twee

Burke, Idaho: Wedged between mountains, the Silver Valley mine town's history of rich resources still echoes down the canyon

Crammed in a narrow canyon of North Idaho's Silver Valley, in perhaps one of the most inconvenient but also beautiful places for a hub of human habitation, are the rusted remains of a once-lively mountain mine town…



  • Arts & Culture

twee

The U.S. House once had a representative for about every 30,000 people, but now lawmakers serve between 543,000 and 991,000 constituents — what happened?

Imagine this: You're voting on a matter of national significance, you get to the front of the line, and the poll worker asks, "What state are you from?"…



  • News/Local News

twee

Tycho's Scott Hansen looks for balance between nature and technology on Infinite Health

For Tycho's Scott Hansen, it all comes back to water…




twee

Haven't been to this intimate of a show in a long time... So great to see @rgenauer and the @assemblyofdust after #agreatlongwhile. Saw #Strangefolk a ton of times in the early 2000s between Chicago and Vermont

marusin posted a photo:

via Instagram ift.tt/2c3to8E




twee

Ireland and the UK: Similarities, Differences, and the Complex Relationship Between Them

A lesson from history.




twee

Cinema Chat: 'Reagan' movie hits theaters, 'Between the Temples' and 'Good One' open in Ann Arbor

WEMU's David Fair was joined by Marquee Arts executive director, Russ Collins on a pre-Labor Day edition of "Cinema Chat". They took time to discuss the new films and special screenings landing on the big screen for your holiday weekend viewing pleasure.




twee

Political Rewind: Tension Between Governor and Mayor As Both Lead Through Virus

Monday on Political Rewind , the relationship between Gov. Brian Kemp and Mayor Keisha Lance Bottoms has frayed, as both officials take opposing views on how to govern during the pandemic. A once productive and collegial relationship is now soured by open fighting. What brought us here? Listen here:




twee

U.S. Ethics Chief Was Behind Those Tweets About Trump, Records Show

In November, the typically straitlaced Office of Government Ethics surprised observers with a series of tweets mimicking Donald Trump's bombastic style, exclamation points and all: "Brilliant! Divestiture is good for you, good for America!" The controversy was two-fold: (1) The OGE doesn't typically air its positions publicly, advising White House transition teams behind the scenes. (2) Trump hadn't promised the total divestitures of business interests implied by the tweets. New records shared with NPR on Friday show that behind the curious tweets was the head of the OGE himself, Director Walter Shaub Jr. In two emails, dated Nov. 30, just several minutes apart, Shaub sent to OGE Chief of Staff Shelley Finlayson the nine tweets that took the Internet by storm that day. He then followed up with a link to a legal document referenced in one of the tweets and writes: "Get all of these tweets posted as soon as humanly possible." The emails were part of a 365-page document shared with NPR in




twee

192: The week between last week and this week

A nerdy debate about the relative term "this week" and "last week" and that mystery week in between them. We got together on March 4th and tried not to talk about the weather too much. Runs about 105 minutes.

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Lirdle - Like Wordle, but with one lie per answer by morspin (MeFi Post)
Word Searches for Dad (and special meta one) by jasondigitized
bondcliff's creation
My portrait of COVID Toronto in maps by sindark (MeFi Post)
Jessamyn's Zipper Epiphany

MeFi
Penta, Mariya: Rejected by shino-boy
The Genetics of Chernobyl's Dogs by bryon
Could you live without a cellphone? by SituationNormal
Kill Six Billion Demons by curious nu
I've heard it too many times to ignore it by DigDoug
Nice social media account, shame if something were to happen to it... by gwint
The thoughts of youth are long, long thoughts by gwint
The natural destination of poor editorial judgment is the court of law. by curious nu
What went wrong at the New York Times? by DarlingBri
Playdough surgery by gottabefunky
Lightning Crashes by Etrigan
All The Malevolence Of A Grade School Music Class In A Box by NoxAeternum
Infinite Mac by Fiasco da Gama
Into the rest of the 20st century by gwint
playing a 2x4 through a tacklebox head into a foamcore cabinet by cortex

AskMe
Tell me about your adventures with pre-internet physical bulletin boards by wowenthusiast
Unsmooth the motion on a hotel tv by quintessence
Help me find the blowup doll of my youth by queensissy
a comment by Larry David Syndrome
a comment by BlueHorse
How do I make a cake when my resources are depleted? by toucan
Please Tell Me about Pre-internet Personals Ads by wowenthusiast

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Kaleidoscope: Kaleidoscope (miniseries, all episodes) by adamrice
Physical: 100: Physical: 100 by autopilot

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Open Gaming Thread: What are you playing right now? by Fizz
Best of the Web anniversaries and transcripts by Pronoiac
New Moderation Team Member by loup
ChatGPT-filter by EndsOfInvention
March is Steering Committee election season by Rhaomi
Snow sounds from Directory Audio




twee

Houston Rockets Face Backlash After Manager Tweets Support For Hong Kong Protests

ARI SHAPIRO, HOST: A bipartisan delegation of Congresspeople is just back from Ukraine. It was a trip designed to strengthen the U.S.-Ukraine alliance, and it was planned before news broke of the whistleblower complaint against President Trump involving that same country. Congressman John Garamendi led the delegation as a senior member of the House Armed Services Committee. And the Democrat from California joins us now. Welcome, Congressman. JOHN GARAMENDI: Good to be with you. SHAPIRO: One central question in the impeachment inquiry is whether President Trump demanded help investigating a political rival in exchange for U.S. aid to Ukraine. And I know that aid was a central topic on your trip, so what did you learn about Ukraine's reliance on American assistance? GARAMENDI: Well, first of all, Ukraine is an extraordinary country. These citizens of that country are determined to be independent. They have been fighting a war against Russia for the last five years. They've lost 13- to 14




twee

Toronto/LA Indie Pop Artist Julian Daniel Invites You to Feel the Heat Between Every Beat with "do you feel me?"

Toronto/Los Angeles-based indie pop artist Julian Daniel is making waves with his infectious new single, “do you feel me?,” a track he hopes will stir listeners' emotions through its seductive…




twee

Jan. 6 Panel Explores Links Between Trump Allies and Extremist Groups

Cassidy Hutchinson, the former White House aide, testified that the former president directed his chief of staff to reach out to Michael Flynn and Roger Stone, who had ties to the Oath Keepers and the Proud Boys.




twee

Hutchinson Testimony Exposes Tensions Between Parallel Jan. 6 Inquiries

That the House panel did not provide the Justice Department with transcripts of Cassidy Hutchinson’s interviews speaks to the panel’s reluctance to turn over evidence.




twee

AGON - BRIDGES BETWEEN WORLDS

http://www.musicxray.com/xrays/2672450 AGON SG - AGON - BRIDGES BETWEEN WORLDS




twee

368: ‘Tweeter and the Monkey Man’, With Dan Moren

Special guest Dan Moren joins the show to talk about the new M2 MacBook Pros and Mac Minis, the state of Mac gaming, and the triumphant return of the full-sized HomePod.




twee

Tweets media crawl data 2024-11-13T07:31:44PST to 2024-11-12T23:36:41PST

Internet Archive crawl data from the Tweets Media crawl, captured by crawl917.us.archive.org:tweets-media from Wed Nov 13 07:31:44 PST 2024 to Tue Nov 12 23:36:41 PST 2024..

This item belongs to: web/tweets-media.

This item has files of the following types: Metadata



  • web/tweets-media

twee

Corporations at COP27, Tweeting as Elon Musk, the labour movement takes a stand, Margaret Sullivan and more

Corporate influence at COP27; cartoonist Jeph Jacques gets booted from Twitter for impersonating Elon Musk; Margaret Sullivan on how to cover Trump and Trumpism; what Ontario unions' victory over Bill 28 means for Canada's labour movement; graphic novelist Cecil Castellucci hopes Shifting Earth will be a path toward climate action; and more.



  • Radio/Day 6

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Jassi Sidhu - Singing Between the Lines

No great departure for the B21 graduate, but an album with plenty of variety.




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Transfer Playlists Between Music Services | Tune My Music




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What's the difference between a module and package in Python? - Stack Overflow




twee

BlackHole: Route Audio Between Apps

BlackHole is a modern macOS virtual audio driver that allows applications to pass audio to other applications with zero additional latency. Perfect for Streamers, Podcasters, and Online Instructors.




twee

'I'm a Natural-Born Killer': Mike Tyson Highlights the Difference Between Him and YouTuber Jake Paul

YouTuber Jake Paul and boxing heavyweight legend Mike Tyson are finally set to battle in their much-anticipated match at AT&T Stadium in Dallas on Friday night.

The post ‘I’m a Natural-Born Killer’: Mike Tyson Highlights the Difference Between Him and YouTuber Jake Paul appeared first on Breitbart.




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Cannabis on the mind: Study finds connection between sleep, memory and marijuana use

As public support for marijuana decriminalization grows, new research is shedding light on the drug’s impact on sleep and memory.





twee

Things Get Hot and Steamy Between MJ and Justin



MJ gets naughty in the office.




twee

Kyrie Irving Says Controversial Mask Tweet Was ‘Nothing COVID Rule Related’

He’s clarifying a comment he made about wearing masks.




twee

Tweet About Bermuda Olympic Team Goes Viral

[Written by Don Burgess] If you ask any non-resident what they know about Bermuda, they will normally say either the Triangle or our shorts. Practically every Olympic Opening Ceremony recognizes our island for wearing Bermuda shorts, but for Paris, the focus was on the Triangle. Buzzfeed News, in an article entitled ‘The 38 funniest jokes about […]




twee

Between 4 And 6 Collisions Being Reported Daily

There are “between 4 and 6 RTCs being reported daily,” and the police are urging people to “slow down, always drive sober, do not drive when stressed or tired, put your phone down and please wear your seatbelt and fasten your helmet.” Acting Superintendent Robert Cardwell said, “By design, it was hoped that increased traffic […]




twee

36 tweets by Darryl Cooper aka @MartyrMade on July 8 2021 on why Trump supporters believe the 2020 election was fraudulent

Darryl Cooper, AKA @MartyrMade, is a podcaster who had a Twitter thread go viral with 13k retweets and 20k likes of the first Tweet alone. This one is 36-Tweets long. It makes very cogent arguments of not only why millions of Trump supporters believe the 2020 election was stolen, but also why we are justified to believe it. Continue reading




twee

Board Game Review: Between Two Castles of Mad King Ludwig

Years ago, on a snowy winter excursion to Bavaria, I took a tour of King Ludwig (Mad King Ludwig) II's  castles. I really feel for the poor chap Ludwig II. He was very excited to be king and wanted to be a *real* king of the old order with power and dominion. Alas, he was born much to late in Germany’s evolution for such things and was reduced constitutionally to being a mere figurehead (such as Queen Elizabeth II is in England today). So he consoled himself by building castles throughout the countryside where he would escape and  fully immerse himself in his pretend kingdom where all subjects worshipped him and did as they were told.  Linderhof was one of the first castles he built and it was pretty modest so the taxpayers didn’t really bat an eye. This was the first stop on our tour.

The same could not be said for his next building project: Castle Neuschwanstein. This grand and glorious castle (just up the hill from his parents’ country castle) was the castle to end all castles. He fancied he’d build himself a castle in medieval style (probably because that was a time when subjects dutifully respected their king or perhaps because it appealed to his alpha-male decorating sense) and he spent his way through a good portion of the national treasury before the impoverished taxpayers had enough and called shenanigans. The castle was never finished, King Ludwig II came to a premature end and within a year the political leadership had turned the castle into a tourist attraction. It was *this* castle, by the way, that Walt Disney held in his mind’s eye when designing the Disney Princess Castles. With the snow falling softly around it, it was truly an amazing site to behold. So beautiful!

With the happy memories of the castle tour, I was drawn to Castles of Mad King Ludwig  when it was released by Bezier Games a few years later.

Another Bezier release – Suburbia – is in my top 10 list, so the positive track record with the publisher was another indicator that I’d probably enjoy Castles. After a bit of research, I found the general consensus in the board game community is that Castles  plays so similar to Suburbia that it feels like a reskin of the game with a castle theme. Players purchase tiles from a market to build a great infrastructure, with various points awarded based on which tiles are used and how they are arranged. After this discovery, I actually didn’t follow through with the purchase, as I’ve never been one who is keen to get every iteration of a game. For example, I rarely keep both the card game and board game version of a given game in my collection – I force myself to pick one and let go of the other. Since Surburbia was so close to my heart, I let go of any ideas to purchase Castles.

A year after Bezier released Castles, Stonemaier Games released Between Two Cities. In BTC, players draft tiles and then use them to build cities collaboratively with other players.  We build one city with the player to our left and a separate city with the player to our right; each of our partners also contributes tiles to our respective cities in common. At the end of the game, all cities are scored and the lower scoring city of the two we helped build is assigned to us as our final score. The player with the highest score at the table wins. It’s a pretty unique approach to scoring and forces you to give both of your cities equal attention throughout the game. I don’t own a copy of this game either, mostly because I only began collecting Stonemaier games after I fell in love with Scythe in 2016, and have focused heavily on acquiring new releases (vs picking up their earlier games). 

In 2018, Stonemaier (in collaboration with Bezier) released Between Two Castles of Mad King Ludwig. This game is designed by Ben Rosset and Matthew O’Malley and it takes the best of Between Two Cities and Castles of Mad King Ludwig and marries it all together. Now we find ourselves at the game table, working to build two castles at once, simultaneously but separately collaborating with our left and right neighbors. At the beginning of each round, each player draws nine tiles, comprised of various indoor and outdoor room types. Each turn, we select 2 tiles to keep (one destined for the castle we are building with the player to our left and the other for the castle we are building with the player to our right).  We pass the rest of the tiles to our neighbor (to the left in round 1 and to the right in round 2). Once everyone has selected their tiles and passed the leftovers, we begin collaborative discussions with each of our neighbors regarding the tiles we selected and where they should be placed within our castles. There are a few straightforward rules governing placement (for example, downstairs rooms can only be placed below the ground level) but generally the selection and placement decisions should be guided by maximizing victory point scoring. Also of note, when the third or fifth regular room tile of the same type is placed, a placement bonus is earned and redeemed immediately. These bonuses provide either additional tiles (including specialty room types) or bonus cards that award conditional victory points at the end of the game. After tile placement, the turns repeat in the same fashion three more times, except that on the last run, there is only 1 tile left after selecting two for placement and that tile is discarded out of the game. Round two begins, and follows the same process as the first round, with the only change being the direction the unselected tiles are passed around the table.

In anticipation of the upcoming Between Two Castles of Mad King Ludwig  expansion release (Secrets and Soirees), I received a review copy of the base game from Stonemaier.

Opening the eye-catching box (with artwork by Agnieszka Dqbrowiecka, Laura Bevon, and Bartlomiej Kordowski), we inventoried the components (cardboard tiles, wooden tokens, plastic coated cards, and score sheets) and set up our first game. The rulebook was easy to follow (as it always is with Stonemaier) and the handy player aids included proved valuable as we worked our way through the game. There were five of us playing that first time, including two teenagers, and I was surprised to see just how varied each team’s castle was from the others.

I worked really hard to give my all to both castles I was constructing, knowing that I would only score for the one that brought in the lower victory point total. I had to to correct my efforts a few times as it started to feel like one castle was building to a much higher score than the other. With both my neighbor on my left and right, I focused on bonus cards and tiles to increase point totals, whereas the competing castle builds leaned more heavily on amassing points directly through the regular room tiles. My strategy worked, and both of the castles I helped build were higher scoring than everyone else’s, giving me the victory even when taking the lower score of the two. In later games, my husband Chris and I played against each other, using the special 2 player rules in which a dummy player (“Ludwig” of course) is controlled by one of the players during the first round and by the other player during the second round. I focused on the same things in these two player games that I had previously at higher player counts. Meanwhile Chris focused almost exclusively on standard room tiles to accumulate points. Every time we played, the castle that Chris and I built together was by far the highest scoring one in the game (scoring highly on regular room tiles thanks to Chris and on bonus tiles and cards thanks to me), and my castle with Ludwig was runner up, giving me the victory again. 

I really really love this game. Much more than I thought I might, given its straightforward and simplistic mechanisms (I usually prefer complex strategy games).  Pick two tiles and arrange, rinse repeat. Sounds like it should get boring fast, but it never does.  I think the real draw of Between Two Castles of Mad King Ludwig,  that keeps engagement and enthusiasm high even among experienced gamers, is the puzzle of having to work both castles at once. Dividing your time between two equally important projects simultaneously that will be scored against each other is a personal challenge, regardless of your skill level, because you’re competing against yourself. That’s genius, and I can’t think of another game I own that implements this kind of scoring. The only drawback to this scoring mechanism is that players who are significantly weaker in strategy or skill than the rest of the group will drag down the scores of their partners, giving a clear advantage to the remaining players who weren’t yoked to the underperformer. Tactfully, since the game scores average in the direction of the weaker player on each team, this is a game to play with a group of your intellectual peers, unless you want to stew in resentment over how irrelevant all of your hard work turned out to be when it came to scoring.

In addition to the puzzle aspect of the game, the quick gameplay (less than an hour), family friendliness, and low level of analysis paralysis all help to make it an excellent go-to game, even on weeknights. 

I’m glad I gave Between Two Castles of Mad King Ludwig  a chance on our game table, and our friends who played with us have already asked when they can come over to play again. I’m quite excited to see what the upcoming Secrets and Soirees expansion adds to the game.

-------------------------------------------------

Publisher: Stonemaier Games
Players: 2-7
Actual Playing Time (vs the guideline on the box): About 45 minutes per game
Game type: card drafting, tile placement, set collection

Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.



  • board game reviews
  • card drafting games
  • set collection games
  • Stonemaier Games
  • tile placement games

twee

Board Game Review: Between Two Castles of Mad King Ludwig Secrets and Soirees Expansion

Between Two Castles of Mad King Ludwig is one of our board game library essentials. There’s a great puzzle aspect to the game, it plays in under an hour, it’s family friendly, and it keeps analysis paralysis to a minimum. It also plays up to seven players, filling that niche when so many other games are capped at 4 or 5. For all of these reasons, when the Secrets and Soirees expansion debuted, we knew we had to have it.

The expansion offers additional room types for your castle, extra bonus cards, two new solo modes, higher player count (up to 8), and a new variant of head to head castle building where each player builds their own exclusive castle.

My personal favorite bit of the expansion is the puppy room!!! Adorable little corgis, just like we have at home.

We have played the expansion dozens of times. The first few months we had the game, we stuck to standard play, with everyone building two castles, and just focused on the fun of the new room types. These are activity rooms, secret rooms, and ballrooms. The activity rooms are thematically just that – clever little rooms themed around activities that give you points for each other room adjacent or penalize you if the listed prohibited room type is within the radius. The secret rooms are quite innovative. Each one has a little arrow printed on the tile pointing up, down, left, or right and takes on the same identity as the room indicated by the arrow, giving players a lot of flexibility based on placement in the castle. The ballrooms score points for specific room types in your neighbors’ castles. I really enjoyed these plays with the expanded room types and have not ever wanted to go back to playing with just the base game tiles again.


More recently, we’ve explored the new variants provided by the expansion. The Mad King’s Demand variant has players each build a single castle instead of managing two castle builds at once. It solves the problem of weaker players bringing a section of the entire table down in scoring and it plays so much more quickly than the regular game, so it can be a good choice for player counts larger than two. While it’s also easier and smoother in a two player game to play this way versus playing with the 3rd NPC player normally required in a two player game, I’m much less fond of using this variant with two players. I like the extra tiles to choose from when a third castle is in the mix; it helps make it a bit more challenging and feels more interactive.

The Automa solo mode is very easy to learn and it’s the most enjoyable solo game I’ve ever played because it feels like you’re actually playing against other players.  I played on level 3 – normal difficulty – and won 58 to 55/55. I actually found myself wishing for longer rounds. The other solo mode (which is dubbed the Introvert variant and noted by the rulebook as technically not an Automa mode) feels less like a game against peers and more like a game of solitaire puzzling. It’s faster than the Automa solo mode and has the quirky hack of allowing you to force the NPC opponent to take a specific tile you don’t mind it having when there’s only one that meets the selection filter used to draft a tile for them. This is because, in this mode, the NPC follows an algorithm to pick between a tile you’ve marked as favored and desired for yourself and all the other tiles in demand under its selection filter that round. If there’s only one tile that meets the filter and you mark another tile you actually want, there’s a 50/50 chance you’ll lose your coveted tile to the NPC. However, if you mark the tile that meets the filter as if you wanted it for yourself, it’s forced to select it. Then you can choose whatever tile you actually prefer for yourself instead. The introverted solo mode is pretty great if you like that sort of thing, but I prefer the feeling of playing against others, so I’ll stick with the Automa solo mode, or competitive play against real life opponents.

With a retail price of just $15 on the Stonemaier website, and having so much quality content in the box, the Secrets and Soirees expansion is a must-have.

-------------------------------------------------

Publisher: Stonemaier Games
Players: 1-8
Actual Playing Time (vs the guideline on the box): About 45 minutes per game
Game type: card drafting, tile placement, set collection

Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.



  • board game reviews
  • card drafting games
  • set collection games
  • Stonemaier Games
  • tile placement games

twee

Somewhere Between Two and Twenty Four Things, Somewhere Between One and Twenty Three of Which are Elephants.

Alt text: a cake, of sorts. Decorated, in a sense, to look like an elephant. Definitely.




twee

Trump's 'TREASON?' Tweet Is Inspiring Some Pretty Clever Parodies

Recently Donald Trump tweeted the word "TREASON?" in light of the New York Times op ed that was published on Wednesday. The article was supposedly written by someone within the Trump Administration, calling themselves part of the "resistance." 

After Trump's "treason" tweet, people on Twitter began making their own amusing parodies, which you can read below!




twee

The Best Memes & Tweets About Four Seasons Total Landscaping

If you haven't been living under a rock for the past week, you're probably familiar with the Four Seasons Total Landscaping drama that occurred earlier this week in Philadelphia. On November 7th, President Trump tweeted that a press conference would be held at the Four Seasons in the Pennsylvania capital. Eight minutes later, Trump tweeted an update - that the conference would actually be taking place at Four Seasons Total Landscaping in the same city. 

The tweets led to a great deal of speculation as to whether the administration had intended to book the hotel. The speculation grew when it became clear that the location, between a sex shop and a crematorium, was probably not their first choice. After Rudy Giuliani spoke to crowds about voter fraud, and even used a convicted sex offender as a witness, the occasion was largely seen as a massive blunder. And as expected, the memes began flowing freely. We've put together some of our favorite examples from the last week, but we're willing to bet this press conference will be talked about for quite a while. Here's hoping Four Seasons Total Landscaping is enjoying the free publicity. 




twee

What is the Difference Between a Paid Listing and Buying a Link?

Paid listings and Pay per Click ads are not the same as buying links. For example, iAquire got hit by Google early this year. The company was selling links for profit of course and even lost their court case due to link selling. The company allowed for clients to pay for relevant links after companies […]




twee

Determination of the relative roll, pitch and yaw between arbitrary objects using 3D complex number

The roll, pitch and yaw of an object relative to another is complex to compute. We use 3D complex number to compute them which makes the computation easier and more intuitive. Roll, pitch and yaw are angles of orientation of an object in space and the conversion of these angles among different reference frames is...




twee

Billy West Recorded Some Choice Donald Trump Tweets in the Voice of Zapp Brannigan

It turns out that there's a VERY fine line between Donald Trump and the Futurama character Zapp Brannigan. Memes with Zapp's image and Trumps tweets started circulating the internet and they caught the attention of Billy West, the voice actor who plays Zapp Brannigan on Futurama. The recordings he made are out of this world.




twee

Better Breaks - A summary of projects funded between Apiril 2014 and March 2015

The Better Breaks funding programme is focused on improving the range and availability of short break opportunities for disabled children and young people, particularly those with multiple support needs, including short break opportunities that families can enjoy together, or which allow parents and siblings to have time away from their caring responsibilities. This is the summary report.




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Creative Breaks, A summary of projects funded between September 2014 and October 2015

The Short Breaks Fund helping to make breaks better and brighter for unpaid carers and cared-for people in Scotland. Launched in 2010 for one year, the fund has now been running for five years and has proved to be a lifeline for many carers. During the past five years the Scottish Government, through Shared Cared Scotland has distributed 12,547,409 to 697 projects to deliver innovative, tailor made breaks to groups and individuals.





twee

How to Distinguish Between Reliable and Unreliable Sources in the Digital Age

In a world overflowing with information, the ability to discern reliable sources has never been more critical. Many individuals resonate with a moment of uncertainty—perhaps it was a social media post that seemed too outrageous, or an article that didn’t quite align with the facts they knew. This is a common experience in today’s digital ... Read more

The post How to Distinguish Between Reliable and Unreliable Sources in the Digital Age appeared first on Star Two.




twee

Qatar suspends role as mediator between Israel and Hamas

The move comes after US officials were quoted saying they would not accept Hamas's presence in Qatar.




twee

Trump Tweets First Video Remarks Since Revealing COVID-19 Diagnosis

President Trump on Friday shared a pre-recorded video message on Twitter saying he is “doing very well” and thanked Americans for their overwhelming support following his early morning announcement of his COVID-19 diagnosis. pic.twitter.com/B4H105KVSs — Donald J. Trump (@realDonaldTrump) October 2, 2020 “I want to thank everybody for the tremendous support,” Trump said in the […]

The post Trump Tweets First Video Remarks Since Revealing COVID-19 Diagnosis appeared first on Hispolitica.




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News24 | Business as usual at Lebombo border post with traffic flowing between SA and Mozambique after unrest

It was business as usual at the Lebombo border post between SA and Mozambique on Saturday morning, with vehicles moving freely between both countries after a shutdown earlier this week.




twee

Rift Between Junior and Senior Developers

I’m worried about AI. I’m not worried about it taking my job. I believe AI is a genuine productivity tool. By which I mean it can make developers produce more. The question is whether those developers are producing something good or not. The difference between an experienced developer and a junior is that an experienced […]




twee

Sport | Difference between good and great is handling pressure, says Kaizer Chiefs legend Baloyi

Former Kaizer Chiefs legend Brian Baloyi says that holding the Kaizer Chiefs No 1 jersey requires a hardened mentality, but he is upbeat over Amakhosi's chances this season.




twee

Reconstruction in Syria: Between Political Pragmatism and Human Rights Idealism




twee

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews




twee

Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles




twee

Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6 [Signal Transduction]

CARM1 is a protein arginine methyltransferase (PRMT) that acts as a coactivator in a number of transcriptional programs. CARM1 orchestrates this coactivator activity in part by depositing the H3R17me2a histone mark in the vicinity of gene promoters that it regulates. However, the gross levels of H3R17me2a in CARM1 KO mice did not significantly decrease, indicating that other PRMT(s) may compensate for this loss. We thus performed a screen of type I PRMTs, which revealed that PRMT6 can also deposit the H3R17me2a mark in vitro. CARM1 knockout mice are perinatally lethal and display a reduced fetal size, whereas PRMT6 null mice are viable, which permits the generation of double knockouts. Embryos that are null for both CARM1 and PRMT6 are noticeably smaller than CARM1 null embryos, providing in vivo evidence of redundancy. Mouse embryonic fibroblasts (MEFs) from the double knockout embryos display an absence of the H3R17me2a mark during mitosis and increased signs of DNA damage. Moreover, using the combination of CARM1 and PRMT6 inhibitors suppresses the cell proliferation of WT MEFs, suggesting a synergistic effect between CARM1 and PRMT6 inhibitions. These studies provide direct evidence that PRMT6 also deposits the H3R17me2a mark and acts redundantly with CARM1.