Also known as coal workers’ pneumoconiosis, black lung is a “job-related disease caused by continued exposure to excessive amounts of respirable coal mine dust,” NIOSH says.

Washington — Democratic lawmakers have renewed their push to ease access to health care and other benefits for coal miners who have black lung disease.

Washington — Aiming to identify cases of black lung disease in current and former miners, NIOSH will provide free, confidential health screenings in Ohio, Pennsylvania, Virginia and West Virginia.

Washington — Easing access to health care and other benefits for coal miners who have black lung disease can help remedy a “devastating” development in the mining community, Sen. Bob Casey (D-PA) says.

[Politics] :
South Korea’s benchmark stock index, the KOSPI, continued its sharp decline for the fourth consecutive day on Wednesday, in the wake of Donald Trump’s victory in the U.S. presidential election last week.  On Wednesday, the KOSPI fell by 65-point-49 points, or two-point-64 percent, closing at ...

[more...]

[Economy] :
The benchmark Korea Composite Stock Price Index tumbled 65-point-49 points, or two-point-64 percent, on Wednesday to close at two-thousand-417-point-08. The tech-heavy KOSDAQ sank 20-point-87 points, or two-point-94 percent, to close at 689-point-65.

[more...]

Smokers who are exposed to radon appear to be at even greater risk for lung cancer, because the effects of smoking and radon are more powerful when the two factors are combined, says a new report by a committee of the National Research Council.

Black lung disease cases in coal miners have been increasing since 2000 for uncertain reasons.

The screenings are designed to support the early detection of black lung disease, a serious but preventable illness caused by prolonged exposure to coal mine dust.

Crystalline silica is one of the most common elements on the planet, just behind oxygen. About 2.3 million workers are exposed to it in their workplace. It’s about 100 times smaller than sand and can be found on construction sites in building materials such as concrete, block, stone, sand, and mortar.

Targeted therapy for lung cancer is based on personalized medicine approach

30% off BULO Black Friday Deals 2021

This Partnership is a significant milestone in 1st Class Medical's commitment to advancing respiratory health awareness, education, and support for individuals affected by chronic obstructive pulmonary disease (COPD) and other lung conditions.

Winning CES awards along with Amazon hit

Driving Forward Together

A New York appellate court ruled that a worker was entitled to benefits for a collapsed lung from an on-the-job exposure. Case: Matter of Bonitto v. Vivid Mechanical LLC, No. CV-23-0192,…

A federal appellate court upheld the imposition of liability for a coal miner’s Black Lung Benefits Act claim on the self-insured parent of his final employer. David Howard spent 17 years…

The U.S. Department of Labor's federal Black Lung Program has set outreach events for current and former coal miners with disabilities related to black lung disease in Indiana, Illinois and Kentucky. Miners' families and…

A federal appellate court ruled that an administrative law judge did not err in relying on a regulatory preamble to support an award of black lung benefits to a veteran…

A federal appellate court upheld an award of black lung benefits to a coal industry employee despite the administrative law judge’s evidentiary error. Case: Coastal Coal Co. LLC v. Harrison, No.

A divided federal appellate court overturned an award of black lung benefits to a coal miner based on an administrative law judge’s misapplication of the burden of proof for a legal…

A federal appellate court upheld an award of compensation under the Black Lung Benefits Act to a worker, finding that the time he spent as a truck driver was “substantially…

A federal appellate court created a split among the circuits on whether the parent company of a self-insuring coal mine operator can be held liable for black lung benefits owed…

A federal appellate court upheld the denial of a coal miner’s third claim for black lung benefits. Case: Hitt v. OWCP, No. 23-1916, 08/15/2024, unpublished. Facts: Robert Hitt worked in the coal…

A federal appellate court rejected an employer’s petition for review of black lung benefits to a miner’s widow. Case: Harman Mining Corp. v. Bartley, No. 22-2283, 08/20/2024, unpublished. Facts: Jerry W. Bartley…

The U.S. 4th Circuit Court of Appeals denied an employer’s challenge to an award of black lung benefits to a longtime coal mine employee. Case: Consol of Kentucky Inc. v. Adams,…

The West Virginia Supreme Court ruled that a former coal miner was entitled to an increased impairment award for the worsening of his occupational pneumoconiosis, even though he had undergone…

A federal appellate court rejected an employer’s challenge to the deadlines for submitting evidence to contest its liability for black lung benefits. Case: Hobet Mining Co. v. Workman, No. 23-1126, 08/02/2024,…

A federal appellate court upheld an award of black lung benefits for a longtime coal miner. Case: Consol PA Coal Co. v. OWCP, No. 23-1892, 09/17/2024, unpublished. Facts: Stephen Hela worked as an…

A federal appellate court ruled that a coal miner was entitled to a presumption that he was totally disabled due to pneumoconiosis, and it upheld an award of black lung…

This hour, journalist Saleem Reshamwala gives us a tour of surprising people and places — Lima, Nairobi, and prehistoric New Jersey — to inspire new perspectives on travel and cultures.

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Original broadcast date: July 30, 2021. This hour, journalist Saleem Reshamwala gives us a tour of surprising people and places — Lima, Nairobi, and prehistoric New Jersey — to inspire new perspectives on travel and cultures.

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Compositions provide a soundtrack for the Cassini probe’s final plunge into planetToronto, ON –After centuries of looking with awe and wonder at the beauty of Saturn and its rings, we can now listen to them, thanks to the efforts of astrophysicists at the University of Toronto (U of T). “To celebrate the Grand Finale of […]

The pilot programme funding marks the largest single investment in lung cancer in Ireland’s history.

Read more: Lung cancer research gets €4.9m boost for early detection

By Research Nester.

Rapid prototyping, 3D printing, or additive manufacturing began back in the 1980s, when the first patent was filed. When the first patent expired, the technology became available to the vast masses, and the latest kind of industrial frontier developed.

BMW: German car maker's profits tumble as sales plunge in China

Fewer young Americans are willing to fight the government’s wars.

[Also published on Antiwar.com. Portions of this article were first published by Responsible Statecraft and are reprinted by permission.]

Of men in the U.S. who turned 18 in 2023, fewer than 40% signed up for the draft – down from more than 60% in 2020 before the start of the war in Ukraine.

This eye-popping and previously undisclosed admission, as well as other revelations equally damning to plans to increase readiness to activate a draft, was included in documents released recently by the Selective Service System (SSS) in response to a Freedom Of Information Act request.

Library - Art Library, Location - OSIZ, Call number - FOLIO N72.F45 F449 2016

Italian made high waist shaping long shorts for tummy and thigh control in high compression. Comes with straps and anti-bacteria gusset.

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The post Girls Plunging In Icy Water appeared first on English Russia.

Left-wing networks had plenty of bad news for their viewers as former President Donald Trump stormed to victory in the Nov. 5 election. Now, they’re getting plenty of bad news […]

The post Insult to Injury: MSNBC and CNN Suffer Staggering Ratings Plunge Following Trump Victory appeared first on The Western Journal.

Guoan Chen
Apr 1, 2002; 1:304-313
Research

Visual Abstract

Juntuo Zhou
Nov 30, 2020; 0:RA120.002384v1-mcp.RA120.002384
Research

Acute lung injury (ALI), is a rapidly progressing heterogenous pulmonary disorder that possesses a high risk of mortality. Accumulating evidence has implicated the activation of the p65 subunit of NF-κB [NF-κB(p65)] activation in the pathological process of ALI. microRNAs (miRNAs), a group of small RNA molecules, have emerged as major governors due to their post-transcriptional regulation of gene expression in a wide array of pathological processes, including ALI. The dysregulation of miRNAs and NF-κB activation has been implicated in human diseases. In the current study, we set out to decipher the convergence of miR-99b and p65 NF-κB activation in ALI pathology. We measured the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNFα) in bronchoalveolar lavage fluid using ELISA. MH-S cells were cultured and their viability were detected with cell counting kit 8 (CCK8) assays. The results showed that miR-99b was up-regulated, while PRDM1 was down-regulated in a lipopolysaccharide (LPS)-induced murine model of ALI. Mechanistic investigations showed that NF-κB(p65) was enriched at the miR-99b promoter region, and further promoted its transcriptional activity. Furthermore, miR-99b targeted PRDM1 by binding to its 3'UTR, causing its down-regulation. This in-creased lung injury, as evidenced by increased wet/dry ratio of mouse lung, myeloperoxidase activity and pro-inflammatory cytokine secretion, and enhanced infiltration of inflammatory cells in lung tissues. Together, our findings indicate that NF-κB(p65) promotion of miR-99b can aggravate ALI in mice by down-regulating the expression of PRDM1.

Nonsmall cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. While mutations in Kras and overexpression of Myc are commonly found in patients, the role of altered lipid metabolism in lung cancer and its interplay with oncogenic Myc is poorly understood. Here we use a transgenic mouse model of Kras-driven lung adenocarcinoma with reversible activation of Myc combined with surface analysis lipid profiling of lung tumors and transcriptomics to study the effect of Myc activity on cholesterol homeostasis. Our findings reveal that the activation of Myc leads to the accumulation of cholesteryl esters (CEs) stored in lipid droplets. Subsequent Myc deactivation leads to further increases in CEs, in contrast to tumors in which Myc was never activated. Gene expression analysis linked cholesterol transport and storage pathways to Myc activity. Our results suggest that increased Myc activity is associated with increased cholesterol influx, reduced efflux, and accumulation of CE-rich lipid droplets in lung tumors. Targeting cholesterol homeostasis is proposed as a promising avenue to explore for novel treatments of lung cancer, with diagnostic and stratification potential in human NSCLC.

The histopathological subtype of lung adenocarcinoma (LUAD) is closely associated with prognosis. Micropapillary or solid predominant LUAD tends to relapse after surgery at an early stage, whereas lepidic pattern shows a favorable outcome. However, the molecular mechanism underlying this phenomenon remains unknown. Here, we recruited 31 lepidic predominant LUADs (LR: low-risk subtype group) and 28 micropapillary or solid predominant LUADs (HR: high-risk subtype group). Tissues of these cases were obtained and label-free quantitative proteomic and bioinformatic analyses were performed. Additionally, prognostic impact of targeted proteins was validated using The Cancer Genome Atlas databases (n=492) and tissue microarrays composed of early-stage LUADs (n=228). A total of 192 differentially expressed proteins were identified between tumor tissues of LR and HR and three clusters were identified via hierarchical clustering excluding eight proteins. Cluster 1 (65 proteins) showed a sequential decrease in expression from normal tissues to tumor tissues of LR and then to HR and was predominantly enriched in pathways such as tyrosine metabolism and ECM-receptor interaction, and increased matched mRNA expression of 18 proteins from this cluster predicted favorable prognosis. Cluster 2 (70 proteins) demonstrated a sequential increase in expression from normal tissues to tumor tissues of LR and then to HR and was mainly enriched in pathways such as extracellular organization, DNA replication and cell cycle, and high matched mRNA expression of 25 proteins indicated poor prognosis. Cluster 3 (49 proteins) showed high expression only in LR, with high matched mRNA expression of 20 proteins in this cluster indicating favorable prognosis. Furthermore, high expression of ERO1A and FEN1 at protein level predicted poor prognosis in early-stage LUAD, supporting the mRNA results. In conclusion, we discovered key differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage LUAD. Some of these proteins could serve as potential biomarkers in prognostic evaluation.