Rassie Erasmus is ruthlessly building a squad that can overcome the inevitable losses of decorated veterans and others to come, and still dominate the matches that matter most in world rugby, writes Lungani Zama.

Spirit Airlines' stock plunged 59% on Wednesday as the budget airline worked with creditors to restructure debt amid reports the company could file for bankruptcy protection within the next few weeks.

Spirit Airlines' stock plunged 59% on Wednesday as the budget airline worked with creditors to restructure debt amid reports the company could file for bankruptcy protection within the next few weeks.

The baht is on course to slip below the key resistance level of 35 to the US dollar after depreciating sharply since government aide Kittiratt Na-Ranong was named the new Bank of Thailand board chairman, raising doubts over the central bank's autonomy, say analysts.

Bogdan Naumovici, om de publicitate, își lansează lungmetrajul de debut pe 28 ianuarie 2025. Comedia „Țăndări”, distribuită de Forum Film, are în distribuție actori precum Alin Florea, Constantin Florescu, Cristian Bota, Nicodim Ungureanu, Cătălin Neamțu, Carmen Tănase, Dan Badea, Alex Conovaru, Sergiu Costache, Robert Tudor, Andreea Samson, și Gabriel Spahiu. De la spoturi publicitare pentru ...

The post Publicitarul Bogdan Naumovici lansează lungmetrajul „Țăndări” în ianuarie 2025 appeared first on Forbes Romania.

Air pollution is one of the leading causes of early deaths worldwide, with particulate matter (PM) as an emerging factor contributing to this trend. PM is classified based on its physical size, which ranges from PM₁₀ (diameter ≤10 μm) to PM_2.5 (≤2.5 μm) and PM_0.5 (≤0.5 μm). Smaller-sized PM can move freely through the air and readily infiltrate deep into the lungs, intensifying existing health issues and exacerbating complications. Lung complications are the most common issues arising from PM exposure due to the primary site of deposition in the respiratory system. Conditions such as asthma, COPD, idiopathic pulmonary fibrosis, lung cancer and various lung infections are all susceptible to worsening due to PM exposure. PM can epigenetically modify specific target sites, further complicating its impact on these conditions. Understanding these epigenetic mechanisms holds promise for addressing these complications in cases of PM exposure. This involves studying the effect of PM on different gene expressions and regulation through epigenetic modifications, including DNA methylation, histone modifications and microRNAs. Targeting and manipulating these epigenetic modifications and their mechanisms could be promising strategies for future treatments of lung complications. This review mainly focuses on different epigenetic modifications due to PM_2.5 exposure in the various lung complications mentioned above.

The main monogenic causes of pulmonary fibrosis in adults are mutations in telomere-related genes. These mutations may be associated with extrapulmonary signs (hepatic, haematological and dermatological) and typically present radiologically as usual interstitial pneumonia or unclassifiable fibrosis. In children, the monogenic causes of pulmonary fibrosis are dominated by mutations in surfactant-related genes. These mutations are not associated with extrapulmonary signs and often manifest radiologically as unclassifiable fibrosis with cysts that can lead to chest wall deformities in adults. This review discusses these mutations, along with most of the monogenic causes of interstitial lung disease, including interferon-related genes, mutations in genes causing cystic lung disease, Hermansky–Pudlak syndrome, pulmonary alveolar proteinosis, lysinuric protein intolerance and lysosomal storage disorders, and their pulmonary and extrapulmonary manifestations.

Background

Lung cancer ranks as the leading cause of cancer-related deaths worldwide. There is evidence that second-hand smoke (SHS) exposure is a risk factor for the development of lung cancer in never-smokers. This systematic review and meta-analysis aims to provide the most accurate quantification of the association between SHS exposure and lung cancer risk in never-smokers.

Der österreichische Rechtsextremist Sellner inszenierte Anfang des Jahres seine Einreise nach Deutschland mit Berichten in sozialen Medien - das hat ein juristisches Nachspiel. Die Staatsanwaltschaft in Wien ermittelt. Von M. Bewarder.

Ausländerfeindliche Einstellungen sind in den ostdeutschen Bundesländern weiterhin verbreiteter als im Westen - doch die Unterschiede werden kleiner. Zugleich sinkt die Zustimmung zur Demokratie, wie eine neue Studie zeigt.

Russische Kriegsschiffe haben am 20. November Cruise Missiles auf Ziele in Syrien abgefeuert und dabei sieben islamistische Stellungen in den nördlich Provincen Raqqa, Idlib and Aleppo getroffen. Col Patrick Ryder kritisierte, bei den russischen Angriffen würden auch gemäßigte syrische Oppositionsgruppe in Mitleidenschaft gezogen. Die Nachrichtensender BBC und Channel 4 veröffentlichten ...

Fellow blogger, instructor, and long distance friend Mr. Timothy dropped us a line this morning with a couple of rather interesting observations. He points out that over the last 10 or so releases (since Glen Ostergaard took over as lead choreographer) there's been a definite uptick in the lunge track length. To be sure, 9 of the 10 longest lunge tracks are Ostergaard-choreographed routines. Since Pump soundtracks need to fit within a ±49 minute time window, something has to give - and it looks like the bicep track has been the primary donor. Which isn't all bad, really... the longer lunge tracks work a much larger group of muscles, burning more calories and building core strength.
Bottom line: Now may be the time to amp up your bicep workout with an extra plate on both sides of the bar. And take an extra deep breath between tracks 6 & 7!

Notice any other trends in the Pump workout over the last couple years? Tell us about it!

Researchers have developed a nanoscale sensor that detects lung cancer simply by analyzing the levels of a chemical called isoprene in your breath. The team believes its breakthrough could unlock a non-invasive, low-cost method to catch the disease early, and potentially save a lot of lives.

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Category: Cancer, Illnesses and conditions, Body & Mind

Tags: Cancer, Lung cancer, Lung, Breathalyzer, Zhejiang University

Although hot tubs may get all the glory, cold-plunge tubs are the ones that really help reduce muscle inflammation and soreness after exercise. The Snowcap tub makes that process more doable than ever, by chilling water without using any ice or refrigerants.

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Category: Fitness & Exercise

Tags: Indiegogo, Cooling, Thermoelectricity, Water

The General Medical Council says there are interim conditions on the doctor's registration.

This work demonstrates a hybrid deep learning (DL) model for lung cancer (LC) detection using CT images. Firstly, the input image is passed to the pre-processing stage, where the input image is filtered using a BF and the obtained filtered image is subjected to lung lobe segmentation, where segmentation is done using squeeze U-SegNet. Feature extraction is performed, where features including entropy with fuzzy local binary patterns (EFLBP), local optimal oriented pattern (LOOP), and grey level co-occurrence matrix (GLCM) features are mined. After completing the extracting of features, LC is detected utilising the hybrid efficient-ShuffleNet (HES-Net) method, wherein the HES-Net is established by the incorporation of EfficientNet and ShuffleNet. The presented HES-Net for LC detection is investigated for its performance concerning TNR, and TPR, and accuracy is established to have acquired values of 92.1%, 93.1%, and 91.3%.

Effectively capturing opportunities requires rapid decision-making. We investigate the speed of opportunity evaluation decisions by focusing on firms' venture termination and venture advancement decisions. Experience, standard operating procedures, and confidence allow firms to make opportunity evaluation decisions faster; we propose that a firm's attentional orientation, as reflected in its project portfolio, limits the number of domains in which these speed-enhancing mechanisms can be developed. Hence firms' decision speed is likely to vary between different types of decisions. Using unique data on 3,269 mineral exploration ventures in the Australian mining industry, we find that firms with a higher degree of attention toward earlier-stage exploration activities are quicker to abandon potential opportunities in early development but slower to do so later, and that such firms are also slower to advance on potential opportunities at all stages compared to firms that focus their attention differently. Market dynamism moderates these relationships, but only with regard to initial evaluation decisions. Our study extends research on decision speed by showing that firms are not necessarily fast or slow regarding all the decisions they make, and by offering an opportunity evaluation framework that recognizes that decision makers can, in fact often do, pursue multiple potential opportunities simultaneously.

Emergency teams rushed to Deoliyan in AJK to save injured people

Rescue efforts underway near the site of the accident in GB on November 12, 2024. — Reporter

Mac McClung sealed back-to-back NBA Slam Dunk contest titles on Saturday night. His final dunk, a reverse slam over 7-foot-1-inch Shaquille O'Neal, earned a perfect score from the judges.

The fate of the Amazon is in jeopardy. Logging, cattle ranching, and soya bean farming are threatening its very existence. But the threat doesn’t end there; carbon dioxide coming from cities thousands of miles away is altering tropical forests and the climate on a much larger scale. In this special edition we travel to Brazil to find out why the fate Amazon is more consequential than ever and meet some of the people fighting to preserve it.

(Claudio da Silva and the Guajajara Guardians of the Forest ride up the Caru River to investigate a report of illegal cutting on Guajajara land. Credit: Sam Eaton/The World)

Washington — NIOSH and the Mine Safety and Health Administration are looking for presenters for a virtual workshop on silica exposure and lung disease in the mining industry, scheduled for Oct. 22-23.

Washington — A new OSHA initiative is aimed at protecting workers in the engineered stone fabrication and installation industries from silica exposure.

Washington — A “fundamental shift” is needed in the mining industry’s approach to coal dust exposure to help mitigate a surge in black lung disease among underground coal miners, according a new report from the National Academies of Sciences, Engineering, and Medicine.

State College, PA — Using a 3D device on a microchip that mimics the behavior of human lungs, researchers from Penn State University will use a $400,000 grant from NIOSH to study the effects of nano-scale coal dust on the lungs of underground miners, the university has announced.

Washington — Proposed legislation that would ease access to health care and other benefits for coal miners who have black lung disease is advancing in the House.

Washington — A new law permanently restores a recently expired excise tax rate increase on coal production, which will help fund health care and other benefits for coal miners who have black lung disease.

San Diego — More than 4,600 coal miners have developed the most severe form of black lung disease since 1970, with nearly half of the cases emerging after 2000, according to a recent study from the University of Illinois at Chicago.

Washington — Decreases in lung function observed among cleanup workers shortly after the 2010 Deepwater Horizon oil rig disaster were no longer apparent within the next few years, results of a new study from the National Institute of Environmental Health Sciences indicate – suggesting that some adverse health effects linked to the spill may resolve over time.

Chicago — Physicians contracted by mine operators to review chest X-rays of coal miners who file “totally debilitating disease” workers’ compensation claims with the Department of Labor’s Federal Black Lung Program may have a bias strongly related to financial conflict of interest, researchers at the University of Illinois at Chicago suggest.

Charlottesville, VA — Coal miners with black lung disease commonly face various mental health issues, including thoughts of suicide, results of a recent study conducted by researchers from the University of Virginia show.

Washington — Proposed legislation would create funding for health care and other benefits for coal miners who have black lung disease by extending, for 10 years, a recently expired excise tax rate increase on coal production.

Chicago — The lung tissue of contemporary coal miners contains higher levels of respirable crystalline silica dust than was found in miners of past generations – which may explain an ongoing surge in cases of the most severe form of black lung disease, researchers at University of Illinois Chicago say.

Triangle, VA — United Mine Workers of America President Cecil Roberts is calling on Congress to advance proposed legislation that would ease access to health care and other benefits for coal miners who have black lung disease.

Washington – A rule listed on the Department of Labor’s spring 2014 regulatory agenda is intended to address problems with the administration of the Black Lung Benefits Act, through which miners receive compensation for disabilities related to pneumoconiosis – also known as “black lung” disease.

Chicago — Coal miners in Kentucky, Virginia and West Virginia may be more than eight times more likely than the general public to die from black lung disease and chronic obstructive pulmonary disease.

Washington — In an effort to detect cases of black lung disease, NIOSH will offer free, confidential health screenings for current and former coal miners in Indiana and Texas.

Wythenshawe, England – Musicians, take note: Cleaning wind instruments immediately after use and allowing them to dry may lower the risk of developing a respiratory condition doctors have nicknamed “bagpipe lung.”

Washington – NIOSH has released recommended limits for controlling occupational exposure to flavoring chemicals diacetyl and 2,3-pentanedione, both of which have been linked to reduced lung function in food flavoring and production industry workers.

Tokyo — Long-term exposure to powdered toner or toner-using machines has no significant impact on lung health, concludes a recent study of copier industry workers by researchers at Japan’s Showa University.

New York – The risk of developing lung cancer increases when workers smoke, are exposed to asbestos and have asbestosis, according to a new study from the American Thoracic Society.

Many workers have been diagnosed with some form of lung condition, such as asthma or chronic obstructive pulmonary disease, which means working in a lung-friendly workplace is key.