twee

Granderson: Justin Turner talks coronavirus relief, his 'Tiger King' tweet and quarantine baseball

The Dodgers' Justin Turner shares his thoughts on his viral 'Tiger King' tweet and how he feels about the latest idea to save the MLB season.




twee

L.A. Affairs: I thought we'd get married. But a house came between us

I wasn't going to plead or beg her to stay. I felt my actions of the past week — and during the more than three years we had been together — had done all my talking for me.




twee

Amid coronavirus celebs' 'Mean Tweets' video combats antisemitism


The video, a spin on Jimmy Kimmel’s 'Mean Tweets' video, features celebrities reading antisemitic posts at a time of increasing coronavirus-related anti-Jewish sentiment.




twee

Elon Musk should be held in contempt for unauthorized tweet about Tesla, SEC says

Tesla Inc.




twee

In a throwback, Musk's tweets target Tesla co-founder Martin Eberhard

Tesla Chief Executive Elon Musk turned to Twitter on Sunday to open up old wounds with one of Tesla's co-founders before announcing he had "deleted" his Twitter account.




twee

News Analysis: If Elon Musk's tweets are nonsense, why does he use them to break Tesla news?

In the "pedo guy" trial, Musk's lawyers dismissed Twitter as a "not a source of facts."




twee

Judge deems Musk's 'funding secured' tweet false and misleading. A trial awaits

Already sanctioned by the SEC on a fraud charge, Elon Musk and Tesla fight a civil suit on his buyout claim.




twee

Review: 'Deerskin' is an entrancingly warped love story between a man and his jacket

Jean Dujardin and Adèle Haenel star in "Deerskin," director Quentin Dupieux's latest darkly absurdist comedy.




twee

Max Verstappen lifts lid on life in lockdown as Red Bull star picks between F1 and esports



Max Verstappen is keeping himself busy by taking part in esports races.




twee

Man Utd fans want Wayne Rooney to replace Jesse Lingard after Derby FA Cup tweet



Manchester United will go up against Wayne Rooney in their FA Cup clash with Derby.




twee

Andrew Lloyd Webber FEUD: What happened between Andrew Lloyd Webber and lyricist Tim Rice?



ANDREW LLOYD WEBBER has written some of the greatest musicals of our time with lyricist Tim Rice - but what happened between them?




twee

Letters: Americans straddle line between hope and wishful thinking during COVID-19 crisis

The worst part of the COVID-19 outbreak for the vast majority of healthy Americans is the uncertainty of the situation, a letter to the editor says.

       




twee

Fatal shootings rekindle long-simmering tension between IMPD and black residents

Two fatal shootings of black men by police and the death of a pregnant pedestrian struck by an officer resurface old scars for Indianapolis.

       




twee

Pete Buttigieg tweets demand for 'transparent investigation' of Dreasjon Reed shooting

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

       




twee

Cognizant Expects To Lose Between $50 Million and $70 Million Following Ransomware Attack

IT services provider Cognizant said in an earnings call this week that a ransomware incident that took place last month in April 2020 will negatively impact its Q2 revenue. ZDNet reports: "While we anticipate that the revenue impact related to this issue will be largely resolved by the middle of the quarter, we do anticipate the revenue and corresponding margin impact to be in the range of $50 million to $70 million for the quarter," said Karen McLoughlin, Cognizant Chief Financial Officer in an earnings call yesterday. McLoughlin also expects the incident to incur additional and unforeseen legal, consulting, and other costs associated with the investigation, service restoration, and remediation of the breach. The Cognizant CFO says the company has now fully recovered from the ransomware infection and restored the majority of its services. Speaking on the ransomware attack, Cognizant CEO Brian Humphries said the incident only impacted its internal network, but not customer systems. More precisely, Humphries said the ransomware incident impacted (1) Cognizant's select system supporting employees' work from home setups and (2) the provisioning of laptops that Cognizant was using to support its work from home capabilities during the COVID-19 pandemic. Humphries said staff moved quickly to take down all impacted systems, which impacted Cognizant's billing system for a period of time. Some customer services were taken down as a precaution.

Read more of this story at Slashdot.




twee

Pete Buttigieg tweets demand for 'transparent investigation' of Dreasjon Reed shooting

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

       




twee

Trump angers Beijing with 'Chinese virus' tweet

The US president used the term despite warnings to avoid stigmatising one region or group.




twee

Why the WHO got caught between China and Trump

President Trump has been critical - but what do others think of the "global guardian of public health"?




twee

Bloomberg insulted Trump with a Darth Vader tweet. Here are six other times Star Wars converged with politics.

From Ronald Reagan's "evil empire" to Mark Hamill battling Ivanka Trump.




twee

NL rookie of the year race between Juan Soto, Ronald Acuna Jr. is impossibly tight

The Braves' Acuna appears to be a runaway winner right now, but a closer look shows Soto had a tremendous impact on the Nationals.




twee

The AFC’s final playoff spot is between the Colts and Ravens and no one else

Even with the Dolphins, Broncos, Bengals and Titans within striking distance, if you are hoping for a dramatic playoff push in the AFC to end the season, bad news: there won’t be any.




twee

John Cusack apologizes for anti-Semitic tweet — after defending why he posted it

In a string of tweets, the actor apologized for retweeting an anti-Semitic meme.




twee

Priyanka Chopra is confronted by Pakistani at Beautycon over tweets about India

The "Quantico" actress was called out during her appearance for a tweet sent during military hostility between the neighboring, nuclear-armed countries.




twee

Donald Trump Jr. is tweeting about Jussie Smollett. Again.

The president's son mocked the former "Empire" actor's legal troubles in numerous tweets this week. And not for the first time.




twee

Differences between European Canal Barge And RIver Cruise

What are the main differences between a European canal hotel barge cruise and a river cruise? I think there are 8 key things you need to know that makes a canal cruise different to a river cruise. By understanding how they differ you can better decide is a river cruise or canal hotel barge cruise is best for your next European river cruising vacation

Note: I travelled as a guest of CroisiEurope on a 6-night hotel barge cruise in France before making this video Croisieurope had no input into the opinions or content of this video.

** Buy my Cruise T-shirts: http://bit.ly/TFTStore
** USA cruisers get great cruise deals CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise
** UK Cruisers get great cruise deals with CRUISE.CO.UK: http://bit.ly/BookCruiseUK

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

Follow Tips For Travellers on:
- Instagram: http://www.instagram.com/garybembridge
- Facebook: http://www.facebook.com/tipsfortravellers
- Twitter: http://www.twitter.com/garybembridge




twee

The Scaramucci story ends like all the others: With a Trump tweetstorm

Welcome to the Resistance, Mooch. Better late than never.




twee

How to Switch AirPods Between Devices (iPhone, iPad, Mac, Apple Watch)

How would you like to switch AirPods between iPhone, iPad, and Mac? Or what if you’d like to switch AirPods from iPhone to Apple Watch or even Apple TV? If you have a pair of AirPods and multiple Apple devices, you can easily switch AirPods and AirPods Pro between any of your other Apple products, ... Read More




twee

strataconf: RT @bostontweetup: WEDS 6PM #BostonHealth7 hosted by @bostonpainpoint @mrkrieger @health_box @strataconf http://t.co/U6tj1uLR2Q @kalyankalwa

strataconf: RT @bostontweetup: WEDS 6PM #BostonHealth7 hosted by @bostonpainpoint @mrkrieger @health_box @strataconf http://t.co/U6tj1uLR2Q @kalyankalwa




twee

News24.com | Drivers burn to death in horror N2 crash between truck and tanker

A horror crash involving a truck and a tanker carrying a flammable substance has led to the closure of the N2, near the Mtunzini Toll Plaza on the KwaZulu-Natal north coast.




twee

Brain manganese and the balance between essential roles and neurotoxicity [Molecular Bases of Disease]

Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.




twee

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation [Signal Transduction]

The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflammatory signaling downstream of various innate immunity receptors. Loss-of-function mutations in the LUBAC components HOIP and HOIL-1 yield a systemic autoinflammatory disease in humans, whereas their genetic ablation is embryonically lethal in mice. Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflammatory disease in mice characterized by chronic proliferative dermatitis (cpdm), which is propagated by TNFR1-induced and RIPK1-mediated keratinocyte cell death. We have previously shown that caspase-1 and -11 promoted the dermatitis pathology of cpdm mice and mediated cell death in the skin. Here, we describe a reciprocal regulation of caspase-1 and LUBAC activities in keratinocytes. We show that LUBAC interacted with caspase-1 via HOIP and modified its CARD domain with linear polyubiquitin and that depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in response to inflammasome activation, unlike what is observed in macrophages. Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death. HOIP processing impeded substrate ubiquitination in the NF-κB pathway and resulted in enhanced apoptosis. These results highlight a regulatory mechanism underlying efficient apoptosis in keratinocytes and provide further evidence of a cross-talk between inflammatory and cell death pathways.




twee

Can the UK Strike a Balance Between Openness and Control?

2 March 2020

Hans Kundnani

Senior Research Fellow, Europe Programme
Rather than fetishizing free trade, Britain should aim to be a model for a wider recalibration of sustainable globalization.

2020-03-02-Johnson.jpg

Boris Johnson speaks at the Old Naval College in Greenwich on 3 February. Photo: Getty Images.

This week the UK will start negotiating its future relationship with the European Union. The government is trying to convince the EU that it is serious about its red lines and is prepared to walk away from negotiations if the UK’s ‘regulatory freedom’ is not accepted – a no-deal scenario that would result in tariffs between the EU and the UK. Yet at the same time the story it is telling the world is that Britain is ‘re-emerging after decades of hibernation as a campaigner for global free trade’, as Boris Johnson put it in his speech in Greenwich a few weeks ago.

The EU is understandably confused. It’s a bit odd to claim to be campaigning for free trade at the exact moment you are creating new barriers to trade. If Britain were so committed to frictionless trade, it wouldn’t have left the EU in the first place – and having decided to leave, it would have sought to maintain a close economic relationship with the EU, like that of Norway, rather than seek a basic trade deal like Canada’s. 

As well as creating confusion, the narrative also absurdly idealizes free trade. Johnson invoked Richard Cobden and the idea that free trade is ‘God’s diplomacy – the only certain way of uniting people in the bonds of peace since the more freely goods cross borders the less likely it is that troops will ever cross borders’. But the idea that free trade prevents war was shattered by the outbreak of the First World War, which brought to an end the first era of globalization.

We also know that the domestic effects of free trade are more complex and problematic than Johnson suggested. Economic liberalization increases efficiency by removing friction but also creates disruption and has huge distributional consequences – that is, it creates winners and losers. In a democracy, these consequences need to be mitigated.

In any case, the world today is not the same as the one in which Cobden lived. Tariffs are at a historically low level – and many non-tariff barriers have also been removed. In other words, most of the possible gains from trade liberalization have already been realized. Johnson talked about the dangers of a new wave of protectionism. But as the economist Dani Rodrik has argued, the big problem in the global economy is no longer a lack of openness, it is a lack of democratic legitimacy.

The UK should therefore abandon this confusing and misleading narrative and own the way it is actually creating new barriers to trade – and do a better job of explaining the legitimate reasons for doing so. Instead of simplistically talking up free trade, we should be talking about the need to balance openness and economic efficiency with democracy and a sense of control, which is ultimately what Brexit was all about. Instead of claiming to be a ‘catalyst for free trade’, as Johnson put it, the UK should be talking about how it is trying to recalibrate globalization and, in doing so, make it sustainable.

In the three decades after the end of the Cold War, globalization got out of control as barriers to the movement of capital and goods were progressively removed – what Rodrik called ‘hyper-globalization’ to distinguish it from the earlier, more moderate phase of globalization. This kind of deep integration necessitated the development of a system of rules, which have constrained the ability of states to pursue the kind of economic policy, particularly industrial policy, they want, and therefore undermined democracy.

Hyper-globalization created a sense that ‘the nation state has fundamentally lost control of its destiny, surrendering to anonymous global forces’, as the economist Barry Eichengreen put it. Throughout the West, countries are all struggling with the same dilemma – how to reconcile openness and deep integration on the one hand, and democracy, sovereignty and a sense of control on the other.

Within the EU, however, economic integration and the abolition of barriers to the movement of capital and goods went further than in the rest of the world – and the evolution of the principle of freedom of movement after the Maastricht Treaty meant that barriers to the internal movement of people were also eliminated as the EU was enlarged. What happened within the EU might be thought of as ‘hyper-regionalization’ – an extreme example, in a regional context, of a global trend.

EU member states have lost control to an even greater extent than other nation states – albeit to anonymous regional rather than global forces – and this loss of control was felt intensely within the EU. It is therefore logical that this led to an increase in Euroscepticism. Whereas the left wants to restore some barriers to the movement of capital and goods, the right wants to restore barriers to the movement of people.

However, having left the EU, the UK is uniquely well placed to find a new equilibrium. The UK has an ideological commitment to free trade that goes back to the movement to abolish the Corn Laws in the 1840s – which Johnson’s speech expressed. It is difficult to imagine the UK becoming protectionist in any meaningful sense. But at the same time, it has a well-developed sense of national and popular sovereignty, and the sense that the two go together – which is why it was so sensitive to the erosion of them through the EU. This means that Britain is unlikely to go to one extreme or the other.

In other words, the UK may be the ideal country to find a new balance between openness and integration on the one hand, and a sense of control on the other. If it can find this balance – if it can make Brexit work – the UK could be a model for a wider recalibration of sustainable globalization. That, rather than fetishizing free trade, is the real contribution the UK can make.

A version of this article was originally published in the Observer.




twee

Non-traditional security cooperation between China and south-east Asia: implications for Indo-Pacific geopolitics

8 January 2020 , Volume 96, Number 1

Xue Gong

The ‘free and open Indo-Pacific’ (FOIP) strategy, actively promoted by the United States with support from its allies and partners, is a significant geopolitical response to China's growing power and expanding influence in Asia and beyond. Beijing has adopted various new strategies to cope with the challenges related to FOIP. One of these strategies is to secure a robust relationship with south-east Asia in order to make these regional states either neutral to or less supportive of the Indo-Pacific vision. In addition to economic statecraft and soft power, Beijing believes that it can also tap into the domain of non-traditional security (NTS) to strengthen relations with this region to position itself better in the intensifying regional geopolitical competition. The article addresses the following question: what is the impact of China's NTS cooperation with south-east Asia on Beijing's geopolitical rivalry with other major powers in the Indo-Pacific region? The article argues that China's NTS cooperation with south-east Asian countries may help China maintain its geopolitical standing in the region, but it is unlikely to lead to any dramatic increase of China's strategic influence in the region. This essentially means that Beijing may be able to prevent ASEAN or most ASEAN member states from lending substantive and strong support to the Indo-Pacific construct, but it will not be able to stop ASEAN states from supporting some elements of the FOIP.




twee

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews




twee

Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles




twee

Trade, Technology and National Security: Will Europe Be Trapped Between the US and China?

Invitation Only Research Event

2 March 2020 - 8:00am to 9:15am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Sir Simon Fraser, Managing Partner of Flint Global; Deputy Chairman, Chatham House
Chair: Marianne Schneider-Petsinger, Senior Research Fellow, US and the Americas Programme, Chatham House

The US and China have entered into an increasingly confrontational relationship over trade and technology. This may force Europe to make difficult choices between the two economic superpowers – or perform a balancing act. Although the recent US-China phase-1 trade deal has eased the relationship for now, the trade and technology tensions are a structural issue and are likely to persist.

The debate over Huawei’s participation in 5G networks is an example of how the UK and other countries may face competing priorities in economic, security and foreign policy. Can Europe avoid a binary choice between the US and China? Is it possible for the EU to position itself as a third global power in trade, technology and standard-setting? What strategies should Europeans adopt to keep the US and China engaged in the rules-based international order and what does the future hold for trade multilateralism?

Sir Simon Fraser will join us for a discussion on Europe’s future role between the US and China. Sir Simon is Managing Partner of Flint Global and Deputy Chairman of Chatham House. He previously served as Permanent Secretary at the Foreign and Commonwealth Office (FCO) and Head of the UK Diplomatic Service from 2010 to 2015. Prior to that he was Permanent Secretary at the UK Department for Business, Innovation and Skills. He has also served as Director General for Europe in the FCO and Chief of Staff to European Trade Commissioner Peter Mandelson.

We would like to take this opportunity to thank founding partner AIG and supporting partners Clifford Chance LLP, Diageo plc, and EY for their generous support of the Chatham House Global Trade Policy Forum.

Event attributes

Chatham House Rule

US and Americas Programme




twee

Brain manganese and the balance between essential roles and neurotoxicity [Molecular Bases of Disease]

Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.




twee

Reconstruction in Syria: Between Political Pragmatism and Human Rights Idealism





twee

Non-traditional security cooperation between China and south-east Asia: implications for Indo-Pacific geopolitics

8 January 2020 , Volume 96, Number 1

Xue Gong

The ‘free and open Indo-Pacific’ (FOIP) strategy, actively promoted by the United States with support from its allies and partners, is a significant geopolitical response to China's growing power and expanding influence in Asia and beyond. Beijing has adopted various new strategies to cope with the challenges related to FOIP. One of these strategies is to secure a robust relationship with south-east Asia in order to make these regional states either neutral to or less supportive of the Indo-Pacific vision. In addition to economic statecraft and soft power, Beijing believes that it can also tap into the domain of non-traditional security (NTS) to strengthen relations with this region to position itself better in the intensifying regional geopolitical competition. The article addresses the following question: what is the impact of China's NTS cooperation with south-east Asia on Beijing's geopolitical rivalry with other major powers in the Indo-Pacific region? The article argues that China's NTS cooperation with south-east Asian countries may help China maintain its geopolitical standing in the region, but it is unlikely to lead to any dramatic increase of China's strategic influence in the region. This essentially means that Beijing may be able to prevent ASEAN or most ASEAN member states from lending substantive and strong support to the Indo-Pacific construct, but it will not be able to stop ASEAN states from supporting some elements of the FOIP.




twee

Bangladesh: The Trade-Off Between Economic Prosperity and Human Rights

Research Event

11 March 2020 - 1:00pm to 2:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

K. Anis Ahmed, Publisher, Dhaka Tribune and Bangla Tribune; Author of Good Night, Mr. Kissinger, Co-director, Dhaka Literary Festival
Meenakshi Ganguly, South Asia Director, Human Rights Watch
Chair: Ed Cumming, Writer, The Independent

Bangladesh's recent gains in economic and social indices, set against its record of corruption and poor civil rights, has at times been termed the ‘Bangladesh Paradox’. Yet this label is overly simplistic; the current situation proves that these trends can coexist.

The Awami League government, in power since 2009, has increased political stability, delivered unprecedented economic and social advances, and adopted a counter-terrorism strategy to stamp out extremist groups. At the same time, it is criticized for curbing civil rights and failing to hold credible elections. However, as the two previous regimes have demonstrated, the rights situation is unlikely to improve even if the Awami League were replaced.

How did worsening rights become a feature of the state irrespective of its political dispensation? An unresolved contest between political and non-political state actors may hold the key to that puzzle. The perils of the current dispensation have recently manifested in weakening economic indicators, which jeopardize the very stability and social progress for which the country has garnered much praise.

Lucy Ridout

Programme Administrator, Asia-Pacific Programme
+44 (0) 207 314 2761




twee

CBD Communiqué: Establishment of a Vibrant Partnership between the Secretariat of the Convention on Biological Diversity and the Civil Society of its Host Country: Signature of an MOU with the Canadian Environmental Network




twee

CBD Communiqué: Partnership Established between Conservation International and the Secretariat of the Convention on Biological Diversity.




twee

CBD Communiqué: Partnership forged between Japan Committee for the International Union for Conservation of Nature and the Secretariat of the Convention on Biological Diversity




twee

CBD News: The signature on 15 November 2014 of a Memorandum of Understanding between the two organisations will ensure joint implementation of the Pacific region's Framework for Nature Conservation and Protected Areas in the Pacific Island Region 2014




twee

CBD News: Each year, migratory birds complete amazing journeys between their breeding and wintering grounds. Migratory birds are a vital part of biodiversity and play a critical role in all ecosystems. They also play an important cultural, aesthetic and e




twee

CBD News: Young people between the ages of 10 and 24 comprise about 1.8 billion people, or about one quarter of the global population. This, according to the United Nations Population Fund, is the largest youth population ever.




twee

CBD News: Montreal/Rome, 9 August 2016 - The 23rd session of the Committee on Forestry (COFO23), which took place in Rome, Italy 18-22 July 2016, took an effective approach that focused on the interlinkages between forest and other sectors and issues, in




twee

CBD News: A Memorandum of Cooperation (MoC) geared towards enhancing cooperation between the Secretariats of the Convention on Biological Diversity (CBD) and the FAO International Treaty on Plant Genetic Resources for Food and Agriculture was signed today




twee

CBD Notification SCBD/OES/DC/AC/88568 (2019-115): Submission of views on possible targets and indicators for the post-2020 global biodiversity framework related to the interlinkages and interdependencies between biodiversity and climate change