Jessica Lewis finished second in the T53 100 metres at the WPA Paris Grand Prix in the French capital today [June 13]. Lewis clocked a time of 16.91sec to finish behind Catherine Debrunner, of Switzerland, in 15.68. Anita Scherrer, of Switzerland, came third in 19.27. Lewis, who competes in the T53 400 tomorrow, hopes to […]

[Written by Stephen Wright] Brian Wellman believes Jah-Nhai Perinchief must focus on “one jump at a time” as he prepares for the triple jump qualifiers at the Stade de France at the Olympic Games in Paris on Wednesday [August 7]. Four-time Olympian Wellman, one of the island’s greatest athletes, has travelled to the French capital […]

[Written by Stephen Wright] Para-athlete Jessica Lewis has reflected on her “unique experience” of representing Bermuda at the Paralympic Games in Paris. Lewis, the island’s most decorated para-athlete, finished fifth in the T53 100 metres and seventh in the T53 400 at the iconic Stade de France last week. The 31-year-old was joined in Paris […]

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[Written by Stephen Wright] Bermuda rower Dara Alizadeh experienced his first victory in an Olympic Games race after winning his E/F semi-final at the Vaires-sur-Marne Nautical Stadium today [July 29]. Alizadeh, who competes in the men’s single sculls, claimed a comfortable win, finishing his two-kilometre race in 7min 33.38sec. The 30-year-old said he was encouraged […]

[Written by Dale Butler] The fifth Pastoral-Parishioners’ Anniversary took place on the grounds of the Christ Anglican Church, Devonshire, on Saturday, September 21, 2024 at 6.00pm with a very appetizing dinner by Kenny’s Kitchen and water donated by John Barritt & Son Limited; an exceptional night of entertainment followed. The tent, lighting, and stage backdrop […]

There has been a two vehicle road traffic collision involving a motorcar and a motorcycle in the area of Barnes Corner in Southampton Parish. A police spokesperson said, “There has been a two vehicle road traffic collision involving a motorcar and a motorcycle in the area of Barnes Corner, Southampton Parish. “Details are limited at […]

[Updated] “There has been a serious road traffic collision involving two motorcycles on Blue Hole Hill, Hamilton Parish,” the police said this evening [Nov 7]. “The roadway is currently closed, with traffic being diverted through the Grotto Bay compound. Motorists heading into or out of the east end are encouraged to delay their departure, if possible […]

I really love the card game Lost Cities, designed by Reiner Knizia. When my husband Christopher and I were first getting to know each other, we used to meet up at Starbucks sometimes and play games. Lost Cities was one of our frequent picks. It’s a head to head, two player game in which both players are trying to outscore each other by laying down ascending runs of card suits on a small board between the two of them. There’s a theme laid over the mechanism (completing expeditions in the lost world) but it’s basically pasted on and so that is the last we will speak of it. So there we were, newly in love, eyeing each other across the table, smiling and flirting, and doing our best to beat one another at Lost Cities. It was awesome. And now, with the roll & write genre having made an impressive rebound a few years ago (let’s not forget the mechanism has actually been around since the 50s with Yatzee), Knizia has ported his award winning game Lost Cities  into this format, releasing Lost Cities Roll & Write  in 2021. 

You can play the new Lost Cities  with up to 5 players, but in an ode to our romantic beginnings, Christopher and I played it exclusively with one another in successive matches.  The components are compact, lacking the pretty illustrations of the original game, and few in number – the rule book, a scorepad, three pentagonal trapezohedron dice (that’s 10 sided dice for the uninitiated), and three 6 sided custom dice with color suit symbols. Oh, and some pencils. That’s it. We could have played on an even smaller Starbucks table if we had this back in our dating days.

The cards from the original game (wager cards and numbered cards 2 to 10, in five different suits) have been translated into dice roll results. On each turn, one player rolls all the dice and chooses one of the six sided dice to represent the suit and one of the ten sided dice to represent the number. A zero on the number die can represent either zero (mimicking the wager card from the original game which serves as a multiplier for the total score in the selected suit) or ten (mimicking the highest card in each suit).

In place of the tableau built up on a central board, each player tracks the progress of wager and number cards they’ve collected for each suit in color coded columns on their individual score sheet. Wager cards have been transformed into little circular boxes to be marked off from a suit column when rolled, while the numbered cards from the original game have expanded to include the number 1 and are recorded as numbers written manually in the square boxes running up each column. Whereas in the original game, only cards higher than the last card played in a suit were permitted to be played on subsequent turns by the same player, in Lost Cities Roll & Write, numbers that are higher than or equal to the last number recorded for a suit may be written into the column after future dice rolls. Expanding beyond the concepts from the original game, Knizia has included artifact icons on select spaces in each column and when those spaces are filled by a player, they may fill in one of the jars in the artifact column. Likewise, he’s included arrow icons on select spaces and when those spaces are filled by a player, they may fill in the next box in one of their suit columns with the number from the previous box in the column – note that it does not have to be the same column in which the arrow was filled.  There’s also a column for filling in dice shapes to represent rolls where a player could not or did not want to use any of the dice results. The latter column is particularly tricky to manage effectively, as it provides a similar point progression as the rest of the columns (negative scores for the first 3 boxes filled and then positive score for the rest) up until the last box in the column. If you color in that box, your score for the dice shapes column drops from 70 to 0. The bonus points awarded in the original game (20 points for laying down at least 8 cards in a suit) have been implemented in Lost Cities Roll & Write  for each column (including the artifact and dice shape columns) as a 20 point bonus to the player who is the first to fill in 7 boxes in the column on the scorepad. The roll & write game ends when either both players have filled in the dice shapes column completely or all eight columns have passed the bonus point marker. In our experience, the completed dice shapes column is a much more common trigger.

I’ve played a ton of roll & write games over the past few years. Some are instant objects of adoration, while others are infuriating piles of poo (I’m looking at you Imperial Settlers R&W). Lost Cities Roll & Write is fantastic; a great addition to the genre. Knizia did an excellent job of translating the feel of the original game into the new mechanism. The iconography is clean and easy to read and the game can be taught and played in less than a half hour. And of course, it takes up very little table real estate, making it perfect for travel or tight spaces (when traveling as a passenger, simply roll the dice into the box cover). If you twisted my arm and forced me to choose between Lost Cities or Lost Cities Roll & Write, I’d be forced to pick the original, but only because of the lovely artwork on the cards and the sentimental value I have attached to the game after my love and I played it in our early days. But who would go around doing such arm twisting? Nobody. Therefore, with a retail price point under $15 for each of these, unless you’re down to your last $15, I recommend you pick up both. Play the card game with someone you love when you have a little more table space. Play the roll & write anywhere, with up to four additional friends. 

-------------------------------------------------

Publisher: Kosmos
Players: 2-5 (We played with 2)
Actual Playing Time (vs the guideline on the box): about 20 minutes per game
Game type: roll & write, dice rolling

Rating:

Rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.

[BULLETIN: Quicklisp now has the latest version of FSet.]

Sycamore, primarily by Neil Dantam, is a functional collections library that is built around the same weight-balanced binary tree data structure (with leaf vectors) that FSet uses.  While the README on that page comments briefly on the differences between Sycamore and FSet, I don't feel that it does FSet justice.  Here is my analysis.

Dantam claims that his library is 30% to 50% faster than FSet on common operations.  While I haven't done comprehensive micro-benchmarking, a couple of quick tests indicates that this claim is plausible.  A look through the internals of the implementation confirms that it is clean and tight, and I must commend him.  There may be some techniques in here that I could usefully borrow.

Most of the performance difference is necessitated by two design choices that were made differently in the two libraries.  One of these Dantam mentions in his comparison: FSet's use of a single, global ordering relation implemented as a CLOS generic function, vs. Sycamore's more standard choice of requiring a comparison function to be supplied when a collection is created.  The other one he doesn't mention: the fact that FSet supports a notion of equivalent-but-unequal values, which are values that are incomparable — there's no way, or at least no obvious way, to say which is less than the other, and yet we want to treat them as unequal.  The simplest example is the integer 1 and the single-float 1.0, which have equal numerical values (and cl:= returns true on them), but which are nonetheless not eql.  (I have a previous blog post that goes into a lot more detail about equality and comparison.)  Since Sycamore expects the user-supplied comparison function to return an integer that is negative, zero, or positive to indicate the ordering of its arguments, there's no encoding for the equivalent-but-unequal case, nor is there any of the code that would be required to handle that case.

Both of these decisions were driven by my goal for the FSet project.  I didn't just want to provide a functional collections library that could be called occasionally when one had a specific need for such a data structure.  My ambition was much grander: to make functional collections into a reasonable default choice for the vast majority of programming situations.  I wanted FSet users (including, of course, myself) to be able to use functional collections freely, with very little extra effort or thought.  While Lisp by itself reaches a little bit in this direction — lists can certainly be used functionally — lists used as functional collections run into severe time complexity problems as those collections get large.  I wanted the FSet collections to be as convenient and well-supported as lists, but without the time complexity issues.

— Or rather, I wanted them to be even more convenient than lists.  Before writing FSet, I had spent years working in a little-known proprietary language called Refine, which happened to be implemented on top of Common Lisp, so it was not unusual to switch between the two languages.  And I had noticed something.  In contrast to CL, with its several different predefined equality predicates and with its functions that take :test arguments to specify which one to use, Refine has a single notiion of equality.  The value space is cleanly divided between immutable types, which are compared by value — along with numbers, these include strings, sets, maps, and seqs — and mutable objects, which are always compared by identity.  And it worked!  I found I did not miss the ability to specify an equality predicate when performing an operation such as "union".  It was just never needed.  Get equality right at the language level, and the problem goes away.

Although FSet's compare generic function isn't just for equality — it also defines an ordering that is used by the binary trees — I thought it would probably turn out to be the case that a single global ordering, implemented as a generic function and therefore extensible, would be fine the vast majority of the time.  I think experience has borne this out.  And just as you can mix types in Lisp lists — say, numbers and symbols — without further thought, so you can have any combination of types in an FSet set, effortlessly.  (A project I'm currently working on actually takes considerable advantage of this capability.)

As for supporting equivalent-but-unequal values, this desideratum flows directly from the principle of least astonishment.  While it might not be too surprising for a set or map implementation to fail distinguish the integer 1 from the float 1.0, it certainly would be very surprising, and almost certainly a source of bugs in a compiler that used it, for it to fail to distinguish two uninterned symbols with the same name.  (I saw a macro expansion recently that contained two distinct symbols that both printed as #:NEW.  It happens.)  A compiler using Sycamore for a map on symbols would have to supply a comparison function that accounted for this; it couldn't just compare the package name and symbol name.  (You'd have to do something like keep a weak hash table mapping symbols to integers, assigned in the order in which the comparison function encountered them.  It's doable, but FSet protects you from this madness.)

Along with those deep semantic design choices, I've spent a lot of time on developing a wide and featureful API for FSet (an effort that's ongoing).  FSet has many features that Sycamore lacks, including:

• seqs, a binary-tree sequence implementation that holds arbitrary Lisp objects (Sycamore ropes hold only characters, which is certainly an important special case, but why restrict ourselves?)
• default values for maps and seqs (the value to return when the key is outside the domain is associated with the collection, not supplied at the call site; this turns out to be a significant convenience)
• generic functions that operate on both lists and FSet collections, to shadow the CL builtins
  
• the powerful map-union and map-intersection operations (I'll blog about these in the future)
• more ways to iterate over the collections (the FSet tutorial has a good summary, about 3/4 of the way down)
• speaking of the tutorial, FSet has lots more documentation

Let me digress slightly to give an example of how FSet makes programming more elegant and convenient.  Joe Marshall just put up a blog post comparing Go(lang) with Common Lisp, which is worth a read on its own; I'm just going to grab a code snippet from there to show a little bit of what programming with FSet is like.  Here's Joe's code:

 (defun collate (items &key (key #'identity) (test #'eql) (merger (merge-adjoin #'eql)) (default nil))
   (let ((table (make-hash-table :test test)))
     (dolist (item items table)
       (let ((k (funcall key item)))
         (setf (gethash k table) (funcall merger (gethash k table default) item))))))

 (defun merge-adjoin (test)
   (lambda (collection item)
     (adjoin item collection :test test)))

And here's what I would write using FSet:

(Well, I would probably move result outside the dolist form to make it clearer what the return value is, but let's go with Joe's stylistic choice here.)

For those who haven't used FSet: the form (map :default (set)) creates a map whose default is the empty set, meaning that lookups on that map will return the empty set if the key is not in the map.  This saves the includef form from having to handle that possibility.

My version makes assumptions, it's true, about how you want to collect the items with a given key; it doesn't give you other choices.  It could, but what would be the point?  It's already using a general set with better time complexity than lists, and saving you from having to write anything like merge-adjoin.  The extensible global equivalence relation means you're not going to need to supply a :test either.

I think the FSet-enhanced code is cleaner, more elegant, and therefore clearer than the plain-CL version.  Don't you agree?  Maybe you wouldn't say it's a huge improvement, okay, but it's a small example; in a larger codebase, I would argue, these small improvements add up.

* * * * *

To summarize: if you just want a library you can call in a few places for specific purposes, Sycamore might work better for you (but think hard if you're writing a comparator for symbols).  FSet can certainly be used that way, but it can be much more.  If you want to see one way in which Common Lisp can be made into a better language, without giving up anything that we love about it, I urge you to give FSet a try.

FSet has changed the way I write Lisp programs.  — an FSet user

(UPDATE: the magnitude of the performance difference between FSet and Sycamore surprised me, and inspired me to do some profiling of FSet.  It turned out that I could get a 20% speedup on one micro-benchmark simply by adding some inline declarations.  Mea culpa, mea culpa, mea maxima culpa; I should have done this years ago.   With that change, the generic function overhead appears to be the only significant cause of the remaining ~20% performance difference.  I tried creating a Sycamore set using a thin wrapper around fset:compare, and the resulting performance was very similar to that of FSet with its new inlines.)

 .

Shares of the company were down 39% at $1.8 after the bell. The stock has fallen nearly 80% this year, while the S&P 500 passenger airlines index jumped 52%. The ultra-low cost carrier is in advanced discussions with bondholders to hammer out a bankruptcy plan that would have support from a…

When faced with pain or discomfort, many turn to massage therapy or chiropractic care to find relief. Understanding the differences between these two approaches is crucial for making an informed decision about which treatment is best for your needs. Understanding Chiropractic Care Chiropractic care focuses on diagnosing and treating musculoskeletal issues, particularly those related to ... Read more

The post Comparing Massage and Chiropractic Care – Which Is Better? appeared first on Star Two.

In Savings and Trust, historian Justene Hill Edwards tells the story of the Freedman's Bank. Created for formerly enslaved people following the Civil War, its collapse cost depositors millions.

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The Paralympic Rowing Cox will compete a year after getting the all clear from cancer.

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A few tips for ensuring that students—particularly those with disabilities and English learners—and their families get the year off to a good start.

See the full guide Preparing Young Children for School Practice Guide › Recent research has identified practices that have the potential to prepare young children to benefit from the learning opportunities they will encounter in school.

AI is everywhere—we’re in a middle of a technology shift that’s as big as (and possibly bigger than) the arrival of the web in the 1990s. Even though ChatGPT appeared almost two years ago, we still feel unprepared: we read that AI will change every job, but we don’t know what that means or how […]

William M. Old
Oct 1, 2005; 4:1487-1502
Research

Visual Abstract

Visual Abstract

Visual Abstract

Mass spectrometry has become an indispensable tool for the characterization of glycosylation across biological systems. Our ability to generate rich fragmentation of glycopeptides has dramatically improved over the last decade yet our informatic approaches still lag behind. Although glycoproteomic informatics approaches using glycan databases have attracted considerable attention, database independent approaches have not. This has significantly limited high throughput studies of unusual or atypical glycosylation events such as those observed in bacteria. As such, computational approaches to examine bacterial glycosylation and identify chemically diverse glycans are desperately needed. Here we describe the use of wide-tolerance (up to 2000 Da) open searching as a means to rapidly examine bacterial glycoproteomes. We benchmarked this approach using N-linked glycopeptides of Campylobacter fetus subsp. fetus as well as O-linked glycopeptides of Acinetobacter baumannii and Burkholderia cenocepacia revealing glycopeptides modified with a range of glycans can be readily identified without defining the glycan masses before database searching. Using this approach, we demonstrate how wide tolerance searching can be used to compare glycan use across bacterial species by examining the glycoproteomes of eight Burkholderia species (B. pseudomallei; B. multivorans; B. dolosa; B. humptydooensis; B. ubonensis, B. anthina; B. diffusa; B. pseudomultivorans). Finally, we demonstrate how open searching enables the identification of low frequency glycoforms based on shared modified peptides sequences. Combined, these results show that open searching is a robust computational approach for the determination of glycan diversity within bacterial proteomes.

We performed an in-depth characterization and comparison of the pediatric and adult urinary glycomes using a nanoLC-MS/MS based glycomics method, which included normal healthy pediatric (1–10 years, n = 21) and adult (21–50 years, n = 22) individuals. A total of 116 N-glycan compositions were identified, and 46 of them could be reproducibly quantified. We performed quantitative comparisons of the 46 glycan compositions between different age and sex groups. The results showed significant quantitative changes between the pediatric and adult cohorts. The pediatric urinary N-glycome was found to contain a higher level of high-mannose (HM), asialylated/afucosylated glycans (excluding HM), neutral fucosylated and agalactosylated glycans, and a lower level of trisialylated glycans compared with the adult. We further analyzed gender-associated glycan changes in the pediatric and adult group, respectively. In the pediatric group, there was almost no difference of glycan levels between males and females. In adult, the majority of glycans were more abundant in males than females, except the high-mannose and tetrasialylated glycans. These findings highlight the importance to consider age-matching and adult sex-matching for urinary glycan studies. The identified normal pediatric and adult urinary glycomes can serve as a baseline reference for comparisons to other disease states affected by glycosylation.

Neoadjuvant therapy in patients with locally advanced rectal cancer (LARC) has achieved good pathologic complete response (pCR) rates, potentially eliminating the need for surgical intervention. This study investigated preoperative methods for predicting pCR after neoadjuvant short-course radiotherapy (SCRT) combined with immunochemotherapy. Methods: Treatment-naïve patients with histologically confirmed LARC were enrolled from February 2023 to July 2023. Before surgery, the patients received neoadjuvant SCRT followed by 2 cycles of capecitabine and oxaliplatin plus camrelizumab. ⁶⁸Ga-labeled fibroblast activation protein inhibitor ([⁶⁸Ga]Ga-FAPI-04) PET/MRI, [¹⁸F]FDG PET/CT, and contrast-enhanced MRI were performed before treatment initiation and before surgery in each patient. PET and MRI features and the size and number of lesions were also collected from each scan. Each parameter’s sensitivity, specificity, and diagnostic cutoff were derived via receiver-operating-characteristic curve analysis. Results: Twenty eligible patients (13 men, 7 women; mean age, 60.2 y) were enrolled and completed the entire trial, and all patients had proficient mismatch repair or microsatellite-stable LARC. A postoperative pCR was achieved in 9 patients (45.0%). In the visual evaluation, both [⁶⁸Ga]Ga-FAPI-04 PET/MRI and [¹⁸F]FDG PET/CT were limited to forecasting pCR. Contrast-enhanced MRI had a low sensitivity of 55.56% to predict pCR. In the quantitative evaluation, [⁶⁸Ga]Ga-FAPI-04 change in SUL_peak percentage, where SUL_peak is SUV_peak standardized by lean body mass, had the largest area under the curve (0.929) with high specificity (sensitivity, 77.78%; specificity, 100.0%; cutoff, 63.92%). Conclusion: [⁶⁸Ga]Ga-FAPI-04 PET/MRI is a promising imaging modality for predicting pCR after SCRT combined with immunochemotherapy. The SUL_peak decrease exceeding 63.92% may provide valuable guidance in selecting patients who can forgo surgery after neoadjuvant therapy.

U.S. Space Force has made public the prototypes of its new uniforms, which immediately drew comparisons to those worn in Star Trek and other science fiction franchises.

Schools are putting in place or considering measures such as extending holiday breaks or shifting back to full-time remote learning.

It's possible there could be an eight-way tie atop the SEC standings at the end of the regular season. Then what will the College Football Playoff committee do?

Yang Hu
Feb 24, 2021; 41:1699-1715
BehavioralSystemsCognitive

On the occasion of the fifth anniversary of the Paris Agreement, the event will highlight the key role of the agricultural sectors in supporting the Paris Agreement. The Paris Agreement, [...]

An increasing number of people in France espouse a clothing-free lifestyle

Paris police said Sunday that 4,000 officers and 1,600 stadium staff will be deployed for a France-Israel soccer match to ensure security a week after violence against Israeli fans in Amsterdam.

With a mission to bridge the gap in health equity in rural communities, Penn State College of Medicine has launched the Center for Advancing Health Equity in Rural and Underserved Communities.

As black-white achievement gaps widen in schools, so, too, do disparities in discipline rates between black and white students, according to a study published Wednesday of 2,000 schools.

"I'm glad God gave me the best one of them all," Parineeti Chopra wrote in her caption

Regulated health insurers found to be in violation laws of that prohibit discrimination in mental healthcare, $597K in fees assessed Insurance Commissioner Trinidad Navarro has announced the completion of the first in a series of Mental Health Parity examinations on health insurers in Delaware. Investigations conducted by the Delaware Department of Insurance uncovered thousands of […]

More than $1.3M in total fines assessed for coverage discrimination Insurance Commissioner Trinidad Navarro has announced the completion of additional Mental Health Parity examinations on regulated health insurers in Delaware. These violations resulted in $735,000 in fines and significant insurer corrections to create a less discriminatory environment in the future. Combined with two examinations completed […]