Five examples each of 3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-ones and the corresponding 1-(4-azido­phen­yl)-3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones have been synthesized in a highly efficient manner, starting from a common source precursor, and structures have been determined for three examples of each type. In each of 3-[5-(2-chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-one, C28H21ClN2O3, (Ib), the isomeric 3-[5-(2-chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-one, (Ic), and 3-[3-methyl-5-(naphthalen-2-yl­oxy)-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn­yloxy)phen­yl]prop-2-en-1-one, C32H24N2O3, (Ie), the mol­ecules are linked into chains of rings, formed by two independent C—H⋯O hydrogen bonds in (Ib) and by a combination of C—H⋯O and C—H⋯π(arene) hydrogen bonds in each of (Ic) and (Ie). There are no direction-specific inter­molecular inter­actions in the structure of 1-(4-azido­phen­yl)-3-[3-methyl-5-(2-methyl­phen­oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C26H21N5O2, (IIa). In 1-(4-azido­phen­yl)-3-[5-(2,4-di­chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C25H17Cl2N5O2, (IId), the di­chloro­phenyl group is disordered over two sets of atomic sites having occupancies 0.55 (4) and 0.45 (4), and the mol­ecules are linked by a single C—H⋯O hydrogen bond to form cyclic, centrosymmetric R22(20) dimers. Similar dimers are formed in 1-(4-azido­phen­yl)-3-[3-methyl-5-(naphthalen-2-yl­oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C29H21N5O2, (IIe), but here the dimers are linked into a chain of rings by two independent C—H..π(arene) hydrogen bonds. Comparisons are made between the mol­ecular conformations within both series of compounds.

Breitburg and her team want to determine just how much stress they cause. Over the next five years they will conduct a series of lab and field experiments that examine how diel-cycling hypoxia and the associated acidification affects the growth and disease rates in striped bass, the eastern oyster and other ecologically and economically important Chesapeake Bay species. They will also study the animals’ behavioral responses to these changes.

The post Smithsonian ecologists to examine “dead zones” in Chesapeake Bay with $1.4 million NOAA grant appeared first on Smithsonian Insider.

In a new paper, Harvard-Smithsonian Center for Astrophysics astronomer Hagai Perets studies the role of binary planetesimals--clumps that orbit each other and jointly mature via three basic processes.

The post New study examines how planetesimals influence the development of a planetary system appeared first on Smithsonian Insider.

A century from now researchers will gather data from a forest in Maryland to see how, during the previous 100 years, varying levels of species […]

The post Smithsonian scientists launch 100-year project to examine the future of forests appeared first on Smithsonian Insider.

The giant panda cub born at the Smithsonian’s National Zoo Aug. 23 received her first veterinary exam late yesterday afternoon and was given a clean […]

The post Panda cub receives first exam appeared first on Smithsonian Insider.

The number and diversity of tectonic landforms in our solar system “is truly remarkable,” Watters and Schultz write. Photographs of these structures have stimulated a range of scholarly investigations.

The post Book Review: Planetary Tectonics examines otherworldly landforms appeared first on Smithsonian Insider.

Forensic anthropologists from the Smithsonian's National Museum of Natural History discover African remains at a Colonial burial site in Maryland. Follow them as they study the remains, reconstruct the face and body, and share what they learn about the African experience in the Chesapeake in the 1600s.

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The post Device at the Smithsonian Environmental Research Center examines how phytoplankton would react if the ozone layer vanished appeared first on Smithsonian Insider.

Around 6:30 a.m. on Aug. 23, 2015 veterinarians examined the cub Mei Xiang gave birth to at 5:35 p.m. Aug. 22, 2015 at the Smithsonian’s […]

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A new report from the National Research Council examines and, when possible, estimates hidden costs of energy production and use.

A new report from the National Research Council lays out options NASA could follow to detect more near-Earth objects (NEOs) – asteroids and comets that could pose a hazard if they cross Earths orbit.

The analysis used by federal agencies to set standards for fuel economy and greenhouse gas emissions for new U.S. light-duty vehicles -- passenger cars and light trucks -- from 2017 to 2025 was thorough and of high caliber overall, says a new report from the National Research Council.

As the gap in life expectancy between the highest and lowest earners in the U.S. has widened over time, high earners have disproportionately received larger lifetime benefits from government programs such as Social Security and Medicare, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

In the United States, most long-distance trips begin in one metropolitan region and end in another less than 500 miles away.

A new report from the National Academies of Sciences, Engineering, and Medicine that examines the regulations governing federally funded research recommends that Congress authorize and the president appoint an independent national commission to examine and update the ethical, legal, and institutional frameworks governing research involving human subjects.

Although the current supply of molybdenum-99 and technetium-99m – isotopes used worldwide in medical diagnostic imaging – is sufficient to meet domestic and global demand, changes to the supply chain before year-end could lead to severe shortages and impact the delivery of medical care, says a new report by the National Academies of Sciences, Engineering, and Medicine.

While workers in the engineering technology (ET) field play an important role in supporting U.S. technical infrastructure and the country’s capacity for innovation, there is little awareness of ET as a field of study or category of employment in the U.S., says a new report from the National Academy of Engineering.

The call for expanding undergraduates’ access to research experiences in science, technology, engineering, and mathematics (STEM) raises questions about their use and potential to increase students’ interest and persistence in these disciplines.

Assistive products and technologies – such as wheelchairs, upper-limb prostheses, and hearing and speech devices – hold promise for partially or fully mitigating the effects of impairments and enabling people with disabilities to work, but in some cases environmental and personal factors create additional barriers to employment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine examines to what extent and in which ways health care utilization -- such as in-patient hospitalizations, emergency department use, and hospital readmission -- reflects disease severity, disability, and ability to perform gainful activity.

While computational reproducibility in scientific research is generally expected when the original data and code are available, lack of ability to replicate a previous study -- or obtain consistent results looking at the same scientific question but with different data -- is more nuanced and occasionally can aid in the process of scientific discovery, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

The U.S. Department of Veterans Affairs (VA) should expand the requirement in its disability compensation process regarding who can diagnose traumatic brain injury (TBI) to include any health care professional with pertinent and ongoing brain injury training and experience, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Rev. Heber Brown III wants people to erase the term “food desert” from their vocabulary.

We tend to think of the process of seeing as fairly objective — that our eyes are similar to cameras, neutrally taking in light and turning it into pictures. But research has shown that biases buried beneath our awareness can powerfully shape how we see.

A new rapid expert consultation from a standing committee of the National Academies of Sciences, Engineering, and Medicine responds to questions from the White House Office of Science and Technology Policy (OSTP) regarding survival of the COVID-19 virus in relation to temperature and humidity and potential for seasonal reduction and resurgence of cases.

A new rapid expert consultation from a standing committee of the National Academies of Sciences, Engineering, and Medicine.

A new rapid expert consultation from a standing committee of the National Academies of Sciences, Engineering, and Medicine responds to questions from the White House Office of Science and Technology Policy (OSTP) regarding the effectiveness of homemade fabric masks to protect others from the viral spread of COVID-19 from potentially contagious asymptomatic or presymptomatic individuals.

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A lot is at stake for students taking Advanced Placement exams, even in normal times. If you score high enough, you can earn college credit. It's also a big factor in college applications. But for some students, the idea of studying right now feels impossible.

"I'm constantly thinking about making sure my family doesn't get sick and I don't get sick," says Elise, a high school junior outside Boston. (We're not using her full name because she's worried about hurting her college applications.)

Concerns about the coronavirus have put most standardized tests, such as the SAT and ACT, on hold this spring. But AP exams are going forward with a new online format — and that's raising questions about fairness.

Elise, 17, says she spent months preparing for what is typically a three-hour, multiple-choice and essay-based exam; she was blindsided when she learned it will now be an online, 45-minute, open-response test.

"I have no idea what I'm going to get when I open that test," she says.

Elise was hoping the College Board, which administers AP exams, would cancel this year's exams, as it did the spring SATs. But since the tests are being offered, she says she feels she has to take them. She worries it would look bad on her college applications if she opted out.

For other students, just the idea of taking the exam at home is causing anxiety. Kayleen Guzman, 17, from Boston says it's hard to find peace and quiet in her house right now.

"Currently, it's me, my mom, my dog, my sister and my stepdad," she explains. "Sometimes I feel like it's too much chaos."

But Guzman is glad she still has the opportunity to take the AP exams at all this year. She says she worked hard in her two AP classes and she wants the chance to earn college credit.

However, it's still unclear how much credit colleges will give students for this year's exams.

"None of us would say that we are confident that a 3 or 4 or 5 on the AP exam this year means the exact same thing as a 3, 4 and 5 on the exam last year," says Harvard University's Andrew Ho, who studies the reliability of educational tests.

Ho says that because of the new format, this year's AP exams won't be measuring the same thing as previous years' exams. For one, the new tests will cover less material. And changing where kids take it — from a proctored classroom to their laptops at home — is a big deal. But Ho adds, "Just because it's not completely comparable doesn't mean the College Board and colleges, through their own policies, couldn't adjust."

Some colleges are already adjusting. The University of California system has come out explicitly to say it won't change the way it credits AP scores. Other colleges that didn't want to go on the record say they are planning to change their policies, but the details weren't ready to share just yet.

In a statement, College Board spokesperson Jerome White said the organization decided to move forward with AP testing to give motivated students the opportunity to earn college credit. He added that the organization is making "a significant financial investment" to make the exams available online, from cheating prevention software to helping students who may not have an Internet connection or access to a computer.

Still, some educators worry that those efforts won't be enough.

"This situation has created a lot of distraction," says Savannah Lodge-Scharff, an AP Physics teacher for Boston Public Schools. She argues that without in-person classes, many students won't be able to engage with the material in the same way. On top of that, financial stress means many of her students are juggling additional responsibilities, like taking care of siblings.

"I have some of my students who are working 40, 50, 60 hours a week at the grocery store right now in the fear their parents are going to be laid off," she explains.

And then there's the question of geographic equity. This year's exams will be administered at the same time worldwide, meaning students in Hong Kong will be up at midnight to take it.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Using archival documents, a new report published online by JAMA Internal Medicine examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease.

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Green Infrastructure (GI), or networks of areas with high ecosystem values, has an increasing presence on the environmental policy agenda. New research has investigated GI policy in urban fringe areas in Northern England and its relationship with the existing green belt policy. The shift towards an 'environmental economy', which values the role of ecosystem services, was found to have helped encourage the uptake of GI.

New research has collated case studies of sustainable development in Poland. These indicate that there are a range of sustainability drivers and barriers, some of which are specific to transition economies in Central and Eastern Europe (CEE). It is hoped that the collection will trigger the development of a CEE database of good sustainability practices.

Extended producer responsibility (EPR) and other regulatory influences are essential to battery recycling in Finland, a new study finds. The researchers compare this with the situation in Chile, where a lack of appropriate legislation prevents recycling companies from overcoming the technical and financial challenges of battery recycling. The study helps policymakers understand how political, social, and cultural factors can support companies in their move towards circular-economy business models.

Insights from a recent Italian study could help local authorities across Europe improve their rates of separate waste collection for recycling. The researchers found higher rates of separate waste collection in municipalities with high-quality governmental institutions for waste collection, non-mountainous terrain and higher income levels. Separating household waste into streams, such as glass or food, for re-use and recycling helps free up resources for a circular economy. Good-quality institutions are the main driver of separate waste collection and can overcome barriers such as low economic prosperity.

An exhibition examining themes of race opens in North London next month.

A NEW exhibition will explore the role of fake news in our lives.

Nature photographer Florian Schulz says the oil spill in the Gulf must serve as a warning as the U.S. seeks oil in the Arctic.

A new report from the Union of Concerned Scientists examines an electric vehicle’s total greenhouse gas emissions.

Deforestation’s impact on climate change has piqued NASA’s interest in documenting its progress across the globe. Here are seven examples of deforestation f

Washington Post energy correspondent Steven Mufson traveled the 1,700-mile path of the controversial tar sands pipeline.

Senate Subcommittee on Superfund, Toxics and Environmental Health will convene today to hear about the effects of everyday chemicals on the health of children.

About 53 million Americans live within 3 miles of a Superfund site. Here's a look at the status of 10 of the country's most prominent listings.

Space law prevents rovers from contaminating H2O on Mars.

Photographer's exploration of the beauty of man-made illumination around the world reflects humankind's dominance over the planet.

One man's trash is another man's art. Take a look at six artists who have taken discarded items and turned them into upscale, high-dollar artwork.

For centuries, art and science have informed one another, and the result has been some spectacular creativity.

The new quarterly journal Comestible is a grab-a-big-cup-of-coffee-and-read-from-cover-to-cover kind of publication.

Drones could rule the skies, but only if their operators follow the rules.

The body is hitting pause on April’s written exams until October but plans to press ahead with its July sittings and multiple choice exams in small groups will continue.

You should be aware that the Institute of Financial Services (ifs) often changes the Certificate of Mortgage Advice and Practice (CeMAP) course content on a yearly basis and sometimes twice a year.