This article will analyze a real example of an electrical switchboard for a potable water well pump, containing a soft starter as one of the major components. Besides the explanation of the wiring diagram and working logic, some technical problems... Read more

The post Soft starter for potable water well pump (wiring diagram, troubleshooting example) appeared first on EEP - Electrical Engineering Portal.

Wastewater pumping stations are very common application examples of three-phase induction motors. There are numerous varieties of power supply and control logic, depending on exact conditions in the place of installation, the role of the pumping station inside a sewer... Read more

The post Design and control considerations for an example of the waste water pumping station appeared first on EEP - Electrical Engineering Portal.

We are updating our site to incorporate the changes that have been made by the updates to the First Certicate in English (FCE) exam from Cambridge English.

This article aims to cover the activity of electrical commissioning. Such a task in its entirety would be immense. Commissioning can mean many things in different instances. This article aims to give a philosophical and high level conceptual overview of... Read more

The post The Challenging Job of an Electrical Commissioning Engineer (Activities and Real World Examples) appeared first on EEP - Electrical Engineering Portal.

Room 29, Parliament Buildings

YSTR-DG.AppDev - oneM2M-Application developer guide: Light control example using HTTP binding

Requirements for inspection and examination services using civilian unmanned aerial vehicles

User Interface (UI) design serves as the critical link connecting users with digital products, culminating in seamless and delightful experiences. UI design is more than just entertaining visuals; it’s the magic wand that transforms digital interactions into seamless and pleasant experiences. Whether you’re a seasoned UI design expert or someone just beginning to explore this […]

The post Unveiling Inspiring UI Design Examples and Insights appeared first on Usability Geek

Our bootcamps are a great study resource for CCIE candidates. No matter whether you’re just starting out on your CCIE training journey, or have been studying for months, an INE bootcamp can help you gauge where you’re at in the study process and what you need to focus on before attempting your CCIE Exams. What [...]

Researchers at the U.S. Department of Energy’s Argonne National Laboratory examined three different types of roofing strategies and their impact on near-surface temperature and cooling energy demand.

Many factors go into determining a roof's wind resistance, from speed and direction to the design and materials used. Westlake Royal Roofing Products takes a closer look at the way concrete roof tiles are a superior choice for wind resistance.

La DGT admite que los conductores no están formados para responder ante riadas, grandes inundaciones y desbordamientos. Leer

El líder del PP traslada a su partido en la UE sus críticas a la actuación de la vicepresidenta durante la DANA y en el grupo popular europeo toman nota: "Llama la atención su desaparición en la crisis" Leer

La Sala de lo Penal debe resolver sobre la admisión de los escritos de Vox, Iustitia Europa y Manos Limpias contra la responsable de Transición Ecológica, candidata a comisaria de Competencia Leer

"Sí, no puedo ser más claro", ha respondido el presidente del Gobierno al ser preguntado expresamente sobre si avala su papel en la DANA Leer

Desde el PP Europeo se apunta también que las políticas "sanchistas" en competencia generan preocupación en la capital comunitaria, y que si los socialistas atacan al candidato italiano de Meloni irán a por la responsable de Transición Ecológica Leer

Muchos opositores se han quejado por los gastos de transporte o de alojamiento que han pagado, al proceder de otras partes de España, e incluso algunos de ellos provienen de diferentes puntos de Europa o incluso de Latinoamérica Leer

Los candidatos tenían de plazo máximo para presentar la solicitud hasta el 4 de noviembre y debían, además, acreditar su solicitud con el certificado de empadronamiento, junto a otros documentos "sin concretar todavía en medio del caos y en muchos casos sin acceso a internet". Leer

Location: Engineering Library- T385.W55 2016

Spokane's skyline boasts three iconic buildings…

Were you really that frozen with fear? Doubtful

There's nothing I can say to this dismissive nonsense that won't get me thrown off Metafilter.

White people are very invested in treating racism as extreme and exceptional when it is in fact commonplace and pervasive. White people are not credible judges of what non-white people describe as experiences of racism. Racism is the Occam's Razor explanation. These so-called academic framings describe patterns that white people would prefer remain undescribed.

We replicate and extend prior work on Florida's Bright Futures merit aid scholarship to consider its effect on college enrollment and degree completion. We estimate causal impacts using a regression discontinuity design to exploit SAT thresholds that strongly determine eligibility....

This item belongs to: texts/godaneinbox.

This item has files of the following types: Archive BitTorrent, Metadata, Text PDF

Versatile London rave-rapper turns more misery into money.

Over 45 new examples of hoaxes, scams and spam e-mails have been published today.

419 scams are on the rise again. We have published 11 new 419 scams on our site. Remember to subscribe to our RSS feed (http://feeds.feedburner.com/shpamee) if you are not already a subscriber of the SHPAMEE Project.

Examining MicroStrategy’s record-shattering $21bn ATM Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter. History, they say, doesn’t repeat, but it often rhymes. Bitcoin-hodling MicroStrategy is an excellent example. In early 2000, MicroStrategy embodied the…

I do a detailed analysis of Cantor’s theory of uncountable sets. The logic of his proofs has some weaknesses. I propose an axiom and a solution to continuum hypothesis. The main idea is: Assumption of Cantor’s proofs: All real numbers (set R) are in a list (list L). This assumption means R=L, considering L as...

An analysis of Cantor’s theory of uncountable sets: The logic of his proofs has some weaknesses. Cantor assumes for both his proofs that all real numbers (set R) are in a list (list L). Considering L as a set this assumption assumes R belongs to L. This makes the claim “a real number is constructed...

By Leo Babauta There’s a practice that I find to be really valuable, and I call it “Examining Beliefs.” If you regularly engage with this, it will transform you. Let’s say there’s something you want to do but you feel stuck — maybe you’re procrastinating a lot, maybe you’re stuck in an old habit. The […]

The post The Practice of Examining Our Beliefs appeared first on zen habits.

Ah, 2024. Another year, another set of resolutions gathering dust by February, right? Not this time. Let’s face it – we’ve all been there, setting lofty goals only to watch them fizzle out faster than a New Year’s Eve sparkler. But here’s the kicker: it’s not about cramming more into your day like it’s a ... Read more

The post How to Set and Crush Your Goals in 2024: Expert Tips and Examples appeared first on LifeHack.

The post 12 Tips for Self-Portrait Photography (+ Examples) appeared first on Digital Photography School. It was authored by Guest Contributor.

Starting a self-portrait project? Want to capture beautiful portrait photos using nothing but a camera, a tripod, and your own ingenuity? Self-portrait photography can be an outstanding creative outlet, and it can be a lot of fun, too. But it can also be very challenging; you have to deal with a variety of factors, including […]

The post 12 Tips for Self-Portrait Photography (+ Examples) appeared first on Digital Photography School. It was authored by Guest Contributor.

Over the past decade, parent advocacy groups led a grassroots movement resulting in most states adopting dyslexia-specific legislation, with many states mandating the use of the Orton-Gillingham (OG) approach to reading instruction. Orton-Gillingham is a direct, explicit, multisensory, structured, sequential, diagnostic, and prescriptive approach to reading for students with or at risk for word-level reading disabilities (WLRD). Evidence from a prior synthesis and What Works Clearinghouse reports yielded findings lacking support for the effectiveness of OG interventions.

New essay anthology examines the future of the international order News release jon.wallace 7 May 2021

Featuring a new essay by Robin Niblett, Chief Executive of Chatham House, and Leslie Vinjamuri, Director of the US and Americas programme.

“Anchoring the World”, a new anthology, features an important new essay by Robin Niblett, Chief Executive of Chatham House, and Leslie Vinjamuri, Director of the US and Americas programme. The essay, “The Liberal Order Begins At Home”, argues powerfully for the revival of a liberal international order.

The essay collection has been produced by the Lloyd George Study Group on World Order, and celebrates the centennial years of Chatham House, Georgetown University’s School of Foreign Service, and the Council on Foreign Relations.

Robin Niblett said:

“In this excellent collection, some authors argue that the United Nations should continue to anchor the international system, while others argue for the creation of a new Concert of Powers.

“Our essay argues that it is both necessary and possible to revive the idea of a liberal international order: necessary (and urgent) because of heightened global competition with China, and possible only if western democracies repair their deep social and economic problems at home.

“We hope this volume carries forward the fortitude and creative spirit that the School of Foreign Service, Chatham House, and the Council on Foreign Relations have brought to the study and practice of international affairs over the past century.”

The Lloyd George Study Group and book were made possible by the generosity of the family of Robert Lloyd George, the great-grandson of British Prime Minister, David Lloyd George.

Anchoring the World is published by Foreign Affairs magazine.

New Chatham House History Examines our Defining Moments News Release NCapeling 18 January 2021

'A History of Chatham House: its People and Influence from the 1920s to the 2020s' will examine the impact on policymaking of our first 100 years.

Innovating Governance: Examples from the Digital Arena 25 February 2020 TO 26 February 2020 — 10:00AM TO 11:30AM Anonymous (not verified) 9 February 2021 Chatham House

The Inclusive Governance Initiative is launched with this roundtable on digital governance.

The Inclusive Governance Initiative, a centenary project which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world, is launched with this roundtable on digital governance.

The event brings together a diverse and multidisciplinary group of leading experts to consider where and how early initiatives around governance of the digital sphere have succeeded – or not – and how they are evolving today.

The conversation will include the debate between multilateral and multi-stakeholder approaches, the opportunities and challenges of collective non-binding commitments, and converting civil society collaboration into policy contribution.

Jong In Han and Sijong Kwak
Trans. Amer. Math. Soc. 377 (), 5561-5581.
Abstract, references and article information

Yadong Yu
Dec 1, 2020; 19:1997-2014
Research

Postoperative recurrence from microscopic residual disease must be prevented to cure intractable cancers, including pancreatic cancer. Key to this goal is the elimination of cancer stem cells (CSCs) endowed with tumor-initiating capacity and drug resistance. However, current therapeutic strategies capable of accomplishing this are insufficient. Using in vitro models of CSCs and in vivo models of tumor initiation in which CSCs give rise to xenograft tumors, we show that dexamethasone induces expression of MKP-1, a MAPK phosphatase, via glucocorticoid receptor activation, thereby inactivating JNK, which is required for self-renewal and tumor initiation by pancreatic CSCs as well as for their expression of survivin, an anti-apoptotic protein implicated in multidrug resistance. We also demonstrate that systemic administration of clinically relevant doses of dexamethasone together with gemcitabine prevents tumor formation by CSCs in a pancreatic cancer xenograft model. Our study thus provides preclinical evidence for the efficacy of dexamethasone as an adjuvant therapy to prevent postoperative recurrence in patients with pancreatic cancer.

A key point in achieving accurate intact glycopeptide identification is the definition of the glycan composition file that is used to match experimental with theoretical masses by a glycoproteomics search engine. At present, these files are mainly built from searching the literature and/or querying data sources focused on posttranslational modifications. Most glycoproteomics search engines include a default composition file that is readily used when processing MS data. We introduce here a glycan composition visualizing and comparative tool associated with the GlyConnect database and called GlyConnect Compozitor. It offers a web interface through which the database can be queried to bring out contextual information relative to a set of glycan compositions. The tool takes advantage of compositions being related to one another through shared monosaccharide counts and outputs interactive graphs summarizing information searched in the database. These results provide a guide for selecting or deselecting compositions in a file in order to reflect the context of a study as closely as possible. They also confirm the consistency of a set of compositions based on the content of the GlyConnect database. As part of the tool collection of the Glycomics@ExPASy initiative, Compozitor is hosted at https://glyconnect.expasy.org/compozitor/ where it can be run as a web application. It is also directly accessible from the GlyConnect database.

AAA+ ATPases constitute a large family of proteins that are involved in a plethora of cellular processes including DNA disassembly, protein degradation and protein complex disassembly. They typically form a hexametric ring-shaped structure with six subunits in a (pseudo) 6-fold symmetry. In a subset of AAA+ ATPases that facilitate protein unfolding and degradation, six subunits cooperate to translocate protein substrates through a central pore in the ring. The number and type of nucleotides in an AAA+ ATPase hexamer is inherently linked to the mechanism that underlies cooperation among subunits and couples ATP hydrolysis with substrate translocation. We conducted a native MS study of a monodispersed form of PAN, an archaeal proteasome AAA+ ATPase, to determine the number of nucleotides bound to each hexamer of the WT protein. We utilized ADP and its analogs (TNP-ADP and mant-ADP), and a nonhydrolyzable ATP analog (AMP-PNP) to study nucleotide site occupancy within the PAN hexamer in ADP- and ATP-binding states, respectively. Throughout all experiments we used a Walker A mutant (PAN^K217A) that is impaired in nucleotide binding as an internal standard to mitigate the effects of residual solvation on mass measurement accuracy and to serve as a reference protein to control for nonspecific nucleotide binding. This approach led to the unambiguous finding that a WT PAN hexamer carried – from expression host – six tightly bound ADP molecules that could be exchanged for ADP and ATP analogs. Although the Walker A mutant did not bind ADP analogs, it did bind AMP-PNP, albeit at multiple stoichiometries. We observed variable levels of hexamer dissociation and an appearance of multimeric species with the over-charged molecular ion distributions across repeated experiments. We posit that these phenomena originated during ESI process at the final stages of ESI droplet evolution.

A state-by-state breakdown shows that Colorado, Rhode Island and Illinois found some evidence that students' familiarity with technology impacted scores on 2014-15 PARCC exams. An analysis in Maryland is pending.

New Jersey is one of many states that have experienced problems with the online administering of standardized testing this year.

At the National Zoo, primates undergo routine checkups to ensure a healthy lifestyle.

The College Board's national experiment with virtual AP exams gets underway this week amid accusations and stern warnings about student cheating.

In 2014, Jane Cook joined the second-ever training class of Penn State Extension Master Watershed Steward volunteers. She was already active in the Monocacy Creek Watershed Association, but since then, she has logged more than 1,000 volunteer hours educating the public and restoring local watersheds.

Wastewater contains nutrients that can overfeed algae, leading to harmful algal blooms and pollution issues in the ocean and other waterways. A new study by researchers at Penn State tracked how these nutrients migrate from disposal sites in the Florida Keys, and the results have already informed wastewater practices in the region.

The UP Police Constable Exam 2024 was conducted on August 23, 24, 25, 30, and 31, 2024.

The mock test papers series-I will commence from November 18, 2024 while that for series-II will begin from December 9, 2024.