Love, joy, worry, and anxiety are just some of the emotions we experience intensely as parents. Join Michael as he offers a personal story and reflection about the complex world of parenting, and our need for Christ to be the best parents we can be.

Much is known about the public life of Alex Salmond - but far less about the man away from the spotlight.

Aim/Purpose: In this paper we propose a framework identifying many of the unintended consequences of information technology and posit that the increased complexity brought about by IT is a proximate cause for these negative effects. Background: Builds upon the three-world model that has been evolving within the informing science transdiscipline. Methodology: We separate complexity into three categories: experienced complexity, intrinsic complexity, and extrinsic complexity. With the complexity cycle in mind, we consider how increasing complexity of all three forms can lead to unintended consequences at the individual, task and system levels. Examples of these consequences are discussed at the individual level (e.g., deskilling, barriers to advancement), the task level (e.g., perpetuation of past practices), as well as broader consequences that may result from the need to function in an environment that is more extrinsically complex (e.g., erosion of predictable causality, shortened time horizons, inequality, tribalism). We conclude by reflecting on the implications of attempting to manage or limit increases of complexity. Contribution: Shows how many unintended consequences of IT could be attributed to growing complexity. Findings: We find that these three forms of complexity feed into one another resulting in a positive feedback loop that we term the Complexity Cycle. As examples, we analyze ChatGPT, blockchain and quantum computing, through the lens of the complexity cycle, speculating how experienced complexity can lead to greater intrinsic complexity in task performance through the incorporation of IT which, in turn, increases the extrinsic complexity of the economic/technological environment. Recommendations for Practitioners: Consider treating increasing task complexity as an externality that should be considered as new systems are developed and deployed. Recommendation for Researchers: Provides opportunities for empirical investigation of the proposed model. Impact on Society: Systemic risks of complexity are proposed along with some proposals regarding how they might be addressed. Future Research: Empirical investigation of the proposed model and the degree to which cognitive changes created by the proposed complexity cycle are necessarily problematic.

Have you ever been to one of those corn mazes that pop up every October?

The complex [Pt(C9H6NO)Cl(C2H4)], (I), was synthesized and structurally characterized by ESI mass spectrometry, IR, NMR spectroscopy, DFT calculations and X-ray diffraction. The results showed that the deprotonated 8-hy­droxy­quinoline (C9H6NO) coordinates with the PtII atom via the N and O atoms while the ethyl­ene coordinates in the η2 manner and in the trans position compared to the coordinating N atom. The crystal packing is characterized by C—H⋯O, C—H⋯π, Cl⋯π and Pt⋯π inter­actions. Complex (I) showed high selective activity against Lu-1 and Hep-G2 cell lines with IC50 values of 0.8 and 0.4 µM, respectively, 54 and 33-fold more active than cisplatin. In particular, complex (I) is about 10 times less toxic to normal cells (HEK-293) than cancer cells Lu-1 and Hep-G2. Furthermore, the reaction of complex (I) with guanine at the N7 position was proposed and investigated using the DFT method. The results indicated that replacement of the ethyl­ene ligand with guanine is thermodynamically more favorable than the Cl ligand and that the reaction occurs via two consecutive steps, namely the replacement of ethyl­ene with H2O and the water with the guanine mol­ecule.

If a software update process fails, it can lead to catastrophic consequences, as seen today with widespread blue screens of death blamed on a bad update by CrowdStrike

Attributing a cyberattack to a specific threat actor is a complex affair, as evidenced by new ESET research published this week

Fast Guard Service has been a provider of armed and unarmed security guards for over a decade; during that time we have learned a lot about your concerns; so we assist you by providing competent security solutions.

AI, despite its hype, often causes delays in manufacturers' automation strategies due to confusion and fear. Fundamentally, AI complements machine vision, which uses handcrafted algorithms needing new formulas and trial-and-error development for each product type or feature.

Women of color want demographic and political representation, just as wealthy white men have had for generations.

In this interview, Palouse Fiber Packaging CEO Kyler Lovgren explains how molded fiber could help businesses remain compliant as a patchwork of state-level packaging regulations crop up.

Federal retirement benefits require specialized advice to maximize. Feds planning to retire need a fiduciary who specializes in federal retirement.

The post Navigating the complexities of federal retirement benefits first appeared on Federal News Network.

A lesson from history.

The complexity and dynamics of the immensely heterogeneous glycoproteome of the prostate cancer (PCa) tumour micro-environment remain incompletely mapped, a knowledge gap that impedes our molecular-level understanding of the disease. To this end, we have used sensitive glycomics and glycoproteomics to map the protein-, cell- and tumour grade-specific N- and O-glycosylation in surgically-removed PCa tissues spanning five histological grades (n = 10/grade) and tissues from patients with benign prostatic hyperplasia (n = 5). Quantitative glycomics revealed PCa grade-specific alterations of the oligomannosidic-, paucimannosidic- and branched sialylated complex-type N-glycans, and dynamic remodelling of the sialylated core 1- and core 2-type O-glycome. Deep quantitative glycoproteomics identified ~7,400 unique N-glycopeptides from 500 N-glycoproteins and ~500 unique O-glycopeptides from nearly 200 O-glycoproteins. With reference to a recent Tissue and Blood Atlas, our data indicate that paucimannosidic glycans of the PCa tissues arise mainly from immune cell-derived glycoproteins. Further, the grade-specific PCa glycosylation arises primarily from dynamics in the cellular makeup of the PCa tumour microenvironment across grades involving increased oligomannosylation of prostate-derived glycoproteins and decreased bisecting GlcNAcylation of N-glycans carried by the extracellular matrix proteins. Further, elevated expression of several oligosaccharyltransferase subunits and enhanced N-glycoprotein site occupancy were observed associated with PCa progression. Finally, correlations between the protein-specific glycosylation and PCa progression were observed including increased site-specific core 2-type O-glycosylation of collagen VI. In conclusion, integrated glycomics and glycoproteomics have enabled new insight into the complexity and dynamics of the tissue glycoproteome associated with PCa progression generating an important resource to explore the underpinning disease mechanisms.

Umut Güçlü
Jul 8, 2015; 35:10005-10014
BehavioralSystemsCognitive

Redox reactions control fundamental biochemical processes, including energy production, metabolism, respiration, detoxification, and signal transduction. Cancer cells, due to their generally active metabolism for sustained proliferation, produce high levels of reactive oxygen species (ROS) compared to normal cells and are equipped with antioxidant defense systems to counteract the detrimental effects of ROS to maintain redox homeostasis. The KEAP1-NRF2 system plays a major role in sensing and regulating endogenous antioxidant defenses in both normal and cancer cells, creating a bivalent contribution of NRF2 to cancer prevention and therapy. Cancer cells hijack the NRF2-dependent antioxidant program and exploit a very unique metabolism as a trade-off for enhanced antioxidant capacity. This work provides an overview of redox metabolism in cancer cells, highlighting the role of the KEAP1-NRF2 system, selenoproteins, sulfur metabolism, heme/iron metabolism, and antioxidants. Finally, we describe therapeutic approaches that can be leveraged to target redox metabolism in cancer.

It is no secret that recent Arab uprisings have placed enormous burdens on the shoulders of BBC Arabic journalists responsible for reporting news from the region.

Covering the Arab world is not always an easy task - we need to mix sensible caution with a dose of courage in covering political issues that attract so many disputed views among Arabic-speaking audiences.

Our guiding principles are the BBC's values, its editorial guidelines, its ethical code, which are our reference points to maintain impartial, balanced and accurate reporting.

Across the Arab world - whether it's Tunisia, Yemen, Egypt or Libya, Bahrain, Syria and Iraq or the many other countries in the region - we know that audiences want access to objective and independent news, far removed from an agenda that favours one party, religion or sect against another. That is why audiences are turning to BBC Arabic.

Last year, our latest figures show that overall audiences to BBC Arabic have risen by more than 17% to a record high of 25.3 million adults weekly. That includes a big surge of 2.9 million in Saudi Arabia and 2.7 million in Egypt, where TV viewers in particular turned to the BBC to better understand the events happening in their own country. Our radio audiences are also holding up despite the reductions in transmission. Online is proving to be more of a challenge, but we are working hard to understand the needs of digital audiences and those for whom social media plays an increasingly important part in their lives.

In 2011, following the fall of the Mubarak leadership, we watched as ordinary Egyptians carried banners saying "Thank you, BBC!" But meeting the high expectation of audiences has a price and sometimes it's been a heavy one.

March 2011 brought a strong reminder of the risks that our staff face in covering the news - one of our reporters was arrested and tortured by Muammar Gaddafi's forces during the Libya uprising. In early 2012, our reporter in Yemen was beaten and received death threats from supporters of the outgoing president.

We are also challenged by those who disagree with our coverage. In countries such as Syria and Bahrain, BBC Arabic has been accused of bias.

The criticism comes from opposition and government alike. It may be a valid argument to say that getting criticism from both sides, in the case of Arab world certainly, is an indication of balanced coverage.

On Syria, for example, we had a series of documentaries looking at the civil war from a number of perspectives.

The first one, exploring what it's like to work for a Syrian television channel that's the mouthpiece of the government, was the butt of criticism and threats from Syrian opposition quarters. We followed it up with a programme charting a day in the lives of six Syrian women, five of whom were anti-government activists.

In our day-to-day news coverage, presenting a variety of voices from Syria is essential to us. And that is what distinguishes BBC Arabic from many media outlets in the Arab world which promote political views and agendas, and that is what we are determined to keep.

BBC Arabic marked its 75th anniversary in January. Arab politicians and ordinary people have expressed their appreciation of our track record of impartiality and trusted news. I am confident that the coming years will see further achievement on all our platforms - TV, radio and online.

Nature-based Solutions (NbS) are a hot topic in environment and landscape planning networks. But are they a silver bullet for solving the climate crisis?

The post Greening gray infrastructure: uncovering the complexity of Nature-based Solutions first appeared on International Water Management Institute (IWMI).

Back in 2013, when we launched the OECD's first international review of school resource policies, we may not have been fully prepared for the detective-type work we were getting into. The OECD Review of School Resources covers 18 school systems and aims to shed light on a part of education policy that has been surprisingly left in the dark.

The world’s growing complexity and diversity present both opportunity and challenge. On the one hand, globalization can bring important new perspectives, innovation, and improved living standards. But on the other, it can also contribute to economic inequality, social division, and conflict.

What's in a name? Apparently a lot in a country like ours, where even today regressive practices like identifying a person's caste by his or her surname or identifying a woman by her husband's name continue unabated, writes Navya P K.

A novel monoclinic phase of human insulin co-crystallized with m-cresol was structurally characterized by means of powder and single-crystal X-ray diffraction.

Controlling pests using their natural enemies can be an environmentally sound alternative to pesticides. However, the complex interactions between different pest control species and the landscape itself can affect the efficiency of such biological pest control, research suggests.

Although there have been significant advances in the understanding and monitoring of atmospheric processes in the last decade, a recent study suggests that uncertainties in their assessment continue to grow and more complex studies are required to understand the precise relationship between atmospheric chemicals, such as air pollutants, and climate change.

Silver Lining encourages strength when facing adversity and overcoming situations of despair - bullying, violence, abuse, trauma - reminding us to practice self love, patience, and acceptance over hate.

"Quasi-elliptic" functions can be given a ring structure in two different ways, using either ordinary multiplication, or convolution. The map between the corresponding standard bases is calculated and given by Eisenstein series. A related structure has appeared recently in the computation of Feynman integrals. The two approaches are related by a sequence of polynomials with interlacing zeroes.

In cite{S 2017}, Suh gave a non-existence theorem for Hopf real hypersurfaces in the complex quadric with parallel normal Jacobi operator. Motivated by this result, in this paper, we introduce some generalized conditions named $mathcal C$-parallel or Reeb parallel normal Jacobi operators. By using such weaker parallelisms of normal Jacobi operator, first we can assert a non-existence theorem of Hopf real hypersurfaces with $mathcal C$-parallel normal Jacobi operator in the complex quadric $Q^{m}$, $m geq 3$. Next, we prove that a Hopf real hypersurface has Reeb parallel normal Jacobi operator if and only if it has an $mathfrak A$-isotropic singular normal vector field.

Turf dancing has become ubiquitous on the trains, providing steady income, a creative platform, and a built-in audience. On a recent Friday, Yaameen Muhammad stood on the West Oakland BART platform, the afternoon sun reflecting off his neon-yellow high-tops.…

Immigration is good for the economy — that's the big picture. It doesn't mean some Americans aren't hurt in their paychecks and opportunities.

This programme of work addresses the conundrum of nuclear weapons as a wicked problem in a complex adaptive system.

Dual first-order methods are essential techniques for large-scale constrained convex optimization. However, when recovering the primal solutions, we need $T(epsilon^{-2})$ iterations to achieve an $epsilon$-optimal primal solution when we apply an algorithm to the non-strongly convex dual problem with $T(epsilon^{-1})$ iterations to achieve an $epsilon$-optimal dual solution, where $T(x)$ can be $x$ or $sqrt{x}$. In this paper, we prove that the iteration complexity of the primal solutions and dual solutions have the same $Oleft(frac{1}{sqrt{epsilon}} ight)$ order of magnitude for the accelerated randomized dual coordinate ascent. When the dual function further satisfies the quadratic functional growth condition, by restarting the algorithm at any period, we establish the linear iteration complexity for both the primal solutions and dual solutions even if the condition number is unknown. When applied to the regularized empirical risk minimization problem, we prove the iteration complexity of $Oleft(nlog n+sqrt{frac{n}{epsilon}} ight)$ in both primal space and dual space, where $n$ is the number of samples. Our result takes out the $left(log frac{1}{epsilon} ight)$ factor compared with the methods based on smoothing/regularization or Catalyst reduction. As far as we know, this is the first time that the optimal $Oleft(sqrt{frac{n}{epsilon}} ight)$ iteration complexity in the primal space is established for the dual coordinate ascent based stochastic algorithms. We also establish the accelerated linear complexity for some problems with nonsmooth loss, e.g., the least absolute deviation and SVM.

There are countless examples of the real world intruding on art, making something that was fine a day ago a grisly mistake now. The pilot episode of X-Files spin-off The Lone Gunmen, which aired six months before 9/11, featured a terrorist plan to fly a plane into the World Trade Center, for instance. And it's likely that The Complex, an interactive movie about dangerous biotechnology, skirts the same issue. After all, nobody wants to fixate on doctors in a life-and-death race against disease when there's a pandemic raging, do they?

Across the world, cities are grappling with climate change. While half of the world’s population now lives in cities, more than 70 percent of carbon emissions originate in cities. The 2015 Paris Climate Agreement, the UN’s 2016 Sustainable Development Goals, and the recent UN Climate Change Conference in Bonn, Germany have all recognized that cities…

ALEXANDRA SHULMAN: I won't be so cravenly woke as to pretend that attractive youth isn't still admired in our society and that its currency doesn't still exist.

ALEXANDRA SHULMAN: I won't be so cravenly woke as to pretend that attractive youth isn't still admired in our society and that its currency doesn't still exist.

Moraes, Marcela Quartim de, author

The more time young adults spend using popular social media, the greater the link to depression, new research suggests.

The finding stems from research—which involved nearly 1,800 men and women between the ages of 19 and 32—that tried to get a handle on how depression and social media habits may interact.

But does greater involvement with social media actually promote depression? Or, are people who are already depressed simply more likely to gravitate to social media? The jury, according to the study authors, is still out.

complete article

On this episode of On the Evidence, we talk about a report that looks at the complicated relationships among nonstandard or changing work schedules, the availability of child care for those schedules, and child well-being. Our guests are Angela Rachidi and Russell Sykes, who coauthored the report.

Rotch Library - HT371.R83 2019