A former top aide to the mayor of Washington D.C. sexually harassed a female employee, according to an internal probe.

If you think you know the full story of how a soccer team became trapped in a Thai cave, a spectacle that drew the breathless attention of the world, you don't…

Leaders from some of Europe’s largest companies will be gathering in Birmingham to discuss the role that open innovation and collaboration can play in boosting the economy

Highlighting the brand’s expansion trajectory in terms of physical retail presence, Sanjay Sharma, Country Head of Shiseido India said that since launching with 15 touchpoints last year, NARS has already doubled its reach to 30 points in India and plans to double again in the next two years.

Net sales rose 40% to $301.1 million for the quarter ended Sept. 30, compared with analysts' average estimates of $285.8 million, as per data compiled by LSEG.

John Moltz, ace reporter from The Daily Planet, returns to the show. Topics include Apple pushing ads through its own built-in apps, car shopping, and the burgeoning Twitter alternative Bluesky.

En 10 AM Hoy por Hoy de Caracol radio estuvieron Luz Marina Pineda y Patricia Cataño, Madres de Catalina Usme y Manuela Vanegas hablando sobre la actuación de la Selección Colombia en el mundial femenino.

En Caracol Radio estuvo María Paula Correa, ex jefa del gabinete del gobierno Duque, narrando su experiencia junto al expresidente y detalles del libro

En Caracol Radio estuvo María Paula Correa, ex jefa del gabinete del gobierno Duque, narrando su experiencia junto al expresidente y detalles del libro

En las primeras horas de la mañana del jueves se reportan problemas de movilidad algunas vías principales de la capital colombiana que provocaron el cierre del portal de Usme como consecuencia de la manifestación.

Cierre del portal Usme afecta a 35,000 usuarios: Gerente de TrasnMilenio

En el programa 6AM de Caracol radio, la senadora Andrea Padilla habló de como Esmeralda Hernández busco su voto junto a funcionarios del gabinete de Petro

En el programa 6AM de Caracol Radio, la senadora Esmeralda Hernández  responde ante las acusaciones de Andrea Padilla, quien asegura que buscaron votos a través de acuerdos con otros ministros para la elección de la Comisión. Por lo anterior, anunció que denunciará a la senadora por calumnia. 

Made Smarter, the movement accelerating the digital transformation of SME manufacturers, recently reached a major milestone - backing North West companies to invest £25m in new technologies.

For an all-star game, there were tight groups comprised of players both familiar and new to each other.

“An assessment night will be held tomorrow [June 27], from 6.30pm to 8.30pm, when candidates can sign up for the next recruit camp, which is planned for July 7 to 19,” the Royal Bermuda Regiment said. A spokesperson said, “Residents are encouraged to attend Warwick Camp this week as the Royal Bermuda Regiment aims to […]

Piráti musí přestat řešit vnitřní spory a vrátit se k tomu, co voliče nejvíc zajímá, říká nový předseda strany Zdeněk Hřib v prvním rozhovoru po zvolení v podcastu Padni komu padni. Nejdůležitější je dle něj zlepšit kampaně, aby pirátští voliči přišli k volbám. Bez nich by dle Hřiba ze sněmovny zmizel liberální hlas.

Sportem ku zdraví, říká se. A k trvalé invaliditě, dodávají jiní. V případě horolezectví to ale může dopadnout mnohem hůř. Všechny ty světově známé vrcholky mají svůj smutný seznam těch, kteří padli při jejich zdolávání. A pochopitelně mezi nimi nechybí ani ženy. Hannelore Schmatz se měla stát první Němkou, která zdolala Mount Everest. Na vrchol se dostala i se svým manželem Gerhardem, jakožto nejstarším pokořitelem hory. Jenže u Everestu je pořádně zrádná i cesta dolů. Hannelore se nakonec stala osudnou.

In light of a recent series of fires in high-rise buildings with combustible facades, including the Grenfell tower fire, the National Fire Protection Association (NFPA) has initiated a project to develop a fire risk assessment tool for these types of buildings to assist local authorities globally with fire safety in their communities.

Fake social media accounts are being used in Romania's ongoing presidential and parliamentary election campaigns to artificially boost the popularity of certain candidates and promote content targeting their opponents, according to an analysis by the Romanian Intelligence Service (SRI). The SRI…

Everyone likes the smell of their own brand. 

You've probably heard that one before, when you were ripping a real stinker in the car and rolling the windows up because you're a sadist. 

via GIPHY

But why do you like torturing innocent bystanders of your disgusting gas? Honestly, being subjected to your farts should be considered torture. Liking your farts is akin to waterboarding. You're a war criminal. You and your farts should sit before an international tribunal. 

Yes, you. 

Anyway, this video explains why you're such a sicko. ASAP Science continues to do great work in under five minutes. 

via The Real Sporcle

See the full video at ChaosMen

The post QuickClips: ChaosMen – Scott DeMarco Fucks Brody Meyer appeared first on QueerClick.

By Keegan Kelly Published: November 11th, 2024

Learn the fundamentals of finance in at our accessible and engaging lectures! Whether you want to get prepared for finance recruiting or just are curious about investing, our sessions will give you a technical education and an understanding of how investing works. Tiger Investments is Princeton’s oldest investment club. As conveyed by our mission statement, financial education rooted in fundamental analysis and equity research are at the heart of our organization. Our curriculum can be found here https://tigerinvestments.princeton.edu/education/

Learn the fundamentals of finance in at our accessible and engaging lectures! Whether you want to get prepared for finance recruiting or just are curious about investing, our sessions will give you a technical education and an understanding of how investing works. Tiger Investments is Princeton’s oldest investment club. As conveyed by our mission statement, financial education rooted in fundamental analysis and equity research are at the heart of our organization. Our curriculum can be found here https://tigerinvestments.princeton.edu/education/

Learn the fundamentals of finance in at our accessible and engaging lectures! Whether you want to get prepared for finance recruiting or just are curious about investing, our sessions will give you a technical education and an understanding of how investing works. Tiger Investments is Princeton’s oldest investment club. As conveyed by our mission statement, financial education rooted in fundamental analysis and equity research are at the heart of our organization. Our curriculum can be found here https://tigerinvestments.princeton.edu/education/

For whatever reason, every election year Broward County always manages to steal the show when it comes to shady campaign practices. The 2020 election cycle is no different, and we are not referring to the embarrassment that is the Broward Republican Executive Committee, yet but there is still plenty of time for that group of misfits to step in it.

The post Smear campaign underway against DeSantis’ sheriff pick appeared first on Shark Tank.

As Suni Williams and Butch Wilmore spend months longer than planned on ISS, three astronauts tell us what life is like in orbit.

McLaren's Lando Norris talks to BBC Sport about why he wants Formula One to retain the "sound and smell" that first sparked his love for the sport.

6 Weird House Smells: Which Ones Are Concerning?

For many Jamaicans, the deceased are more than just loved ones who have passed on; they are cherished family members who deserve to look as presentable as they did in life. In a culture where the appearance of the deceased is paramount, morticians...

Visual Abstract

Visual Abstract

Sean A Burnap
Dec 7, 2020; 0:RA120.002305v1-mcp.RA120.002305
Research

We have previously shown that multimers of plasma pentraxin-3 (PTX3) were predictive of survival in patients with sepsis. To characterize the release kinetics and cellular source of plasma protein changes in sepsis, serial samples were obtained from healthy volunteers (n=10, 3 time-points) injected with low-dose endotoxin (LPS) and analyzed using data-independent acquisition (DIA) MS. The human plasma proteome response was compared to an LPS-induced endotoxemia model in mice. Proteomic analysis of human plasma revealed a rapid neutrophil degranulation signature, followed by a rise in acute phase proteins. Changes in circulating PTX3 correlated with increases in neutrophil-derived proteins following LPS injection. Time course analysis of the plasma proteome in mice showed a time-dependent increase in multimeric PTX3, alongside increases in neutrophil-derived myeloperoxidase (MPO) upon LPS treatment. The mechanisms of oxidation-induced multimerisation of PTX3 were explored in two genetic mouse models: MPO global knock-out mice and LysM CreNox2KO mice, in which NADPH oxidase 2 (Nox2) is only deficient in myeloid cells. Nox2 is the enzyme responsible for the oxidative burst in neutrophils. Increases in plasma multimeric PTX3 were not significantly different between wildtype and MPO or LysM CreNox2KO knock-out mice. Thus, PTX3 may already be stored and released in a multimeric form. Through in vivo neutrophil depletion and multiplexed vascular proteomics, PTX3 multimer deposition within the aorta was confirmed to be neutrophil-dependent. Proteomic analysis of aortas from LPS-injected mice returned PTX3 as the most upregulated protein, where multimeric PTX3 was deposited as early as 2 h post-LPS along with other neutrophil-derived proteins. In conclusion, the rise in multimeric PTX3 upon LPS injection correlates with neutrophil-related protein changes in plasma and in aortas. MPO and myeloid Nox2 are not required for the multimerisation of PTX3; instead, neutrophil extravasation is responsible for the LPS-induced deposition of multimeric PTX3 in the aorta.

Proportionality in the Conduct of Hostilities: The Incidental Harm Side of the Assessment Research paper sysadmin 6 December 2018

Clarification of international humanitarian law is important in ensuring compliance with the rule of proportionality, but a culture of compliance within armed forces and groups is also crucial.

Summary

• Military operations are taking place with increasing frequency in densely populated areas. Such operations result in loss of life and harm to civilians, as well as damage to civilian objects, (including infrastructure providing essential services). In order to protect civilians, it is imperative that armed forces and groups comply with the rules of international humanitarian law on the conduct of hostilities, including the rule of proportionality.
• The rule of proportionality prohibits attacks which may be expected to cause incidental loss of civilian life, injury to civilians, damage to civilian objects or a combination thereof, which would be excessive in relation to the concrete and direct military advantage anticipated. This research paper analyses the key steps that belligerents must take to give effect to the rule, with a particular focus on one side of proportionality assessments – the expected incidental harm.
• Those undertaking proportionality assessments before or during an attack must consider whether the expected harm will be caused by the attack, and whether that harm could be expected (that is, was it reasonably foreseeable).
• For the purpose of proportionality assessments, injury to civilians includes disease, and there is no reason in principle to exclude mental harm, even though it is currently challenging to identify and quantify it. Damage to civilian objects includes damage to elements of the natural environment.
• Once the incidental harm to be considered has been identified, a value or weight must be assigned to it. This is then balanced against the value or weight of the military advantage anticipated from the attack to determine whether the harm would be excessive.
• In the determination of whether the expected incidental harm would be excessive compared to the anticipated military advantage, ‘excessive’ is a wide but not indeterminate standard.
• Belligerents should develop methodologies so that those planning and deciding attacks are provided with all necessary information on expected incidental harm, and to assist them in assigning weight to the incidental harm to be considered.
• If it becomes apparent that the rule of proportionality will be contravened, the attack in question must be cancelled or suspended.
• Clarification of the law is important in ensuring compliance with the rule of proportionality, but a culture of compliance within armed forces and groups, inculcated by their leaders, is also crucial.

The Chatham House Sustainable Laboratories Initiative: Prior Assessment Tool Other resource sysadmin 14 June 2019

Laboratories are critical for supporting effective infectious disease surveillance and outbreak response. This tool is meant to help structure a conversation between funding partners and recipient countries on how to most effectively establish or repurpose laboratories in low-resource environments.

Introduction

Laboratories are critical for supporting effective infectious disease surveillance and outbreak response, and lack of adequate laboratory capacity is a global challenge. As part of global health security initiatives, cooperative threat reduction efforts and international development programmes, sophisticated laboratories have been provided to mitigate biological threats and bolster a country’s capacity for detection, diagnosis and storage of high-consequence pathogens. Very often, these use the assumptions, standards and templates applied in high-income countries. However, it can be difficult or even impossible to sustain these facilities in low-resource environments. There can sometimes be limited local technical capacity and capability, which can result in a high reliance on imported expertise, skills, equipment and other resources. Sustainability can therefore be hard to achieve. In addition, when a funding partner withdraws, the laboratories can become disused, foundering without the trained personnel and financial resources to sustain them.

To help address this situation, a proposal gaining increasing support internationally is to adopt an approach based on a local risk assessment, whereby laboratories are appropriately and optimally tailored to the local risks and to the resources available, both in the short and longer term, without compromising biosafety and biosecurity.

A Chatham House workshop was convened in Abuja, Nigeria, in 2018 to explore what West African countries would find most appropriate in terms of building laboratory capacity, what the main challenges have been so far, and what needs to be done to improve the sustainability of laboratories in the region. It emerged that there was a need for a more structured conversation between the funding partner and recipient country early in the process – prior to embarking on the detailed planning phase for the establishment or repurposing of a laboratory. This should involve careful consideration and an assessment of existing and planned capacity, needs and contextual issues, together with proposals for how to address the issues revealed, so that any ensuing laboratory demonstrably supports the national strategy and therefore flourishes.

When monarch butterflies migrate, they produce one of the most iconic wildlife spectacles in the world — and provide us with an important indicator of ecological health, says photographer Jaime Rojo. Telling a story about our relationship to the natural world, he shares his experience photographing these mesmerizing insects deep in their remote mountain habitats in Mexico, diving into the latest research into the mysteries of their multi-thousand-mile journey and sharing how each of us can join the growing movement to protect them.

TED Fellow and chemosensory researcher Paule Joseph unveils the hidden power of a sense that's too often overlooked: smell. She delves into the science behind smell — from how it evokes memory and emotion to its potential for early disease detection — and advocates for the creation of a baseline test for taste and smell that could open the door to more comprehensive health care.

Massachusetts is the fifth state to join the Innovative Assessment Demonstration Authority created through the Every Student Succeeds Act, which allows states to experiment with new forms of testing.

Utah education officials have abruptly canceled a $44 million contract with a Minnesota-based standardized-testing company amid a flurry of technological glitches that have created uncertainty about whether this year's test scores will be validated.

Georgia wants to allow districts to use a series of "formative assessments" instead of one big test at the end of the year.