In Matthew 7:15-19, Jesus tells His disciples how to tell good teachers from bad teachers. He tells them to look at the fruit. Is Jesus telling people to look at the lives of other teachers to see if they have good works? No! Not at all. Listen to the study to see what Jesus IS teaching and why this is important for properly understanding the gospel.

MineHub Technologies e IBM anunciaron hoy una colaboración para utilizar la tecnología blockchain con el objetivo de mejorar la eficiencia operativa, logística, financiamiento y reducir los costos en la cadena de suministro de concentrados minerales de alto valor, desde la mina hasta el comprador final.

IBM Security annonce le lancement de QRadar Advisor with Watson, avec de nouvelles fonctionnalités pour les plateformes sécurisées par IA : elles bénéficient désormais d'une meilleure compréhension des comportements cybercriminels et peuvent tirer des leçons des mesures de sécurité mises en place au sein d'une entreprise. IBM Security a également adopté le modèle Open Source MITRE ATT&CK, une base de données qui s'appuie sur les constats concrets de la communauté de sécurité pour soutenir les analystes dans leur compréhension de l'évolution des attaques et de leurs possibles conséquences.

IBM Security a annoncé aujourd'hui les résultats de l'IBM X-Force Threat Intelligence Index annuel 2019, qui a révélé que les mesures de sécurité et la prise de conscience accrues poussent les cybercriminels à modifier leurs techniques en quête d'un meilleur retour sur investissement. En conséquence, le rapport détaille deux changements majeurs, à savoir un détournement surprenant des attaques de type ransomware et une diminution du recours aux logiciels malveillants.

Emmy Nominee Leslye Headland to write, produce, and serve as showrunner for new untitled Star Wars series for Disney+.

Minecraft or as I prefer to call it “Minecrack” is a game that was recently recommend to my by a friend. At first glance the game looks like a throwback to the original Atari or Nintendo game systems (think Mario Bros type graphics minus having to jump on walking mushrooms) The game essentially has the look of a giant Lego world consisting entirely of blocks, the animals, trees, even the water are all blocks. There’s also no set point system or objective you have to reach in order to beat the game. But despite this the game is exceptionally addictive. I personally found it very easy to spend a few hours on it before I realized how much time had gone by.

For those eagerly waiting for the first half of the first half of the Mincraft adventure update, the wait is finally over. And no I’m not talking about some buggy pre release that is a pain in the ass to properly install that’s been out for just over a week prior. As of Sept 14 it’s available to the masses who are looking to feed their “minecrack” addiction........... Because of the recent changes I figured it was time for an updated Minecraft review covering some of the recent changes. This is not a complete review on the 1.8 adventure update, just what I’ve seen and experienced in the game so far to give you an idea what to expect..........

With November being scheduled as the “official” release of Minecraft the team at Mojang are hard at work putting together Minecraft’s 1.9 update. This is possibly the last update before the release and like the 1.8 adventure update will be packed full of new features, crafting recipes and other stuff. Details at this point are scarce, but from the information that’s out there here are some of the things that could be included in the new 1.9 update..........

Wondering when Minecraft’s 1.9 update is coming out, very soon. Very soon as in how long it takes to download the pre release just released today. Or if you prefer to wait for a non buggy version like 1.8 it should be out in a few days once the team at Mojang get player feedback to fix potential bugs...........

Like Minecraft but looking for something a little different? Recently PC Gamer briefly reviewed a new game called Blockade Runner (Click here to see the PC Gamer review) essentially bringing something like Minecraft into space. Players currently are able to build their own spaceships, or space stations from scratch in much the same way Minecraft’s creative mode works, but in zero g. Unlike Minecraft however (unless your using a mod) you can attach different weapons to your creations and fly them around, blasting other ships and asteroids to pieces........................

The judges have now submitted their scores, they have been counted and verified and we can now reveal the 2016 Self Management Shortliste

The teacher recently traveled to Italy and came back to class before noticing the symptoms, according to a source familiar with the situation.

Good news for bugs that weigh less than a sesame seed.

A Texas grand jury has been hearing evidence that could form the basis for criminal charges related to the opioid overdose death of Angels pitcher Tyler Skaggs.

Print readers of the Los Angeles Times are no doubt familiar with Donald Sterling's advertisements.

As states start lifting stay-at-home orders amid the coronavirus outbreak, workers will play a key role in determining if the economy bounces back.

My immigrant parents lost their jobs because of COVID-19. The CARES Act won't help because they're in the U.S. illegally. At 22, I was the breadwinner.

John Ratcliffe is a Trump loyalist who now promises to speak truth to power.

Reasons for cutting scenes from a movie vary. Here's why 'Little Women,' 'Jojo Rabbit,' 'Parasite' and others didn't keep everything they shot.

The Envelope likes to judge a film's chances of winning the best picture Oscar by seeing whether it echoes any previous winners, and these do. Sort of.

"The Irishman," "1917," "The Lion King," "Star Wars: The Rise of Skywalker," "Avengers: Endgame" — a rundown of the visual-effects Oscar finalists.

A luxurious house in "Parasite" and visions of '80s urbanism in "Joker" paint vivid pictures of haves and have nots for #Oscars2020.

The Times examined the filmographies of the last five years' worth of lead-actor academy award nominees to see how many female filmmakers they've worked with.

Hispanic, Latino or both? White or a person of color? The identity debate sparked after some declared Banderas a "person of color" when the Oscars' overwhelmingly white acting nominations were announced.

From Martin Scorsese to Idina Menzel, the audience at Sunday's Academy Awards ceremony was perplexed by Eminem's performance of his 2002 hit "Lose Yourself."

Eddie Jones has signed a new long-term England contract as he looks to win the Rugby World Cup for the first time.

A LOCUST plague and the spreading coronavirus could cause famine of "biblical" proportions in East Africa, experts have warned.

I REMEMBER receiving some parenting advice from a taxi driver when I was heavily pregnant with my first child almost a decade ago. "For the first 10 years all they want is your love," declared the cabbie. "For the next 10 years all they want is your money."

Jihadists linked to al-Qaida and the Islamic State organization have been overrunning gold mines, forcing the miners to sell them the gold exclusively, which is then smuggled and sold across the border in places like Benin, Ghana or Togo.

This year's IndyStar Sports Awards show will be streamed online and available on-demand starting June 18.

Woody Myers, the presumptive Democratic nominee for governor, thinks Gov. Eric Holcomb is making a big mistake in how he's reopening the economy.

Part of the Going for gold promo for the BBC UK Homepage

The following article, Rush Limbaugh Predicts Joe Biden Won’t Be The Dem Nominee: “Something’s Gonna Happen”, was first published on 100PercentFedUp.com.

Is Joe Biden going to become the Democrat nominee and run against Trump in the fall?

Continue reading: Rush Limbaugh Predicts Joe Biden Won’t Be The Dem Nominee: “Something’s Gonna Happen” ...

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Chatham House is pleased to announce the nominees for the 2016 Chatham House Prize.

Chatham House is pleased to announce the nominees for the 2017 Chatham House Prize.

Philip L. Ross
Dec 1, 2004; 3:1154-1169
Research

Bacterial biofilms are cellular communities that produce an adherent matrix. Exopolysaccharides are key structural components of this matrix and are required for the assembly and architecture of biofilms produced by a wide variety of microorganisms. The human bacterial pathogens Escherichia coli and Salmonella enterica produce a biofilm matrix composed primarily of the exopolysaccharide phosphoethanolamine (pEtN) cellulose. Once thought to be composed of only underivatized cellulose, the pEtN modification present in these matrices has been implicated in the overall architecture and integrity of the biofilm. However, an understanding of the mechanism underlying pEtN derivatization of the cellulose exopolysaccharide remains elusive. The bacterial cellulose synthase subunit G (BcsG) is a predicted inner membrane–localized metalloenzyme that has been proposed to catalyze the transfer of the pEtN group from membrane phospholipids to cellulose. Here we present evidence that the C-terminal domain of BcsG from E. coli (EcBcsGΔN) functions as a phosphoethanolamine transferase in vitro with substrate preference for cellulosic materials. Structural characterization of EcBcsGΔN revealed that it belongs to the alkaline phosphatase superfamily, contains a Zn2+ ion at its active center, and is structurally similar to characterized enzymes that confer colistin resistance in Gram-negative bacteria. Informed by our structural studies, we present a functional complementation experiment in E. coli AR3110, indicating that the activity of the BcsG C-terminal domain is essential for integrity of the pellicular biofilm. Furthermore, our results established a similar but distinct active-site architecture and catalytic mechanism shared between BcsG and the colistin resistance enzymes.

Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability is dynamically regulated by endocytic trafficking, and direct protein kinase C (PKC) activation acutely diminishes DAT surface expression by accelerating DAT internalization. Previous cell line studies demonstrated that PKC-stimulated DAT endocytosis requires both Ack1 inactivation, which releases a DAT-specific endocytic brake, and the neuronal GTPase, Rit2, which binds DAT. However, it is unknown whether Rit2 is required for PKC-stimulated DAT endocytosis in DAergic terminals or whether there are region- and/or sex-dependent differences in PKC-stimulated DAT trafficking. Moreover, the mechanisms by which Rit2 controls PKC-stimulated DAT endocytosis are unknown. Here, we directly examined these important questions. Ex vivo studies revealed that PKC activation acutely decreased DAT surface expression selectively in ventral, but not dorsal, striatum. AAV-mediated, conditional Rit2 knockdown in DAergic neurons impacted baseline DAT surface:intracellular distribution in DAergic terminals from female ventral, but not dorsal, striatum. Further, Rit2 was required for PKC-stimulated DAT internalization in both male and female ventral striatum. FRET and surface pulldown studies in cell lines revealed that PKC activation drives DAT-Rit2 surface dissociation and that the DAT N terminus is required for both PKC-mediated DAT-Rit2 dissociation and DAT internalization. Finally, we found that Rit2 and Ack1 independently converge on DAT to facilitate PKC-stimulated DAT endocytosis. Together, our data provide greater insight into mechanisms that mediate PKC-regulated DAT internalization and reveal unexpected region-specific differences in PKC-stimulated DAT trafficking in bona fide DAergic terminals.

Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs. Recently, we reported that in human hepatoma-derived HuH-7 cells, GGA is metabolically labeled from ¹³C-mevalonate. Several cell-free experiments have demonstrated that GGA is synthesized through geranylgeranial by oxygen-dependent oxidation of geranylgeraniol (GGOH), but the exact biochemical events giving rise to GGA in hepatoma cells remain unclear. Monoamine oxidase B (MOAB) has been suggested to be involved in GGOH oxidation. Here, using two human hepatoma cell lines, we investigated whether MAOB contributes to GGA biosynthesis. Using either HuH-7 cell lysates or recombinant human MAOB, we found that: 1) the MAO inhibitor tranylcypromine dose-dependently downregulates endogenous GGA levels in HuH-7 cells; and 2) siRNA-mediated MAOB silencing reduces intracellular GGA levels in HuH-7 and Hep3B cells. Unexpectedly, however, CRISPR/Cas9-generated MAOB-KO human hepatoma Hep3B cells had GGA levels similar to those in MAOB-WT cells. A sensitivity of GGA levels to siRNA-mediated MAOB downregulation was recovered when the MAOB-KO cells were transfected with a MAOB-expression plasmid, suggesting that MAOB is the enzyme primarily responsible for GGOH oxidation and that some other latent metabolic pathways may maintain endogenous GGA levels in the MAOB-KO hepatoma cells. Along with the previous findings, these results provide critical insights into the biological roles of human MAOB and provide evidence that hepatic MAOB is involved in endogenous GGA biosynthesis via GGOH oxidation.

Joseph Reid
Proc. Amer. Math. Soc. 148 (2020), 2331-2343.
Abstract, references and article information

Belinda S. O’Connell
Aug 1, 2001; 14:
Articles

Secretary for Constitutional & Mainland Affairs Erick Tsang today visited the temporary operation centre for the special scheme for delivering urgently needed prescription medication to Hong Kong people in Guangdong and Fujian.

Under the compulsory quarantine arrangements, many Hong Kong people who are staying in Guangdong and Fujian provinces are unable to attend follow-up consultations in Hong Kong to replenish their prescription medication and return to the Mainland on the same day.

The Government introduced a special scheme on February 24 to deliver medicine to them, with priority given to those who would run out of prescription medication by end-April.

Mr Tsang was pleased to learn that as of April 29, prescription medication deliveries had been made to more than 7,600 Hong Kong residents in need.

He thanked the Hong Kong Federation of Trade Unions for offering voluntary services for the drug delivery scheme with its well-established service networks on the Mainland.

Mr Tsang also thanked the Pharmaceutical Society of Hong Kong and Hong Kong Pharmaceutical Care Foundation for deploying pharmacists to the temporary operation centre to help verify drug records and patients' information.

During his visit, he gave encouragement to participating volunteers and thanked them for their support for the scheme.

Mr Tsang said as the expiry date for the Compulsory Quarantine of Certain Persons Arriving at Hong Kong Regulation has been extended to June 7, the special scheme will be extended and give priority to cases in which prescription drugs will run out on or before that date.

Call 2343 2255 for enquiries about the scheme.