The initial public offering of Central Depository Services (CDSL) was subscribed by 2.09 times on Monday, the first day of its offering with investors bidding for 5.19 crore shares against 2.48 crore shares reserved.

The initial public offering (IPO) of Eris Lifesciences was subscribed 0.75 times on Monday with investors bidding for 1.20 crore shares of the 1.59 crore shares on offer. The qualified institutional buyers bid 70.23 lakh shares against the 86.17 lakh shares reserved for them.

Canada’s stock exchanges have long had the lead as the place for energy infrastructure companies to list. This includes green energy, as well as the fossil fueled sort. Because Canada’s reporting rules are somewhat less stringent, and its markets less liquid than those in the U.S., the large number of offerings trade at lower valuations and higher yields than do their (few) U.S.-listed equivalents.

The Lebanese Ministry of Information reported Tuesday the security situation in the northern city of Tripoli has deteriorated dramatically.

Libyan rebels have heavily attacked an airport in the capital Tripoli, killing six civilians and inflicting damage in and around the facility. Several civilians were also injured in the attack on Mitiga International Airport on Saturday, the country’s internationally-recognized government said. The Libyan Interior Ministry said at least 80 rockets were fired in the attack,...

TUNIS: Jet fuel tanks at Tripoli’s Mitiga airport were targeted in an attack on Saturday that caused a large fire, Libya’s National Oil Corp said.Mitiga is the last functioning airport in the Libyan capital, though civilian flights stopped in March because of repeated shelling even...

Cashlez will use the IPO proceeds to purchase a 61.31 per cent stake in IT solution provider Softorb Technology Indonesia (STI).

The post SEA digest: Indonesia’s Cashlez raises $5.8m in IPO; KB Kookmin Card to buy Thai firm appeared first on DealStreetAsia.

• Sarries players urged to focus on international future
• ‘I’m quite confident that they will make good decisions’

Maro Itoje and Mako Vunipola have been urged to make “good decisions” for their international careers by the England defence coach, John Mitchell, with both players yet to commit to Saracens next season.

Itoje had hoped to receive dispensation to continue his England career while spending next season on loan in France at Racing 92 rather than in the Championship with relegated Saracens. However, that move was blocked by the other Premiership clubs since it did not meet “exceptional circumstances”, the loophole that allows England’s head coach, Eddie Jones, to select overseas-based players in the event of an injury crisis.

Imports of counterfeit and pirated goods are worth nearly half a trillion dollars a year, or around 2.5% of global imports, with US, Italian and French brands the hardest hit and many of the proceeds going to organised crime, according to a new report by the OECD and the EU’s Intellectual Property Office.

Recent seizures of fake medical supplies being marketed as protection against Covid-19 underscore the need to address a growing international trade in counterfeit pharmaceuticals that is costing billions of euros a year and putting lives at risk, according to the OECD and the EU’s Intellectual Property Office.

OECD Deputy Secretary-General Doug Frantz and EUIPO Executive Director António Campinos will launch the joint report “Trade in Counterfeit and Pirated Goods: Mapping the Economic Impact” at 12:00 CET on Monday 18 April at the OECD Conference Centre in Paris.

England stars Maro Itoje and Mako Vunipola are yet to commit to playing for Saracens in the Championship next season. Two French clubs have already expressed interest in Itoje.

EXCLUSIVE: Billy Vunipola has played a supporting role in rugby's version of House of Cards. The No 8 turned political pawn as his name was touted in promises for World Rugby elections

Fighting between forces loyal to rival governments over Libya's capital intensified Saturday with heavy artillery shelling hitting the sole functioning airport in Tripoli, setting jet fuel tanks ablaze and damaging passenger planes, authorities in west Libya and the UN said. The Tripoli-based Transportation Ministry said one of the damaged aircraft had been scheduled to leave Tripoli to bring back Libyans stranded in Spain by the coronavirus lockdown. It blamed east-based forces fighting to take the capital for over a year for the attack. Libya has been in turmoil since 2011, when a civil war toppled long-time dictator Moammar Gadhafi, who was later killed. The country has since split between rival administrations in the east and the west, each backed by armed groups and foreign countries. Brega Petroleum Marketing Company said the shelling at Mitiga airport set its jet fuel tanks on fire. The company, which is part of Libya's National Oil Corporation, shared footage of apparent ...

Although a significant increase, Android Marshmallow still lies below Android Lollipop, and Kitkat on the list. As per the latest distribution numbers, Android Lollipop 5.0 and v5.1 together run on 35% Android devices, followed by Android Kitkat 4.4 with a 27.7% share.

Fighting between forces loyal to rival governments over Libya's capital intensified Saturday with heavy artillery shelling hitting the sole functioning airport in Tripoli, setting jet fuel tanks ablaze and damaging passenger planes, authorities in west Libya and the UN said.

Munusamy, 26, was reportedly murdered in Gummidipoondi on Friday, by his neighbour Sanjay after a fight broke out between them, since the former refus

Ripon sinkhole concerns halt Harrogate council homes plans  BBC News

Ripon sinkhole: British Geological Survey says area susceptible to holes  BBC News

In this work, two methods of high-resolution X-ray data refinement: multipole refinement (MM) and Hirshfeld atom refinement (HAR) – together with X-ray wavefunction refinement (XWR) – are applied to investigate the refinement of positions and anisotropic thermal motion of hydrogen atoms, experiment-based reconstruction of electron density, refinement of anharmonic thermal vibrations, as well as the effects of excluding the weakest reflections in the refinement. The study is based on X-ray data sets of varying quality collected for the crystals of four quinoline derivatives with Cl, Br, I atoms and the -S-Ph group as substituents. Energetic investigations are performed, comprising the calculation of the energy of intermolecular interactions, cohesive and geometrical relaxation energy. The results obtained for experimentally derived structures are verified against the values calculated for structures optimized using dispersion-corrected periodic density functional theory. For the high-quality data sets (the Cl and -S-Ph compounds), both MM and XWR could be successfully used to refine the atomic displacement parameters and the positions of hydrogen atoms; however, the bond lengths obtained with XWR were more precise and closer to the theoretical values. In the application to the more challenging data sets (the Br and I compounds), only XWR enabled free refinement of hydrogen atom geometrical parameters, nevertheless, the results clearly showed poor data quality. For both refinement methods, the energy values (intermolecular interactions, cohesive and relaxation) calculated for the experimental structures were in similar agreement with the values associated with the optimized structures – the most significant divergences were observed when experimental geometries were biased by poor data quality. XWR was found to be more robust in avoiding incorrect distortions of the reconstructed electron density as a result of data quality issues. Based on the problem of anharmonic thermal motion refinement, this study reveals that for the most correct interpretation of the obtained results, it is necessary to use the complete data set, including the weak reflections in order to draw conclusions.

The crystallization of amidase, the ultimate enzyme in the Trp-dependent auxin-biosynthesis pathway, from Arabidopsis thaliana was attempted using protein samples with at least 95% purity. Cube-shaped crystals that were assumed to be amidase crystals that belonged to space group I4 (unit-cell parameters a = b = 128.6, c = 249.7 Å) were obtained and diffracted to 3.0 Å resolution. Molecular replacement using structures from the PDB containing the amidase signature fold as search models was unsuccessful in yielding a convincing solution. Using the Sequence-Independent Molecular replacement Based on Available Databases (SIMBAD) program, it was discovered that the structure corresponded to dihydrolipoamide succinyltransferase from Escherichia coli (PDB entry 1c4t), which is considered to be a common crystallization contaminant protein. The structure was refined to an Rwork of 23.0% and an Rfree of 27.2% at 3.0 Å resolution. The structure was compared with others of the same protein deposited in the PDB. This is the first report of the structure of dihydrolipo­amide succinyltransferase isolated without an expression tag and in this novel crystal form.

Tiny and transparent the marine crustacean Paraphronima gracilis sees the world through two large eyes that envelope its head like a high-tech space helmet. Now, […]

The post Bizarre ocean amphipod has 16 retinas in each eye appeared first on Smithsonian Insider.

Scott J. Neal, Qingxiang Zhou, and Francesca Pignoni

The specification of organs, tissues and cell types results from cell fate restrictions enacted by nuclear transcription factors under the control of conserved signaling pathways. The progenitor epithelium of the Drosophila compound eye, the eye imaginal disc, is a premier model for the study of such processes. Early in development, apposing cells of the eye disc are established as either retinal progenitors or support cells of the peripodial epithelium (PE), in a process whose genetic and mechanistic determinants are poorly understood. We have identified Protein Phosphatase 2A (PP2A), and specifically a STRIPAK-PP2A complex that includes the scaffolding and substrate-specificity components Cka, Strip and SLMAP, as a critical player in the retina-PE fate choice. We show that these factors suppress ectopic retina formation in the presumptive PE and do so via the Hippo signaling axis. STRIPAK-PP2A negatively regulates Hpo kinase, and consequently its substrate Wts, to release the transcriptional co-activator Yki into the nucleus. Thus, a modular higher-order PP2A complex refines the activity of this general phosphatase to act in a precise specification of cell fate.

Georgi Dimchev
Apr 9, 2020; 133:jcs239020-jcs239020
Articles

AdWeek ranks its top 10 favorites for 2011, including Chipotle's sustainable food initiative and Nissan Leaf's all-electric world.

Tesla Motors, maker of the Tesla Roadster electric sports car, hopes to sell 10 million shares of the company during its IPO on June 29.

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'Dippin’ in my Tesla' not likely to get radio playtime, but it won't make your ears bleed either.

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Could Chipotle be the world's most environmentally friendly fast-food chain?

Our food blogger shares her thoughts after visiting the sustainable chain restaurant for the first time.

Tesla Motors raised $266 million during its IPO with shares selling for more than the $14 to $16 target range.

For a limited time, watch a 90-second video and receive a coupon to a fast food chain that’s trying to do it right.

Car-sharing service Zipcar is betting that name recognition will boost sales of its common stock in an upcoming initial public offering.

Meant to satisfy vegans and carnivores, the shredded organic tofu filling is now available at all Chipotle restaurants.

The restaurant chain known for sourcing free-range meats and organic ingredients ups its game by sourcing GMO-free ingredients.

This article provides lots of information about iPod. It talks about the many iPod generations and its main features, as well as multimedia capability.

This article is a brief history of iPod. It describes how it started, the goals for this music player and how the name iPod came into being.

This article describes the many iPods generations and features that made this product one of the most popular mp3 mp4 players of all times.

Tripods are a great way of getting steady films with your camcorder. Unfortuantely, a tripod is not always handy. We will show you how to choose a camcorder that will help to assure you capture smooth, high quality films.

Dr. Schwartz of Harmony Place Monterrey helping guide individuals through Bipolar Disorders