LLM-powered multiagent persona simulation for imagination enhancement and business insights. - microsoft/TinyTroupe

OpenCoder is an open and reproducible code LLM family which matches the performance of Top-Tier Code LLM. We provide not just the final models, but also the reproducible training data, the complete data processing pipeline, rigorous experimental ablation results, and detailed training protocols for open scientific research.

man pages for UNIX, BSD, Linux, SunOS, HP-UX, AIX, Minux, Ultrix, Plan9, Darwin, XFree86, & Perl Man & Info Pages, plus Application manuals

Americans gave Republicans a mandate to "enact President Trump's agenda," Sen. Rick Scott (R-FL) said on Tuesday as he vies for the Senate leadership position.

The post Senate Majority Leader Contender Rick Scott: America Gave Us a Mandate to ‘Enact President Trump’s Agenda’ appeared first on Breitbart.

Rob Grabowski and Tom Antonson caught Weezer, The Flaming Lips and Dinosaur Jr. In The Act during the Rosemont, Il stop of the Voyage To The Blue Planet Tour on September 6th . Check out Rob's photos and Tom's review!

The Canadian Pharmacy Spammers are at it again, or should we say still at it again.

A fake Facebook message, taking you to some online pharmacy site.

Rosa Daniel wants you to come to Rome to pick up a high priority package.

Malware distributed via Dropbox with the help of fake eFax e-mails

Fax or malware? This is clearly malware.

The most confusing Paypal phishing scam ever!

Ben jij altijd op zoek naar sterke content-ideeën waarmee je jouw socialmedia-kanalen kunt vullen? Dan komt een contentplanning goed van pas. Daarmee kun je vast vooruitkijken en belangrijke themadagen en inhaakmomenten noteren: een fijne leidraad. Of je nu (Belgische of Nederlandse) nationale feestdagen wil uitlichten of minder bekende dagen die goed aansluiten bij jouw product […]

Skiing power couple Mikaela Shiffrin and Aleksander Aamodt Kilde have announced they’re engaged to be married.

When it opens on Sept. 14, Pure Elevations will be among the city’s first public consumption spaces.

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By Fran Kritz, NPR

The ancient scourge of tuberculosis for years was the deadliest infectious disease. Then SARS-CoV-2 came along and grabbed the notorious title of #1 killer: In 2020, COVID-19 was responsible for 3.5 million deaths worldwide vs 1.5 million for TB.The 2024 Global Tuberculosis Report, published last week by the World Health Organization, puts TB back in the top slot with 1.25 million deaths in 2023 compared to 320,000 COVID-19 deaths. There's also been an increase of hundreds of thousands of new TB cases in 2023 compared to the year prior.

The 1.25 million TB deaths in 2023 is down from 2022’s number of 1.32 million (which that year was second to the COVID toll). But it's still indefensibly high, say public health leaders.

“The fact that TB still kills and sickens so many people is an outrage, when we have the tools to prevent it, detect it and treat it,” said Tedros Adhanom Ghebreyesus, WHO director-general, in a statement issued on October 29.

According to the report, approximately 8.2 million people were newly diagnosed with TB in 2023 — the highest number since WHO began global TB monitoring in 1995 and a “notable increase” from 7.5 million people newly diagnosed in 2022.

TB sleuths are trying to figure out the reasons behind the increase. Anand Date, global TB branch chief at the Centers for Disease Control and Prevention, says population growth may account for the increase in cases last year -- and that it may take until the 2024 to find out if that is so or if the leap in 2023 reflects an undercount of annual TB totals during the pandemic.

“Disruptions to TB programs during the height of the pandemic led to more people going undiagnosed and untreated for TB. [And] guidance to shelter in place may have also limited the spread of TB, says Yogan Pillay, who heads efforts to improve TB program delivery at the Bill and Melinda Gates Foundation (which is a funder of NPR and this blog).

COVID-19 did trigger a new setback in the effort to control TB. But most of the reasons the infection persists are frustratingly well-known, says Lucica Ditiu, executive director of the Stop TB Partnership. There's too little money for research, treatment. and patient care needs. And there's stigma that can keep the most common victims of TB, impoverished people including migrants and sex workers, from seeking help or being offered treatment.

In addition, health conditions like malnutrition, diabetes and smoking that can exacerbate TB and keep medications from being fully effective, says Luke Davis, a TB and HIV specialist at the Yale School of Public Health. “TB is unusual,” says Davis, in that most people who are exposed to the bacteria won’t progress to infectious TB. Only about 10% do, and they are usually among the world’s poorest people often with poor health to begin with, which exacerbates their condition.”

So what's the solution?

And that brings us to the Tedros point. The world knows how to vanquish TB — but is not doing a good job.

Money reigns as perhaps the biggest obstacle to conquering tuberculosis. A spokesperson for WHO tells NPR: “Compared with global funding targets for TB set at the 2023 U.N. high-level meeting on TB, there are large funding shortfalls for TB research as well as prevention, detection and treatment services. To close these gaps, more funding is needed from both domestic sources in the countries most impacted by TB and from international donors.”

Global funding for TB prevention and care decreased in 2023 from $6 billion in the three previous years to $5.7 billion and remains far below the yearly target of $22 billion, according to WHO.

What would more money bring? WHO cites expanded rapid diagnostic testing as critical. Then treatment can start sooner. And people wouldn’t have to travel long distances to a clinic then wait for days for the results.

Increased funding would also help reimburse families for lost wages and food and travel expenses incurred as they go for treatment. Those costs keep some patients and their families from seeking care.

The WHO report and other investigations also say that countries burdened by TB also have to step up and spend more money on prevention, diagnosis and treatment. A report by MSF/Doctors Without Borders published last month, for example, found that, only 5 out of 14 countries have adapted their guidelines — based on WHO recommendations -- to initiate TB treatment in children when symptoms strongly indicate TB disease, even if bacteriological tests are negative.

And increased funding would speed up the pace of research says the CDC’s Date. Funding for TB research has stagnated at around $1 billion per year, constraining progress, according to WHO. The target at the U.N. meeting: $5 billion per year by 2027. “The world also has the most promising R&D pipeline of new TB tools in decades,” says Pillay. “What’s needed now is greater investment to deliver on the promise of that pipeline and ensure patients and those at risk of TB have affordable and equitable access to these tools when they are available.”

Vaccines in the works

Pillay says there are more than a dozen TB vaccine candidates in clinical trials, including one whose late stage (stage 3) clinical trial is sponsored by the Gates Medical Research Institute. The trial began recruiting patients last March. That vaccine candidate is called M72/AS01E and if proven effective would be the first new TB vaccine in 100 years. The lone TB vaccine available now is not predictably effective in adults, and can cause a false positive result on TB skin tests.

But even an effective vaccine won’t do that much good if there aren’t funds to purchase it for countries impacted by TB. Janeen Madan Keller, deputy director of the Global Health Policy Program at the Center for Global Development, based in Washington, D.C., says that while Gavi, The Vaccine Alliance, pays for [a variety of] vaccines in some of the poorest countries such as Afghanistan, Burundi and the Democratic Republic of the Congo, some countries with high rates of TB are middle income countries, like Indonesia, and no longer eligible for support. Ahead of a TB vaccine’s approval, says Keller, there needs to be a better match of policy and funding.

“Often it seems that when we find a way to help vanquish TB,” says Lucica Ditiu, “we also find another barrier.”

Fran Kritz is a health policy reporter based in Washington, D.C., and a regular contributor to NPR. She also reports for the Washington Post and Verywell Health. Find her on X: @fkritz

Dear Eric: I am newly in love and engaged. My fiancé and I are both in our early 70s. Quite a few of my friends (not my close friends but others) have responded to the news with: how cute! Somehow the fact that we have fallen in love and plan to marry is "cute."

"The communities I identify with still struggle with the aftermath of historical events."

Freddie Freeman homered for the third straight game and Walker Buehler pitched another World Series gem as the Los Angeles Dodgers beat the New York Yankees 4-2 on Monday night for a 3-0 lead in the Fall Classic.

A recent spate of Xcel power outages across metro Denver has prompted the Colorado Public Utilities Commission to consider opening an investigation.

The Colorado Public Utilities Commission is looking into recent power outages reported by Xcel Energy customers.

For people living near a gasoline storage facility in Commerce City, the company’s decision to cancel its expansion near an elementary school was an environmental victory.

A Delta Airlines flight flying from Detroit landed safely at Denver International Airport on Monday after a mid-flight mechanical issue damaged the plane’s nose.

Ella Hagen won her second Class 4A cross country crown on Saturday at the Norris Penrose Event Center.

"When you’re doing a thing, and you’re having fun at it, or you’re having an adventure, you never know where that falls in with the best times of your life."

The allegations in the ICU come as the Aurora VA has been roiled by controversy in recent months. When clinicians do raise concerns to management, they say they're met with admonition and retaliation.

Christina and Tracey talk about their surprise engagement.

Raven-Symone addresses controversial gay marriage tweet.

Keke Palmer chats with Raven-Symoné.

The truth is loose: The Broncos are colts, an increasingly younger team tasked with cobbling together a foundation for the future. They are cheaper, shrewder investments, their signings requiring Google searches for statistics and correct spellings of names.

Courtland Sutton and the Broncos were still celebrating his 32-yard touchdown catch in the second quarter Sunday when the tremor preceding the earthquake rippled.

The play explores the gulf between immigrant parents and their first-gen children.

Paige: Will Mose Frazier be the Next Great Free Agent to make the Broncos' roster?

Guests have a rare opportunity to glimpse Boulder artifacts during a private tour of the Museum of Boulder’s Collections Facility, where out-of-commission museum objects go to rest when they’re not on display.

With little wiggle room against the NFL salary cap, how real is the possibility that the Broncos will have to say goodbye to a significant contributor or two in free agency?

BET GOSPEL is the home of inspiration.

How to Use Images From Your Phone to Search the Web

Nicholas Moodley’s attorneys argued the charges had to be dismissed after a paralegal who worked in the Denver DA’s office told one of Moodley’s friends that prosecutors believed they’d “got it wrong."

A wildfire northwest of Fort Collins on Tuesday burned 15 to 30 acres.

BET's four part documentary on the history of hip hop.

Check out these old school photos.

These brands are probably sitting in your closet somewhere.

The connection between hip hop and sneakers is obvious

Check out who will be appearing on the four-part special.

Pharrell’s vivid memories of hip hop.

When were you introduced to hip hop?

The definitive history of hip hop.

Check out these great quotes from The Message.