sme

Judge chides Delaware counties in outdated assessments suit




sme

Transforming Assessment to Improve Teaching and Learning

Although public and educators' concerns are growing about testing, performance assessment done well can strengthen instruction and enhance learning, says Linda Darling-Hammond.




sme

Innovative Assessments: Widening the Horizon

States are developing new forms of assessment, including assessments of learning and assessments for learning.




sme

ESSA and Performance Assessments: Where States Go From Here

A recent summit meeting on assessment held in Virginia by Jobs for the Future suggests that that state may have solved some of the political challenges that have held back the advance of performance assessment.




sme

New Hampshire Gets Approval to Try Out Local Assessments

The state will be allowed to use competency-based tests developed by local and state officials, trying them out with a handful of districts in lieu of statewide tests.




sme

Performance Assessments and Students with Disabilities

Performance assessments have the potential to ensure that instruction for students with disabilities is aligned with state standards.




sme

As CFP rankings punish SEC teams, do we smell bias against this proud and mighty league?

The CFP's annual love affair with the SEC appears finished. The latest rankings dropped a hammer on the mighty league where "it just means more."




sme

Assessment shows technical capacity on the rise since 2012

Further to Council-endorsed adjustments to the 2016-17 Programme of Work and Budget (PWB) made in 2015, an assessment of the technical capacity of the Organization by a team of independent [...]




sme

Ask Smithsonian: What Makes Skunk Spray Smell So Terrible?

Did you ever think you’d hear the words "skunk," "anti-aircraft weaponry" and "nipple squirters" in the same sentence? Brace yourself and watch this one-minute video, where Ask Smithsonian host Eric Schulze sticks his nose into the science of skunk spray.




sme

These Mesmerizing Carvings Tell a Mysterious Tribe's Story

Clues into the disappearance of the ancient Picts lie in the tiny Scottish village of Aberlemno: 1,700-year-old Pictish stones, marked with some very unusual carvings.




sme

Heat Waves Can Make Bumblebees Lose Their Sense of Smell, Study Finds. Here's Why That's a Problem

Female worker bees, which forage for the whole colony, struggle more to detect scents in the heat than males do, per the recent research




sme

See 15 Mesmerizing Photos of Hidden Scenes Only Visible Through a Microscope

Winners of the Nikon Small World Photomicrography Competition captured insects, cancer cells, cat claws and more




sme

People Born Without a Sense of Smell Have Different Breathing Patterns, Study Finds

Study participants with lifelong anosmia sniffed less than those with a normal sense of smell. Future research could shed light on whether this has negative implications for their health




sme

Why Does Rain Smell and More Questions From Our Readers

You asked, we answered




sme

SolidWorks Helps Maesa Studio Create Elegant, Cost-Effective Packaging For Top Cosmetic Brands

Sharing Information Between Design and Production Eliminates Budget Overruns That Erode Customers’ Profits




sme

Title IX Rule Details How K-12 Schools Must Address Sexual Harassment, Assault

The Education Department outlines when and how schools must respond to reports of sexual assault and harassment under the Trump administration's interpretation of Title IX, the federal law that prohibits sex discrimination.




sme

OPAIR announces inaugural cohort of Assessment Champions

Penn State’s Office of Planning, Assessment, and Institutional Research has designated its inaugural cohort of Assessment Champions for 2024-25. This new program recognizes individuals who are deeply committed to enhancing student learning through learning assessment.




sme

Penn State Smeal's Palumbo-Miele named 2024 Women in Supply Chain award winner

Donna Palumbo-Miele, executive director of the Center for Supply Chain Research at the Penn State Smeal College of Business, has been awarded the 2024 Women in Supply Chain award by Food Logistics and Supply & Demand Chain Executive.




sme

New innovation fund for Penn State Smeal students to explore AI initiatives

Dan and Robyn Ives recently made a $100,000 commitment to create the Dan and Robyn Ives AI Innovation Initiatives Fund in the Penn State Smeal College of Business. Their annually funded gift will give Smeal’s eLearning Design and Innovation Group $20,000 a year over the next five years to explore the challenges and opportunities that AI presents for Smeal students, faculty and staff and to expand educational and experiential learning opportunities around AI.




sme

Penn State Smeal program supports military veteran entrepreneurs

Jeffrey Goldberg and Matthew Vogt contribute a significant portion of the sales of their company, Sky Devil Wines, to veterans and veteran-specific causes. In 2018 they established a fund that is now named the Sky Devil Veteran's Entrepreneur Fund. The first two recipients of proceeds from that fund were recently named.





sme

Teachers Should Design Student Assessments. But First They Need to Learn How

"When the day came to administer the first test I had designed," writes Brandon Lewis, "my heart sank."




sme

What Is Performance Assessment?

Here's a handy glossary on terms like project-based learning, competency-based learning, and standards-based grading.




sme

Common Assessments a Test for Schools' Technology

As the two big groups of states craft common-assessment systems, experts warn that the smallest details could undermine their work.




sme

Readiness Assessments Fuel Testing Jitters

The collection and use of data about just how prepared individual children are to enter kindergarten can be a ticklish proposition.





sme

Curran McCready named to Penn State Smeal Finance Advisory Board

Penn State Smeal College of Business alumnus Curran McCready was recently appointed to the college’s Finance Advisory Board.




sme

Delaware State Housing Authority Launches Resident Housing Survey To Inform Statewide Housing Needs Assessment

Dover, Del. February 21, 2023 – Now through Friday, March 31, the Delaware State Housing Authority (DSHA) invites all residents to complete a confidential housing survey that will guide housing agencies and local jurisdictions in their efforts to:  Prioritize housing and housing-related services, Develop more targeted program and policy responses, and Better coordinate the use […]



  • Delaware State Housing Authority
  • News
  • Resident Housing Survey

sme

Delaware State Housing Authority Shares Preview Of The 2023 Housing Needs Assessment Report

Government officials and community members gather in Dover to learn of qualitative, quantitative, and projection data to solve the housing crisis Dover, Del. October 10, 2023 – Delawareans, including government officials, nonprofit and for-profit partners, and service providers, joined the Delaware State Housing Authority (DSHA) at POLYTECH Adult Education Center to hear preliminary findings from the […]



  • Delaware State Housing Authority
  • Delaware Housing Needs Assessment

sme

Hugging grandmas and businessmen

OM Chile's Intensive Training participants spend a morning sharing the gospel in a local plaza in Santiago.




sme

DOJ, Elsmere PD Secure Delaware’s First Ever Forced Labor Conviction

An Elsmere man will serve a lengthy prison sentence after pleading guilty to multiple felonies, including Delaware’s first conviction under a Forced Labor statute originally passed in 2014. On October 13, Martin Ortiz-Lozano, 34, was sentenced to fifteen years in prison after pleading guilty to two counts of Child Abuse in the First Degree and one […]



  • Department of Justice
  • Department of Justice Press Releases
  • News

sme

New Sexual Harassment Law Extends Protections

Wilmington, DE. December 26, 2018– There’s an important new law affecting Delaware workplaces – the new Delaware sexual harassment law effective January 1, 2019. Sexual harassment has been illegal in Delaware workplaces for over 20 years. However, the definition has never been clearly spelled out in the law until now. There are also new requirements […]




sme

DPH Community Assessments Underway to Inform Future COVID-19 Response Efforts and Improve Health

The Delaware Division of Public Health (DPH) will conduct a series of community health assessments to better understand the concerns and needs of Delaware communities during the COVID-19 pandemic and to improve the overall health in Delaware in the future.




sme

DPH Community Assessments Underway To Inform State Health Improvement Plan

DOVER, DE (OCT. 27, 2022) – As part of the Delaware State Health Improvement Plan (SHIP), the Delaware Division of Public Health (DPH) will conduct a series of community health assessments. The health assessments will help improve understanding of the health concerns and needs of Delaware communities and to improve the future health in Delaware. DPH […]




sme

Elsmere Police Department Earns State Accreditation

Delaware State Senate Spiros Mantzavinos, Chief Laura Giles, Elsmere Mayor Eric Scott Thompson, Secretary Nathaniel McQueen Jr. ELSMERE, DE – After completing a long and arduous process, the Elsmere Police Department became the seventh police agency to earn State accreditation through the Delaware Police Accreditation Commission (DPAC). “The State accreditation process raises the standards for […]



  • Department of Safety and Homeland Security
  • News

sme

2024 State Assessment Results Show Pandemic Recovery Continuing

New statewide student assessment results reinforce students’ continued need for help to recover from pandemic school building closures.




sme

DPH Invites Public Comment on 2023 Delaware Statewide Health Assessment

The Delaware Division of Public Health (DPH) and Delaware SHA/SHIP Partnership Coalition are seeking public input on the draft 2023 Delaware State Health Assessment (SHA), a statewide assessment identifying the primary health needs of Delawareans. The SHA is conducted every five years and will inform the co-creation of a State Health Improvement Plan (SHIP) with […]



  • Delaware Health and Social Services
  • Division of Public Health
  • DE Division of Public Health
  • Delaware Division of Public Health
  • delaware ship
  • State health assessment

sme

Foodtech exporter Flavourtech smells opportunity in the Netherlands

Flavourtech sets up in the Netherlands’ leading food research centre to connect with clients and undertake R&D.




sme

Pacific Confronting Growing Climate Change Impacts, Official US Assessment Finds

Pacific Confronting Growing Climate Change Impacts, Official US Assessment Finds Pacific Confronting Growing Climate Change Impacts, Official US Assessment Finds
ferrard

News Release

Explore

News Release

Explore




sme

In Hawai‘i and the Pacific Islands, Climate Change Means Billions of Dollars of Coastal Damage, Widespread Coral Death and Human Health Risks, Official US Assessment Finds

In Hawai‘i and the Pacific Islands, Climate Change Means Billions of Dollars of Coastal Damage, Widespread Coral Death and Human Health Risks, Official US Assessment Finds In Hawai‘i and the Pacific Islands, Climate Change Means Billions of Dollars of Coastal Damage, Widespread Coral Death and Human Health Risks, Official US Assessment Finds
hasegaws

News Release

Explore

News Release

Explore




sme

Proteas to face India at Kingsmead




sme

Sedibeng mayor accuses municipal manager of smear campaign




sme

Desperate Dolphins and Titans seek redemption at Kingsmead




sme

IDF Chief of Staff Halevi sends a message to Hamas during assessment in Jabalya


Halevi gave this message after the IDF killed 1,000 Hamas terrorists in the northern Gazan city and additionally captured another 1,000 terrorists.




sme

to write a letter of harassment in workplace

to write a letter of harassment in workplace




sme

Update of the Readiness Assessment for Cross-Border Paperless Trade: Bangladesh

This report highlights Bangladesh’s cross-border paperless trade readiness, outlines the significant legal and technical gaps it still needs to address, and provides a comprehensive action plan.




sme

Cosmetic Eye Procedure May Ease Migraines, Small Study Says

Title: Cosmetic Eye Procedure May Ease Migraines, Small Study Says
Category: Health News
Created: 8/22/2014 12:36:00 PM
Last Editorial Review: 8/25/2014 12:00:00 AM




sme

Rapid Loss of Smell May Be an Early Sign of Alzheimer's

Title: Rapid Loss of Smell May Be an Early Sign of Alzheimer's
Category: Health News
Created: 7/29/2022 12:00:00 AM
Last Editorial Review: 7/29/2022 12:00:00 AM




sme

As Pandemic Eases, It's Boom Times for Cosmetic Surgeons

Title: As Pandemic Eases, It's Boom Times for Cosmetic Surgeons
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM




sme

Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models [Articles]

Early detection of drug-drug interactions (DDIs) can facilitate timely drug development decisions, prevent unnecessary restrictions on patient enrollment, resulting in clinical study populations that are not representative of the indicated study population, and allow for appropriate dose adjustments to ensure safety in clinical trials. All of these factors contribute to a streamlined drug approval process and enhanced patient safety. Here we describe a new approach for early prediction of the magnitude of change in exposure for cytochrome P450 (P450) CYP3A4-related DDIs of small-molecule anticancer drugs based on the model-based extrapolation of human-CYP3A4-transgenic mice pharmacokinetics to humans. Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. Predictions of the magnitude of change in exposure deviated at most 0.99- to 1.31-fold from clinical trial results for inhibition with itraconazole, whereas exposure predictions for the induction with rifampicin were less accurate, with deviations of 0.22- to 0.48-fold. Results for the early prediction of DDIs and their clinical impact appear promising for CYP3A4 inhibition, but validation with more victim and perpetrator drugs is essential to evaluate the performance of the new method.

SIGNIFICANCE STATEMENT

The described method offers an alternative for the early detection and assessment of potential clinical impact of CYP3A4-related drug-drug interactions. The model was able to adequately describe the inhibition of CYP3A4 metabolism and the subsequent magnitude of change in exposure. However, it was unable to accurately predict the magnitude of change in exposure of victim drugs in combination with an inducer.