Read the in depth Review of AMD Radeon RX 6900 XT Graphics Card PC Components. Know detailed info about AMD Radeon RX 6900 XT Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of AMD Radeon RX 6700 XT Graphics Card PC Components. Know detailed info about AMD Radeon RX 6700 XT Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of ZOTAC GAMING GeForce RTX 3080 Ti AMP Holo Graphics Card PC Components. Know detailed info about ZOTAC GAMING GeForce RTX 3080 Ti AMP Holo Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of NVIDIA GeForce RTX 3070 Ti Graphics Card PC Components. Know detailed info about NVIDIA GeForce RTX 3070 Ti Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of NVIDIA GeForce RTX 4090 Graphics Card PC Components. Know detailed info about NVIDIA GeForce RTX 4090 Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of AMD Radeon RX 7900 XTX Graphics Card PC Components. Know detailed info about AMD Radeon RX 7900 XTX Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of GIGABYTE GeForce RTX 4070 Ti AERO OC 12G Graphics Card PC Components. Know detailed info about GIGABYTE GeForce RTX 4070 Ti AERO OC 12G Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of NVIDIA GeForce RTX 4070 Graphics Card PC Components. Know detailed info about NVIDIA GeForce RTX 4070 Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of AMD Radeon RX 7600 Graphics Card PC Components. Know detailed info about AMD Radeon RX 7600 Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Any State Bank of India account holder in order to activate their ATM card or a debit card can go to the online portal of SBI and do so by clicking on the e-services tab.

The police Criminal Investigation and Detection Group raided a SIM (Subscriber Identity Module) card scam hub in Pasay last week.

[Dabanga] Melbourne, Australia -- A 52-year-old man was jailed in Australia today, after he deceived his Sudanese wife into leaving Australia, and subsequently left her stranded in Sudan. A Sudanese family law expert has hailed the verdict as "a victory for women". The man, who is an Australian citizen, was charged by Australian Federal Police in 2022, under exit trafficking legislation, enacted by Australia to combat human trafficking that pivots on the departure, instead of the arrival of the victim. Neither names may be revealed for

[Mastercard Foundation] Addis Ababa, Ethiopia -- Dereja, in partnership with the Ministry of Labor and Skills (MOLS) and the Mastercard Foundation, will host the 5th National Career Expo on November 6 - 7, 2024, at Millennium Hall, Addis Ababa. The event will connect over 30,000 skilled professionals to the job market.

TEHRAN: Iranian bank cards can now be used in Russia, state television reported, as the two countries linked their banking systems in the latest bid to counteract sanctions.

Iranian banks have been excluded since 2018 from the SWIFT international financial messaging service, which governs the vast majority of transactions worldwide.

The move is part of a raft of sanctions that were re-imposed on Iran after the United States withdrew from a landmark 2015 nuclear deal.

Iranian bank cards can now be used in Russia, state television channel IRINN said on Monday, showing the withdrawal of money using an Iranian bank card from an ATM in Russia.

Iranians can now use their cards in Russia to pay for in-store purchases

The operation was made possible by connecting Iran’s interbank network Shetab to its Russian equivalent Mir, the channel said.

Iranians can currently withdraw money in Russia, and will in the future be able to use their cards to pay for in-store purchases, it added.

“The plan is also going to be implemented in other countries that have a wide range of financial and social interactions with Iran, for example Iraq, Afghanistan and Turkiye,” it said.

Both Iran and Russia have sought to counteract the effects of sanctions on their economies.

Since the start of Russia’s invasion of Ukraine in 2022, Moscow has faced mounting sanctions, and its ties with Tehran have grown closer in parallel.

Ukraine and its Western allies have since the start of the conflict accused Iran of supplying Russia with both drones and missiles for use in the war.

Tehran and Moscow signed an agreement in June to strengthen their cooperation in the banking sector.

In the future, Russians will also be able to use their bank cards in Iran, IRINN said, without specifying when.

Russia has been pushing for the creation of an international payment platform as an alternative to the SWIFT service, from which key Russian banks have also been excluded since 2022.

Published in Dawn, November 13th, 2024

The British Heart Foundation’s Reflections of Research competition showcases beautiful images captured by researchers studying heart and circulatory disease

Title: Survival More Likely With Exercise-Related Cardiac Arrest: Study
Category: Health News
Created: 8/30/2012 6:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Newer Breathing Tube Might Save More Cardiac Arrest Patients
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM

Title: Not So Sudden: Many Seek Medical Help 2 Weeks Before Cardiac Arrest
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Title: Rising Number of U.S. Cardiac Arrests Tied to Opioid Abuse
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Title: AHA News: New Report Details What to Know About Cardiovascular Disease Symptoms
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

The antitumor effect of cardiotonic steroids (CTS) has stimulated the search for new methods to evaluate both kinetic and thermodynamic aspects of their binding to Na⁺/K⁺-ATPase (IUBMB Enzyme Nomenclature). We propose a real-time assay based on a chromogenic substrate for phosphatase activity (pNPPase activity), using only two concentrations with an inhibitory progression curve, to obtain the association rate (k_on), dissociation rate (k_off), and equilibrium (K_i) constants of CTS for the structure-kinetics relationship in drug screening. We show that changing conditions (from ATPase to pNPPase activity) resulted in an increase of K_i of the cardenolides digitoxigenin, essentially due to a reduction of k_on. In contrast, the K_i of the structurally related bufadienolide bufalin increased much less due to the reduction of its k_off partially compensating the decrease of its k_on. When evaluating the kinetics of 15 natural and semisynthetic CTS, we observed that both k_on and k_off correlated with K_i (Spearman test), suggesting that differences in potency depend on variations of both k_on and k_off. A rhamnose in C3 of the steroidal nucleus enhanced the inhibitory potency by a reduction of k_off rather than an increase of k_on. Raising the temperature did not alter the k_off of digitoxin, generating a H (k_off) of –10.4 ± 4.3 kJ/mol, suggesting a complex dissociation mechanism. Based on a simple and inexpensive methodology, we determined the values of k_on, k_off, and K_i of the CTS and provided original kinetics and thermodynamics differences between CTS that could help the design of new compounds.

Oxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of advanced glycation end product (RAGE) interaction contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed the impact of β-caryophyllene (BCP) on activating cannabinoid type 2 receptors (CB2Rs) against diabetic complication, mainly cardiomyopathy and investigated the underlying cell signaling pathways in mice. The murine model of DCM was developed by feeding a high-fat diet with streptozotocin injections. After the development of diabetes, the animals received a 12-week oral BCP treatment at a dose of 50 mg/kg/body weight. BCP treatment showed significant improvement in glucose tolerance and insulin resistance and enhanced serum insulin levels in diabetic animals. BCP treatment effectively reversed the heart remodeling and restored the phosphorylated troponin I and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a expression. Ultrastructural examination showed reduced myocardial cell injury in DCM mice treated with BCP. The preserved myocytes were found to be associated with reduced expression of AGE/RAGE in DCM mice hearts. BCP treatment mitigated oxidative stress by inhibiting expression of NADPH oxidase 4 and activating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. Also, BCP suppressed cardiac fibrosis and endothelial-to-mesenchymal transition in DCM mice by inhibiting transforming growth factor β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling. Further, BCP treatment suppressed nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome activation in DCM mice and alleviated cellular injury to the pancreatic tissues evidenced by significant elevation of the number of insulin-positive cells. To demonstrate a CB2R-dependent mechanism of BCP, another group of DCM mice were pretreated with AM630, a CB2R antagonist. AM630 was observed to abrogate the beneficial effects of BCP in DCM mice. Taken together, BCP demonstrated the potential to protect the myocardium and pancreas of DCM mice mediating CB2R-dependent mechanisms.

The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. Methods: The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). Results: The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5–4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23–2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56–4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101–400 (unadjusted HR, 3.09; 95% CI, 2.57–3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41–6.05) were at increased risk of MACEs. Conclusion: The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging.

Neuroendocrine tumor (NET) metastases to the heart are found in 1%–4% of NET patients and have been reported primarily in the form of individual cases. We investigated the prevalence, clinical characteristics, imaging features, and outcomes of NET patients with cardiac metastases on ⁶⁸Ga-DOTATATE PET/CT. Methods: ⁶⁸Ga-DOTATATE PET/CT of 490 consecutive patients from a single institution were retrospectively reviewed for sites of metastases. The cumulative cardiovascular event rate and overall survival of patients with cardiac NET metastases (CNMs) were compared with those of a control group of metastatic NET patients without cardiac metastases. In patients with CNMs, the cardiac SUV_max with and without normalization to the myocardial background uptake was compared with a separate cohort of 11 patients with active cardiac sarcoidosis who underwent ⁶⁸Ga-DOTATATE PET/CT for research purposes. Results: In total, 270 patients with metastatic NETs were identified, 9 (3.3%) of whom had CNMs. All 9 patients had grade 1–2 gastroenteropancreatic NETs, most commonly from the small intestine (7 patients). The control group consisted of 140 patients with metastatic grade 1–2 gastroenteropancreatic NETs. On Kaplan–Meier analysis, there was no significant difference in the risk of cardiovascular adverse events (P = 0.91 on log-rank test) or mortality (P = 0.83) between the metastatic NET patients with and without cardiac metastases. The degree of cardiac DOTATATE uptake was significantly higher in CNMs than in patients with cardiac sarcoidosis without overlap, in terms of both cardiac SUV_max (P = 0.027) and SUV_max–to–myocardial background ratio (P = 0.021). Conclusion: Routine ⁶⁸Ga-DOTATATE PET/CT can be used to identify CNMs in 3% of patients with metastatic NETs. CNMs do not confer added cardiovascular or mortality risk. A distinguishing feature of CNMs is their high degree of DOTATATE uptake compared with focal myocardial inflammation.

Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular homeostasis. Reduced NO production or increased scavenging during disease conditions with oxidative stress contribute to endothelial dysfunction and NO deficiency. In addition to the classical enzymatic NO synthases (NOS) system, NO can also be generated via the nitrate-nitrite-NO pathway. Dietary and pharmacological approaches aimed at increasing NO bioactivity, especially in the cardiovascular system, have been the focus of much research since the discovery of this small gaseous signaling molecule. Despite wide appreciation of the biological role of NOS/NO signaling, questions still remain about the chemical nature of NOS-derived bioactivity. Recent studies show that NO-like bioactivity can be efficiently transduced by mobile NO-ferroheme species, which can transfer between proteins, partition into a hydrophobic phase, and directly activate the soluble guanylyl cyclase-cGMP-protein kinase G pathway without intermediacy of free NO. Moreover, interaction between red blood cells and the endothelium in the regulation of vascular NO homeostasis have gained much attention, especially in conditions with cardiometabolic disease. In this review we discuss both classical and nonclassical pathways for NO generation in the cardiovascular system and how these can be modulated for therapeutic purposes.

Alveolar capillary dysplasia (ACD) is a fatal disorder that typically presents in the neonatal period with refractory hypoxemia and pulmonary hypertension. Lung biopsy is traditionally required to establish the diagnosis. We report a 22-mo-old male who presented with anemia, severe pulmonary hypertension, and right heart failure. He had a complicated hospital course resulting in cardiac arrest and requirement for extracorporeal membrane oxygenation. Computed tomography of the chest showed a heterogenous pattern of interlobular septal thickening and pulmonary edema. The etiology of his condition was unknown, lung biopsy was contraindicated because of his medical fragility, and discussions were held to move to palliative care. Rapid whole-genome sequencing (rWGS) was performed. In 2 d it resulted, revealing a novel FOXF1 gene pathogenic variant that led to the presumptive diagnosis of atypical ACD. Cases of atypical ACD have been reported with survival in patients using medical therapy or lung transplantation. Based on the rWGS diagnosis and more favorable potential of atypical ACD, aggressive medical treatment was pursued. The patient was discharged home after 67 d in the hospital; he is currently doing well more than 30 mo after his initial presentation with only one subsequent hospitalization and no requirement for lung transplantation. Our case reveals the potential for use of rWGS in a critically ill child in which the diagnosis is unknown. rWGS and other advanced genetic tests can guide clinical management and expand our understanding of atypical ACD and other conditions.

Motorists have been urged to plan ahead with a major bridge due to close for work is carried out.  

Inti Creates has made a living creating 2D side-scrolling action-platformers. So when it officially revealed Card-en-Ciel, a dungeon-diving, roguish card-collector that draws its inspiration from games like Slay the Spire and Mega Man Battle Network, it turned some heads. Indeed, this latest production represents a fairly significant departure for the independent developer, even as it embraces a familiar philosophy when it comes to art direction, music, and character design. The question remains: is this the start of something special for Inti Creates or still a work in progress?

The story in Card-en-Ciel takes place in the not-too-distant future, where citizens increasingly turn to "full-dive" games, fully immersive virtual reality experiences. As these games became more popular and ubiquitous, criminal activity within the virtual space exploded. This activity, referred to collectively as "full-dive crimes", became such a problem that ordinary citizens took it upon themselves to fight back. One such crusader is Neon Nanashiki, the self-described Gaming Chair Detective. When Neon receives a suspicious email with the subject line "Please save the world", he logs into the virtual space, which turns out to be the back-end of the full-dive game Rust Tactics. There he meets a strange girl named Ancie, who explains that data from some game worlds is leaking into others, creating monsters and dungeons. Soon, Neon and Ancie team up to resolve the errors and anomalies.

Despite a very promising premise, Card-en-Ciel doesn't do enough with its story. Ultimately, it's difficult to get invested in the stakes or the characters. Neon is your boilerplate archetypal hero, Ancie is frustratingly submissive, and the mystery villain generic and forgettable. There's also a some fan service here, which feels out of place. To be fair, there are some amusing conversations inside dungeons where Neon and Ancie talk about the type of game they're exploring, leading to several self-deprecating meta jokes at Inti Creates' expense, but for the most part there isn't a lot to latch on to. It hurts also that the studio dropped the ball in terms of visual storytelling. You select dungeons from a menu list, instead of traveling to them physically, and each dungeon — despite representing a wildly different game and genre — has roughly the same layout and look.

It's strange that dungeons are so alike, because every one of the 300 collectible cards is entirely unique, with its own statistics, portrait art, and voice sample. As a result, collecting and experimenting with different cards is quite fun. Clearly, a lot of time, energy, and attention-to-detail went into the audiovisual design of each and every card.

The same can be said for the card-battling mechanics. Inti Creates obviously took the time to sort out the various rules and synergies of each card type, allowing for many different approaches and strategies. At the simplest level, each card can be used to produce an effect or for movement along each battle map's 6x3 grid. The effects fall into three general categories of break, damage, and support. Using a card with a break effect will reduce a monster's attack power and chip away at its balance. If you reduce the enemy's balance to zero, it will enter breakdown, rendering it unable to act for one turn and opening it up to double the output from damage cards. In addition, triggering a breakdown will recover your cost by one. You only have three cost (action points) at the start of each turn, and each card has an individual cost between zero and three.

Things get even more interesting with the introduction of muse cards and special skills. Once you recruit a muse card, you can activate it by fulfilling certain conditions, for example by forging three zero-cost cards. The muse will then begin their performance, bestowing unique effects during battle. Not only that, but the performance will award Neon Special Skill energy, which allows him to convert any card to a significantly more powerful variant for a turn. Consequently, in each dungeon it's important to unlock muses and then recruit cards likely to trigger the muse and/or reap the rewards of a performance. When you do this right, and lay waste efficiently to the monsters and bosses in a dungeon, it feels amazing.

The problem, as mentioned before, is that each dungeon feels like the exact same thing. Apart from a specific final boss, who represents the protagonist of the fictional game world, almost everything is identical. Neon crosses the same generic square rooms & bridges and fights the same monsters over and over. It just gets boring after a while. Inti Creates really should have designed each dungeon with a layout and aesthetic unique to the IP on display.

Then there's the issue with Grand Battle dungeons. These are climactic dungeons at the end of each chapter where you face off against the mystery villain. Regrettably, the rules here are different. No cards and muses can be obtained in these areas; rather you bring with you every card and muse you've accumulated to that point. The problem here is threefold: one, it removes the rogue-like flavor of standard dungeons, where you need to build a powerful deck from square one; two, it creates a lot of bloat in your deck; and three, it opens up the opportunity for irksome chain reactions, where a single card might trigger a half dozen muse performances one after the other.

Card-en-Ciel partially makes up for some samey, tiresome dungeons with a huge amount of replay value. Indeed, the game is incredibly generous when it comes to content and replayability. Not only are there 300+ cards to collect, but there are 12 total main dungeons, each of which can be experienced at 11(!) different difficulty levels. And once you beat the game, you'll begin to unlock four secret dungeons. Moreover, there are daily & weekly dungeons, plus online network battles where you can fight opponents from around the world using a randomly generated starting deck. If you're someone who loves the core gameplay, you could spend dozens of hours with Card-en-Ciel. If you're more of a one-and-done sort of player, expect roughly 15 hours. Note: Inti Creates announced last week that the game will receive new content, including post-game dungeons, each month for at least five months starting this November.

For a new IP, Card-en-Ciel shows potential. The premise is intriguing, the core rules and mechanics provide a strong foundation for tactical decision-making, and the replay value is absurdly high. Regrettably, the campaign that houses everything is a slight letdown, due to clichéd storytelling, forgettable characters, and generic, tedious dungeons. By retaining the core card-collecting system and enhancing the narrative and structural pieces, Inti Creates could have something special on its hands. 

Full Article - https://www.vgchartz.com/article/462883/card-en-ciel-ns/

Martin Lewis has warned Tesco customers of a piece of small print that could see £18m worth of Clubcard points wasted.

Pikachu ex, found in the new Pokemon TCG set Surging Sparks, has seen its value soar with players spending over $500 for the latest card. Here's why.

$329/£300 graphics card is said to be "future ready" for your 1080p gaming needs.

The British Heart Foundation’s Reflections of Research competition showcases beautiful images captured by researchers studying heart and circulatory disease

Note to readers: After a period of inactivity CardioBrief is coming back, but with some big differences. This website, CardioBrief.Org, will remain my personal website. A new website, CVCTCardiobrief.com, will be the new home for my “professional” blogging activities. To develop this website I have joined forces with the global CVCT Forum. I look forward to...

Click here to continue reading...

We still don’t know what COVID-19 is doing to the heart or how we should be investigating it and treating it. Last month JAMA Cardiology published a German cohort study of 100 patients recently recovered from COVID-19… A number of striking problems with the study were noted on Twitter…...

Click here to continue reading...

At this moment in time the pre-pandemic cardiology research agenda needs to be completely reprioritized. There are two broad areas that now take precedence over all existing research concerns. On the one hand, researchers need to achieve a better understanding of the staggering incidence of deferred or delayed treatment of cardiovascular events and conditions as...

Click here to continue reading...

Barclaycard Arrival Plus now with EMV

Barclaycard Travel Community presents the #IHAVEARRIVED contest. Sign up and tell us your most memorable travel story for a chance to win an unforgettable vacation experience!

Commercial for the new JetBlue Card

INRIX: 10 Cities with Worst Traffic

Hennessy V.S new ad creative celebrates the true story of Auguste Piccard, the first man to reach the stratosphere, and his son Jacques, the first man to reach the deepest depths of the ocean.

Buy a new Clayton home and receive gift cards from Lowe�s* to build your dream backyard.

Cardinal Health, which provides medical products and services to many of America�s most prestigious medical institutions, introduces the Hospital Quality at Home� brand.

March of Dimes volunteer ambassador and world famous photographer Anne Geddes is featured in a PSA to raise awareness about preventing preterm birth and give more babies a healthy start in life.

I was lucky enough to get to attend the Nebula Awards this year, and I was there in my new role as a Director at Large. This meant that, instead of ghosting in to see my friends, I was meeting a lot of people and exchanging business cards. Someone noticed a habit of mine that […]

The British Heart Foundation’s Reflections of Research competition showcases beautiful images captured by researchers studying heart and circulatory disease