Starting from SPB23.1, a new option, Allow DRCs to surrounding metal, has been added in the Etch-Back form to allow DRCs to the surrounding objects. form to allow DRCs to the surrounding objects.

The Allow DRCs to surrounding metal option lets you see and adjust objects instead of the current behavior, which sacrifices the width of the mask for the trace.

• When this option is turned off, it maintains the EB mask to another object clearance.
• When this option is enabled, it keeps the EB mask to the EM trace edge clearance and shows a DRC if the EB mask to another object spacing is out of rule.

Dwayne Johnson's appearance on "The Tonight Show" ended in a pillow fight with Jimmy Fallon.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

The conclusion that Donald Trump is a fascist has gone mainstream, gaining wide publicity and affirmation in recent weeks. Such understanding is a problem for Trump and his boosters. At the same time, potentially pivotal in this close election, a small proportion of people who consider themselves to be progressive still assert that any differences […]

Slackliners set world record, balancing at 2,500 metres high between hot air balloons

A male fourth-year business administration student of PHINMA Cagayan de Oro College stressed that the delay [of allowances] could affect students’ academic performance, especially those who do not have parents to rely on like him.

A sovereign exposure exchange is a cost-effective risk management tool used by multilateral development banks (MDBs) to reduce sovereign portfolio concentration risks. It provides capital relief for MDBs by exchanging loan guarantees on credit exposure from borrowing countries where an MDB is highly concentrated for exposure to countries where the MBD’s exposure is lower or nonexistent.

X-ray videos of Japanese eels swallowed whole by dark sleeper fish have revealed how the eels can make a daring escape from being digested

Title: Toddlers Can Die From Swallowing Parents' Drug Detox Meds
Category: Health News
Created: 8/29/2013 12:35:00 PM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: Get Cooking With Elegant, Flavorful Scallops
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Ketamine is a glutamate receptor antagonist that was developed over 50 years ago as an anesthetic agent. At subanesthetic doses, ketamine and some metabolites are analgesics and fast-acting antidepressants, presumably through targets other than glutamate receptors. We tested ketamine and its metabolites for activity as allosteric modulators of opioid receptors expressed as recombinant receptors in heterologous systems and with native receptors in rodent brain; signaling was examined by measuring GTP binding, β-arrestin recruitment, MAPK activation, and neurotransmitter release. Although micromolar concentrations of ketamine alone had weak agonist activity at μ opioid receptors, the combination of submicromolar concentrations of ketamine with endogenous opioid peptides produced robust synergistic responses with statistically significant increases in efficacies. All three opioid receptors (μ, , and ) showed synergism with submicromolar concentrations of ketamine and either methionine-enkephalin (Met-enk), leucine-enkephalin (Leu-enk), and/or dynorphin A17 (Dyn A17), albeit the extent of synergy was variable between receptors and peptides. S-ketamine exhibited higher modulatory effects compared with R-ketamine or racemic ketamine, with ~100% increase in efficacy. Importantly, the ketamine metabolite 6-hydroxynorketamine showed robust allosteric modulatory activity at μ opioid receptors; this metabolite is known to have analgesic and antidepressant activity but does not bind to glutamate receptors. Ketamine enhanced potency and efficacy of Met-enkephalin signaling both in mouse midbrain membranes and in rat ventral tegmental area neurons as determined by electrophysiology recordings in brain slices. Taken together, these findings support the hypothesis that some of the therapeutic effects of ketamine and its metabolites are mediated by directly engaging the endogenous opioid system.

SIGNIFICANCE STATEMENT

This study found that ketamine and its major biologically active metabolites function as potent allosteric modulators of μ, , and opioid receptors, with submicromolar concentrations of these compounds synergizing with endogenous opioid peptides, such as enkephalin and dynorphin. This allosteric activity may contribute to ketamine’s therapeutic effectiveness for treating acute and chronic pain and as a fast-acting antidepressant drug.

It's just the core trio this week, as Chris tosses a coin to his hunting horn partner Kelley, and Anna Marie rolls her eyes as Chris cracks terrible jokes about what the Vita really means. We all consider MiHoYo's bottom line, as well as whether we're classified as normies.

The post RPG Cast – Episode 580: “Marshmallow Is Canon” appeared first on RPGamer.

A DWP employee who has been working in the welfare system for 42 years has shared some key advice for new claims for the likes of PIP and Attendance Allowance

The long-standing mystery of how supermassive black holes grew so huge so quickly could be solved by decaying dark matter

A newly identified smartphone vulnerability can reveal the floor plans of where you are and what you are doing - and it is possible that companies or intelligence agencies are already making use of it

The US military has prioritised deploying high-altitude balloons that can carry out surveillance

EA FC 25 players can snag some big freebies this week, with EA Sports celebrating the Ballon d'Or in style for all Ultimate Team players with some of the best players around.

While many states focused on issues like abortion and immigration throughout this election cycle, voters in California and Colorado approved tougher crime laws.

Latex balloons designed to collect high-altitude data can become a threat after they burst

Now is the time to check out this free total conversion of Fallout 4.

The show stars Ella Purnell, Aaron Moten, Kyle MacLachlan, and Walton Goggins, among others, and quickly gained popularity with a massive 65 million views within 16 days of its Season 1 release in April

"If Jupiter doesn’t have a surface, what does it have? "

The 2024 presidential election will have enormous consequences for the climate, and the health and future of children

Several downballot races in the 2024 presidential election will carry implications for climate policy far beyond state lines

The General Pharmaceutical Council has said it is “double, treble, quadruple-checking” for any “flexibility” that would allow all overseas candidates to sit the March 2021 registration assessment exam in their countries of residence.

The General Pharmaceutical Council has said most candidates living in countries with a two-hour or more time difference from the UK will be able to apply to sit the registration assessment at home.

Learn how to take simple x/y coordinates, and create map polygons shaped like holiday images, that can be plotted using SAS/Graph's PROC GMAP.

Feb 2, 2024

Jacqueline L. Hazelton's Bullets not Ballots: Success in Counterinsurgency Warfare (Cornell University Press, 2021) is the subject of a Roundtable Review.

EY�s Natalie Deak on how hedge fund managers are pursuing growth

Virginia Bioinformatics Institute Video Case Study

Cooking Lesson

Kamala Harris is blasting Donald Trump for vowing to protect women whether they “like it or not” at the same time he is calling for Republican Liz Cheney to be shot in the face. We get response from The Nation's abortion access correspondent Amy Littlefield and talk about 10 states with abortion rights on the ballot, including Arizona, Nevada, Florida, South Dakota and Missouri. Trump's remarks are a “succinct and clear definition of patriarchy,” says Littlefield. She argues the 2024 election will be decided in large part by white women and whether they will vote for abortion rights. Trump is “laying out the bargain that white patriarchy has offered for white women in this country,” says Littlefield. “He is saying, 'White women, we will protect you from Brown and Black men.'”

In a major piece for Mother Jones magazine on “Why Ballot Measures Are Democracy’s Last Line of Defense,” voting rights correspondent Ari Berman discusses abortion ballot measures in 10 states, important down-ballot races in Wisconsin and elsewhere, and the movement to abolish or reform the Electoral College.

While Democratic candidates suffered major losses in this year’s U.S. elections, elsewhere on the ballot voters supported liberal positions. In the wake of tightening federal and state restrictions on abortion, historic ballot measures enshrining the right to an abortion passed in seven states, while other initiatives to raise the minimum wage and codify marriage equality also won by wide majorities. We’re joined by Chris Melody Fields Figueredo of the Ballot Initiative Strategy Center to examine the role of ballot measures, a form of direct democracy, in elections, and why this “powerful tool” may be at risk as conservatives flood elected office. “Because we are resisting, we are winning on these progressive issues, they are trying to take that power away from us.”

The American Trucking Associations (ATA) expressed what it called its “grave concerns” about media reports that the Environmental Protection Agency (EPA) may be on the verge of granting the state of California waivers to implement potentially harmful and unrealistic emissions rules on the industry. Under California rules, new Class 8 heavy truck models would be zero-emission next year. Diesel and gasoline-powered drayage trucks must retire after 18 years to guarantee that they meet a zero-emission requirement by 2035.

These easy scalloped potatoes combine the creaminess of the classic side dish with the ease of frozen hash browns. You don’t even have to thaw them out! I thought I was finished writing about scalloped potatoes. I posted my first scalloped potatoes recipe in my second month of blogging, way back in 2006. Then ten...

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The post Easy Scalloped Potatoes (Vegan Hash Browns Casserole) appeared first on FatFree Vegan Kitchen.

Happy Halloween, minions! Let’s go out with a bang, shall we? :D

Bakeries get a lot of leeway this time of year, since Halloween is supposed to have ugly gross stuff:

 

But there's raspberry jam soaked zombie faces, and then there's... uh... this:

Took me a solid minute to figure it out:

A banana shooting laser beams.

(I am SO GOOD AT THIS, you guys.)

 

Yep, bakers are once again trying to collectively punk the world, churning out ridiculous Halloween designs each more baffling than the last:

Aliens? Amoebas?
This guy?

 

I actually see this design a lot:

The angry toilet paper has sprouted arms, and is pulling itself to freedom.

 

While this roll vows revenge on airbrushes everywhere:

"I am not 'pretty,' I AM THE TERRIFYING TP! Here to WIPE you out! Mwuah-ha-haaawhy are you laughing?"

 

Next we have an ice cream swirl wearing a traffic cone about to be impaled by a trident.
Because if THAT doesn't say "Happy Halloween"... then don't worry 'cuz the board does:

 

For some reason ghost sperm are always a big seller this time of year:

They look kinda confused, though, right?
Like they can't tell if they're coming or going.

[HEYO.]

 

Also confused? Me, after looking at this thing:

They managed to get icing absolutely everywhere except on top of the cupcakes.
Now that's scary.

 

And finally, a possessed stove burner:

Because haunted appliances are SO hot right now.

("It burns. IT BURRRRNS!")

 Have fun tonight, gang! Remember, this is the one night of the year when it’s OK to have candy for dinner, so take FULL advantage.

There's a ghost of a chance Brittany D., Carrie, Ginny V., Karen S., Megan S., Karrie T., Jennifer K., Jennifer R., & Shannon T. will be ordering out tonight. You're welcome, ladies!

******

P.S. Today's TP ghost cakes led me to the best home accessory ever:

THIS, my friends, is a "Talking Toilet Paper Spindle." You record your own message, which it will play back when your guests spin the roll. [rubbing hands together evilly] I can't wait to use this baby at our next Christmas party.

*****

And from my other blog, Epbot:

The Dutch Government has announced that businesses may further delay payment of certain tax dues that were frozen in response to the COVID-19 pandemic.

The United Arab Emirates has released a new law that would allow businesses to use movable property to secure bank and commercial loans.

Cyprus's Department of Taxation has announced businesses will be allowed more time to make their monthly value-added tax payments for the periods ending December 31, 2020, and January 31, 2021.

The Singaporean Government has announced it will amend provisions on transfer pricing adjustments in the draft Income Tax (Amendment) Bill 2021, which includes measures announced in the 2021 Budget, following a consultation.

France has extended the October 15 property tax payment deadline for businesses affected by measures to contain COVID-19.

The Italian Government will allow tax payments that were deferred during the COVID-19 lockdown to be paid in instalments over a two-year period.

The UK Government has announced that the temporary GBP1m (USD1.31m) cap for the Annual Investment Allowance (AIA) will be extended until January 1, 2022.

Highlights: Allocates over 2% for health of the nation Setting up of 157 new nursing colleges in collaboration wi

Highlights: The Medical Treatment of CGHS Pensioners (PORB) increased significantly from (and) #8377;4,296.40 crores to (and) #

A cancer diagnosis can devastate more than just a person's health. New research from Beth Israel Deaconess Medical Center and Harvard Medical School reveals