Legislative effort to end rating practice announced Insurance Commissioner Trinidad Navarro and the Consumer Federation of America (CFA) today released Gender Disparities in Auto Insurance Pricing, a new report that shows many women are being charged more by auto insurers based solely on their gender. Data shows that many Delaware women pay more per year […]

NEW CASTLE (April 7, 2022) – The Department of Health and Social Services (DHSS) has launched a new website called CostAware to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical claims in Delaware. Hospital […]

CostAware Compares Health Care Costs Based on Delaware Medical Claims NEW CASTLE (March 3, 2023) – The Delaware Department of Health and Social Services (DHSS) announced today the launch of a new version of its CostAware website, designed to help Delawareans understand how their health care dollars are spent by comparing the variation of average […]

NEW CASTLE – The Delaware Department of Health and Social Services (DHSS) announced today enhancements to the CostAware website, designed to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical and pharmacy claims in Delaware. […]

Comparing Logistic Regression and Decision Tree - Which of our models is better at predicting our outcome? Learn how to compare models using misclassification, area under the curve (ROC) charts, and lift charts with validation data. In part 6 and part 7 of this series we fit a logistic regression [...]

Getting Started with Python Integration to SAS Viya for Predictive Modeling - Comparing Logistic Regression and Decision Tree was published on SAS Users.

The BMW Championship begins next week at the Wilmington Country Club and will bring thousands of visitors to northern Delaware for the nearly weeklong event that concludes on Sunday, August 21, 2022. DelDOT is reminding residents and vistors to expect heavier traffic volumes on area roads during the tournament, and will be working with Delaware […]

Unfair treatment of mental health conditions and other compliance issues uncovered, must be corrected. The Delaware Department of Insurance today announced the completion of its first follow-up Mental Health Parity and Addiction Equity Act (“Mental Health Parity”) examination, which also included reviews of complaint and grievance handling, policyholder services, claims, utilization review, and pharmacy review. […]

“What’s our plan if we get hit by a big flood?” While this question may be plenty familiar to emergency management professionals, city administrators, legislators, and other leaders in coastal regions that are known for their exposure to potentially disastrous weather events, these days it’s being asked in some unexpected [...]

The post Four technology tips for government leaders preparing for flood disasters appeared first on Government Data Connection.

Rajya Sabha MP Raghav Chadha marked his 36th birthday in Varanasi.

Paris Region has kept its fDi European Region of the Future title, while Dublin Region holds on to second place and North Rhine-Westphalia is in third. 

Paris — Paris police said Sunday that 4,000 officers and 1,600 stadium staff will be deployed for a France-Israel soccer match to ensure security in and around the stadium and on public transportation a week after violence against Israeli fans in Amsterdam.  France and Israel are playing in a UEFA Nations League match Thursday.  “There's a context, tensions that make that match a high-risk event for us,” Paris police chief Laurent Nuñez said on French news broadcaster BFM TV, adding authorities “won't tolerate” any violence.  Nuñez said that 2,500 police officers would be deployed around the Stade de France stadium, north of the French capital, in addition to 1,500 others in Paris and on public transportation.  “There will be an anti-terrorist security perimeter around the stadium,” Nuñez said. Security checks will be “reinforced,” he added, including with systematic pat-downs and bag searches.  Nuñez said that French organizers have been in contact with Israeli authorities and security forces to prepare for the match.  Israeli fans were assaulted last week after a soccer game in Amsterdam by hordes of   young people apparently riled up by calls on social media to target Jewish people,   according to Dutch authorities. Five people were treated at hospitals and dozens were arrested after the attacks, which were condemned as antisemitic by authorities in Amsterdam, Israel and across Europe.  On Sunday, Dutch police detained several people for taking part in a demonstration in central Amsterdam that had been outlawed following the violence targeting Israeli fans, a local broadcaster reported.  French Interior Minister Bruno Retailleau confirmed Friday that the France-Israel match would go ahead as planned.  “I think that for a symbolic reason we must not yield, we must not give up,” he said, noting that sports fans from around the world came together for the Paris Olympics this year to celebrate the “universal values” of sports. 

The Paris climate agreement's goals "are in great peril" and 2024 is on track to break new temperature records, the United Nations warned Monday as COP29 talks opened in Baku.

At the biggest summit since Copenhagen, negotiators from developed and developing countries converge in Paris to hammer out a meaningful international agreement to combat climate change.

Macron and Starmer lay wreath at Paris' Tomb of the Unknown Soldier on Armistice Day

Would God redeem sinners at the cost of His own Son’s blood, then cast those same blood-bought believers aside? Having brought us to salvation at so great a price, would He then withhold any grace from us? Won’t He finish what He started? Romans 8:32 provides us with a clear and emphatic answer.

So, the worst has happened. American voters have apparently just elected the most chaotic and kleptocratic individual in their country’s political history as their president. (We say ‘apparently’, because these days nothing can be certain about the integrity of the US political or electoral system – as is the case with far too many other […]

Regional disparities within and among Chinese provinces have declined, but are still a serious problem.

For approval in 2023.

Averting an asteroid strike will need many of the same skills we must hone to tackle climate change and future pandemics

Ancient stone goods found across France may have been made by skilled craftspeople in what is now Paris, who traded along vast networks

Title: Health Tip: Preparing for the First Day of School
Category: Health News
Created: 8/27/2014 7:35:00 AM
Last Editorial Review: 8/27/2014 12:00:00 AM

BACKGROUND:Training in mechanical ventilation is a key goal in critical care fellowship education. Web-based simulators offer a cost-effective and readily available alternative to traditional on-site simulators. However, it is unclear how effective they are as teaching tools. In this study, we evaluated the test scores of fellows who underwent mechanical ventilation training by using a web-based simulator compared with fellows who used an on-site simulator during a mechanical ventilation course.METHODS:This was a nonrandomized controlled trial conducted as part of a mechanical ventilation course that involved 70 first-year critical care fellows. The course was identical except for the simulation technology used. One group of instructors used a traditional on-site simulator, the ASL 5000 Lung Solution (n = 39). The second group was instructed in using a web-based simulator, VentSim (n = 31). Each fellow completed a pre-course test and a post-course test by using a validated, case-based ventilator waveform examination that consisted of 5 questions with a total possible score of 100. The primary outcome was a comparison of the mean scores on the posttest between the 2 groups. The study was designed as a non-inferiority trial with a predetermined margin of 10 points.RESULTS:There was no significant difference in the mean ± SD pretest scores between the web-based and the on-site groups (21.1 ± 12.6 and 26.9 ± 13.6 respectively; P = .11). The mean ± SD posttest scores were 45.6 ± 25.0 for the web-based simulator and 43.4 ± 16.5 for on-site simulator (mean difference 2.2; one-sided 95% CI –7.0 to ∞; Pnon-inferiority = .02 [non-inferiority confirmed]). Changes in mean ± SD scores (posttest – pretest) were 25.9 ± 20.9 for the web-based simulator and 16.5 ± 15.9 for the on-site simulator (mean difference 9.4, one-sided 95% CI 0.9 to ∞; Pnon-inferiority < .001 [non-inferiority confirmed]).CONCLUSIONS:In the education of first-year critical care fellows on mechanical ventilation waveform analysis, a web-based mechanical ventilation simulator was non-inferior to a traditional on-site mechanical ventilation simulator.

Purpose The posterior superior alveolar (PSA) block injection is one of many techniques used to provide profound anesthesia for invasive dental procedures. This technique has a high success rate but is not without complication risks. The purpose of this study was to determine if pulpal anesthesia of the maxillary second molar could be achieved using a reduced needle depth of 10mm or 5mm compared to the traditional needle depth of 16mm.Methods Sixty participants were asked to participate in three sessions. Each session started with a pre neural response test, followed by one randomized needle depth PSA injection, and ending with a post neural response test. The neural response test consisted of two parts, a cold refrigerant and a dental probe, on the buccal and interproximal surface of the maxillary second molar. After receiving a positive neural response, each participant received a posterior superior alveolar block injection using a short (21mm), 27-gauge dental needle with a randomized needle penetration depth of 16mm, 10mm, or 5mm. A post neural response test consisting of the same two parts as the pre-test was conducted on the maxillary second molar to evaluate for profound anesthesia.Results Positive neural responses were obtained from 100% of the participants (n=167) during the pre-tests. Study results demonstrated an 85% success rate at the traditional 16mm needle depth and a 93% and 92% success rates for the reduced needle depths of 10mm and 5mm, respectively. Pulpal anesthesia of the maxillary second molar had been achieved at all three needle depths with no statistically significant difference in the rate of success. Furthermore, there were no adverse events observed.Conclusion The reduced needle depth technique showed promise in achieving desired results of pulpal anesthesia with a reduced risk for complications associated with the PSA block injection. Additional studies are recommended to achieve evidence-based support for this reduced needle depth technique.

The analysis of extractables and leachables and subsequent risk assessment is an important aspect of the determination of biocompatibility for many medical devices. Leachable chemicals have the potential to pose a toxicological risk to patients, and therefore it is required that they be adequately characterized and assessed for potential safety concerns. One important consideration in the assessment of leachables is the choice of a suitable simulating solvent intended to replicate the use condition for the device and its biological environment. This aspect of study design is especially difficult for blood-contacting medical devices due to the complexity of simulating the biological matrix. This publication reports a comparison of the extracting power of different binary solvent mixtures and saline in comparison with whole blood for a bloodline tubing set connected to a hemodialyzer. Ten different known extractables, spanning a range of physicochemical properties and molecular weights, were quantified. The results indicated that for low-molecular-weight analytes, a suitable exaggeration for whole blood can be obtained using a low-concentration ethanol/water mixture (20%), and in general, extracted quantity increases with the concentration of alcohol cosolvent. For polyvinylpyrrolidone, the opposite trend was observed, as solubility of the polymer was found to decrease with increasing alcohol concentration, resulting in lower extracted quantities at high alcohol concentrations. Analysis of ethanol/water concentrations in the extract solutions post extraction indicated no change in solvent composition.

SEquence Evaluation through k-mer Representation (SEEKR) is a method of sequence comparison that uses sequence substrings called k-mers to quantify the nonlinear similarity between nucleic acid species. We describe the development of new functions within SEEKR that enable end-users to estimate P-values that ascribe statistical significance to SEEKR-derived similarities, as well as visualize different aspects of k-mer similarity. We apply the new functions to identify chromatin-enriched lncRNAs that contain XIST-like sequence features, and we demonstrate the utility of applying SEEKR on lncRNA fragments to identify potential RNA-protein interaction domains. We also highlight ways in which SEEKR can be applied to augment studies of lncRNA conservation, and we outline the best practice of visualizing RNA-seq read density to evaluate support for lncRNA annotations before their in-depth study in cell types of interest.

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC₅₀ and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC₅₀ values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

The phase 3 VISION trial demonstrated that [¹⁷⁷Lu]Lu-PSMA-617 prolonged progression-free survival and overall survival (OS) in prostate-specific membrane antigen [PSMA]–positive metastatic castration-resistant prostate cancer (mCRPC) patients who progressed on taxane-based chemotherapy and androgen receptor–signaling inhibitors (ARSIs). The U.S. expanded-access program (EAP; NCT04825652) was opened to provide access to [¹⁷⁷Lu]Lu-PSMA-617 for eligible patients until regulatory approval was obtained. This study aimed to evaluate the efficacy and safety profile of [¹⁷⁷Lu]Lu-PSMA-617 within the EAP and compare the results with those from the VISION trial. Methods: Patients enrolled in the EAP at 4 institutions in the United States with available toxicity and outcome data were included. Outcome measures included OS, a prostate-specific antigen (PSA) response rate (RR) of at least 50%, and incidences of toxicity according to Common Terminology Criteria for Adverse Events version 5.0. Differences in baseline characteristics, outcome data, and toxicity between the EAP and VISION were evaluated using t testing of proportions and survival analyses. Results: In total, 117 patients with mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP between May 2021 and March 2022 were eligible and included in this analysis. Patients enrolled in the EAP were more heavily pretreated with ARSI (≥2 ARSI regimens: 70% vs. 46%; P < 0.001) and had worse performance status at baseline (Eastern Cooperative Oncology Group score ≥ 2: 19% vs. 7%; P < 0.001) than VISION patients. EAP and VISION patients had similar levels of grade 3 or higher anemia (18% vs. 13%; P = 0.15), thrombocytopenia (13% vs. 8%; P = 0.13), and neutropenia (3% vs. 3%; P = 0.85) and similar PSA RRs (42% vs. 46%; P = 0.50) and OS (median: 15.1 vs. 15.3 mo; P > 0.05). Conclusion: Patients with PSMA-positive mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP were later in their disease trajectory than VISION patients. Patients enrolled in the EAP achieved similar PSA RRs and OS and had a safety profile similar to that of the VISION trial patients.

BACKGROUND AND PURPOSE:

Physician-industry relationships can be useful for driving innovation and technologic progress, though little is known about the scale or impact of industry involvement in neuroradiology. The purpose of this study was to assess the trends and distributions of industry payments to neuroradiologists.

The head of one of the world's largest oil companies has had it with government flip-flopping.

Chris gets cheesecake from rats. Kelley punches worms to get her Tifa back. And Josh funds a re-dub of Yakuza with Mark Hamil. Now excuse us as we go attend tonight's brawl at the local Waffle House.

The post RPG Cast – Episode 717: “I Went to Tokyo Disneyland in Paris” appeared first on RPGamer.

Here we see data representing the sales through to consumers and change in sales performance of the three current platforms (PlayStation 5, Xbox Series X|S, and Nintendo Switch) and two legacy platforms (PlayStation 4 and Xbox One) over comparable periods for 2021, 2022, 2023, and 2024. Also shown is the market share for each of the consoles over the same periods.

Year to Date Sales Comparison (Same Periods Covered)

Market Share (Same Periods Covered)

2021 – (January 2021 to October 2021)

2022 – (January 2022 to October 2022)

2023 – (January 2023 to October 2023)

2024 – (January 2024 to October 2024)

"Year to date" sales for 2021, 2022, 2023, and 2024 sales are shown in series at the top of the table and then just below a comparison of 2024 versus 2023 and 2024 versus 2022 is displayed.  This provides an easy-to-view summary of all the data.

Total Sales and Market Share for Each Year

Microsoft

• Xbox Series X|S
• 0.09 million units sold year-to-date
• Down year-on-year 0.03 million units (-23.2%)

Nintendo

• Nintendo Switch
• 2.47 million units sold year-to-date
• Down year-on-year 0.75 million units (-23.4%)

Sony

• PlayStation 5
• 1.16 million units sold year-to-date
• Down year-on-year 0.94 million units (-44.9%)
• PlayStation 4
• 0.01 million units sold year-to-date
• Down year-on-year 0.05 million (-77.2%)

Note: VGChartz 2024 estimates through October includes 44 weeks, while 2023, 2022, and 2021 estimates includes 43 weeks.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463009/ps5-vs-xbox-series-xs-vs-switch-2024-japan-sales-comparison-charts-through-october/

The VGChartz sales comparison series of articles are updated monthly and each one focuses on a different sales comparison using our estimated video game hardware figures. The charts include comparisons between the PlayStation 5, Xbox Series X|S, and Nintendo Switch, as well as with older platforms. There are articles based on our worldwide estimates, as well as the US, Europe, and Japan.

This monthly series compares the aligned Japanese sales of the PlayStation 5 and PlayStation 4.

The PlayStation 5 launched in November 2020 in Japan, while the PlayStation 4 launched in February 2014. This does mean the holiday periods for the two consoles do not lineup.

PS5 Vs. PS4 Japan:

Gap change in latest month: 277,262 - PS4

Gap change over last 12 months: 300,542 - PS4

Total Lead: 234,400 - PS4

PlayStation 5 Total Sales: 6,121,649

PlayStation 4 Total Sales: 6,356,049

October 2024 is the 48th month the PlayStation 5 has been available for. In the latest month, the gap grew in favor of the PlayStation 4 when compared to the aligned launch of the PlayStation 5 by 0.28 million units.

In the last 12 months, the PS4 has outsold the PS5 by 0.30 million units. The PS5 is currently behind the PS4 by 0.23 million units.

The 48th month for the PS5 in Japan is October 2024, while for the PS4 it is January 2018. The PS5 has sold 6.36 million units, while the PS4 sold 6.12 million units during the same timeframe.

The PS4 crossed 7 million in month 53, 8 million in month 61, and 9 million in month 72. The PS4 has sold 9.68 million units to date. The PS5 is currently 3.56 million units behind the lifetime sales of the PS4 in Japan.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463011/ps5-vs-ps4-sales-comparison-in-japan-october-2024/

Averting an asteroid strike will need many of the same skills we must hone to tackle climate change and future pandemics

With the vision of a billion developers, AI is evolving from a specialized tool to a platform that democratizes coding. As AI’s

The post Preparing for a Billion Developers appeared first on Gigaom.

NPR's Leila Fadel talks with actor Patrick Dempsey about his efforts to raise money for cancer treatment and prevention.

A New Campaign Inspiring Women to Share Something They Believe is Worth Saying, Launching During The Golden Globes

Stag�s Leap Wine Cellars celebrates the 40th anniversary of The Judgment of Paris, which helped to elevate the esteem of American wine worldwide

Eva Longoria :30 English

March of Dimes volunteer ambassador and world famous photographer Anne Geddes is featured in a PSA to raise awareness about preventing preterm birth and give more babies a healthy start in life.

Originally theorized by Happy Hobbit, a music industry blog seems to confirm the song name.

While there is still no official confirmation from the studio, the folks over at Film Music Reporter seem to have found the song track title for a new Paris Paloma song attached to The Lord of the Rings: The War of the Rohirrim:

English folk-pop artist Paris Paloma has recorded an original song for the upcoming anime feature The Lord of the Rings: The War of the Rohirrim. The track, entitled The Rider, written by Phoebe Gittins (who co-wrote the project’s screenplay with Arty Papageorgiou and Jeffrey Addiss & Will Matthews) & composer David Long and performed by Paloma, will be featured in the movie.

Where is the Horse and The Rider

Paris Paloma is fresh on the music scene having released her first album earlier this year. Kellie from Happy Hobbit is a huge fan and in this TikTok posted a few months ago she speculated that Paloma was involved in The War of the Rohirrim. Just last week at NYCC, Executive Producer Philippa Boyens teased a great new song without revealing the artist. You can watch the full panel on our YouTube.

On this week's TORN Tuesday, Kellie explains who Paris Paloma is and why she is perfect to be involved in the story of Rohan's shieldmaidens. Segment starts at 1:17:00

Ancient stone goods found across France may have been made by skilled craftspeople in what is now Paris, who traded along vast networks

Belgian Tom Boonen becomes only the second rider to win the Paris-Roubaix classic for the fourth time.

New research shows improved access to psychotherapy for pregnant and postpartum women struggling with depression and anxiety. Additionally, these women are now paying less out-of-pocket for treatment.

A groundbreaking study has unveiled a critical issue of therapeutic inertia in treating women with medlinkmultiple sclerosis/medlink (MS), underscoring

Black patients with bmedlinktriple-negative breast cancer/medlink (TNBC)/b received immunotherapy at significantly lower rates than white patients.

bHighlights:/bul class="group-list punch-points"li 93% of organ donations come from living donors, revealing a striking imbalance/li liWomen,

A recent global study published in Lancet Public Health reveals significant disparities in health outcomes between men and women, shedding light on the

Data Comparing NUCYNTA(R) (tapentadol) Tablets to Oxycodone Immediate Release Tablets Presented at 2010 American Pain So