Title: AHA News: After Three Strokes, He 'Overheard' the Grim Prognosis and Fought Back
Category: Health News
Created: 8/20/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

The potential for more than one distinct hematolymphoid neoplasm to arise from a common mutated stem or precursor cell has been proposed based on findings in primary human malignancies. Particularly, angioimmunoblastic T-cell lymphoma (AITL), which shares a somatic mutation profile in common with other hematopoietic malignancies, has been reported to occur alongside myeloid neoplasms or clonal B-cell proliferations, with identical mutations occurring in more than one cell lineage. Here we report such a case of an elderly woman who was diagnosed over a period of 8 years with diffuse large B-cell lymphoma, polycythemia vera, and AITL, each harboring identical somatic mutations in multiple genes. Overall, at least five identical nucleotide mutations were shared across multiple specimens, with two identical mutations co-occurring at variable variant allele frequencies in all three specimen types. These findings lend credence to the theory that a common mutated stem cell could give rise to multiple neoplasms through parallel hematopoietic differentiation pathways.

Exoplanets in binary star systems usually orbit both stars, but astronomers have now spotted three planets orbiting one or the other star in a pair

Three people have been taken to hospital after a car mounted the pavement and smashed into a restaurant in Piccadilly Circus, the Metropolitan Police have said.

Home users can opt in for a single year of updates at $30 per PC—not 3 years.

Demand for observing time on Webb outpaces supply by a factor of nine.

Hombale Films and Prabhas will begin their three-film partnership with ‘Salaar 2’, to be directed by Prashanth Neel

Apple just announced October 2024’s new Apple Arcade games with NBA 2K25 Arcade Edition as the headliner. Following yesterday’s news …

Continue reading "‘NBA 2K25 Arcade Edition’ Headlines October 2024’s New Apple Arcade Releases With Three App Store Greats"

Climate activists won against Shell in 2021 when a Dutch court commanded the oil giant to reduce its carbon emissions by 45 percent by the end of 2030. Three years later, Shell managed to win its appeal against this ruling. In the court's view, Shell doesn’t have a “social standard of care” to curtail emissions, the BBC reports.

The 2021 ruling was noteworthy, as it was the first time a court made a private company obey the 2015 Paris Agreement in addition to Dutch law. However, the appeals court judge said that while Shell had an obligation to reduce emissions, a 45 percent cut could not be established as there is no universally accepted amount. Shell’s statement says it’s planning to reduce its products’ carbon intensity by a comparatively paltry 15 to 20 percent by 2030 compared to a 2016 baseline.

The 2021 ruling would only be effective in the Netherlands as well. Shell wouldn’t have been legally obligated to follow the lower court's ruling for its operations outside Dutch territory. Now even that small gain is off the table for now.

The activists, who are largely associated with Milieudefensie (the Dutch branch of Friends of the Earth), issued a statement promising to continue the fight against climate change. “Large polluters are powerful. But united, we as people have the power to change them,” said Donald Pols, Director of Milieudefensie. They’re now trying to take the case to the Supreme Court, but getting a final verdict will likely take years.

This article originally appeared on Engadget at https://www.engadget.com/science/shell-wins-appeal-in-dutch-court-after-three-year-battle-against-green-groups-165543894.html?src=rss

Mumbai (AFP) Nov 2, 2024
Indian security forces killed three suspected militants in two separate firefights in disputed Kashmir, the army and a senior police official said Saturday. Muslim-majority Kashmir has been divided between rivals India and Pakistan since their independence from British rule in 1947 and is home to a long-running insurgency. The first firefight broke out after Indian troops moved to check

Canadian rental prices fell 1.2 per cent in October compared to the same time last year. It's the first time that annual rents have declined since July 2021, according to a new report.

A review of 47,282 tree species by the International Union for Conservation of Nature found that more than one third are at risk of extinction

At dusk and dawn, the sky dances with three phases of in-between light

<p>The European Commission (EC) granted marketing authorization for<b>&nbsp;</b>three ustekinumab biosimilars<b>:&nbsp;</b>Samsung Bioepis’ Eksunbi on 12 September 2024; Formycon’s Fymskina, and Fresenius Kabi’s&nbsp;Otulfi on 25 September 2024.</p>

Yesterday’s conference sessions surfaced interesting questions and approaches regarding the post-acute sector, bundled payment, emergency medicine and anesthesia. Post-Acute Focus: With more and more focus on the need to rationalize and re-organize the post-acute sector, we have seen multiple industry leaders start to evolve their strategies.  I blogged yesterday about AccentCare’s interesting strategy in the...… Continue Reading

Chinese officials had approached the Indian government for more information but had since been reportedly told by the Indian government that the information presented was sufficient to justify the listing.

For 18 months after Charlie’s death, my only desire was to grieve. I celebrate how deeply I let myself experience my grief and how completely I prioritized myself during this time. I took a sabbatical, and only did what I felt like doing. At first it was mostly crying in bed. After a couple of […]

From the discovery of new elements to the testing of novel theories of gravity, total solar eclipses have helped spark scientific progress for centuries

I know we've all been tempted sometimes, minions, but these people actually did it.

UP TOP!

ON THE TRAY!

IN THE FLAY!

Er, flag. She meant flag. But I guess this works.

And extra credit to the teacher who did NOT tell her baker where to stick it, but instead handed over a notepad with all her kids' names on it, so the baker could just copy them on to the cake.

Sadly, the baker stuck it anyway:

Right where the sun won't shine!

(You know, because they're inside.)

Thanks to Annie, Trinity L., Kaye P., &amp; Molly H. for teaching us all a lesson on following directions.

Also teachers, if you're looking for a new notepad, I'm really liking these:

Everything Is Fine Notepads

*****

And from my other blog, Epbot:

America has not been attacked like this since 9/11. Six unelected people forcing their christian nationalist agenda on a population of three hundred and forty million is not a Democracy. It is tyranny.

It was late winter when my sabbatical began, and it’s late spring as it comes to an end. Next week I return to my post after three months’ paid leave, courtesy of Automattic’s sabbatical benefit. Three months. A season. With full pay, and zero work responsibilities. In a job full of rewards, this is perhaps the greatest […]

The post The gift of a three-month sabbatical appeared first on Zeldman on Web and Interaction Design.

It wants commitments on prices and 5G if the creation of the UK's biggest mobile network is to go ahead.

Switzerland has signed protocols to its double taxation agreements with Cyprus, Liechtenstein, and Malta to implement minimum standards developed as part of the OECD's BEPS project.

France has extended the October 15 property tax payment deadline for businesses affected by measures to contain COVID-19.

Switzerland has signed protocols to its double taxation agreements with Cyprus, Liechtenstein, and Malta to implement minimum standards developed as part of the OECD's BEPS project.

The European Commission is undertaking infringement proceedings against Belgium regarding the taxation of shares held by life insurance companies, the taxation of income from savings deposits, and the deductibility of alimony payments.

The European Commission is undertaking infringement proceedings against Belgium regarding the taxation of shares held by life insurance companies, the taxation of income from savings deposits, and the deductibility of alimony payments.

Chronic kidney disease (CKD) cases among women have nearly tripled globally in the past three decades, marking a significant rise in this health concern

An intense monsoon season in Pakistan means the country’s food system faces the challenge of both extreme floods and extended droughts.

The post Three months of floods, or nine months of drought first appeared on International Water Management Institute (IWMI).

Three crucial actions have been suggested by global health authorities to reform regulations and ensure fair distribution of medical supplies during emergencies (!--ref1--).

Advaxis has announced that the U.S. Food and Drug Administration (FDA) has lifted the clinical hold on IND applications of its three drugs. Advaxis is

Concerns regarding Medicare's potential insolvency among those under 65 have heightened, with 73% now expressing apprehension about its availability when

Rebadge engineering of automobiles is becoming a trend in India. Before we go onto finding out how and why, with some of the examples that have currently gained significance of a product in the Auto-market, let’s...

Uttar Pradesh Chief Minister Yogi Adityanath is set to visit poll-bound Maharashtra on Tuesday where he will address three public meetings and campaign for Maharashtra Deputy Chief Minister Devendra Fadnavis, including several other Bharatiya Janata Party (BJP) candidates.

With less than a week to go for campaigning to end in poll-bound Maharashtra, Prime Minister Narendra Modi is set to address three public meetings on Tuesday and campaign for MahaYuti candidates in the state.

There’s no shortage of digital banks in Nigeria and, in general, in Africa. As the region continues to experience rapid growth in mobile usage and the corresponding growing young population, these fintechs think this is the right time to provide financial services to every market category, from the banked to the unbanked. We’ve covered a […]

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It takes a veritable army to make TechCrunch Disrupt — which takes place October 18–20 in San Francisco — the well-oiled experience that savvy startuppers have come to know and love. And we couldn’t do it nearly as well without our incredible volunteers. If you’re looking for a no-budget way to experience Disrupt up close […]

© 2024 TechCrunch. All rights reserved. For personal use only.

In the trial of Elizabeth Holmes, prosecutors have shown texts, emails and audio clips portraying her in her own words. WSJ’s Shelby Holliday asked Sara Randazzo about key pieces of evidence and what to expect. Photo: Nick Otto/AFP via Getty Images

Three former Minneapolis police officers face federal charges that they violated George Floyd’s civil rights during his May 2020 arrest. Here’s what you need to know about the officers and the upcoming trial. Photo: Erin Ailworth/The Wall Street Journal

GoPro has introduced its next-generation of compact action cameras -- the Hero 11 Black, Hero 11 Black Creator Edition, and the Hero Black Mini. According to the brand, the Hero 11 Black is the "world's most versatile camera" and is meant

Prime Minister Narendra Modi is set to embark on a significant three-nation tour starting on November 16, aimed at strengthening India's global presence and enhancing bilateral relations. The highlight of this tour is his participation in the G20 Summit in Rio

Prime Minister Modi will attend the G20 summit in Brazil, focusing on global issues and meeting world leaders during his three-nation tour.

Currently headquartered in Goregaon East, Mumbai, Will Wall Realty is rapidly expanding its footprint.

Noodles possess a special charm; they're soft yet springy, swirling effortlessly around your fork or chopsticks while soaking up every bit of flavour from a delicious broth or sauce. Warm, filling, and comforting, they're a go-to favourite for quick meals. But

Porsche introduces three new Taycan models, enhancing performance and efficiency for diverse customer needs in the electric vehicle market.

Noida International Airport, named Jewar Airport, is set to start commercial flight operations on April 17, 2025.

London : Faber & Faber (Plays), 2011.

Abingdon, Oxon ; New York, New York : Routledge, Taylor & Francis Group : Earthscan, from Routledge, 2015.