McLaren are leading the constructor's championship but are only 29 points ahead of Ferrari, with Leclerc an obvious threat and team mate Carlos Sainz qualifying fifth and Mercedes' George Russell sixth.

Like other competitive exams, this too requires careful preparation.

English language poets of the Indian diaspora were celebrated at a recent event in London.

The IOC, with 111 members currently, is in charge of the Olympic Games and the multi-billion dollar industry linked to the world's biggest multi-sports event.

Opposition accuses CM of turning a blind eye to the infiltration of the IAS by fundamentalists

State govt. is considering disciplinary action against N. Prasanth, Special Secretary, Agriculture department, for his social media comments on Additional Chief Secretary A. Jayathilak

Officials subjected to punitive action are Industries department Director K. Gopalakrishnan and Special Secretary, Agriculture, N. Prasanth.

Drawing parallels with Haryana, the Prime Minister asserted that earlier, in Haryana, people had to pay a huge sum of money and wait for a letter from leaders to get a job, but when the BJP, which formed the government in the state, made the 'kharchi-parchi' system disappear.

The Defence Minister represented India at the swearing-in ceremony of Nigerian President Bola Ahmed Tinubu during an unprecedented three-day visit to the African nation.

While the Supreme Court of India’s striking down of caste-based practices in prisons is significant, the directive to remove caste references from prison records needs reconsideration

Civil services aspirants, who have been protesting over the deaths of the three students, called the compensation a gimmick, and a strategy to dilute the issue

The government’s suspension orders on Monday night cited both officers’ actions as serious indiscipline and violations of the All India Service Conduct Rules, 1968. 

The communication from the Information and Broadcasting Ministry said there is a view that a small group exercises editorial control on its pages

Es necesario un cambio cultural para evitar seguir perjudicando a las investigadoras

Un estudio hace que los científicos se replanteen cómo se desarrollan las infecciones bacterianas

Kolkata tram service, having just three routes with only two functional, resumes after Durga Puja suspension due to traffic congestion concerns

He was serving as Special Secretary in the Agricultural Department in Kerala government until his suspension on Monday.

City slumped to a fourth consecutive loss in all competitions with a 2-1 defeat at Brighton and Hove Albion in the Premier League on Saturday

Can I do IAS exam preparation while pursuing CA

The UK is tightening rules on sexist stereotyping in ad campaigns. Critics argue recruitment in the industry must change too

‘I aspire to become a modern version of Tiffany’

Princeton University-based researchers have found that machine-learning programs can acquire the cultural biases embedded in the patterns of wording, from a mere preference for flowers over insects, to discriminatory views on race and gender.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

This book explores how developing-country governments have institutionalized ties with emigrants and their descendents. It offers an unprecedented taxonomy of 45 diaspora-engaging institutions found in 30 developing countries, exploring their activities and objectives. It also provides important practitioner insights from Mali, Mexico, and the Philippines.

This edited volume examines the development impact of diasporas in six critical areas: entrepreneurship, capital markets, "nostalgia" trade and "heritage" tourism, philanthropy, volunteerism, and advocacy.

Ce manuel pratique et simple d’utilisation à l’usage des décideurs et des praticiens fait le point des mesures les plus récentes prises par les pouvoirs publics en direction des diasporas. La question qui se pose aux responsables politiques n’est pas tant de savoir si les diasporas peuvent être utiles à leur pays d’origine, mais comment elles le sont et quels types de politiques et de programmes publics sont à même de favoriser ces relations.

This practical handbook highlights policies and programs that can magnify the resources, both human and financial, that emigrants and their descendants contribute to development. It gives concrete examples of policies and programs that have been effective, and pulls out both useful lessons and common challenges associated with the topics at hand.

This edited volume develops a pragmatic approach to the engagement of highly skilled members of the diaspora for the benefit of their countries of origin. The book, edited by a World Bank senior economist, is based on empirical work in middle-income and high-income economies.

Ravi Zacharias (date: 5/10/2020 - Rank: 6)

In a major administrative reshuffle amid the lockdown, the Madhya Pradesh government has transferred 50 Indian Administrative Service (IAS) officers, including some additional chief secretaries,...

A proxy advisory firm has raised objections to the corporate governance structure at Zee Learn, part of the Essel group, expressing concerns over the company’s capital allocation decision, related-party transactions and acquisition of MT Educare.

The Syrian government said Tuesday it suspects a U.N.-backed inquiry based its reporting on highly questionable testimonies.

The illusion that learning from home is taking place is a conscious bias that is remiss of the context.

While 62 percent of transportation has been restored, locals say bus service has been left behind

Just hours after President Donald Trump announced that he intends to withdraw the United States from Paris Climate Agreement, three state governors announced the formation of the United States Climate Alliance, a union that will work to reduce greenhouse gas emissions, even as national leadership on climate change falters.

For now, the alliance includes California, New York and Washington State. The governors of those states, Jerry Brown, Andrew Cuomo, and Jay Inslee, respectively, released a statement on Thursday describing how the new alliance will build state-level partnerships to continue aggressive American action on climate change and uphold the goals and standards of the Paris Agreement.

"The president has already said climate change is a hoax, which is the exact opposite of virtually all scientific and worldwide opinion," said Governor Brown in the statement. "I don't believe fighting reality is a good strategy—not for America, not for anybody. If the president is going to be AWOL in this profoundly important human endeavor, then California and other states will step up."

Governor Cuomo echoed that sentiment. Trump's "reckless decision to withdraw from the Paris Climate Agreement has devastating repercussions not only for the United States, but for our planet," he said. "This administration is abdicating its leadership and taking a backseat to other countries in the global fight against climate change."

California, New York, and Washington combined are home nearly 70 million people, about 20 percent of the US population. And their governments have already begun to take action. For example, the California State Senate passed legislation on Wednesday that mandates California to develop 100 percent of its electricity from renewable resources by 2045.

So far, no other states have signed on to the alliance, though 61 American mayors also pledged on Thursday that their cities will uphold the tenets of the Paris Climate Agreement.

These mothers deserve a huge round of applause!

These mothers deserve a huge round of applause!

CARACAS, Venezuela (AP) - After fleeing Venezuela along with millions of others amid the country's grueling humanitarian crisis, Misael Cocho made his way by bus to Peru - where he got odd jobs and sent money home monthly to support his mother and his 5-year-old son.

But just after Cocho ...

The election watchdog has revealed that it is pressing ahead with plans to hand itself powers to prosecute campaigners and political parties, putting itself on a collision course with ministers. The Electoral Commission is planning to publish a consultation setting out proposals to hand itself a "prosecutions capability", despite senior Tories insisting that the body is "not trusted to be impartial". The disclosure comes after the Metropolitan Police confirmed that it had ended investigations into Darren Grimes and Alan Halsall, two pro-Brexit campaign figures, two years after a referral by the commission for alleged breaches of spending rules. The move prompted calls for the commission to be "overhauled", with Mr Grimes describing the body as a "kangaroo court" that was not "fit for purpose". Separately, the National Crime Agency found no evidence that any criminal offences were committed by Arron Banks, another prominent Brexiteer, after another referral by the watchdog. Last night Matthew Elliott, who was chief executive of the official Vote Leave campaign, claimed that the commission's record showed that if it acquired the new powers, "there will be countless travesties of justice, and democracy will be undermined.” Sir Bernard Jenkin, the former chairman of the Commons public administration committee, said: "These proposals appear to be doubling down on a failed system. Parliament should change it." Another Conservative MP said: "I can't think of any public body that is less deserving of prosecuting powers than the Electoral Commission, who have shown themselves to be biased and, frankly, vindictive." Last year Jacob Rees-Mogg, now the leader of the Commons, and Brandon Lewis, who has also been appointed to Boris Johnson's cabinet, both expressed alarm at the watchdog's plans to hand itself powers currently exercised by the police and Crown Prosecution Service - after the move was revealed by this newspaper. The watchdog has faced repeated accusations of bias against bodies that campaigned for Brexit in 2016, which it strongly denies. The commission claims it could hand itself the powers without ministers bringing forward legislation, by altering its enforcement policy following a public consultation - due to open in the coming weeks. But MPs warned that some groups could be unfairly targeted. Speaking last year, while Tory chairman, Mr Lewis pointed out that one senior figure at the commission - the same official spearheading the proposals - had previously said that she would "not want to live under a Tory government". He suggested the body was not seen as a "fair" arbiter. As a backbencher, Mr Rees-Mogg called for the Conservatives to formally oppose the move, saying: "The Electoral Commission is not trusted to be impartial and a number of its leading figures have said very prejudicial things about Brexit." The commission's corporate plan for the period from 2020 to 2025 states: "To deter people from committing offences, and to make sure we can respond proportionally if they do, we will continue to build the capacity to prosecute suspected offences. We will consult on the way we approach the use of prosecutions." An Electoral Commission spokesman said: “Later this year we will be consulting with political parties, the police and the CPS on changes to our enforcement policy, which includes a prosecutions capability, and will bring our regulatory work in line with a wide range of other regulators. “Extending our work in this direction would enable us to bring lower order offences before the courts in a way which is swift and proportionate, freeing up the resources of the police and prosecutors and delivering more effective regulation of political finance to support public confidence.” Mr Elliott said: “The Electoral Commission’s track record at conducting investigations is woeful. "In the case of Leave campaigners ... they assumed that we were guilty until proven innocent ... Thankfully, the Metropolitan Police and Crown Prosecution Service looked at the evidence thoroughly, and saw through the conspiracy theories that the Electoral Commission had believed without question." The commission insisted it was "right that potential electoral offences are properly investigated by the appropriate authority". A spokesman said there was "no substance to allegations that the Commission is biased", saying the organisation had investigated campaigners and parties across the political spectrum.