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Enhanced antifungal activity of siRNA-loaded anionic liposomes against the human pathogenic fungus Aspergillus fumigatus

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03225J, Communication
Open Access
Yidong Yu, Theresa Vogel, Sina Hirsch, Jürgen Groll, Krystyna Albrecht, Andreas Beilhack
Application of anionic liposomes co-loaded with amphotericin B and siRNA demonstrates a temporary antifungal effect lasting 3–4 days, highlighting their therapeutic potential.
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ipo

Contactless manufacturing of TERS-active AFM tips by bipolar electrodeposition

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03068K, Paper
Yuhan HUANG, David Talaga, Gerardo Salinas, Patrick Garrigue, Gary Sean Cooney, Stéphane Reculusa, Alexander Kuhn, Sébastien Bonhommeau, Laurent Bouffier
Tip-enhanced Raman spectroscopy (TERS) is a powerful technique for nanoscale chemical imaging. However, its worldwide expansion is still limited by the challenging fabrication of cheap, robust and efficient TERS tips...
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A liposome-based assay for cancer biomarker detection: exploring the correlation between platelet-derived microvesicles and NSCLC-associated miRNAs

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03704A, Paper
Mohamed Aimene Benariba, Kanza Hannachi, Sha Zhu, Yuting Zhang, Xiaoli Wang, Nandi Zhou
This research reveals a significant correlation between PMVs and their associated miRNA. Additionally, the liposome-based assay demonstrates enhanced sensitivity with calcium-induced platelet activation.
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ipo

Correction: Clodronate-nintedanib-loaded exosome–liposome hybridization enhances the liver fibrosis therapy by inhibiting Kupffer cell activity

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90028F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keqin Ji, Mingrui Fan, Dong Huang, Lingna Sun, Bingqin Li, Ruoting Xu, Jiajing Zhang, Xuan Shao, Yanzuo Chen
To cite this article before page numbers are assigned, use the DOI form of citation above.
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ipo

Swiggy’s IPO to deliver ₹9,000 crore in employee wealth for 5,000 employees

Nearly 5,000 current and former employees are set to benefit, with around 500 Swiggy employees to enter the ‘crore-pati’ club when the firm makes its stock market debut, according to sources




ipo

ACME Solar Holdings IPO enters Day 2 with 0.52 subscription

Retail portion covered fully on Day 1




ipo

Swiggy IPO: Geojit assigns ‘subscribe’ rating; IPO gets lukewarm response

Geojit considers Swiggy’s strong brand recall, diversified offerings, integrated app, rapid scaling, consistent innovation, expansion of dark stores, and promising industry outlook.




ipo

Swiggy IPO: Mehta Equities recommends ‘subscribe’

According to Rajan Shinde, Research Analyst at Mehta Equities, Swiggy’s market cap to sales ratio of 7.8x appears fairly valued compared to competitor Zomato.




ipo

Swiggy IPO: Choice Equity Broking assigns ‘subscribe for long term’ despite profitability concerns 

Analysts view Swiggy’s diverse portfolio, encompassing food delivery, grocery services, and restaurant reservations, as a competitive advantage over rivals like Zomato.




ipo

Swiggy IPO: SAMCO Securities alerts investors on profitability concerns

Swiggy confronts intense competition from Zomato in the food delivery sector, potentially impacting its market share and customer acquisition costs.




ipo

Swiggy IPO subscribed 35% on Day 2

Swiggy IPO: Retail portion booked 0.84 times, QIBs 0.28 times, NIIs 0.14 times, and employee portion 1.15 times.




ipo

Bajaj Broking issues cautious stance on Swiggy IPO

While acknowledging Swiggy’s growth potential in hyperlocal commerce, Bajaj Broking cautions investors about ongoing financial risks.




ipo

Swiggy IPO: Motilal Oswal recommends only high-risk investors to subscribe for long-term

Swiggy operates in an oligopoly market: Motilal report




ipo

Will Swiggy IPO sail through on last day?

Issue subscribed 0.35 times so far with retail investors portion receiving 0.85 times




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ACME Solar Holdings IPO issue closes today

Thanks to higher participation from retail investors, offer subscribed 0.7 times so far




ipo

Ambani's Reliance Jio IPO set for 2025, retail debut much later, sources say

Mukesh Ambani targets a 2025 Mumbai listing for his telecom business Jio, valued by analysts at over $100 billion, and plans to launch his retail unit's IPO much later, two sources told Reuters




ipo

Ascend is expanding adiponitrile




ipo

Lilly to spin off Elanco Animal Health in IPO




ipo

iPod Touch will be available “while supplies last,” says Apple discontinuing the iPod after 20 years

Music experiences will be integrated across other devices like iPhone, Apple Watch, iPad and Mac




ipo

Niva Bupa Health IPO enters Day 2 with 0.65x

QIB, retail portion get response




ipo

Niva Bupa Health Insurance IPO sees tepid response on day 2 

The retail portion of the IPO emerged as the only fully subscribed category, receiving 1.02 times the shares reserved for retail individual investors (RIIs)




ipo

ACME Solar IPO sees mixed response, retail portion subscribed 2.4x 




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Swiggy IPO subscribed 2.15 times so far on Day 3

Swiggy IPO targets ₹11,327.43 crore through a combination of fresh issue worth ₹4,499 crore and offer for sale of 17.51 crore shares worth ₹6,828.43 crore




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Zinka Logistics fixes IPO price band at ₹259-₹273

Zinka Logistics IPO, which opens on November 13, will include a fresh issue worth up to ₹550 crore and an offer for sale of up to 20,685,800 equity shares by promoters and selling shareholders




ipo

NSE awaiting NoC from SEBI before filing draft prospectus for IPO

Aims to strengthen commodities segment, predicts market cap to double in 10 years




ipo

ACME Solar IPO oversubscribed, strong response from QIBs and retail investors

Reflects investor confidence in renewable energy sector; significant listing gains seen




ipo

Swiggy IPO oversubscribed by 3.59x led by QIBs, employees

Raises ₹5,085 crore from institutional investors; company betting big on enhancing quick commerce segement




ipo

Wealthy investors may take pre-IPO route after losing QIB tag

Large family offices and ultra-high-net-worth individuals, who typically establish their own AIFs and invest via the QIB route but are otherwise ineligible for QIB status individually, will be affected by SEBI guidelines, say experts




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Everstone Capital evaluates exit options for Translumina, Everlife; IPO most likely

The IPO is likely to be in the range of $300-350 million, sources say




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Niva Bupa Health Insurance IPO Day 3 Highlights: Niva Bupa IPO subscribed 1.80 times

Niva Bupa Health Insurance IPO, Niva Bupa IPO GMP Updates November 11, 2024: Track Niva Bupa Health Insurance IPO subscription status here




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Niva Bupa IPO subscribed 1.43x by midday on final day

The retail individual investors’ portion currently leads the subscription status at 2.14 times, with bids for 6.71 crore shares




ipo

Start-ups line up for IPOs amid bullish market, investor demand

VC-backed companies are now looking at the euphoria in the market to list and return capital to their investors




ipo

Rosmerta Digital Services IPO to open on Nov 18; eyes ₹206 cr




ipo

ACME Solar debuts today after IPO oversubscribed 2.75 times

The shares have been priced at ₹289, the upper limit of its price range




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Zinka Logistics IPO opens today at ₹259-273 price band

Logistics major raised ₹501 crore from anchor investors




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Green dipolar aprotic solvents for the dynamic polycondensation of high-performance polyimide membranes

Green Chem., 2024, Advance Article
DOI: 10.1039/D4GC04279D, Paper
Open Access
E. San José, M. R. de la Viuda, F. J. Carmona, C. Soto, L. Palacio, P. Prádanos, A. Hernández, A. Tena
Guidelines for the evaluation of green solvents were revisited and integrated into a decision diagram. GVL, Cyrene™, DMC, NOP, DEC, DMI, GBL, NBP, Rhodiasolv® PolarClean, and DMSO showed the potential to substitute hazardous polar aprotic solvents.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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ipo

IPO-bound Hyundai raises Rs 8,315 cr from investors

Hyundai Motor India (HMIL) raised Rs 8,315 crore from anchor investors on Monday, setting the stage for the country's biggest-ever maiden share sale.




ipo

Lulu becomes largest IPO in UAE this year

Lulu Retail announced on Wednesday that its initial public offering (IPO) was oversubscribed 25 times across all tranches, excluding cornerstone investors, generating demand exceeding $37 billion-a record for a private sector IPO in the United Arab Emirates. The company is controlled by Kerala-based business tycoon MA Yusuff Ali. The final offer price for Lulu shares was set at AED 2.04 per share, raising a total of $1.72 billion (AED 6.32 billion), making it the largest IPO in the UAE in 2024 to date.




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At Rs 1.2 trn, IPO mopup set to hit new high in 2024

The calendar year 2024 is set to go down as the best year for initial public offerings (IPOs) in terms of funds raised. Following the IPOs of food delivery major Swiggy and two other companies slated for next week, this year's total will reach nearly Rs 1.2 trillion, going past 2021's record tally of Rs 1.19 trillion. Swiggy's Rs 11,327 crore IPO, the sixth-largest in India, and solar energy firm Acme Solar Holdings' Rs 2,900 crore IPO opened on Wednesday (Nov 6), while health-tech firm Sagility India's Rs 2,106 crore IPO opened a day earlier.









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Mako Vunipola and Maro Itoje's future with Saracens up in the air with both yet to sign new deals

England stars Maro Itoje and Mako Vunipola are yet to commit to playing for Saracens in the Championship next season. Two French clubs have already expressed interest in Itoje.




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Billy Vunipola: 'It wouldn't be right for me to play for Tonga'

EXCLUSIVE: Billy Vunipola has played a supporting role in rugby's version of House of Cards. The No 8 turned political pawn as his name was touted in promises for World Rugby elections




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Tripoli airport shelling hits fuel tanks, passenger plane-ministry

Shelling of Tripoli's Mitiga airport early on Saturday, part of an intensified barrage of artillery fire on the capital in recent days, hit fuel tanks and damaged passenger planes, the Transport Ministry said in a statement. Mitiga is the last functioning airport in the Libyan capital, though civilian flights stopped in March because of repeated shelling even before the country imposed a lockdown over the coronavirus pandemic. Brega Petroleum Marketing Company, part of the National Oil Corporation, said its jet fuel tanks at Mitiga caught fire after coming under attack and firemen were working to control the blaze.





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NF-{kappa}B mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages [Signal Transduction]

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.




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Dennis Alcapone ‘fell in love’ with ‘Lollipop Girl’ Millie Small

In 1964, Millie Small made one of only two or three trips back to her homeland, Jamaica, and it is an occasion that is engraved in singer Dennis Alcapone’s heart. He was fortunate enough to have actually seen the sensational My Boy Lollipop singer...




ipo

S Chand aims to raise Rs 728 crore from IPO

Leading textbook publisher S Chand has priced its initial public offering (IPO) in a price band of Rs 660 to Rs 670 per equity share.