En 6AM Hoy por Hoy de Caracol Radio estuvo Juan Felipe Harman, director de la Agencia Nacional de Tierras, para hablar sobre las denuncias por los presuntos trabajos de inteligencia y contrainteligencia que se estarían ejecutando desde la ANT.

Juan Guillermo Zuluaga, exgobernador del Meta, habló sobre si el Gobierno está haciendo caso omiso a la advertencia del fortalecimiento de las disidencias en inmediaciones de Bogotá

En 6AM Hoy por Hoy de Caracol Radio estuvo Alejandro Castañeda, presidente de Andeg, quien habló sobre cuál es la situación energética actual de Colombia y por qué es tan preocupante la disminución de los embalses.

Alfred Ballesteros, director de la CAR, indico en 6AM, cuál es el nivel de los embalses, en Cundinamarca 

La Dian volvió a fracasar en el recaudo de impuestos

Gob. Antioquia en 6AM

Jaime Granados, abogado de Álvaro Uribe Vélez, habló en 6AM sobre qué detonó el abogado Miguel Ángel del Río en medio de la audiencia preparatoria contra su defendido

El senador Ariel Ávila, estuvo en 6AM, para abordar cómo será la transición y en qué consisten los 7 acuerdos que destaparon el camino para la reforma al Sistema General de Participaciones.

En 6AM de Caracol Radio estuvo Guillermo Herrera, presidente de la Cámara Colombiana de la Construcción (Camacol), quien habló sobre cuál es la situación actual del sector constructor en Colombia, afirmando que “hay un recorte importante para el 2025 en el sector vivienda. No tendremos los 50 mil subsidios que estamos esperando, sino que serán cerca de 20.500 para la adquisición de vivienda nueva en Colombia”

The most exciting and substantial Coleman release of the last few years.

La Audiencia de Barcelona condenó al activista Marcel Vivet a cinco años de cárcel por golpear a un policía y el TSJC rebajó la pena a un año y medio La Audiencia de Barcelona ha rechazado amnistiar al independentista Marcel Vivet, con una condena ya extinguida por golpear a un mosso d’esqu via Pocket

Microdosing has been growing in popularity alongside growing cultural acceptance of psychedelics and increased research into their potential as mental health tools. Most psychedelic drugs are illegal according to the federal government, however, so even though microdosing has inched its way into the mainstream lexicon, it simultaneously remains part of an underground culture.

"As a descendant of Lebanese heritage, I find it insulting and remiss that Friednash can't seem to acknowledge the toll this conflict is exacting upon innocent Lebanese civilians caught in the middle of this conflict. By his logic, failing to mention the collateral damage to the Lebanese people is actually anti-Lebanese." -- Peter Murr, Denver

Social media users alleged bias against former President Donald Trump when a Google search on Election Day for “where to vote” returned an interactive map to find a person’s polling station when including the word “Harris” but not “Trump.” The reason is because “Harris” is a county in Texas, whereas “Trump” is not a location.

The post Google’s ‘Where to Vote’ Search Result Reflects Quirk of Candidate Surname, Not Bias appeared first on FactCheck.org.

Behind the Bylines: Breaking news coverage is the backbone of news, and in Israel, it comes with the added intensity of wartime coverage within the war. Joanie Margulies has been doing just that.

(Written Nov. 1)  Let’s cut to the chase: Vice President Kamala Harris now looks slightly more likely than not to be the next president of the United States. To be […]

The post Unbiased analysis: Harris has slight political edge appeared first on Quin Hillyer.

Oscar Piastri leads Lando Norris to a McLaren one-two in sprint qualifying at the Sao Paulo Grand Prix.

Lando Norris takes two points out of Max Verstappen's championship lead with victory in the sprint race at the Sao Paulo Grand Prix.

Ligand bias is the ability of ligands to differentially activate certain receptor signaling responses compared with others. It reflects differences in the responses of a receptor to specific ligands and has implications for the development of highly specific therapeutics. Whereas ligand bias has been studied primarily for G protein–coupled receptors (GPCRs), there are also reports of ligand bias for receptor tyrosine kinases (RTKs). However, the understanding of RTK ligand bias is lagging behind the knowledge of GPCR ligand bias. In this review, we highlight how protocols that were developed to study GPCR signaling can be used to identify and quantify RTK ligand bias. We also introduce an operational model that can provide insights into the biophysical basis of RTK activation and ligand bias. Finally, we discuss possible mechanisms underpinning RTK ligand bias. Thus, this review serves as a primer for researchers interested in investigating ligand bias in RTK signaling.

Matthew Kennedy, University of Waterloo, has been awarded the 2025 Ciprian Foias Prize in Operator Theory by the American Mathematical Society (AMS). Kennedy has been honored for his wide-ranging and innovative work on group C*-algebras, according to the citation.

From the citation

The 2025 Ciprian Foias Prize in Operator Theory is awarded to Matthew Kennedy for his wide-ranging and innovative work on group C*-algebras, which combines ideas from operator theory, topological dynamics and group theory, and has led to the solution of several open problems, in particular to characterizations of C*-simple groups and groups with the unique trace property. His paper “An intrinsic characterization of C*-simplicity,” on which the award is based, is the culmination of earlier work in collaboration with Kalantar, Breuillard, and Ozawa. The methods introduced in this work, namely an operator-algebraic theory of boundaries, have subsequently found applications in the study of more general classes of C*-algebras and to dynamical systems.

Response of Matthew Kennedy

I am deeply honored to receive the 2025 Ciprian Foias Prize in Operator Theory. I am thankful to all of my collaborators, and especially to my good friend Mehrdad Kalantar. The genesis of the theory of operator-algebraic boundaries is in my first paper with Mehrdad and, despite our excitement at the time, neither of us had any idea how far these ideas would take us. I am also thankful to my colleagues for their continuous encouragement, and in particular to Narutaka Ozawa for his insight and generosity. My work rests on the foundations built by many other mathematicians, and I want to acknowledge the visionary work of Furstenberg and Hamana, which has been so important to my career. Finally, I am grateful to my advisor, Ken Davidson, for his guidance over the years, and to my family and friends for their love and support. 

Biographical sketch of Matthew Kennedy

Matthew Kennedy studied at the University of Waterloo, where he obtained his PhD in 2011 under Ken Davidson. His thesis on free semigroup algebras earned the 2012 Doctoral Prize from the Canadian Mathematical Society. In 2011, he joined Carleton University as an assistant professor, and in 2015, he returned to the University of Waterloo, where he is now a full professor and university research chair. In 2020, he received the Israel Halperin Prize for outstanding work in operator algebras.

About the prize

The Ciprian Foias Prize in Operator Theory is awarded for notable work in operator theory published in a recognized, peer-reviewed venue during the preceding six years. The prize, awarded every three years, was established in 2020 in memory of Ciprian Foias (1933-2020) by colleagues and friends. He was an influential scholar in operator theory and fluid mechanics, a generous mentor, and an enthusiastic advocate of the mathematical community.

The 2025 prize will be presented at the 2025 Joint Mathematics Meetings in Seattle.

Learn more about the prize.

Contact: AMS Communications

*****

The American Mathematical Society is dedicated to advancing research and connecting the diverse global mathematical community through our publications, meetings and conferences, MathSciNet, professional services, advocacy, and awareness programs.

Xinting Zhang
Dec 8, 2020; 0:RA120.002306v1-mcp.RA120.002306
Research

Protein quality control is maintained by a number of integrated cellular pathways that monitor the folding and functionality of the cellular proteome. Defects in these pathways lead to the accumulation of misfolded or faulty proteins that may become insoluble and aggregate over time. Protein aggregates significantly contribute to the development of a number of human diseases such as amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease. In vitro, imaging-based, cellular studies have defined key biomolecular components that recognize and clear aggregates; however, no unifying method is available to quantify cellular aggregates, limiting our ability to reproducibly and accurately quantify these structures. Here we describe an ImageJ macro called AggreCount to identify and measure protein aggregates in cells. AggreCount is designed to be intuitive, easy to use, and customizable for different types of aggregates observed in cells. Minimal experience in coding is required to utilize the script. Based on a user-defined image, AggreCount will report a number of metrics: (i) total number of cellular aggregates, (ii) percentage of cells with aggregates, (iii) aggregates per cell, (iv) area of aggregates, and (v) localization of aggregates (cytosol, perinuclear, or nuclear). A data table of aggregate information on a per cell basis, as well as a summary table, is provided for further data analysis. We demonstrate the versatility of AggreCount by analyzing a number of different cellular aggregates including aggresomes, stress granules, and inclusion bodies caused by huntingtin polyglutamine expansion.

Gonadal soma-derived factor (gsdf) has been demonstrated to be essential for testicular differentiation in medaka (Oryzias latipes). To understand the protein dynamics of Gsdf in spermatogenesis regulation, we used a His-tag "pull-down" assay coupled with shotgun LC-MS/MS to identify a group of potential interacting partners for Gsdf, which included cytoplasmic dynein light chain 2, eukaryotic polypeptide elongation factor 1 alpha (eEF1α), and actin filaments in mature medaka testis. As for the interaction with TGFβ-dynein being critical for spermatogonial division in Drosophila melanogaster, the physical interactions of Gsdf-dynein and Gsdf-eEF1α were identified through a yeast 2-hybrid (Y2H) screening of an adult testis cDNA library using Gsdf as bait, which were verified by a paired Y2H assay. Co-immunoprecipitation of Gsdf and eEF1α was defined in adult testes as supporting the requirement of a Gsdf and eEF1α interaction in testis development. Proteomics analysis (data are available via ProteomeXchange with identifier PXD022153) and ultrastrutural observations showed that Gsdf deficiency activated eEF1α-mediated protein synthesis and ribosomal biogenesis, which in turn led to the differentiation of undifferentiated germ cells. Thus, our results provide a framework and new insight into the coordination of a Gsdf (TGFβ and eEF1α complex in the basic processes of germ cell proliferation, transcriptional and translational control of sexual RNA which may be fundamentally conserved across phyla during sexual differentiation.

The bias may make it harder for depressed and anxious people to take a risk on a new relationship, job or other career opportunity.

After a summer of protests over racial injustice, school districts are embracing anti-bias programs. The problem is: Few studies show they work.

The principal advice column takes on communicating district decisions you disagree with, optimizing virtual lunch bunches, and more.

The CFP's annual love affair with the SEC appears finished. The latest rankings dropped a hammer on the mighty league where "it just means more."

How can something like a tiny, harmless spider or a clown make your heart race and your palms sweat? And for the love of all things science, how can you make these fears stop? Find out in this one-minute video, where Ask Smithsonian host Eric Schulze delves deep into the dark recesses of our minds to get at the facts behind our phobias.

The 237-million-year-old remains are among the oldest silesaurid fossils ever found, adding to paleontologists' understanding of this still-mysterious group of prehistoric reptiles

As expected, the Education Department has delayed a rule that would require states to take a standardized approach in evaluating districts for minority bias in special education.

Schools are not preparing students to enter an increasingly diverse world, writes high school senior Zoë Jenkins.

When a student noticed that no one was teaching her classmates about racism, she took matters into her own hands, Catherine Gewertz reports.

Midfielder Matias Harte, of State College, was named the AMCC’s Offensive Player of the Week, and defender Owen Myers, of Spring Grove, was selected the conference’s Defensive Player of the Week.

Children adapt their attitudes toward reading to conform to their classmates' perceived gender stereotypes, in ways that put boys at a disadvantage, according to a new study in the journal Child Development.

The way education media and policymakers frame education debates can have longer-term effects on how the public thinks about students, and which policies they are likely to support to improve students' learning.

Provides information on insurance processes for property damage As Tropical Storm Isaias approaches Delaware, residents are urged to prepare for dangerous winds over 55 miles per hour and up to 6 inches of rain. Storm surges, localized flooding, tree damage, power outages, and other threats to life and property are possible, according to the National […]

Commissioner Navarro encourages caution in repairs, meets with community Tropical Storm Isaias produced tornado activity, heavy rain and flooding, hail, and strong winds throughout the state, causing significant destruction in several Delaware communities. Insurance Commissioner Trinidad Navarro visited residents and assessed damage on Wednesday. “While measuring the full extent of this storm will take time, […]

NEW CASTLE (Septiembre 26 del 2022) – Una pequeña sesión de audiencia realizada por la División de Servicios de Manutención de Menores (DCSS, por sus siglas en inglés) llevó a que a más de 1,000 padres sin custodia fueron notificados que la suspensión de sus licencias de Delaware ha sido levantada. La División se enteró […]

Smryna – The Delaware Emergency Management Agency (DEMA) Emergency Operations Center is requesting that Delaware residents with damage to their properties fill out the following survey report linked below.  This information is important to help determine eligibility for a disaster declaration.   Delaware Damage Report – Click Here Residents with severe damage or other direct evidence […]

A controversy over a WhatsApp group named 'Mallu Hindu Officers', allegedly administered by Kerala Industry and Commerce Department Director K. Gopalakrishnan, is in the spotlight.

The Pinarayi Vijayan government in Kerala has suspended two officers of the Indian Administrative Service (IAS) on disciplinary grounds. K Gopalakrishnan, director of Industries and Commerce, faced the action over a religion-based WhatsApp group for

Kerala IAS officer N Prashanth aka 'Collector Bro', who has been suspended on disciplinary grounds after he publicly criticised a senior officer, has over 3 lakh followers on Facebook and 50,000 on Instagram

Hi,

My query is regarding importing of layout.

After importing, we see that the imported transistor instances and vias are all referring to the library in which they are imported, instead of referring to the technology library.

Please let me know how we can refer them to the technology library.

Will surely provide more details if my query is unclear.

Thanks,

Mallikarjun.

How do we purge/remove the duplicated vias in the same location of the PCB editor? These vias are not the one stacked and they are just blind vias running in internal layers 12-14. I find there is an additional copy of the blind via at the same location. Not sure what caused this issue.

How can I place stacked vias with the size exact same cut width without metals around?
As the red part only in the image below?

Up to 18 countries across Latin America have joined China’s new Belt and Road Initiative, hoping to boost their infrastructure development and investment.