Discover agate meaning: learn how this beautiful crystal supports emotional healing, balance, and grounding energy, making it a must-have for spiritual wellness.

We're about to dive into the world of parasitology, taking a close look at one of the most common parasitic worms infecting humans: Ascaris lumbricoides. This large roundworm is responsible for a type of intestinal nematode infection that affects millions of people worldwide, especially in areas with poor sanitation.

There are not many usable precedents for what J. D. Vance can do with a one-term vice presidency.

It has fundamentally transformed the United States, and it influenced this election cycle.

We wouldn’t blame you if you try to do all of your tech shopping around the holidays. That’s when you can typically get the best sales, both on relatively affordable gear and (more importantly) on big-ticket items. But it would be wrong to think that only the most expensive tech is worth gifting. Since we at Engadget test a plethora of gadgets every year, we know that there are some hidden (and not so hidden) tech gems at lower price ranges — you just have to know where to find them. That’s where we come in — these are the best tech gifts under $50 that you can get this year.

Check out the rest of our gift ideas here.

This article originally appeared on Engadget at https://www.engadget.com/computing/accessories/best-gifts-under-50-holiday-stocking-stuffers-130049028.html?src=rss

Los Angeles CA (SPX) Nov 05, 2024
Imagining a vast ice sheet sprawling over Canada and extending down into what is now the northern United States, reaching as far south as Pennsylvania, Ohio, Indiana, Michigan, and Wisconsin, helps us grasp the scope of ancient glacial coverage between 19,000 and 26,000 years ago. Yet, while picturing this immense ice mass is fascinating, the present-day implications of its retreat - parti

Canadians are watching the U.S. election results with trepidation, knowing they have no control over the outcome that will still affect them. Polling shows Vice-President Kamala Harris and former president Donald Trump are neck-and-neck. 

A pair of ruby slippers worn by Judy Garland in The Wizard of Oz are on the auction block nearly two decades after a thief stole the iconic shoes, convinced they were adorned with real jewels.

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.

Une ado qui aurait été enlevée de force par ses propres frères était en panique et criait d’appeler le 911, selon un témoin appelé au procès.

As people gather to remember those who fought and died to protect this country in past wars, a new poll suggests many Canadians know little about their country's history.

A MINE could deliver water security to vegetable growers on the Lindenow Flats in East Gippsland.

THE stocks of cattle exporter Wellard have crashed.

Quand Chantale Boivin a ressenti les premiers symptômes d’une dystonie cervicale, elle s’est dit que ses torticolis à répétition étaient dus au stress

Raising deep concern over the partnership between Swiggy Instamart and PharmEasy for a rapid drug delivery model, the All India Organization of Chemists and Druggists (AIOCD) has apprised the Drug Controller

The Department of Pharmaceuticals (DoP) has upheld the retail price fixation of National Pharmaceutical Pricing Authority (NPPA) for Mumbai─based Aristo Pharmaceuticals for its multivitamin tablets with

Placon, an innovator in the medical packaging market, announced the release of a new stock line of BargerGard TPU pouches and tip protectors.

It is difficult to disentangle Russian and Chinese scientists from international science cooperation. That is a good thing

Today’s guest post comes from Chris Dowd, Senior VP of Market Development at ConnectiveRx.

Chris examines three key trends that will affect patient support programs: the Inflation Reduction Act (IRA), legal/regulatory battles over copay adjustment programs, and uncertainties following a national election. He then outlines three actions that should guide manufacturers' preparation.

To learn more, register for ConnectiveRx’s free webinar on December 11: The Perfect Storm? Patient Support Programming in 2025 and Beyond.

Read on for Chris’s insights.
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The government implied wholesalers had more personal protective equipment in stock than was the case during the first wave of the COVID-19 pandemic, the Healthcare Distribution Association has said.

Consultations on the reclassification of two progestogen-only contraceptive pills from prescription-only to pharmacy medicines have been launched.

On this date 349 years ago, Samuel Pepys relates in his famous diary a remarkable story about an upcoming medical experiment. As far as I can tell, this is the first written description of a paid research subject.

According to his account, the man (who he describes as “a little frantic”) was to be paid to undergo a blood transfusion from a sheep. It was hypothesized that the blood of this calm and docile animal would help to calm the man.

Some interesting things to note about this experiment:

• Equipoise. There is explicit disagreement about what effect the experimental treatment will have: according to Pepys, "some think it may have a good effect upon him as a frantic man by cooling his blood, others that it will not have any effect at all".
• Results published. An account of the experiment was published just two weeks later in the journal Philosophical Transactions. 
• Medical Privacy. In this subsequent write-up, the research subject is identified as Arthur Coga, a former Cambridge divinity student. According to at least one account, being publicly identified had a bad effect on Coga, as people who had heard of him allegedly succeeded in getting him to spend his stipend on drink (though no sources are provided to confirm this story).
• Patient Reported Outcome. Coga was apparently chosen because, although mentally ill, he was still considered educated enough to give an accurate description of the treatment effect. 

Depending on your perspective, this may also be a very early account of the placebo effect, or a classic case of ignoring the patient’s experience. Because even though his report was positive, the clinicians remained skeptical. From the journal article:

The Man after this operation, as well as in it, found himself very well, and hath given in his own Narrative under his own hand, enlarging more upon the benefit, he thinks, he hath received by it, than we think fit to own as yet.

…and in fact, a subsequent diary entry from Pepys mentions meeting Coga, with similarly mixed impressions: “he finds himself much better since, and as a new man, but he is cracked a little in his head”.

The amount Coga was paid for his participation? Twenty shillings – at the time, that was exactly one Guinea.

[Image credit: Wellcome Images]

In the spirit of the Halloween season, IEEE Spectrum presents a pair of stories that—although grounded in scientific truth rather than the macabre—were no less harrowing for those who lived them. In today’s installment, Robert Langer had to push back against his field’s conventional wisdom to pioneer a drug-delivery mechanism vital to modern medicine.

Nicknamed the Edison of Medicine, Robert Langer is one of the world’s most-cited researchers, with over 1,600 published papers, 1,400 patents, and a top-dog role as one of MIT’s nine prestigious Institute Professors. Langer pioneered the now-ubiquitous drug delivery systems used in modern cancer treatments and vaccines, indirectly saving countless lives throughout his 50-year career.

But, much like Edison and other inventors, Langer’s big ideas were initially met with skepticism from the scientific establishment.

He came up in the 1970s as a chemical engineering postdoc working in the lab of Dr. Judah Folkman, a pediatric surgeon at the Boston Children’s Hospital. Langer was tasked with solving what many believed was an impossible problem—isolating angiogenesis inhibitors to halt cancer growth. Folkman’s vision of stopping tumors from forming their own self-sustaining blood vessels was compelling enough, but few believed it possible.

Langer encountered both practical and social challenges before his first breakthrough. One day, a lab technician accidentally spilled six months’ worth of samples onto the floor, forcing him to repeat the painstaking process of dialyzing extracts. Those months of additional work steered Langer’s development of novel microspheres that could deliver large molecules of medicine directly to tumors.

In the 1970s, Langer developed these tiny microspheres to release large molecules through solid materials, a groundbreaking proof-of-concept for drug delivery.Robert Langer

Langer then submitted the discovery to prestigious journals and was invited to speak at a conference in Michigan in 1976. He practiced the 20-minute presentation for weeks, hoping for positive feedback from respected materials scientists. But when he stepped off the podium, a group approached him and said bluntly, “We don’t believe anything you just said.” They insisted that macromolecules were simply too large to pass through solid materials, and his choice of organic solvents would destroy many inputs. Conventional wisdom said so.

Nature published Langer’s paper three months later, demonstrating for the first time that non-inflammatory polymers could enable the sustained release of proteins and other macromolecules. The same year, Science published his isolation mechanism to restrict tumor growth.

Langer and Folkman’s research paved the way for modern drug delivery.MIT and Boston Children’s Hospital

Even with impressive publications, Langer still struggled to secure funding for his work in controlling macromolecule delivery, isolating the first angiogenesis inhibitors, and testing their behavior. His first two grant proposals were rejected on the same day, a devastating blow for a young academic. The reviewers doubted his experience as “just an engineer” who knew nothing about cancer or biology. One colleague tried to cheer him up, saying, “It’s probably good those grants were rejected early in your career. Since you’re not supporting any graduate students, you don’t have to let anyone go.” Langer thought the colleague was probably right, but the rejections still stung.

His patent applications, filed alongside Folkman at the Boston Children’s Hospital, were rejected five years in a row. After all, it’s difficult to prove you’ve got something good if you’re the only one doing it. Langer remembers feeling disappointed but not crushed entirely. Eventually, other scientists cited his findings and expanded upon them, giving Langer and Folkman the validation needed for intellectual property development. As of this writing, the pair’s two studies from 1976 have been cited nearly 2,000 times.

As the head of MIT’s Langer Lab, he often shares these same stories of rejection with early-career students and researchers. He leads a team of over 100 undergrads, grad students, postdoctoral fellows, and visiting scientists, all finding new ways to deliver genetically engineered proteins, DNA, and RNA, among other research areas. Langer’s reputation is further bolstered by the many successful companies he co-founded or advised, like mRNA leader Moderna, which rose to prominence after developing its widely used COVID-19 vaccine.

Langer sometimes thinks back to those early days—the shattered samples, the cold rejections, and the criticism from senior scientists. He maintains that “Conventional wisdom isn’t always correct, and it’s important to never give up—(almost) regardless of what others say.”

Value-based care contracting is especially difficult for behavioral health providers, Taft Parsons III, chief psychiatric officer at CVS Health/Aetna, pointed out during a conference this week.

The post CVS Health Exec: Payers Need to Stop Making Behavioral Health Providers Jump Through Hoops In Order to Participate in Value-Based Care appeared first on MedCity News.

Many companies are entering the digital youth mental health space, but it’s important to know which ones are effective, according to a panel of investors at the Behavioral Health Tech conference.

The post Measuring Impact in Digital Youth Mental Health: What Investors Look For appeared first on MedCity News.

AbbVie schizophrenia drug candidate emraclidine failed to beat a placebo in two Phase 2 clinical trials. The drug, once projected to compete with Bristol Myers Squibb’s Cobenfy, is from AbbVie’s $8.7 billion acquisition of Cerevel Therapeutics.

The post AbbVie Drug Expected to Rival Bristol Myers’s New Schizophrenia Med Flunks Phase 2 Test appeared first on MedCity News.

Neurogene’s Rett syndrome gene therapy has preliminary data supporting safety and efficacy of the one-time treatment. But a late-breaking report of a serious complication in a patient who received the high dose sent shares of the biotech downward.

The post Neurogene Gene Therapy Shows Signs of Efficacy in Small Study, But an Adverse Event Spooks Investors appeared first on MedCity News.

SINGAPORE - When an online retailer began selling his products on e-commerce platform Qoo10 in August 2023, he did not bat an eyelid when it took 30 to 45 days for the platform to disburse his first payout, compared with about three to seven days for other e-commerce sites he was using. But nearly a year later in July, payments owed to his business by Qoo10 had ballooned to about $1.6 million, as the platform’s payment delays exceeded two months and disbursements began trickling in, in smaller amounts. The Singaporean, who wanted to be known only as Mr T and did not wish to divulge what he sold, pulled the plug on his Qoo10 shop this year in the middle of July, and filed a civil claim with the courts. He obtained a default judgment in October for Qoo10 to pay him what he is owed, after the e-commerce site failed to serve a notice of intention to contest or not contest the claim. Mr T, who added that he had borrowed nearly $1 million from banks, friends and relatives to pay his suppliers, said: “I am not holding out hope that I will get much, or any, of my money back from Qoo10... By this point, I just want closure because it’s been so stressful.”

Fugitive lawyer Charles Yeo, who is in custody in the UK, is currently awaiting an extradition hearing, reported CNA on Tuesday (Nov 12).  A court date for the extradition hearing has not been determined, but Yeo is set to attend a bail hearing on Friday, according to the report. In an Instagram post on Nov 1, the former chairman of the Reform Party said the Singapore government had made a formal request for his extradition. In his post, Yeo also said that he will be presenting himself, together with his legal team, at Westminster Magistrates Court on Nov 11. Yeo left Singapore in July 2022 after being charged earlier that year with multiple offences relating to harassment and wounding the religious feelings of Christians in several social media posts. In August 2022, a warrant of arrest was issued against him for breaching the conditions for overseas travel while on bail.  He was allowed to travel to Vietnam for work, but failed to return to Singapore and claimed he was seeking political asylum in the UK. 

My first editor, Rukun Advani, once described himself as ‘a composite hybrid of the Indian and the Anglo-European’, who sought to reconcile ‘within himself those varying cultural influences which chauvinistic nationalists could only see as contradictions.’ This self-characterization I might avow as my own. One mark of the Anglo-European in me is that, unlike members [...]

Oct 6, 2020

Simon Saradzhyan writes that the benefits that discontinuing the war on Russia’s terms can generate for defending or advancing Russia’s vital interests will exceed the costs of doing so.

Dec 15, 2017

To ministers and heads of state, he was a sought-after adviser, pointing the way toward reforms that boosted farm yields, educational standards, and economic prosperity. To the scientific community, he was an unstinting champion of innovation and rigorous evidence. To his students, he was a passionate teacher and mentor. To thousands of his fans on social media, he was a fount of insight, optimism, and good humor. To us, he was a dear friend and extraordinary colleague.

Dec 18, 2017

Our colleague Calestous Juma—who passed away on December 15 at age 64 after a long illness—was a pioneering, prolific, and influential scholar/practitioner in science and technology policy for sustainable well-being. He joined Harvard Kennedy School (HKS) in 1999 as Director of the Science, Technology, and Innovation Project (a joint venture of the Belfer Center for Science and International Affairs and the Center for International Development) and became Professor of the Practice of International Development in 2002, a position in which he maintained his exceptional productivity and engagement with policy, despite illness, up to the time of his death.

Dec 19, 2017

Celebrating the life and achievements of Professor Calestous Juma.

Mar 28, 2024

We have heard much about the puzzle that US economic performance under President Joe Biden has been much stronger than voters perceive it to be.  But the current episode is just one instance of a bigger historical puzzle:  the US economy has since World War II consistently done better under Democratic presidents than under Republican presidents.  This fact is even less widely known, including among Democratic voters, than the truth about Biden’s term.  Indeed, some poll results suggest that more Americans believe the reverse, that Republican presidents are better stewards of the economy than Democrats.

Jul 24, 2024

The defining tension in Middle Eastern politics today—and the most combustible pile of tinder—is between the State of Israel and the Islamic Republic of Iran. The antagonism between the two countries has existed for more than forty years. It has played out across the region for more than twenty years within the context of the Middle East’s wider tumult. It has not been restricted to diplomacy, either, but has played out through various means: covert, proxy, political and psychological warfare. Observers of this conflict have as a result tended to describe this state of affairs with obscure terms: “cold” war, “shadow” war, or other words that allude to the existence of an active and geopolitically consequential antagonism but imply an ambiguity that plain old “war” never could.

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Chase launches new Ultimate Rewards website offering customers enhanced, personalized rewards.

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EY�s Natalie Deak on how hedge fund managers are pursuing growth

Associates at VPI share their stories in honor of National Pet Cancer Awareness Month. Find out how you can help #CurePetCancer, visit www.CurePetCancer.com

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See how easy it is to apply for a mortgage through Vanderbilt Mortgage and Finance, Inc.

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