Coloradans have rejected a proposed ban on mountain lion and bobcat hunting -- a hit for wildlife advocates who have worked to outlaw or change the practice for years.

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The noncoding RNA BC200 is elevated in human cancers and is implicated in translation regulation as well as cell survival and proliferation. Upon BC200 overexpression, we observed correlated expression of a second, smaller RNA species. This RNA is expressed endogenously and exhibits cell-type-dependent variability relative to BC200. Aptamer-tagged expression constructs confirmed that the RNA is a truncated form of BC200, and sequencing revealed a modal length of 120 nt; thus, we refer to the RNA fragment as BC120. We present a methodology for accurate and specific detection of BC120 and establish that BC120 is expressed in several normal human tissues and is also elevated in ovarian cancer. BC120 exhibits remarkable stability relative to BC200 and is resistant to knockdown strategies that target the 3' unique sequence of BC200. Combined knockdown of BC200 and BC120 exhibits greater phenotypic impacts than knockdown of BC200 alone, and overexpression of BC120 negatively impacts translation of a GFP reporter, providing insight into a potential translational regulatory role for this RNA. The presence of a novel, truncated, and stable form of BC200 adds complexity to the investigation of this noncoding RNA that must be considered in future studies of BC200 and other related Alu RNAs.

ATP-binding cassette transporter subfamily G member 2 (ABCG2) is a membrane-bound transporter responsible for the efflux of various xenobiotics and endobiotics, including protoporphyrin IX (PPIX), an intermediate in the heme biosynthesis pathway. Certain genetic mutations and chemicals impair the conversion of PPIX to heme and/or increase PPIX production, leading to PPIX accumulation and toxicity. In mice, deficiency of ABCG2 protects against PPIX-mediated phototoxicity and hepatotoxicity by modulating PPIX distribution. In addition, in vitro studies revealed that ABCG2 inhibition increases the efficacy of PPIX-based photodynamic therapy by retaining PPIX inside target cells. In this review, we discuss the roles of ABCG2 in modulating the tissue distribution of PPIX, PPIX-mediated toxicity, and PPIX-based photodynamic therapy.

ABSTRACTTraining health workers is one of the biggest challenges and cost drivers when introducing a new contraceptive method or service delivery innovation. PATH developed a digital training curriculum for family planning providers who are learning to offer subcutaneous DMPA (DMPA-SC), including through self-injection, as an option among a range of contraceptive methods. The DMPA-SC eLearning course for health workers includes 10 lessons with an emphasis on informed choice counseling and training clients to self-inject. In partnership with Ministries of Health in Senegal and Uganda, the course was rolled out in select areas in 2019–2020, including during the COVID-19 pandemic when physical distancing requirements restricted in-person training. We conducted evaluations in both countries to assess the practical application of this digital training approach for contraceptive introduction. The evaluation consisted of a post-training survey, an observational assessment conducted during post-training supportive supervision, and an estimation of training costs.In both countries, a majority (88.6% in Uganda and 64.3% in Senegal) scored above 80% on a DMPA-SC knowledge test following the training. In Senegal, where there was a comparison group of providers trained in person, those providers scored similar on the post-test to eLearners. Providers in both groups and in both countries felt more prepared to administer DMPA-SC or offer self-injection to clients after receiving a supervision visit (93%–98% of eLearners felt very prepared after supervision as compared to 45%–72% prior). The evaluation results suggest that digital approaches offer a number of benefits, can be cost-effective, and are most optimal when blended with in-person training and/or supportive supervision.

There is a growing interest in the use of medicinal plants to treat a variety of diseases, and one of the most commonly used medicinal plants globally is Cannabis sativa. The two most abundant cannabinoids (⁹-tetrahydrocannabinol and cannabidiol) have been governmentally approved to treat selected medical conditions; however, the plant produces over 100 cannabinoids, including cannabichromene (CBC). Although the cannabinoids share a common precursor molecule, cannabigerol, they are structurally and pharmacologically unique. These differences may engender differing therapeutic potentials. In this review, we will examine what is currently known about CBC with regards to pharmacodynamics, pharmacokinetics, and receptor profile. We will also discuss the therapeutic areas that have been examined for this cannabinoid, notably antinociceptive, antibacterial, and anti-seizure activities. Finally, we will discuss areas where new research is needed and potential novel medicinal applications for CBC.

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have further refined the subclassification of DLBCL, based on recurrent genetic abnormalities. Here, we describe a distinct case of DLBCL that presented in leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations of CD79B, MyD88, TP53, TBL1XR1, and PIM1 genes, indicating that this lymphoma would be best classified as MCD/C5 DLBCL, an ABC subtype. Despite an initial good clinical response to BTK inhibitor ibrutinib, anti-CD20 antibody rituxan, alkylating agent bendamustine, and hematopoietic stem-cell transplant, the lymphoma relapsed, accompanied by morphologic and molecular evidence of disease progression. Specifically, the recurrent tumor developed loss of TP53 heterozygosity (LOH) and additional chromosomal changes central to ABC DLBCL pathogenesis, such as PRDM1 loss. Acquired resistance to ibrutinib and rituxan was indicated by the emergence of BTK and FOXO1 mutations, respectively, as well as apparent activation of alternative cell-activation pathways, through copy-number alterations (CNAs), detected by high-resolution chromosomal microarrays. In vitro, studies of relapsed lymphoma cells confirmed resistance to standard BTK inhibitors but sensitivity to vecabrutinib, a noncovalent inhibitor active against both wild-type as well as mutated BTK. In summary, we provide in-depth molecular characterization of a de novo leukemic DLBCL and discuss mechanisms that may have contributed to the lymphoma establishment, progression, and development of drug resistance.

A new digital-first Gaelic language production will be launched in Scotland after a joint agreement between BBC Alba and BBC Scotland.

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Express Sport writers have decided who should replace Gary Lineker

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Match of the Day presenter Gary Lineker has sealed a new agreement with the BBC just hours after his exit was confirmed.

Emma Raducanu has been crowned BBC Sports Personality of the Year on another history-defining night for Britain’s teenage phenomenon.

By Tom Garry, in Salford

Mary Earps said she felt “very honoured and humbled” to receive “the ultimate all-round sporting accolade”, after being named as the BBC’s Sports Personality of the year ahead of runner-up Stuart Broad to continue women’s sport’s strong recent run in the event.

The 2025 HSBC SVNS season will wrap up May 3-4 at Dignity Health Sports Park in Carson, Calif., where the champions will be crowned at the 2028 Olympic rugby sevens venue.

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Gary Lineker is leaving ‘MOTD’ at the end of this season, after a glittering 25-year tenure as the host of the BBC’s flagship football show. Nick Hilton looks back at the pundit’s highs and lows, from predatory striker to top broadcaster and media mogul

The former striker will depart the programme at the end of the 2024/25 season

CBC has announced it's investing more in local and regional news. The coverage includes up to 25 journalists in more than a dozen communities and four new daily local podcasts.

The proposed American Privacy Rights Act (APRA) has taken its first step U.S. House legislative process with several issue disagreements becoming more evident. On May 23, the U.S. House Committee on Energy and Commerce Subcommittee on Data, Innovation and Commerce approved the updated APRA, advancing the bill to full committee consideration. Just prior to the […]

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Behind the scenes with Natalie Morales and Erica Hill at the 12th Annual MORE/SHAPE Women�s Half-Marathon on April 19, 2015.

One thing ive found myself doing lately now that im sorta 'well fuck that twitter shit' is i am rambling on a LOT more when i type stuff. This can be viewed as a good or bad thing. Maybe for me it's not a bad thing. It's a bit like working in a 4 panel comic format. You can do a lot with a four panel setup, almost the first entire chapter of MT is all 4 panel. It has its own kinda pacing, setup, delivery, variables, etc. But there are things i can...

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Cyber Correspondent Joe Tidy has an AI clone of himself built to see how sophisticated they can be.

Earlier this year we launched a new version of the BBC News mobile site, making it easier and quicker to use. This week we've begun the process of directing all mobile users automatically to that site. This means that anyone who visits BBC News on their mobile will be taken to the version of the site best suited to the type of phone they are using.

Many of you already visit the mobile site regularly but, up until now, people looking for BBC News on their phone will often have found themselves on the desktop version of the site, which is designed for desktop PCs, macs and laptops - all with much bigger screens. If you are using this desktop version on your phone it can be awkward to pinch, zoom and scan the stories on a small mobile screen.

This image shows how the mobile site displays on a smartphone - compared with the desktop version:

To tackle this, we've been working over the past six months to improve and add to the mobile site, taking on board your feedback about how you'd like to see it develop.

We've recently added video clips for iPhone and Android users, and made it easier to navigate the site. (We hope to extend this video service to other types of mobile in the future.) We've also added easier ways of getting to local news and weather services, something many of you asked for. You can read more about those changes here.

So, we're confident that the mobile site now has the wide range of content you are looking for and that it offers a better experience on a small screen than the desktop site, which is why we are taking the step of automatically redirecting mobile users there.

Of course, you may be happy to keep visiting the desktop site on your mobile and if you want to continue doing so just scroll to the bottom of the page and tap on the link for the desktop site. Your choice will be remembered for the next time you visit.

Similarly, if you use a mobile and find that you're not redirected to the new site, you can scroll to the bottom of the page and select the mobile site.

This is the latest stage in the ongoing work by our News product team on responsive design - a way of presenting our content to you in the most suitable way by detecting the type of device you are using and displaying the format best adapted for it. We are doing similar work to optimise the site for tablet users too.

The number of people coming to BBC News on mobile continues to grow. In an average week, 13.3m users worldwide use their mobile or tablet to visit the BBC News site and apps - around one-third of total users to BBC News Online.

If you are one of them, our aim is to offer you the full range and depth of BBC News content, whatever device you are using, whilst also making best use of the screen size.

We hope you'll like using the new mobile site, and if you'd like to leave comments and feedback about it, or have questions, please post them below. Or you can tweet your views using the hashtags #bbcnews #responsive

Update: Thanks for your comments. Here are some answers to the questions posted below:

John Walsh – Kindle: As a tablet device, albeit with a smaller screen than some makes, Kindles currently default to the desktop site. Users of any device including Kindles are certainly free to use the mobile version if they prefer by clicking the link at the bottom of the screen. Our aim is to further improve the experience for progressively larger screen sizes over time.

Jesse Moore - HTC: We know there are some devices that are incorrectly classified by our systems, often due to the fact that some devices have different identifiers dependent on the mobile network they are on. In any case we will certainly be doing everything we can to correct errors and ensure the redirection behaves as it should. In the meantime, please use the “Mobile Site” link at the foot of the page should you wish to use the mobile site – the selection will be remembered as long as cookies are not cleared. At this time the redirect only applies to the BBC Homepage and the News site.

Cogito Ergo Sum - Windows phone: This change applies to the browser experience, which is already designed to work for Windows Phone although at present we are unable to provide video for those devices.

Costmeabob - We take accessibility for our services seriously so, for example, our browser and applications are designed to work with Voiceover on iOS. 

Tim Stey - If you do still prefer the desktop version you can select the link at the bottom of the page and you’ll be taken to it. Your choice will be remembered next time you visit the site. We are working on enhancing the mobile site still further to include more content where the technology allows it - but with navigation more suited to a smaller screen size. 

 Josh Tumath - This blog post might be of interest, about our overall approach to responsive design published in March by Chris Russell, head of product for BBC News Online.

Steve Herrmann is editor of the BBC News website.

This week marks 15 years since BBC Online was born. At about the same time, the BBC's news website also went live. The number of people visiting the news site has grown enormously over the years, and here you can see how traffic has increased, spiking at key news events, and how the appearance of the site's front page has changed over the years too. Meanwhile, for the 15th anniversary, the BBC's Director of Future Media Ralph Rivera has blogged about the significance of BBC Online today and the continuing importance of innovation to the BBC.

Steve Herrmann is editor of the BBC News website.

This week viewers to BBC World News have been watching a series of reports focusing on the Arab uprisings, two years after they first began. Correspondents have been in Damascus, Tunis, Cairo, the Syria-Lebanon border and elsewhere. Their eyewitness TV reporting is accompanied by further explanation and analysis on our website, bbc.com/news. These are expert journalists, with years of experience and knowledge, living the story on behalf of the audience. They demonstrate our commitment to reporting the world, and bringing clarity to complex events.

Until now, however, viewers in the world's biggest TV market, the US, have found it hard to access BBC reporting of this kind. The market is saturated with TV channels, but for the past couple of years we've been very focused on securing widespread carriage on the distribution systems which bring TV into most homes.

So today the BBC is delighted to announce we have agreed to a partnership with the US cable giant - Time Warner Cable - and through this and other deals, a further 10 million homes in the US will have access to BBC World News 24 hours a day, seven days a week.

This means by the end of this year we will be available in 25 million homes, including those in most of the major markets - New York, Washington DC, Los Angeles, Chicago, Boston. There is still some way to go before we can say we have reached everyone - but 2012 has been a year of significant breakthroughs for us in the US.

The BBC is already well-known in America through its partnerships with public radio, through the success of our website BBC.com/news, and because of our nightly broadcast on public television fronted by Katty Kay. We believe our brand of high-quality, intelligent and non-partisan journalism has something to offer US audiences, and we're determined to make access to our services as simple as possible.

The timing could not be better. We're just a few weeks away from the first broadcasts of BBC World News from our brand new headquarters in central London. Three new studios, a big investment in production and journalism, and working more closely with BBC journalists working in English and 27 other languages - it's more than just a new home, it's a new start. We're delighted to share that even more widely.

Richard Porter is controller of English at BBC Global News

BBC World News will soon be available in Burma. Those are words that, even six months ago, I would not have imagined writing. But Burma, a byword for media censorship and repression, is starting to open up.

In September I visited Burma to begin the negotiations which led to this breakthrough in BBC distribution. I was struck by how rapid the media changes are for a country where state media had been long stuck in a repressive timewarp.

A World Service team visited the state broadcaster. We saw the most surreal newsroom I have ever visited. There were no journalists there. "Why not?" we asked. "We don't need them yet. The news hasn't arrived."

We learnt the news is literally delivered once a day by the state news agency. The job of the journalists was to read it out, word for word, unaltered.

But those journalists and editors are now keen to have the BBC's help in learning about open and balanced journalism. It will be a long road, given the ingrained habits of censorship and self-censorship.

But the BBC, through its pioneering media development charity BBC Media Action, is able to offer training to editors and journalists to teach them what independent journalism is. Even officials from the Ministry of Information, the former censors, asked if they could go on BBC journalism courses. Alongside the desire for training, the opening up of Burma to international broadcasters is naturally to be welcomed.

However, there is a long way to go. The massively popular BBC Burmese service, which we estimate is listened to by more than eight million people a week, is not yet allowed to broadcast within Burma. It is transmitted only on shortwave, faithfully listened to, as Aung San Suu Kyi has done for so many years. We urge the government to fully open its airwaves.

And we told the Burmese government that the BBC would continue to scrutinise the country closely. Indeed, as it becomes possible for our journalists to travel within the country, reports such as Fergal Keane's recent searing Newsnight film on human rights abuses in Rakhine state, will form a key part of the BBC's role in the country.

We will also continue to report the progress being made in the political and economic spheres.

At this early stage of opening up, it is hard to know if the hopes of media freedom will be fulfilled, but it is at least an encouraging sign that the BBC can now report from and to the country in English.

Authoritarian governments everywhere are asking themselves if they can and should hold back the free flow of news any more. And, as they ask themselves these questions, politicians, officials and journalists are looking to the BBC as the international exemplar of quality, impartial and independent journalism.

Peter Horrocks is the director of BBC Global News

Moving BBC World News, the BBC's largest television channel, from west London to New Broadcasting House in the centre of the city is a huge project that has taken years of planning.

Relaunching and rebranding every hour of its 24 hours of output to give audiences around the world a new exciting polished HD product has made that huge project even more challenging.

Hopefully on Monday at 1200 GMT, the hard work of our 100 dedicated staff will give our audiences a bolder, brighter, more engaging look for the channel they trust to give them independent, objective news and analysis from more correspondents, in more locations, than any other international broadcaster.

Meticulous planning began about three years ago - everything from the new look of our studios to bicycle parking. We tested our studio systems - literally to breaking point - then fixed them and began the dual-running piloting that has split our newsroom teams between those keeping us on air back at Television Centre and those training and developing our programmes in our new home.

We're calling our new location The World's Newsroom because it truly reflects the world we report. We now work with colleagues from 27 language services who report for us from far flung bureaus and in London, allowing us to celebrate their unique expertise - something no other broadcaster can offer.

Audiences have also told us they want to engage more with the stories we tell - to feel closer to the issues we report. We're going to help you "live the story" with us. It's our new channel ethos.

Our correspondents - expert, brave, tough, determined - live and work where they report, and we want audiences to understand their passion for the stories they cover. So expect a new style of reporting from the field. And we'll be everywhere for our relaunch with live and exclusive reports planned from Syria, China, the US and Burma to name just a few.

In the studio, trusted and familiar presenters will be sharing the day's top stories - with a sprinkling of new faces on air. We'll have a more dynamic look, with robot cameras whizzing around our studios, improved graphics and high definition screens to enhance our ability to explain and analyse. We even have some virtual reality surprises planned.

We're also developing new long-form programmes, so expect to see new hard-hitting and timely documentary series. There'll be fresh new editions of favourites such as HARDTalk with Stephen Sackur (our interrogator-in-chief), Click for the latest on tech and Health Check for medical breakthroughs.

BBC World News has come a long way since it launched as a shoestring commercial operation in a backroom at Television Centre more than 20 years ago. Our audiences have grown massively. We're required viewing from the President's White House in Washington to the President's Blue House in Seoul. And in an era when bad mortgages in the US can trigger a global economic meltdown, we know there is a huge appetite for world news delivered fast, accurately and objectively.

We hope you'll enjoy our new look. And we hope you'll join us in the world's newsroom.

Andrew Roy is head of news for BBC World News

It is no secret that recent Arab uprisings have placed enormous burdens on the shoulders of BBC Arabic journalists responsible for reporting news from the region.

Covering the Arab world is not always an easy task - we need to mix sensible caution with a dose of courage in covering political issues that attract so many disputed views among Arabic-speaking audiences.

Our guiding principles are the BBC's values, its editorial guidelines, its ethical code, which are our reference points to maintain impartial, balanced and accurate reporting.

Across the Arab world - whether it's Tunisia, Yemen, Egypt or Libya, Bahrain, Syria and Iraq or the many other countries in the region - we know that audiences want access to objective and independent news, far removed from an agenda that favours one party, religion or sect against another. That is why audiences are turning to BBC Arabic.

Last year, our latest figures show that overall audiences to BBC Arabic have risen by more than 17% to a record high of 25.3 million adults weekly. That includes a big surge of 2.9 million in Saudi Arabia and 2.7 million in Egypt, where TV viewers in particular turned to the BBC to better understand the events happening in their own country. Our radio audiences are also holding up despite the reductions in transmission. Online is proving to be more of a challenge, but we are working hard to understand the needs of digital audiences and those for whom social media plays an increasingly important part in their lives.

In 2011, following the fall of the Mubarak leadership, we watched as ordinary Egyptians carried banners saying "Thank you, BBC!" But meeting the high expectation of audiences has a price and sometimes it's been a heavy one.

March 2011 brought a strong reminder of the risks that our staff face in covering the news - one of our reporters was arrested and tortured by Muammar Gaddafi's forces during the Libya uprising. In early 2012, our reporter in Yemen was beaten and received death threats from supporters of the outgoing president.

We are also challenged by those who disagree with our coverage. In countries such as Syria and Bahrain, BBC Arabic has been accused of bias.

The criticism comes from opposition and government alike. It may be a valid argument to say that getting criticism from both sides, in the case of Arab world certainly, is an indication of balanced coverage.

On Syria, for example, we had a series of documentaries looking at the civil war from a number of perspectives.

The first one, exploring what it's like to work for a Syrian television channel that's the mouthpiece of the government, was the butt of criticism and threats from Syrian opposition quarters. We followed it up with a programme charting a day in the lives of six Syrian women, five of whom were anti-government activists.

In our day-to-day news coverage, presenting a variety of voices from Syria is essential to us. And that is what distinguishes BBC Arabic from many media outlets in the Arab world which promote political views and agendas, and that is what we are determined to keep.

BBC Arabic marked its 75th anniversary in January. Arab politicians and ordinary people have expressed their appreciation of our track record of impartiality and trusted news. I am confident that the coming years will see further achievement on all our platforms - TV, radio and online.

The BBC has "agreed in principle a contract extension through to the 2026 World Cup," with Lineker.

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