Control and Prevention and other public health officials, more than 3,600 long-term care facilities nationwide have been impacted by the virus, including 13 in Iowa.

Yet, in the face of this challenge, our long-term care workers are performing with a valor we have not seen during peacetime in a generation; maybe two.

While many of us are hunkered down in our homes teleworking and spending time with our families, these caregivers are leaving their families to provide care for the loved ones of others. What these caregivers are doing and what they are sacrificing is remarkable. We owe them our gratitude, and we owe them our best efforts to address their critical needs.

Adequate PPE and routine testing for long-term care are paramount. While there has been significant attention paid to providing hospitals with PPE, it is imperative we not overlook those working in long-term care.

More than 70% of long-term care facilities nationwide report they lack enough PPE. This not only puts our caregivers at risk, it also puts the people they care for at greater risk. Preventing the introduction of the virus and containing its spread in nursing homes and assisted living facilities is one of the most important things we must do to relieve pressure on hospitals now.

Testing is a critical area where more support is needed. There are protocols in place to limit the spread of the virus once it is in a facility, including establishing isolation wings where those who have the virus are kept apart from the rest of the residents and are cared for by staff who do not interact with those in the rest of the building. But the virus leaves many of those infected without symptoms, these steps cannot be effectively implemented without broader testing.

We applaud Gov. Kim Reynolds’ recent action to broaden testing for some of Iowa’s long-term care staff. Equally important is the plan to address potential staff shortages which may result from expanded testing. Since a test result only captures an individual’s infection status for a fixed period of time, long-term care staff and residents must be prioritized at the highest level to receive ongoing testing to effectively identify infections and respond as early as possible.

Those one the front lines of this fight need the tools to confront, contain and ultimately defeat the virus. There is reason to be hopeful. Even though residents of long-term care are particularly at risk, most recover from the virus. Caregivers can do even more amazing work if we get them the tools they need: protective equipment, testing and staffing.

It is time to rally around our long-term care residents and staff, and give them the support they need and deserve.

Brent Willett is president and CEO of the Iowa Health Care Association.

Several hundred cars were parked outside a food bank in San Antonio on Good Friday — the food bank fed 10,000 people that day. Such scenes, increasingly common across the nation and evocative of loaves and fish, reflect the cruel facts about the wealthiest nation in the world: 80 percent of Americans live paycheck to paycheck, and 100 percent of Americans were unprepared for the COVID-19 pandemic. People are hungry due to macroeconomic and environmental factors, not because they did something wrong. Although everyone is at risk in this pandemic, the risk is not shared equally across socioeconomic classes. Universal basic health care could resolve this disparity and many of the moral and economic aspects associated with the pandemic.

Increases in the total output of the economy, or the gross domestic product (GDP), disproportionately benefit the wealthy. From 1980 to 2020, the GDP increased by 79 percent. Over that same time, the after-tax income of the top 0.01 percent of earners increased by 420 percent, while the after-tax income of the middle 40 percent of earners increased by only 50 percent, and by a measly 20 percent for the bottom 50 percent of earners. At present, the top 0.1 percent of earners have the same total net worth as the bottom 85 percent. Such income inequality produces poverty, which is much more common in the U.S. than in other developed countries. Currently 43 million Americans, or 12.7 percent of the population, live in poverty.

At the same time, 30 million Americans are uninsured and many more are underinsured with poorly designed insurance plans. The estimated total of uninsured and underinsured Americans exceeds 80 million. In addition, most of the 600,000 homeless people and 11 million immigrants in the U.S. lack health care coverage. Immigrants represent an especially vulnerable population, since many do not speak English and cannot report hazardous or unsafe work conditions. Furthermore, many immigrants avoid care due to fear of deportation even if they entered the country through legal channels.

Most people in poverty and many in the middle class obtain coverage from federal programs. On a national level, Medicaid is effectively a middle-class program and covers those living in poverty, 30 percent of adults and 60 percent of children with disabilities as well as about 67 percent of people in nursing homes. In Iowa, 37 percent of children and 48 percent of nursing home residents use Medicaid. Medicaid also finances up to 20 percent of the care provided in rural hospitals. Medicare, Medicaid and the Children’s Hospital Insurance Program (CHIP) together cover over 40 percent of Americans.

In addition to facilitating care, health care policy must also address the “social determinants of health,” since the conditions in which people live, work, and play dictate up to 80 percent of their health risks and outcomes. This means that health care reform requires programs in all facets of society. Winston Churchill first conceptualized such an idea in the early 20th century as a tool to prevent the expansion of socialism, arguing that inequality could persist indefinitely without social safety nets. Since that time most developed countries have implemented such social programs, but not the US.

All developed countries except the U.S. provide some type of universal basic health care for their residents. Universal basic health care refers to a system that provides all people with certain essential benefits, such as emergency services (including maternity), inpatient hospital and physician care, outpatient services, laboratory and radiology services, treatment of mental illness and substance abuse, preventive health services (including vaccinations), rehabilitation, and medications. Providing access to these benefits, along with primary care, dramatically improves the health of the community without imposing concerns regarding payment. Perhaps not coincidentally, the U.S. reports a lower life expectancy and higher rates of infant mortality, suicide and homicide compared to other developed countries.

Countries such as Canada, Great Britain, Denmark, Germany, Switzerland, Australia, and Japan all produce better health care outcomes than the U.S. at a much lower cost. In fact the U.S. spends about twice the percentage of its GDP on health care compared to these countries. With that being said, the Affordable Care Act of 2010 (ACA), which facilitated a decrease in the rate of the uninsured in the U.S. from 20 percent to 12 percent, also decreased the percentage of the GDP spent on health care from 20.2 percent to 17.9 percent in just 10 years. For this reason, most economists agree that universal basic health care would not cost more than the current system, and many would also argue that the total costs of the health care system cannot be further reduced unless everyone has access to basic care.

Achieving successful universal basic health care requires a serious long-term commitment from the federal government — contributing to Medicaid and financing its expansion are not enough. It requires courage from our elected leaders. The ACA took several important steps toward this goal by guaranteeing coverage for preexisting conditions, banishing lifetime maximums for essential services, and mandating individual coverage for everyone, though Congress repealed this final provision in 2017. At present, the ACA requires refinement and a public option, thereby preserving private and employer-based plans for those who want them.

Without universal basic health care the people living at the margins of society have no assurances that they will have access to basic health care services, especially during times of pandemic. Access to food and medications is less reliable, large families live together in small spaces, and public transportation facilitates frequent exposure to others. Childhood diseases such as asthma, chronic diseases such as diabetes, and diseases related to smoking such as COPD and cancer are all likely to worsen. Quarantine protocols also exacerbate the mental health crisis, further increasing rates of domestic violence, child abuse, substance abuse, depression, and suicide. In the last six weeks over 30 million Americans have applied for unemployment benefits, and as people become unemployed, many will lose health insurance.

Access to basic health care without economic or legal consequences would greatly enhance all aspects of pandemic management and response, from tracing contacts and quarantining carriers to administering tests and reinforcing supply chains. The COVID-19 pandemic has disproportionately affected minorities and the impoverished in both mortality and livelihood. Universal basic health care helps these vulnerable populations the most, and by reducing their risk it reduces the risk for everyone. In this way, universal basic health care supports the best interests of all Americans.

Like a living wage, universal basic health care aligns with the Christian tradition of social justice and is a moral and economic imperative for all Americans. Nurses, doctors, and other health care providers often observe a sharp contrast between the haves and have-nots when seeing patients. The homeless, the hungry, the unemployed, the working poor, the uninsured; people without families, patients with no visitors, those who live alone or lack support systems; refugees and immigrants — all of these people deserve the fairness and dignity provided by universal basic health care and programs which improve the social determinants of their health. The ACA moved U.S. toward this goal, but now it requires refinement and a public option. The COVID-19 pandemic highlights the urgency of this imperative by demonstrating how universal basic health care could decrease the risks to those less fortunate, thus significantly decreasing the risks to everyone.

James M. Levett, MD, serves on the board of Linn County Public Health and is a practicing cardiothoracic surgeon with Physicians’ Clinic of Iowa. Pramod Dwivedi, MS, DrPH (c), is the health director of Linn County Public Health.

Durant cette période de confinement, les créatifs rivalisent d’ingéniosité pour rester créatifs et continuer leur pratique. C’est le cas du photographe Florian W.  Mueller. Contraint de rester chez lui avec son fils de 6 ans et donc dans l’impossibilité de voyager pour réaliser des projets, il a opté pour la création à domicile. Lorsque son […]

Background

CEDAR RAPIDS — After a bitter battle between residents and one of the city’s major employers — Cargill — with the city of Cedar Rapids in the middle, in December, the Cedar Rapids City Council approved a $6.5 million, 12-track, 200-car rail yard located between the Rompot neighborhood and Prairie Park Fishery.

Cargill wanted to buy and put the rail yard on a 28-acre city-owned site on Stewart Road SE. Construction required rezoning the land to industrial use and a change to the city’s future land use map — putting city officials in the spotlight.

The rail yard was needed for more supply chain stability and to protect jobs at the corn-milling plant, at 1710 16th St. SE and not far from the rail yard site, company officials said. Cargill officials planned to submit final paperwork within a month of the vote, begin construction in early spring and have the rail yard operating by the end of the year.

A lot and nothing.

Before construction was to begin, the city required Cargill to provide a third-party appraisal of the land. The city had provided an initial value of $83,200, which Cargill agreed to match. However, the value of the land has been in question as nearby properties ranged from $20,000 to $30,000 an acre, which was far greater than the $3,000 per acre value the city used.

City officials say the appraisal has not been submitted, nor has Cargill sought the required permits before construction can begin.

This delay began well before disruptions from the coronavirus pandemic and after lawsuits were filed to block the rail yard.

Rompot resident and state Sen. Rob Hogg, who is a lawyer, filed two lawsuits against the City Council — one each challenging the rezoning vote and the vote to change the future land use map. Numerous neighbors and others in opposition to the rail yard have joined the lawsuit, which Hogg supported.

Meanwhile, Cargill intervened on behalf of the city. At this point, sides still are arguing whether to expand the record to include additional evidence. Dates for a hearing have not been set.

So, the status of the contentious rail yard and a timeline for construction remains in limbo.

“We don’t have anything new to share at this point regarding work and timelines specific to the development of the rail yard,” Kelly Sheehan, a spokeswoman for Cargill, said in late April.

In normal times, Chew on This focuses on restaurant openings and closings. These are not normal times, with restaurants closed except to carryout, curbside and delivery. We know these businesses still need support from the community to survive, so each week we are going to highlight five local restaurants.

These are just a few of the many places offering barbecue; look up your favorite restaurants on Facebook or call to find out what they have.

If you don’t want to leave the house, try a delivery service like Chomp, GrubHub or MyTown2Go. Check with the restaurant to make sure they’re affiliated with a delivery service before ordering.

124 Second Ave. NW, Mount Vernon; (319) 535-1060, facebook.com/bigsbbq

Get a growler of house-brewed beer to pair with your barbecue. Every Wednesday features a wings special; check the Facebook page for additional daily specials.

6677 16th Ave. SW, Cedar Rapids; (319) 378-4777, facebook.com/austinbluesbbq

Call in advance orders from 3 to 7 p.m. Wednesday to Friday and pickup from the food truck parked in the parking lot or stop by the truck parked at Cassill Motors, 2939 16th Ave. SW, Cedar Rapids, from 11 a.m. to 1 p.m. Wednesdays and Fridays.

1940 Lower Muscatine, Iowa City, (319) 354-7427 and 745 Community Dr., North Liberty, (319) 665-2486; jimmyjacksribshack.com

This Iowa City staple has classic dishes like ribs, smoked chicken and brisket and can even please vegetarians with a portobello sandwich.

525 S. Gilbert St., Iowa City, (319) 338-1419 and 125 E. Zeller St., North Liberty, (319) 626-4227; mosleysbarbecue.com

Try a family-style meal for curbside pickup, featuring four sandwiches or a slab of ribs, plus sides and cornbread, or order off the menu.

288 Blairs Ferry Rd. NE, Cedar Rapids; (319) 206-3806, willieraysqshack.com

This tiny establishment was made for social distancing, with drive-through the only option for service even before the pandemic. Get one of the daily specials or order a la carte.

Comments: (319) 398-8339; alison.gowans@thegazette.com

It’s been a few months since the release of the Recipe Card Blocks PRO plugin, and our team continued to release new updates constantly for both versions of the plugin: Free & PRO. As we’ve released many major updates for both versions in the past months, let’s make a quick overview of the most important changes and new features we’ve […]

When I wrote about The Golden Age of x86 Gaming, I implied that, in the future, it might be an interesting, albeit expensive, idea to upgrade your video card via an external Thunderbolt 3 enclosure.

I'm here to report that the future is now.

Yes, that's right, I paid $500

We’re working on redesigning the Pagebreak Podcast website and decided to get some caricatures of us made by Ricardo Gimenes.Check ’em out! We’re SO CUTE!

When you’re a freelancer and you start to work directly with your clients, there’s something crucial you need to know. Your design is not the one and only, most important aspect of the transaction. While presenting your client with an amazing design is the final goal, there are a lot of other things at stake […]

Read More at 7 Biggest Mistakes Freelance Designers Make That Will Ruin Their Career

Patients with disabilities must receive the same level of lifesaving medical treatment from hospitals during the coronavirus pandemic as able-bodied patients, the Trump administration said.

Belum pernah bermain judi sbobet online? Tenang saja, saya akan memberikan ulasan tentang bagaimana caranya untuk menjadi salah satu member di judi casino terpercaya. Untuk penjelasan yang lebih lengkap lagi, silahkan simak ulasan yang ada di bawah ini. Situs judi sbobet online memang menjadi favorit bagi para pemain saat ini. Ada banyak sekali orang yang …

More "Cara Bergabung Bersama Judi Casino Sbobet Terpercaya"

The post Cara Bergabung Bersama Judi Casino Sbobet Terpercaya appeared first on Situs Agen Judi Live Casino Online Indonesia Terpercaya.

Print Peppermint is one of the most refreshingly creative online printers on the internet at the moment. Their endless range of high-end business cards with unique special finishes like: foil stamping, die-cutting, embossing, letterpress, and edge painting, coupled with a meticulously curated family of thick premium papers make them a rather deadly force. Move over Moo and […]

The post Giveaway: 500 Holographic Raised Foil Business Cards – 100% Free appeared first on WebAppers.

In this tutorial we’ll draw a funny cartoon car in a simple stylized flat car. We don’t actually need any advanced drawing skills or even a tablet to create this stylized object as we’ll be working with basic geometric shapes and the most useful tools of Adobe Illustrator. Such simple and trendy illustrations are perfect […]

The post How to Draw a Stylized Flat Car in Adobe Illustrator appeared first on Vectips.

By Jennifer Stitt Aeon In 1957, the world watched in wonder as the Soviet Union launched Sputnik 1, the first artificial satellite, into outer space. Despite Cold War anxieties, The New York Times admitted that space exploration ‘represented a step … Continue reading →

Every day thousands of business cards exchange hands, and these business cards often get lost in mounds of other cards. Often, clients are unable to reach you just because they couldn't find your...

The truth is, all family members are both a source of joy and a burden at one time or another. That’s what family life is: the art of weaving webs of joy between strands of pain is what creates the intricate fabric of family love. It’s not the people in our care who burden us; it’s our anger over circumstances...

It happens slowly, like that metaphorical frog you’ve heard about. Possessiveness and controlling behavior in TBI caregivers is something that creeps up on you, and I suspect it is common — not because people are trying to be annoying, but because they care so much and want to see that their loved one is treated well in every respect.

I didn’t even know who or what I was angry at. Fate? Bad luck? The person who hit my husband with her car?

Tags: coronavirus, Feilding Cage, healthcare, policy, Reuters

By The Conversation While it’s true that Earth’s temperatures and carbon dioxide levels have always fluctuated, the reality is that humans’ greenhouse emissions since the industrial revolution have put us in uncharted territory. Written by Dr Benjamin Henley and Assoc … Continue reading →

By Jennifer Stitt Aeon In 1957, the world watched in wonder as the Soviet Union launched Sputnik 1, the first artificial satellite, into outer space. Despite Cold War anxieties, The New York Times admitted that space exploration ‘represented a step … Continue reading →

You know you've made it BIGTIME when you're a face card in a WordPress card game! @angrycreative @Kickstarter https://t.co/tFbB4ROhKS #WordPress #WooCommerce pic.twitter.com/WMPf5sffkM — Magnus Jepson (@mjepson) December 13, 2017

Adam offers advice to caregivers of a loved one with TBI and/or PTSD — from simply trying to see how that person's life has changed to helping him get involved in confidence-boosting activities.

Dark-schemed One Pager built using Webflow for product designer Cai Cardenas. Neat touch with the waving emoji animation and how the links match the brand colors. Full Review

By Melissa Hellmann Yes! Magazine A new report revealed surprising results when Oakland overhauled its lunch menu at 100-plus schools by serving less meat and more fruits and vegetables. When her eldest son was in elementary school in the Oakland … Continue reading →

By Jessica Corbett Common Dreams Analyses show how demand for electric vehicles and rapidly falling renewable energy prices could take down oil and gas industry As an increasing number of nations make plans for banning gas and diesel vehicles within … Continue reading →

I talk a big game about self-care, but the truth is: life happens. We can’t all be perfect in our self care routines all the time. We’re human. The name of the game is progress, not perfection. But how do we avoid getting so far off track, that the occasional slip turns into a trend? If you’re feeling a bit drained, disconnected, or even sick, it might be time for a reset. In this episode, I share a few strategies I use to help me check-in and course correct. Is it time for a self-care reboot? Enjoy! FOLLOW CHASE: instagram | twitter | website Listen to the Podcast Subscribe   This podcast is brought to you by CreativeLive. CreativeLive is the world’s largest hub for online creative education in photo/video, art/design, music/audio, craft/maker, money/life and the ability to make a living in any of those disciplines. They are high quality, highly curated classes taught by the world’s top experts — Pulitzer, Oscar, Grammy Award winners, New York Times best selling authors and the best entrepreneurs of our times.

The post Self-Care Reboot appeared first on Chase Jarvis Photography.

I am huge fan of the universe of Star Wars, it is amazing how vast and detailed this it can be. I am also a lover of the playing cards designs, you can big array of topics from sexy to nerdy ones. Just like this ones, a complete set of playing cards based on the …

Star Wars Playing Card Deck Read More »

Taking your first steps in programming is like picking up a foreign language. At first, the syntax makes no sense, the vocabulary is unfamiliar, and everything looks and sounds unintelligible. If you’re anything like me when I started, fluency feels impossible. I promise it isn’t. When I began coding, the learning curve hit me — hard. I spent ten months teaching myself the basics while trying to stave off feelings of self-doubt that I now recognize as imposter syndrome.

We derive the non-relativistic $c oinfty$ and ultra-relativistic $c o 0$ limits of the $kappa$-deformed symmetries and corresponding spacetime in (3+1) dimensions, with and without a cosmological constant. We apply the theory of Lie bialgebra contractions to the Poisson version of the $kappa$-(A)dS quantum algebra, and quantize the resulting contracted Poisson-Hopf algebras, thus giving rise to the $kappa$-deformation of the Newtonian (Newton-Hooke and Galilei) and Carrollian (Para-Poincar'e, Para-Euclidean and Carroll) quantum symmetries, including their deformed quadratic Casimir operators. The corresponding $kappa$-Newtonian and $kappa$-Carrollian noncommutative spacetimes are also obtained as the non-relativistic and ultra-relativistic limits of the $kappa$-(A)dS noncommutative spacetime. These constructions allow us to analyze the non-trivial interplay between the quantum deformation parameter $kappa$, the curvature parameter $eta$ and the speed of light parameter $c$.

The central aim of this paper is to study (regional) fractional Poincar'e type inequalities on unbounded domains satisfying the finite ball condition. Both existence and non existence type results are established depending on various conditions on domains and on the range of $s in (0,1)$. The best constant in both regional fractional and fractional Poincar'e inequality is characterized for strip like domains $(omega imes mathbb{R}^{n-1})$, and the results obtained in this direction are analogous to those of the local case. This settles one of the natural questions raised by K. Yeressian in [ extit{Asymptotic behavior of elliptic nonlocal equations set in cylinders, Asymptot. Anal. 89, (2014), no 1-2}].

Let $Gamma$ be a discrete group acting properly discontinuously and isometrically on the three-dimensional anti-de Sitter space $mathrm{AdS}^{3}$, and $square$ the Laplacian which is a second-order hyperbolic differential operator. We study linear independence of a family of generalized Poincar'{e} series introduced by Kassel-Kobayashi [Adv. Math. 2016], which are defined by the $Gamma$-average of certain eigenfunctions on $mathrm{AdS}^{3}$. We prove that the multiplicities of $L^{2}$-eigenvalues of the hyperbolic Laplacian $square$ on $Gammaackslashmathrm{AdS}^{3}$ are unbounded when $Gamma$ is finitely generated. Moreover, we prove that the multiplicities of extit{stable $L^{2}$-eigenvalues} for compact anti-de Sitter $3$-manifolds are unbounded.

Making changes to a program to optimize its performance is an unscalable task that relies entirely upon human intuition and experience. In addition, companies operating at large scale are at a stage where no single individual understands the code controlling its systems, and for this reason, making changes to improve performance can become intractably difficult. In this paper, a learning system is introduced that provides AI assistance for finding recommended changes to a program. Specifically, it is shown how the evaluative feedback, delayed-reward performance programming domain can be effectively formulated via the Monte Carlo tree search (MCTS) framework. It is then shown that established methods from computational games for using learning to expedite tree-search computation can be adapted to speed up computing recommended program alterations. Estimates of expected utility from MCTS trees built for previous problems are used to learn a sampling policy that remains effective across new problems, thus demonstrating transferability of optimization knowledge. This formulation is applied to the Apache Spark distributed computing environment, and a preliminary result is observed that the time required to build a search tree for finding recommendations is reduced by up to a factor of 10x.

After several weeks of not playing because of a concussion and then failing  several baseline tests, Briana Scurry became very worried.

"I knew I was in trouble ... I didn't know how much trouble," says retired soccer star Briana Scurry.

The Cannabis Issue During normal times, I-90 Green House is like a destination resort for marijuana lovers.…

There are no legal skirmishes in Ford v Ferrari.…

By Adam Liptak The New York Times Company…

For parents of budding artists and creative types, it can often seem like the arts get short shrift in the K-12 curricula, especially at a time when STEM — short for science, technology, engineering and math — is the buzzword in education and the most visible casualties of school budget cuts are librarians and music teachers.…

ProPublica’s health reporter Caroline Chen explains what the conversation around asymptomatic coronavirus carriers is missing, and what we need to understand if we’re going to beat this nefarious virus together. By Caroline Chen, ProPublica In the early days of the coronavirus outbreak in the U.S., around the last week of February, I joked to a colleague that maybe now, finally, people would learn how to wash their hands properly.…

The present invention relates to a process for preparing a compound of formula wherein: R2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR3R4, —CN or CO2R5; R3, R4 and R5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

Provided are processes for the oxidative cleavage of a double bond in an unsaturated carboxylic acid. The process includes contacting the unsaturated carboxylic acid with a mild oxidizing agent and agitating the unsaturated carboxylic acid and the mild oxidizing agent for a time sufficient to cleave a double bond of the unsaturated carboxylic acid and produce a product comprising an aldehyde. The process is typically carried out in a mill, such as a ball, hammer, attrition, or jet mill.

Described herein are dicarboxylate-capped estolide compound and methods of making the same. Exemplary dicarboxylate-capped estolide compounds include those of the formula x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected from 0 to 20; W is, independently for each occurrence, selected from —CH2— and —CH═CH—; z is an integer selected from 1 to 40; n is an integer equal to or greater than 0; R5 is selected from hydrogen, optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, and an estolide residue; and R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said at least one compound is independently optionally substituted.

Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain pyridyl-amino-pyrazine carbonitrile compounds that, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or thymidylate synthase (TS) inhibitor; (d) a microtubule targeted agent; and (e) ionizing radiation.

A primer solution for enhanced adhesion to a rigid substrate for aviation and aerospace applications includes an aminosilane-capped polyurethane prepolymer and a first solvent. The first solvent reacts with or modifies the surface of the rigid substrate, enabling the primer solution including the aminosilane-capped polyurethane prepolymer to become a part of the surface of the rigid substrate.

1,4-Dihydropyridine-3-carboxylate derivatives are produced having vasodilating and hypotensive action.

Carbohydrate substituted dibenzo[d,g][1,3,2]dioxaphosphocin compounds of formula I ##STR1## where A is a carbohydrate residue are effective stabilizers for polymers processed at elevated temperatures and subject to thermal or oxidative degradation.