'The Late Show with Stephen Colbert', in the meantime, makes the shortlist in the Entertainment field, and Stacey Abrams' 'All In: The Fight for Democracy' gets nominated in the Documentary category.

'The Late Show with Stephen Colbert', in the meantime, makes the shortlist in the Entertainment field, and Stacey Abrams' 'All In: The Fight for Democracy' gets nominated in the Documentary category.

Hey Gang! New track is up.  This one was fun to do.  All the drum sounds at :48 were gathered running around my work’s basement garage with a ping pong ball, metal pipe Levitra Online, and a field recorder.  Only 1 person came down and gave me angry looks while I was recording!  You can […]

El exministro habló desde Cartagena sobre los retos que enfrenta el sector de hidrocarburos y la incidencia del Acuerdo de Escazú en protección ambiental.

La Luciérnaga se enciende para hablar del galardón que recibió la jugadora de fútbol colombiana Linda Caicedo. Además, le contamos sobre los debates alrededor de la minería ilegal. También, ¿Porqué alias “Timochenko” regreso a los titulares de noticias?
La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

En 10AM Hoy por Hoy habló Edwin Corredor, hermano de Julián David Corredor, uno de los 21 mineros muertos de Sutatausa, sobre la tragedia. vida de su ser querido.

En 10AM Hoy por Hoy de Caracol Radio estuvo Daniel Rojas, nuevo ministro de Educación, para hablar de los retos que tiene el sector y los objetivos del Gobierno.

El exministro de Salud, cree que la intervención a la EPS Sanitas, es muestra de un revanchismo ideológico que se está anteponiendo al mismo sistema en el país.

La jefe de la cartera de Educación,  Aurora Vergara, se refirió a la posesión de José Ismael Peña como el nuevo rector de la Universidad Nacional

En Caracol Radio estuvo Ivonne Consuelo González, presidenta de la Asomineros

Andres Camacho, ministro de Minas y Energía, estuvo en 6AM para hablar del acuerdo entre el Gobierno y los transportadores que se manifestaron en los últimos días.

Alberto Caicedo. Colombiano en Tampa, habló en 6AM sobre las medidas que implementarán para mitigar consecuencias del paso del Huracán.

Ivonne González, presidenta de la Asociación de Mineros y Joyeros de Vetas, estuvo en 6AM para abordar la problemática alrededor del decreto 044 del 2024.

Juan Camilo Nariño, presidente de la Asociación Colombiana de Minería, estuvo en 6AM para ampliar la problemática sobre los efectos alrededor del decreto 044 del 2024.

Juan Camilo Nariño, presidente de la Asociación Colombiana de Minería, estuvo en 6AM para ampliar la problemática sobre los efectos alrededor del decreto 044 del 2024.

"If you take politics as a game, you have to play underneath the rules. You can't appear to be disagreeable; you have to appear to voters as someone who’s getting things done."

He was the godson of track and field legend Carl Lewis.

The 38th annual Denton Hurdle Memorial Awards will take place on Thursday at Warwick Academy starting at 6:30pm, with the event serving to honor some of the Island’s top young athletes. A spokesperson said, “These awards, honoring the late teacher, are used to highlight, recognize and reward the finest primary, middle and senior school student-athletes. Fifty three […]

Some time ago, I discussed the concept of a mineral moon shot. Basically, you take a photo of the moon, or a stack of photos, and then process them to bring out the colouration of different areas of the surface. Different areas, the seas, the mountains, the plains, have different minerals on the surface that … Continue reading "Another mineral moon"

Carlson: So now we’re arming the Taliban and marooning our own citizens in Afghanistan. Who could possibly have seen that coming. Glenn Greenwald is one of the few journalists who did see it coming. He writes for Substack where all … Continue reading →

Eeeeeeee! Just saw that THE SPELLSHOP is a nominee for the Goodreads Choice Awards 2024!!! Thanks so much! This makes my day! I'm so thrilled and so grateful! Voting is open now! 

https://www.goodreads.com/choiceawards/readers-favorite-romantasy-books-2024

 The Victorian novelist Anthony Trollope, on a tour of the United States, passed through Utah, and decided to drop in on Brigham Young. It did not go well. From Trollope's autobiography:

"I did not achieve great intimacy with the great polygamist of Salt Lake City. [...] He received me in his doorway, not asking me to enter, and inquired whether I was not a miner. When I told him that I was not a miner, he asked me whether I earned my bread. I told him I did. "I guess you're a miner," said he. I again assured him I was not. "Then how do you earn your bread?" I told him I did so by writing books. "I'm sure you're a miner," said he. Then he turned upon his heel, went back into the house, and closed the door."

"For this playlist, I’ve strung together some favorite songs that reflect the subject matter and themes of the stories and that serve as fuel for my creative process."

Conspiracy theory purveyor Infowars and most of its assets are set to go on the auction block Wednesday, with Alex Jones waiting to see if he will be allowed to stay or if he will get kicked off its online platforms. The private auction is being held as part of Jones' personal bankruptcy, which…

Language in this video, obviously.

The post The Best Works of Sergey Maksimishin: Prominent Russian Photographer appeared first on English Russia.

The National Science Foundation has awarded a $52.66 million grant to fund a major infrastructure upgrade to the Simons Observatory in the Atacama Desert of Chile. Upgrades are expected to take about five years; the resulting facility will be known as the Advanced Simons Observatory (ASO).

Ronald Surtz, professor of Spanish and Portuguese languages and literatures, emeritus, died peacefully at home in Cranbury, New Jersey, on Nov. 14. He was 75.

Lisk taught biology at Princeton for 30 years before transferring to emeritus status in 1990.

In the 2024 election, Donald Trump easily carried many predominantly Hispanic rural areas like Hidalgo County, Texas, and some mostly non-white precincts, such as mostly Asian areas of Brooklyn. As journalist Josh Kraushaar noted, “Trump carried PASSAIC County, New Jersey. Majority/Hispanic electorate and home to a sizable Orthodox Jewish constituency. Was a Dem stronghold for […]

The post Prominent law professor blames Harris loss on ‘white supremacy’ and ‘toxic masculinity’ appeared first on Liberty Unyielding.

The latest investment insights and market developments.

The following article, Tom Homan – Trump’s Nominee for the Border, was first published on Conservative Firing Line.

Former Director of ICE Tom Homan is the Trump Nominee for “Border Czar.” But he isn’t the only nominee being named on this Veteran’s Day. Homan is one tough cookie- he will be charged with overseeing the deportations of criminal migrants, as well as the Northern border, aviation security, and maritime security. It’s a tall …

Continue reading Tom Homan – Trump’s Nominee for the Border ...

Philip L. Ross
Dec 1, 2004; 3:1154-1169
Research

New essay anthology examines the future of the international order News release jon.wallace 7 May 2021

Featuring a new essay by Robin Niblett, Chief Executive of Chatham House, and Leslie Vinjamuri, Director of the US and Americas programme.

“Anchoring the World”, a new anthology, features an important new essay by Robin Niblett, Chief Executive of Chatham House, and Leslie Vinjamuri, Director of the US and Americas programme. The essay, “The Liberal Order Begins At Home”, argues powerfully for the revival of a liberal international order.

The essay collection has been produced by the Lloyd George Study Group on World Order, and celebrates the centennial years of Chatham House, Georgetown University’s School of Foreign Service, and the Council on Foreign Relations.

Robin Niblett said:

“In this excellent collection, some authors argue that the United Nations should continue to anchor the international system, while others argue for the creation of a new Concert of Powers.

“Our essay argues that it is both necessary and possible to revive the idea of a liberal international order: necessary (and urgent) because of heightened global competition with China, and possible only if western democracies repair their deep social and economic problems at home.

“We hope this volume carries forward the fortitude and creative spirit that the School of Foreign Service, Chatham House, and the Council on Foreign Relations have brought to the study and practice of international affairs over the past century.”

The Lloyd George Study Group and book were made possible by the generosity of the family of Robert Lloyd George, the great-grandson of British Prime Minister, David Lloyd George.

Anchoring the World is published by Foreign Affairs magazine.

US election rhetoric on migration undermines Washington’s soft power in Latin America Expert comment jon.wallace 23 October 2024

As US public opinion hardens, the Democratic party takes a tougher stance, and Donald Trump proposes mass deportations, Latin American leaders note a lack of long-term policy.

The US’s broken immigration system has become a central theme of the 2024 election campaign. But the discussion on immigration, undocumented immigrants, and asylum seekers – increasingly lurching into dehumanizing rhetoric – extends beyond US borders. 

As one former senior director of the National Security Council told me, ‘when the president travels or meets with heads of state from Latin America what comes up –regardless of the country – isn’t US–Cuba policy or even trade. It’s immigration’. How the US talks about and treats citizens of Latin American and the Caribbean matters to elected politicians in the region. 

The roots of the US immigration debate go deep and will not be easily resolved, even with a sweeping reform of the system. 

According to a January 2024 Pew survey, 78 per cent of Americans ‘say the large number of migrants seeking to enter the country at the Mexico border is either a crisis (45 per cent) or a major problem (32 per cent)’. Worries about the border are not limited to Republican voters: 73 per cent of Democrats feel that the issue is either a crisis or major problem. 

Despite the heated popular temperature, the numbers of undocumented immigrants encountered at the US–Mexico border has actually dropped in recent months. US Customs and Border Protection (USCBP) reported 301,981 encounters with irregular border crossings in December 2023; by August 2024 this had dropped to 107,473.  

Nevertheless, illegal border crossings have increased under Biden. During his administration USCBP reported 8 million encounters along the Mexico border compared to 2.5 million under Donald Trump. 

Mexico

Any attempt to address the issue promises to affect US relations with Mexico, requiring the cooperation of newly elected president Claudia Sheinbaum. Her predecessor and founder of her Morena party, leftist Andres Manuel Lopez Obrador (AMLO), proved an unexpectedly cooperative partner for the previous Trump administration and Biden White House. 

But that came at a cost, particularly for Biden. In return for AMLO’s cooperation, the US soft-pedalled criticism over his failures to disrupt narcotics trafficking and criminal networks and for his steady weakening of checks on executive power. 

Mexico’s borders with other countries are also under pressure. Mexico remains the primary sending country to the US. But political repression and insecurity in countries including Cuba, Ecuador, Guatemala and Venezuela has pushed their citizens to travel across Mexico to the US. Economic collapse and humanitarian crises in Cuba and Venezuela have further fuelled the flight.

Rhetoric

The Kamala Harris and Trump campaigns have struck different positions on how to stem the flow of illegal immigration. But as US public opinion shifts, both parties are talking tougher. 

Harris is continuing Biden’s hardening stance, including the controversial move to bar those who cross the border illegally from applying for asylum. 

Biden’s early ‘roots’ strategy, to provide economic and security support in countries from where migrants are travelling, has fallen by the wayside. 

The Trump campaign is taking more extreme positions. The Republican presidential candidate mentions immigration in almost every campaign speech. 

He proposes to carry out the ‘largest deportation in US history’, using ICE personnel, the National Guard and local police forces to round up undocumented immigrants, including in their workplaces. 

The campaign has also pledged to end birth-right citizenship and Biden’s programme of parole for humanitarian reasons. Trump also plans to restore his first term policies including construction of the border wall. 

Trump’s proposals provide little opportunity for a broad, bipartisan consensus on immigration. Should he win in November he is likely, as he did in his first term, to attempt to push his policies via executive action, opening up challenges in federal court. 

A Harris victory would at least create space for the resurrection of the Biden administration’s 2024 immigration enforcement bill, originally supported by moderate Republican leadership in the Senate, but defeated following pressure from Trump. 

The bill would have toughened enforcement at the border – increasing funding for detention centres, asylum hearings and for local governments and border patrols. It would also permit ICE to shut down the border when crossings surpassed an average of 5,000 per day or 8,500 on a single day.

Undermining US influence

But such legislation, while promising to address domestic US perceptions of the crisis, threatens to reduce US soft power in Latin America. That would be counterproductive at a time when the US is attempting to consolidate global support in its competition with China and conflict with Russia. 

For Latin American leaders, US rhetoric on immigration rankles. The priorities of Latin American and Caribbean leaders and their voters are long term: economic growth, improved security, and climate change. These issues require investment and commitment from an engaged and reliable US partner. Sadly, Latin Americans can see such issues are not on the domestic agenda in US politics. 

To improve regional perceptions of US intentions after the election, new policy should seek to address the root causes of migration. That will require a multi-pronged, bipartisan approach that focuses attention and resources on US neighbours south of the border.  

The US’s immigration system will need to broaden paths for legal immigration to meet US labour needs, while delivering increased support for border security, and accelerated (and humane) processes for detaining and repatriating illegal border crossers and asylum claims.  

But any sustainable answer also requires addressing the multifaceted reasons driving migrants north. Any future US administration will need to risk unpopularity with some voters at home and engage with sending countries and their neighbours. 

New Chatham House History Examines our Defining Moments News Release NCapeling 18 January 2021

'A History of Chatham House: its People and Influence from the 1920s to the 2020s' will examine the impact on policymaking of our first 100 years.

Minerals and Metals for a Low-Carbon Future: Implications for Developing Countries 30 October 2017 — 5:00PM TO 8:00PM Anonymous (not verified) 13 October 2017 Chatham House, London

This roundtable will explore two sides of minerals and metals for a low-carbon future - the growing demand for metals required for low-carbon technology and the technological and policy innovations that will be required to manage the carbon footprint of the mining sector and its wider energy and industrial linkages. Based around a presentation and scenarios developed by the World Bank, this roundtable discussion will assess which strategic metals will likely rise in demand in order to deliver a low-carbon future, before exploring the possible implications for resource-rich developing countries. In particular, what does a growing demand of minerals for a clean energy future mean for governments and industry, and how might developing countries benefit from this trend? What impact might growth of the mining sector have on a sustainable and climate-smart development? Can renewable energy and other clean tech innovations in the mining industry help reduce the carbon footprint of the sector and related industries, and under what circumstances? And how fit-for-purpose are current donor approaches to the mining sector in an increasingly carbon-constrained world?

Attendance at this event is by invitation only.

Mining and the Circular Economy: Implications for the Minerals and Metals Industries 6 November 2017 — 4:00PM TO 5:30PM Anonymous (not verified) 31 October 2017 Chatham House, London

Visualizing the Data: The Evolution of Trade Tensions in Metals and Minerals Markets 18 January 2018 — 4:30PM TO 6:00PM Anonymous (not verified) 19 December 2017 Chatham House, London

Over the past decade, producer countries such as South Africa, Zambia, Indonesia, the DRC and, most recently, Tanzania have restricted exports of unprocessed precious metals, copper, nickel, cobalt and other minerals in an attempt to support, or create, downstream processing industries and jobs or increase revenues. These moves have invariably created tensions with trading partners. Research suggests that export restrictions are not the best way to achieve such policy objectives and can instead harm the producer country’s economy and undermine the functioning of international metals and minerals.

Drawing on OECD and Chatham House research on resource trade, the speaker will present analysis and data visualizations exploring the drivers of past export restrictions and their political and economic impacts. They will also consider how the drivers of ‘resource nationalist measures’ are changing, whether and where export restrictions might present strategic and economic risks in the current context, and the extent to which producer and consumer governments and international governance mechanisms are prepared to address them.

Attendance at this event is by invitation only.

Mining, Minerals and Metals Expert Roundtable: Forest-Smart Mining Report Launch 10 May 2019 — 5:30PM TO 6:30PM Anonymous (not verified) 12 April 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

Paweł Hitczenko and Nick Wormald
Proc. Amer. Math. Soc. 152 (), 5411-5427.
Abstract, references and article information

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling, and endocytosis. GlcNAc is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting platelet-derived growth factor receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, whereas genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone)-induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage. Our data identify N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggest that oral GlcNAc may be neuroprotective in demyelinating diseases like MS.

17 July 2020

The subcellular localization of Arf family proteins is generally thought to be determined by their corresponding guanine nucleotide exchange factors. By promoting GTP binding, guanine nucleotide exchange factors induce conformational changes of Arf proteins exposing their N-terminal amphipathic helices, which then insert into the membranes to stabilize the membrane association process. Here, we found that the N-terminal amphipathic motifs of the Golgi-localized Arf family protein, Arfrp1, and the endosome- and plasma membrane–localized Arf family protein, Arl14, play critical roles in spatial determination. Exchanging the amphipathic helix motifs between these two Arf proteins causes the switch of their localizations. Moreover, the amphipathic helices of Arfrp1 and Arl14 are sufficient for cytosolic proteins to be localized into a specific cellular compartment. The spatial determination mediated by the Arfrp1 helix requires its binding partner Sys1. In addition, the residues that are required for the acetylation of the Arfrp1 helix and the myristoylation of the Arl14 helix are important for the specific subcellular localization. Interestingly, Arfrp1 and Arl14 are recruited to their specific cellular compartments independent of GTP binding. Our results demonstrate that the amphipathic motifs of Arfrp1 and Arl14 are sufficient for determining specific subcellular localizations in a GTP-independent manner, suggesting that the membrane association and activation of some Arf proteins are uncoupled.

Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-B via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its coreceptor, MD-2, results in production of pro-inflammatory cytokines that initiate adaptive immune responses. LOS can also be absorbed by cells and activate intracellular inflammasomes, causing the release of inflammatory cytokines and pyroptosis. Studies of LOS and LPS have shown that their inflammatory potential is highly dependent on lipid A phosphorylation and acylation, but little is known on the location and pattern of these posttranslational modifications. Herein, we report on the localization of phosphoryl groups on phosphorylated meningococcal lipid A, which has two to three phosphate and zero to two phosphoethanolamine substituents. Intact LOS with symmetrical hexa-acylated and asymmetrical penta-acylated lipid A moieties was subjected to high-resolution ion mobility spectrometry MALDI-TOF MS. LOS molecular ions readily underwent in-source decay to give fragments of the oligosaccharide and lipid A formed by cleavage of the ketosidic linkage, which enabled performing MS/MS (pseudo-MS³). The resulting spectra revealed several patterns of phosphoryl substitution on lipid A, with certain species predominating. The extent of phosphoryl substitution, particularly phosphoethanolaminylation, on the 4'-hydroxyl was greater than that on the 1-hydroxyl. The heretofore unrecognized phosphorylation patterns of lipid A of meningococcal LOS that we detected are likely determinants of both pathogenicity and the ability of the bacteria to evade the innate immune system.

Adaptive thermogenesis is highly dependent on uncoupling protein 1 (UCP1), a protein expressed by thermogenic adipocytes present in brown adipose tissue (BAT) and white adipose tissue (WAT). Thermogenic capacity of human and mouse BAT can be measured by positron emission tomography-computed tomography quantifying the uptake of ¹⁸F-fluodeoxyglucose or lipid tracers. BAT activation is typically studied in response to cold exposure or treatment with β-3-adrenergic receptor agonists such as CL316,243 (CL). Currently, it is unknown whether cold-stimulated uptake of glucose or lipid tracers is a good surrogate marker of UCP1-mediated thermogenesis. In metabolic studies using radiolabeled tracers, we found that glucose uptake is increased in mildly cold-activated BAT of Ucp1^–/– versus WT mice kept at subthermoneutral temperature. Conversely, lower glucose disposal was detected after full thermogenic activation achieved by sustained cold exposure or CL treatment. In contrast, uptake of lipoprotein-derived fatty acids into chronically activated thermogenic adipose tissues was substantially increased in UCP1-deficient mice. This effect is linked to higher sympathetic tone in adipose tissues of Ucp1^–/– mice, as indicated by elevated levels of thermogenic genes in BAT and WAT. Thus, glucose and lipoprotein handling does not necessarily reflect UCP1-dependent thermogenic activity, but especially lipid uptake rather mirrors sympathetic activation of adipose tissues.