Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

Global markets rallied on the back of optimism that most governments were gearing up to at least partially reopen their economies following lockdowns to prevent the spread of the coronavirus.

Oil headed for its first back-to-back weekly gain since February as output cuts from the biggest producers and a nascent recovery in demand began to rebalance a market awash with crude.

An AI-powered digital assistant to take notes for you? It’s already happening in the workplace, but classroom note taking could prove harder to automate.

Two alumni and one community partner contribute clinical medicine and research experience during the pandemic

Germany's Shekiera Martinez, at 16, has written herself into UEFA's record books by scoring nine goals in a final tournament.

Partick Thistle have released, in full, a letter sent by the club to SPFL chiefs following the news that league reconstruction has been scrapped - confirming the Jags' relegation.

PARTICK Thistle today branded the SPFL a "disgrace" for failing to inform them that league reconstruction had been abandoned and revealed they are "deeply angered" by Ladbrokes Premiership clubs scuppering the plans.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
ARTICLES

Ivana Martinčić, once a player in the Croatian women's top division, speaks about her pride at being selected to referee the 2018 Women's U19 EURO final.

The horse racing authority is pleading for a partial restart of the industry under Level 4 of the lockdown, warning that a prolonged suspension of activity could lead to massive financial impact and job losses.

Starting May 11 through June 26, a section of Pollock Road between Shortlidge Road and Bigler Road will be closed for facade repair on the Millennium Science Complex at University Park.

The north section of Lot Red A located between the Earth and Engineering Sciences Building and the West Campus Intramural Fields at University Park will permanently close beginning Monday, May 11. All vehicles, including University department vehicles, must be removed from this area by Sunday night, May 10.

Dover, Del. (August 15, 2017) – The Award Winners XVII reception and award ceremony will be held at the Biggs Museum of American Art, Dover on Wednesday, August 30 from 5 – 7 p.m. The event will feature special performances by three of the eighteen 2017 Individual Artist Fellows. Attendees can experience the work of […]

As currently funded, $278 million project would unfairly burden electric ratepayers on Delmarva WILMINGTON, Del. – Delaware Governor John Carney and Maryland Governor Larry Hogan on Tuesday sent a letter to members of the Federal Energy Regulatory Commission, urging commissioners to expedite their review of the $278 million Artificial Island transmission line project and consider a […]

DELAWARE DIVISION OF THE ARTS ANNOUNCES  2018 INDIVIDUAL ARTIST FELLOWSHIP AWARDEES Seventeen Delaware artists are being recognized by the Division for the high quality of their artwork. Work samples from 124 Delaware choreographers, composers, musicians, writers, folk and visual artists were reviewed by out-of-state arts professionals, considering demonstrated creativity and skill in their art form. […]

Division of the Arts to Honor 17 Artist Fellows at Annual Reception and Award Ceremony June 13 New this year, the Award Winners Exhibition will display contemporary art alongside historical decorative arts and travel to two new locations Dover, Del. (June 8, 2018) – The Award Winners XVIII reception and award ceremony will be held […]

Program to include a re-enactment of the July 11, 1804 duel between Alexander Hamilton and political rival Aaron Burr which resulted in Hamilton’s passing on July 12, 1804.

Twenty Delaware artists and three Honorable Mentions to receive recognition Wilmington, Del. (January 14, 2019) – Twenty Delaware artists are being recognized by the Division for the high quality of their artwork. Work samples from 136 Delaware choreographers, composers, musicians, writers, folk and visual artists were reviewed by out-of-state arts professionals, considering demonstrated creativity and skill […]

Wilmington, Del. (September 12, 2019) – The Delaware Division of the Arts is pleased to announce several upcoming events featuring 2019 Individual Artist Fellows.  Delaware’s Individual Artist Fellowships recognize artists for their outstanding quality of work and provide monetary awards. Individual Artist Fellows are publicly acknowledged and benefit from the additional exposure to their work.  […]

Nineteen Delaware artists and two Honorable Mentions to receive recognition Wilmington, Del. (January 14, 2020) – Nineteen Delaware artists are being recognized by the Division for the high quality of their artwork. Work samples from 139 Delaware choreographers, composers, musicians, writers, folk and visual artists were reviewed by out-of-state arts professionals, considering demonstrated creativity and […]

JK Tyre has resumed partial operations in India after adhering to the guidelines laid down by the government and getting permissions from local and state authorities.

A look at how Kesavananda Bharti saved the Indian constitution

"You see the camera and are unnerved," wrote Kartik

With the passing of former State Senator Roger Martin on Thursday, October 27 Governor Carney has ordered the United States and Delaware flags at state buildings and facilities be flown at half-staff beginning Friday morning, November 3 as a mark of respect for Mr. Martin and his service to Delaware. Mr. Martin was elected to […]

Participants in Delaware's Women, Infants and Children (WIC) program can now use special coupons to purchase fresh fruits and vegetables at 11 Delaware farmers' markets under a pilot program beginning this week.

Delaware will hold its 16th Drug Take-Back Day on Saturday, April 28, 2018, to help reduce the risk of prescription medications being diverted for misuse. Delawareans can discard their expired or unused medications at 24 locations statewide between 10 a.m. and 2 p.m.

WILMINGTON, Del. – In support of a movement to transform how health care is delivered and paid for in the state, Delaware was one of eight states chosen to participate in a National Governors Association initiative to harness data systems to inform health policymaking. Joining Arkansas, Colorado, Indiana, Iowa, Minnesota, Vermont and Washington, Delaware’s team […]

The Delaware Division of Public Health (DPH) is engaging dental providers in the launch of a statewide campaign directed at increasing awareness about the addictive nature of opioid medications used after dental procedures.

Sat., Oct. 26, 2019: Delaware residents can safely dispose of their unused or expired prescription medications at designated sites throughout the state as part of the 18th National Prescription Drug Take-Back Day.

Washington D.C. – Division of Public Health (DPH) Director Dr. Karyl Rattay participated in a Congressional briefing for members of the U.S. Senate and U.S. House of Representatives on Capitol Hill today, November 7, 2019, regarding maternal and infant health as part of a panel discussion hosted by March of Dimes. The briefing, “Making the […]

Due to construction, the bus stop on Basin Rd. at the News Journal, # 239, will be temporarily closed starting today, Friday, February 21 until approximately Monday, September 21. Riders should board at the temporary bus stop located on Basin Rd. about 230 feet north of the current stop.

Thanks for riding! For your traveling convenience download the free DART Transit app.

Please be advised that SEPTA Train Service to Claymont and Wilmington will resume daily service effective Sunday, May 10

For more information and schedule details, please visit www.septa.org. 

Thanks for riding!

Due to road construction on Delaware Ave., the following Route 10 bus stops will be temporarily closed starting Monday, May 11 through Friday, May 15 from 8 AM to 5 PM each day.

Temporarily closed stops:

Going to Rising Sun Lane

Delaware Ave. at Lincoln St. #3814

Delaware Ave. at DuPont St. #1396

Board at the stops located on Delaware Ave. at Clayton St., #131 or Union St. at 17^th St., #1399

Going to Routes 273 & 7 Park & Ride

Delaware Ave. at Union St. #1468

Delaware Ave. at Lincoln St. #1469

Delaware Ave. at DuPont St. #1471

Delaware Ave. at Clayton St. #138

Board at the bus stops on Delaware Ave. at Bancroft Parkway #1466 OR Delaware Ave. at Broom St. #1473.

Thanks for riding! For your traveling convenience download the free DART Transit app.

Kerry Cunningham of SiriusDecisions talks about how AI can power the B2B revenue engine