Arsenal forward Alessia Russo unlocks her phone to reveal her go-to songs, poetry skills and the football idol she chats to on social media.

1. iPhone SE 4 expected to launch in March 2025, supply chain data suggests  Business Standard
2. iPhone SE4 is likely to launch soon and here are 5 big upgrades we are expecting  India Today
3. Apple iPhone SE 4 to launch next year, likely to become the cheapest iPhone to support Apple Intelligence...  Moneycontrol
4. iPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why  Hindustan Times
5. iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report  Gadgets 360

The CEO of a California gay charity has been charged with embezzling almost a million bucks of the organization’s money. The charity official, Jacob Joseph Aaron Rostovsky, has been charged with 53 felony counts including fraudulent claims, grand theft, misappropriation of public funds, insurance fraud, perjury and money laundering, according to KTLA-TV. The DA said […]

The post CEO of Gay Nonprofit Charged for Stealing Organization’s Money appeared first on The Lid.

In what seems like the work of a typical Democrat, Kama Harris raised one billion dollars for her campaign… and finished it $20 million in debt. Imagine what she would have done to the United States which would have started out bankrupt if Harris had entered the White House. How do you have an actual […]

The post Typical Democrat: Harris Raised One BILLION for her Campaign… Ended it $20 Million In Debt appeared first on The Lid.

Apple has released iOS 17.7.1 and iPadOS 17.7.1 for iPhone and iPad users who are not running iOS 18, which was just updated to includes support for Apple Intelligence with iOS 18.1 and iPadOS 18.1. The software updates include important security fixes, making them important updates to install if you’re still running the prior major ... Read More

Apple Intelligence is here on Mac, iPhone, and iPad, and while the system requirements are strict, the Apple devices that are new and powerful enough to use the AI tools now gain some really fantastic features. We’re going to show you six helpful Apple Intelligence features and uses that you’ll find beneficial to your workflow, ... Read More

If you have several iPhone’s, as many people do when they buy a new iPhone, upgrade, get a hand-me-down, develop iPhone software, or develop mobile sites or apps where you test things on multiple devices, you might be in a situation where iPhone Mirroring on the Mac is using an iPhone that you do not ... Read More

The iOS 18 update is a fun one with some intriguing new features, mostly for visual tweaks like adding dark mode icons and color hues, and of course there’s Apple Intelligence AI features if your iPhone is new enough to support those features. One of the other major changes in iOS 18 and iPadOS 18 ... Read More

The itinerary on my 13-day Norwegian cruise was too packed. Spending only two of the 13 days at sea left me exhausted, even as a seasoned cruiser.

Denzel Washington may have let slip that director Ryan Coogler is working on a third "Black Panther" film, which Marvel has not yet announced.

A nuclear-powered aircraft carrier, like American carriers, would be a major jump for China, giving its navy a global reach.

The Houthis launched a complex attack consisting of anti-ship missiles and drones, a Pentagon spokesperson said Tuesday.

Donald Trump's proposed tariffs would hit the consumer tech sector, raising prices on US consumers' favorite gadgets, an October report found.

Paramount Plus, Peacock, and the Paramount Network all have a hand in the Yellowstone franchise, but it can be tricky to stream episodes.

Amid calls for ongoing protests after violent clashes on Thursday, South Africa's High Commissioner to Mozambique Siphiwe Nyanda has declared "Maputo is almost under siege".

PORT LOUIS, Nov 10 - Mauritius was holding a parliamentary election on Sunday with Prime Minister Pravind Kumar Jugnauth and his main rivals all promising to tackle a cost of living crisis in the Indian Ocean archipelago.

Ever since that first childhood moment when I clapped two pot lids together and discovered the sounds that rang out, I’ve been fascinated by what sound can do to spark imagination and share information. I don’t use cookware as cymbals these days but am more quietly appreciative of how meaningful and beautiful the sounds around us can be.

When we’re asked to switch to explicit, systematic instruction, many teachers worry that we’ll no longer be able to tailor our teaching to the students in front of us. Calls for whole-class phonics instruction lasting 30-45 minutes, for example, summon fears that our  students will be bored by concepts they already know or aren’t yet ready for.

With more and more online marketplaces popping up, many individuals prefer to pay for items, whether they be new or second hand using the PayPal Goods and Services option. The PayPal ‘Goods and Services’ option gives buyers further peace of mind with the PayPal guarantee. If the seller does not provide what they have described, […]

The post Factoring In PayPal Fees When Sending Money Using the Goods and Services Option appeared first on Tips and Tricks HQ.

If you are the type of person that likes to spoil a game from the off then Brighter Shores is… Continue reading Brighter Shores infinite money glitch – get cash rich with all the money you will ever need

The post Brighter Shores infinite money glitch – get cash rich with all the money you will ever need appeared first on ReadWrite.

Many fans of Huawei on Friday were disappointed that its much-anticipated phone, Mate XT - more than twice the price of the iPhone 16 Pro Max - was not available for walk-in customers.

Uber Safari is launching this week, offering riders in Cape Town the opportunity to go on a one-day game drive to a private reserve for $200.

A Minnessota maker named Caleb Olson built the Poopcopter, an autonomous drone that seeks out dog-doo and retrieves it for disposal.

He describes it as the "world's first aerial bound self-guided dog poop removal system." See it in action below.

"The Poopcopter is capable of scanning areas defined by a user, your backyard for example, and as it scans it's performing real-time computer vision using the camera which is inside the drone," Olson says. — Read the rest

The post The Poopcopter is a DIY autonomous drone that finds and collects dog-doo appeared first on Boing Boing.

The following article, ‘Burn The System Down’: Democrats Now Face Charges They Are The Ones Trying To Destroy Democracy, was first published on Conservative Firing Line.

Protecting democracy was a catch phrase that Democrats have used for years to explain their hatred of now President-elect Donald Trump. He was, after all, they said, a “Hitler.” He would be a dictator. He would use the military against his political opponents, jailing them and worse. The only salvation for America’s “democracy” would be …

Continue reading ‘Burn The System Down’: Democrats Now Face Charges They Are The Ones Trying To Destroy Democracy ...

Steve Jobs' 2005 Stanford Commencement Address

No one wants to die, even people who want to go to Heaven don't want to die to get there.

And yet, death is the destination we all share. No one has ever escaped it.

And that is as it should be. Because death is very likely the single best invention of life.

It's life's change agent; it clears out the old to make way for the new.

[…]

Your time is limited, so don't waste it living someone else's life. Don't be trapped by dogma, which is living with the results of other people's thinking. Don't let the noise of others' opinions drown out your own inner voice, heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.

None of us should ever have to face death to accept the inflexible and, too-often, novel sense of scarcity that it introduces.

In fact, it'd be great if we could each skip needing outside permission to be awesome by not waiting until the universe starts tapping its watch.

A simple start would involve each of us learning to care just a little more about a handful of things that simply aren't allowed to leave with us--whether today, tomorrow, or whenever. Because, I really believe a lot of nice things would start to happen if we also stopped waiting to care. A whole lot of nice things.

If that sounds like fancy incense for hippies and children, perhaps in a way that seems frankly un-doable for someone as practical and important and immortal as yourself, then go face death.

Go get cancer. Or, go get crushed by a horse Or, go get hit by a van. Or, go get separated from everything you ever loved forever.

Then, wonder no longer whether caring about the modest bit of time you have here is only for fancy people and the terminally-ill.

Because, the sooner you care, the better you'll make. The better you'll do. And the better you'll live.

Please don't wait. The universe won't.

Finding ways to save money is much easier than you think, because you’re probably spending money you don’t have to spend.

The article 3 Easy Steps to Save Money for Travel originated at EverInTransit.com

There's a reason Hitler holds a special place of disgrace in public memory. He combined the ambition and destruction of Attila The Hun with the personal malice of a serial killer.

The post The REAL Harm Done By Calling Everyone You Don’t Like ‘Hitler’ Is BIGGER Than Lefties Think appeared first on Clash Daily.

Whichever candidate is sworn into office this January is the President who will be making decisions about how America and her legacy is remembered.

The post AMERICA’S BIG BIRTHDAY: An Election Argument Everyone Seems To Be Missing appeared first on Clash Daily.

While the rest of us were busy cheering (or crying) about the election results, the world kept turning and events continued to unfold at home and around the world.

The post Trump Scores Three Big Wins Less Than One Day After The Election appeared first on Clash Daily.

Did you know that the Marines just celebrated their 249th birthday? This is one helluva tribute.

The post VETERAN’S DAY: You’re Gonna Love What One Patriotic Coffee Company Did For The Marines! appeared first on Clash Daily.

You know it's bad when you give the Democrats a whoopin and the corprate media clowns have no choice but to concede your point.

The post GLORIOUS: Scott Jennings Gets Van Jones To Cry ‘Uncle’ Live On CNN appeared first on Clash Daily.

A.F. Branco Cartoon – Trump supporters are rooting for Rick Scott to be the next Senate Majority Leader, hoping he..

For more A.F. Branco cartoons, go to WesternJournal.com/cartoons.

The post Ditch Mictch Clones appeared first on The Western Journal.

President-elect Donald Trump will begin his second term by putting pieces of his first one back in place, according to incoming White House Chief of Staff Susie Wiles. Wiles made […]

The post Trump's New Chief of Staff Susie Wiles Discloses His Day One Plans: Report appeared first on The Western Journal.

Candidates and pundits were not overstating things when they characterized the 2024 election as the most important in decades or perhaps even in the nation’s entire history. Every election is […]

The post Only One Thing Can Cool the Nation's Political Rhetoric appeared first on The Western Journal.

New York Judge Juan Merchan — who is overseeing President-elect Donald Trump’s business records case — agreed to freeze the case until Nov. 19. There was to be a hearing […]

The post Judge Juan Merchan Grants Request from Trump's Legal Team and DA in NY Hush Money Case appeared first on The Western Journal.

Sir Kenny Dalglish hailed nine-time Major champion Gary Player and expressed his delight at Liverpool's position at the top of the Premier League during his visit to South Africa this weekend.

One on One with John DeDakis, Dec. 4, 2022 My interview with the impressive John DeDakis. John DeDakis is a former CNN Senior Copy Editor and writer for the Emmy and Peabody-Award winning news program “The Situation Room with Wolf Blitzer” from 2005-2013. He is also the author of the Lara Chadwick Mystery series. DeDakis […]

Marcelo Campos, Matthew Jenssen, Marcus Michelen and Julian Sahasrabudhe
J. Amer. Math. Soc. 38 (), 179-224.
Abstract, references and article information

An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactamases (SBLs) with carbapenems also produces β-lactones. We report studies on the factors determining β-lactone formation by class D SBLs. We show that variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp105, Val120, and Leu158, using OXA-48 numbering) impact on the relative levels of β-lactones and hydrolysis products formed. Some variants, i.e. the OXA-48 V120L and OXA-23 V128L variants, catalyze increased β-lactone formation compared with the WT enzymes. The results of kinetic and product studies reveal that variations of residues other than those directly involved in catalysis, including those arising from clinically observed mutations, can alter the reaction outcome of class D SBL catalysis. NMR studies show that some class D SBL variants catalyze formation of β-lactones from all clinically relevant carbapenems regardless of the presence or absence of a 1β-methyl substituent. Analysis of reported crystal structures for carbapenem-derived acyl-enzyme complexes reveals preferred conformations for hydrolysis and β-lactone formation. The observation of increased β-lactone formation by class D SBL variants, including the clinically observed carbapenemase OXA-48 V120L, supports the proposal that class D SBL-catalyzed rearrangement of β-lactams to β-lactones is important as a resistance mechanism.

Hdac3 is a lysine deacetylase that removes acetyl groups from histones and additional proteins. Although Hdac3 functions within mesenchymal lineage skeletal cells are defined, little is known about Hdac3 activities in bone-resorbing osteoclasts. In this study we conditionally deleted Hdac3 within Ctsk-expressing cells and examined the effects on bone modeling and osteoclast differentiation in mice. Hdac3 deficiency reduced femur and tibia periosteal circumference and increased cortical periosteal osteoclast number. Trabecular bone was likewise reduced and was accompanied by increased osteoclast number per trabecular bone surface. We previously showed that Hdac3 deacetylates the p65 subunit of the NF-κB transcriptional complex to decrease DNA-binding and transcriptional activity. Hdac3-deficient osteoclasts demonstrate increased K310 NF-κB acetylation and NF-κB transcriptional activity. Hdac3-deficient osteoclast lineage cells were hyper-responsive to RANKL and showed elevated ex vivo osteoclast number and size and enhanced bone resorption in pit formation assays. Osteoclast-directed Hdac3 deficiency decreased cortical and trabecular bone mass parameters, suggesting that Hdac3 regulates coupling of bone resorption and bone formation. We surveyed a panel of osteoclast-derived coupling factors and found that Hdac3 suppression diminished sphingosine-1-phosphate production. Osteoclast-derived sphingosine-1-phosphate acts in paracrine to promote bone mineralization. Mineralization of WT bone marrow stromal cells cultured with conditioned medium from Hdac3-deficient osteoclasts was markedly reduced. Expression of alkaline phosphatase, type 1a1 collagen, and osteocalcin was also suppressed, but no change in Runx2 expression was observed. Our results demonstrate that Hdac3 controls bone modeling by suppressing osteoclast lineage cell responsiveness to RANKL and coupling to bone formation.

How Women are Transforming Indonesia Interview sysadmin 20 May 2019

In a series exploring women in international affairs, Isabel Dunstan speaks to Gitika Bhardwaj about the rise of the women’s movement in Indonesia.

Southeast Asia has one of the highest records of gender-based violence in the world and Indonesia was recently ranked as the second most dangerous place for women in the Asia-Pacific. What is the state of women’s rights and gender equality in Indonesia?

It is true that Indonesia has high rates of violence against women, however, it’s difficult to know the realities of women’s experiences because in the past the data has been somewhat unreliable. This has been due to reasons such as a lack of reporting mechanisms available to survivors of violence and the fact that discussing sexual violence is a taboo and, if reported, can result in stigmatization which limits the number of survivors who have come forward.

However, the first reliable nationwide survey on gendered violence in Indonesia was conducted in 2017 by the Indonesian Ministry of Women and Child Protection and the United Nations Population Fund. Interestingly, it showed that Indonesia’s rates of violence against women are on par with the global rate which is that 1 in 3 women are affected by sexual violence in their lifetime.

It’s therefore difficult to generalize that Indonesia is an unsafe place for women because it’s an extremely diverse country. There is a growing middle class while there is pervasive poverty. There is religious diversity where the eastern-most province of Aceh is the only province in the country where Sharia law is enforced, whereas in the western-most province of West Papua, the dominant religion is Christianity and the ways of life are completely different.

Nevertheless, violence against women is high in Indonesia and can happen in all places – rich or poor, east or west – and has different manifestations from street harassment and trafficking to domestic violence and workplace harassment.

In some parts of the country there are high rates of child marriage too and, according to UNICEF, 14 per cent of girls in Indonesia are married by the time they turn 18 which is shocking when we think about how child marriage limits girls’ access to education and makes them more vulnerable to sexual violence and therefore restricts their futures.

Child marriage is high in Indonesia in part due to rooted gender norms, low levels of education and discriminating legislation, such as the marriage law, which states that, although it is legal to marry at 21, girls can marry at 16 and boys can marry at 19 with parental consent. But this can be even lower meaning parents could get their daughters married at as young as 13. So the law is fundamentally unfair between girls and boys and the women’s movement in Indonesia has been fighting extremely hard to reform legislation that discriminates against women and girls.

From the country’s first female president, Megawati Sukarnoputri​, to incumbent finance minister Sri Mulyani Indrawati – who was voted ‘Best Minister in the World’ in 2018 – and maritime​ and fisheries minister Susi Pudjiastuti – who has become notorious for her tough stance against illegal fishing activities – how are women progressing in Indonesian politics?

Indonesia has come a long way since becoming a democracy in 1998. Before that, the second president and dictator, Suharto, ruled the country for almost 32 years and increased the inequality gap between men and women during his reign.

Since the fall of Suharto, however, gender equality is explicitly enshrined in Indonesia’s constitution and the country has ratified the Convention on the Elimination of Violence Against Women.

The country has also been undergoing a process of democratization which has involved slowly decentralizing its power. This means that greater authority has been distributed to the 34 provincial governments outside of the capital of Jakarta.

Furthermore, to aid gender equality, a quota system requiring political parties to be made up of 30 per cent women has been put in place, although remnants of Suharto’s old system of cronyism remain, limiting the impact of the quotas translating to more women in provincial parliaments.

But the defining approach to furthering gender equality in Indonesia has been through gender mainstreaming and gender-responsive budgeting which can be seen throughout provincial administrations in the country.

This means there is the intention to ensure infrastructure, health and education outcomes include results that address specific gender equality gaps. The challenge for effective gender mainstreaming, however, is the political will to translate the approach into well-resourced programmes from one province to another.

Nevertheless, we have just seen Indonesia go through the most incredible presidential and legislative elections last month – won by the current president, Joko Widodo, who has often been called the ‘Barack Obama of Southeast Asia’ and whose existing cabinet has the highest number of women in the country’s history. This is not simply a matter of filling seats in the cabinet with women – such as the wives and sisters of male politicians – because it’s required by law. But, rather, there are some incredible female political figures who are there because they are strong, smart and capable.

You’ve rightly mentioned Minister of Maritime Affairs and Fisheries, Susi Pudjiastuti, who is a fabulous role model for a lot of women particularly women who have not had tertiary education because she entered politics through an unorthodox route.

Then there’s Minister of Finance, Sri Mulyani Indrawati, who is also the former leader of the World Bank and is such an inspiration to a lot of women who are looking to work in public life because of her experience as well as her work to include gender mainstreaming in state budgets.

There is also Minister of Women’s Empowerment and Child Protection, Yohana Susana Yembise, who is a Papuan woman, as well as many more female public figures.

Alexander S. Hebert
Jan 1, 2014; 13:339-347
Technological Innovation and Resources

Yue Chen
May 1, 2007; 6:812-819
Research

Lawrence E. Ostrowski
Jun 1, 2002; 1:451-465
Research

Albrecht Gruhler
Mar 1, 2005; 4:310-327
Research

Yasushi Ishihama
Sep 1, 2005; 4:1265-1272
Research

HIV Type 1 (HIV-1) and simian immunodeficiency virus (SIV) display differential replication kinetics in macrophages. This is because high expression levels of the active host deoxynucleotide triphosphohydrolase sterile α motif domain and histidine-aspartate domain–containing protein 1 (SAMHD1) deplete intracellular dNTPs, which restrict HIV-1 reverse transcription, and result in a restrictive infection in this myeloid cell type. Some SIVs overcome SAMHD1 restriction using viral protein X (Vpx), a viral accessory protein that induces proteasomal degradation of SAMHD1, increasing cellular dNTP concentrations and enabling efficient proviral DNA synthesis. We previously reported that SAMHD1-noncounteracting lentiviruses may have evolved to harbor RT proteins that efficiently polymerize DNA, even at low dNTP concentrations, to circumvent SAMHD1 restriction. Here we investigated whether RTs from SIVmac239 virus lacking a Vpx protein evolve during in vivo infection to more efficiently synthesize DNA at the low dNTP concentrations found in macrophages. Sequence analysis of RTs cloned from Vpx (+) and Vpx (−) SIVmac239–infected animals revealed that Vpx (−) RTs contained more extensive mutations than Vpx (+) RTs. Although the amino acid substitutions were dispersed indiscriminately across the protein, steady-state and pre-steady-state analysis demonstrated that selected SIVmac239 Vpx (−) RTs are characterized by higher catalytic efficiency and incorporation efficiency values than RTs cloned from SIVmac239 Vpx (+) infections. Overall, this study supports the possibility that the loss of Vpx may generate in vivo SIVmac239 RT variants that can counteract the limited availability of dNTP substrate in macrophages.

Global Britain: One year on 29 March 2022 — 6:00PM TO 7:15PM Anonymous (not verified) 15 March 2022 Chatham House and Online

How has Britain positioned itself on the global stage a year after exiting the EU single market and the release of the UK government’s Integrated Review?

How has Britain positioned itself on the global stage a year after exiting the EU Single Market and the release of the Integrated Review? This event will be followed by a reception 

Global Britain in a divided world is Dr Robin Niblett’s final research paper for Chatham House as director. It assesses the UK’s performance against the objectives outlined in the UK government’s Integrated Review of Security, Defence, Development and Foreign Policy, published in March 2021, shortly after the UK formally left the European Union (EU) single market in the final chapter of the Brexit process.

The paper argues Britain has done a credible job of strengthening the liberal democratic community’s voice and security at a time when it was at best in recovery mode, particularly in convening and supporting international responses to COVID-19 and climate change, as well Russia’s invasion of Ukraine.

However, to play a constructive long-term role on the world stage, the UK must rebuild its relationship with the EU and avoid being excluded from closer US-EU cooperation. In addition, Brexit has provided some new opportunities to pursue trade deals with countries whose comparative advantages are complimentary to the UK. While these deals will have a minimal economic impact, they could be important for expanding the UK’s geo-economic engagement at a time of intense geopolitical competition.

Lastly, although British soft power appears to have weathered the Brexit storm thus far, this is being undermined by recent severe cuts to foreign assistance and a failure to support refugees. As a solo middle power, accusations of hypocrisy are deeply damaging. Conversely, there will be no more precious asset in the future for Britain’s influence in the world than a reputation for consistency.

A panel of experts join Dr Niblett to explore these issues and others, such as how Britain could help contribute to international efforts to resolve the conflict in Ukraine, and the risks and opportunities of the UK’s ‘tilt’ to the Indo-Pacific.

This event also marks the launch of the UK in the World project which brings together Chatham House’s networks and expert research to identify key priorities, partners, and pathways for the UK to project its values and interests, as well as learn from other countries, as it charts a course in an increasingly fractured and competitive world.

This event is part of Chatham House’s ongoing work on the UK’s role in the world.

Read the transcript