Archives, Room Use Only - TF64.L8 H43 1849

Workers rush to Tiruppur Railway Station, only to be disappointed

4.75 lakh e-tokens issued for liquor sale in Delhi

Archan Chakraborty, Wei-Cheng Lin, Yu-Tsun Lin, Kuang-Jing Huang, Pei-Yu Wang, Yi-Feng Chang, Hsiang-Iu Wang, Kung-Ting Ma, Chun-Yen Wang, Xuan-Rong Huang, Yen-Hsien Lee, Bi-Chang Chen, Ya-Ju Hsieh, Kun-Yi Chien, Tzu-Yang Lin, Ji-Long Liu, Li-Ying Sung, Jau-Song Yu, Yu-Sun Chang, and Li-Mei Pai

Under metabolic stress, cellular components can assemble into distinct membraneless organelles for adaptation. One such example is cytidine 5'-triphosphate synthase (CTPS), which forms filamentous structures under glutamine deprivation. We have previously demonstrated that histidine (His)-mediated methylation regulates the formation of CTPS filaments to suppress enzymatic activity and preserve the CTPS protein under Gln deprivation, which promotes cancer cell growth after stress alleviation. However, it remains unclear where and how these enigmatic structures are assembled. Using CTPS-APEX2-mediated in vivo proximity labeling, we found that SNAP29 regulates the spatiotemporal filament assembly of CTPS along the cytokeratin network in a keratin 8 (KRT8)-dependent manner. Knockdown of synaptosome-associated protein 29 (SNAP29) interfered with assembly and relaxed the filament-induced suppression of CTPS enzymatic activity. Furthermore, APEX2 proximity labeling of keratin 18 (KRT18) revealed a spatiotemporal association of SNAP29 with cytokeratin in response to stress. Super-resolution imaging suggests that during CTPS filament formation, SNAP29 interacts with CTPS along the cytokeratin network. This study links the cytokeratin network to the regulation of metabolism by compartmentalization of metabolic enzymes during nutrient deprivation.

Eric Peterman, Mindaugas Valius, and Rytis Prekeris

During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. While the regulators of cytokinetic ring formation and contraction are well-established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin-regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of sub-plasma membrane actomyosin network within the furrow by recruiting MST4 kinase and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during late stages of cytokinetic furrowing.

Thomas O'Loughlin, Antonina J. Kruppa, Andre L. R. Ribeiro, James R. Edgar, Abdulaziz Ghannam, Andrew M. Smith, and Folma Buss

Optineurin (OPTN) is a multifunctional protein involved in autophagy, secretion as well as NF-B and IRF3 signalling and OPTN mutations are associated with several human diseases. Here we show that, in response to viral RNA, OPTN translocates to foci in the perinuclear region, where it negatively regulates NF-B and IRF3 signalling pathways and downstream pro-inflammatory cytokine secretion. These OPTN foci consist of a tight cluster of small membrane vesicles, which are positive for ATG9A. Disease mutations linked to POAG cause aberrant foci formation in the absence of stimuli, which correlates with the ability of OPTN to inhibit signalling. Using proximity labelling proteomics, we identify the LUBAC complex, CYLD and TBK1 as part of the OPTN interactome and show that these proteins are recruited to this OPTN-positive perinuclear compartment. Our work uncovers a crucial role for OPTN in dampening NF-B and IRF3 signalling through the sequestration of LUBAC and other positive regulators in this viral RNA-induced compartment leading to altered pro-inflammatory cytokine secretion.

Mike Okamoto poses as Shogun Santa with visitors to Japanese Village. ; Credit: Chava Sanchez/KPCC

LA’s Asian Santa tradition is back. Shogun Santa has returned to Little Tokyo after a big loss in the community last year.  

This content is from Southern California Public Radio. View the original story at SCPR.org.

Quick Claim Settlement will enable the company to settle claims of up to Rs. 20,000/- and release the settlement amount within 30 minutes in customer’s bank account.

Bengaluru police has opened an account on short video-making platform TikTok to reach out to the people in an engaging and entertaining manner, an official said on Friday.

At a tiny outpost in the middle of Antarctica, Russian scientists are poised to become the first humans to reach a massive liquid lake that has been cut off fro

The big Japanese auto show is all about plug-in and hydrogen cars — and some even drive themselves.

The world's busiest metro system is hoping that complimentary noodles will convince morning commuters to adjust their riding habits.

Topics

Let's become a Tokyo-born hero.

HealthyTOKYO, a pioneer in the Japanese CBD oil market and the company behind the first vegan cafe in Haneda Airport announced the launch of their flagship brand, made-in-Japan CBD oil - HealthyTOKYO Yuzu Citrus 400.

Diamond Trading Platform, Supports B2B And B2C Trade In Diamonds

The revolutionary service token that offers investors an easy opportunity to profit from price drops in the crypto market.

Consensus-driven Inflationary + Deflationary Token

Travel guide made by locals focuses on Kamakura and Enoshima, two small towns located one hour from Tokyo and the venue for the sailing competitions for the 2020 Tokyo Olympics, helps visitors to explore Zen and samurai culture, local life, and more.

Having a wide spectrum of clients from the ICO days, to corporate solutions on smart ledger technologies, Blockchain App Factory has now come up with the most comprehensive approach to Security Token Offerings.

HealthyTOKYO opens Japan's first dedicated CBD shop & cafe in fashionable Harajuku, Tokyo. This unique store offers a delicious vegan menu of hand-crafted CBD oil infused sweets and drinks and the widest retail range of CBD products in Japan.

EQ Token 2 IEO Phase

Live Online Interactive Stock Analysis Training Wednesday, April 1st, 2020 at 4pm PDT (7pm EDT)

A successful path for brands means they must keep the platform’s content standards top of mind as well as make regular posts and participate in what’s trending.

Please visit Marketing Land for the full article.

In order to prevent the spread of COVID-19, September's Tokyo Game Show 2020 has been cancelled, organizers announced Thursday. ...

In order to prevent the spread of COVID-19, September's Tokyo Game Show 2020 has been cancelled, organizers announced Thursday. ...

Under the e-token system, customers are given specific time for purchasing alcohol so that there is no violation of social distancing norms by people queuing up outside liquor stores.

A comparison of the different pathways that municipal solid waste (MSW) is going in large metropolitan centres such as Toyko, Paris and Mexico City is presented in the article ‘La recogida de basura en Mega-ciudades: En el marco de la sostenibilidad’ by Fabian Tron. Available in Revista INVI v.25 n.70 12/2010 on Scielo in Spanish.
[See image gallery at www.sankey-diagrams.com]
While the data on waste quantities itself is quite old and dates back to 2005, I found the system how household waste is handled differently in these three cities quite interesting. To get an idea of the “weight” of the different pathways, I decided to do a remake of the three figures as Sankey diagrams. Here is the one for Tokyo.

[See image gallery at www.sankey-diagrams.com]
Flows are in 1000 tonnes (kt) per year. There is an informal sector (Economia Informal) where waste streams are not under control of the municipality. The largest part of non-recyclable household waste goes directly to incineration or “reduction”. The remainder is led to treatment plants and eventually most of it ends up in landfill (Vertedero). Note that smaller flow quantities are over-emphasized and are not to scale (otherwise they would hardly be visible in the diagram).

If you want to see the two other Sankey diagrams, please let me know in the comments.

Ginza. Tokyo, Japan 2012 Follow me @benhuang.photography

Ginza. Tokyo, Japan 2012 Follow me @benhuang.photography

Ikebukuro. Tokyo, Japan 2012 Follow me @benhuang.photography

Prada Omotesando building by Herzog and De Meuron

Tower by Jun Mitsui

My favorite home product company, many of their products are designed by Naoto Fukasawa

Omotesando Koffee, a one man espresso bar hidden in a residential area

It was installed in the first floor of an eighty year old traditional house set to be demolished

The only seating in a small front garden

We show weak-strong uniqueness and stability results for the motion of a two or three dimensional fluid governed by the Navier-Stokes equation interacting with a flexible, elastic plate of Koiter type. The plate is situated at the top of the fluid and as such determines the variable part of a time changing domain (that is hence a part of the solution) containing the fluid. The uniqueness result is a consequence of a stability estimate where the difference of two solutions is estimated by the distance of the initial values and outer forces. For that we introduce a methodology that overcomes the problem that the two (variable in time) domains of the fluid velocities and pressures are not the same. The estimate holds under the assumption that one of the two weak solutions possesses some additional higher regularity. The additional regularity is exclusively requested for the velocity of one of the solutions resembling the celebrated Ladyzhenskaya-Prodi-Serrin conditions in the framework of variable domains.

We propose some new mixed finite element methods for the time dependent stochastic Stokes equations with multiplicative noise, which use the Helmholtz decomposition of the driving multiplicative noise. It is known [16] that the pressure solution has a low regularity, which manifests in sub-optimal convergence rates for well-known inf-sup stable mixed finite element methods in numerical simulations, see [10]. We show that eliminating this gradient part from the noise in the numerical scheme leads to optimally convergent mixed finite element methods, and that this conceptual idea may be used to retool numerical methods that are well-known in the deterministic setting, including pressure stabilization methods, so that their optimal convergence properties can still be maintained in the stochastic setting. Computational experiments are also provided to validate the theoretical results and to illustrate the conceptional usefulness of the proposed numerical approach.

The Cannabis Issue People have been enjoying cannabis for recreational purposes for centuries, including in the United States since the early 1900s. That means weed was in America a good 50 years or so before the invention of rock 'n' roll.…

Security measures for tokens comprise storing security rules associated with a generated token in a memory. A processor, communicatively coupled to the memory, accesses the security rules associated with the generated token and determines whether to encrypt the generated token by applying at least a portion of the security rules to the generated token. The processor encrypts the generated token. An interface, communicatively coupled to the processor, communicates the encrypted token to a mobile device associated with a user.

Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed. The ligands chelate to a BF2 center to produce the fluorescent dye. The disclosed dyes combine longer Stokes shifts (approximately 100 nm) with increased quantum yields. They are also photostable in aqueous and organic solutions for several hours. These dyes may be used in the labeling of biomolecules for bioimaging and assays. Also disclosed are methods for the synthesis of these dyes.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

A system and method for securing tokens to be cleaned includes a tray with a curved surface defining a channel extending along a first direction and spacers projecting from the curved surface into the channel. The spacers are disposed at regular intervals along the first direction. The curved surface also has at least one opening. The tokens may be inserted into the channel between adjacent spacers and the tray holding the tokens can be submerged into a cleaning liquid. Identical trays containing tokens can also be stacked and together submerged into the cleaning liquid. The tray holding the tokens can be placed on a drying surface that has a drainage hole, and wetness remaining on the tokens can be sucked through the hole in the channel and the drainage hole by a vacuum or blown through the hole in the channel and drainage hole by an air blower.

Despite Morgan Schneiderlin drawing first blood at Britannia Stadium, two second-half goals from Stoke sends Saints away without a point.

STOKE Park Infant School was built in 1988/89 to replace the Victorian building which became an infant school in 1958.

IF THIS is a taste of what is to come for Saints under George Burley next season, then roll on August.

To be kicked off on May 5, the 'Happy at Home: #OneCommunity LIVE' event will run every evening at 8 P.M. ET until Saturday, May 9, on the social media platform.

Under the e-token system, customers are given specific time for purchasing alcohol so that there is no violation of social distancing norms by people queuing up outside liquor stores.

PluginFox has launched an exclusive sale on two audio plugins by Tokyo Dawn Labs, offering a 50% discount for a limited time only. NOVA Gentleman’s Edition MKII is a parallel dynamic equalizer. Appearing in the familiar layout of a parametric equalizer, the plugin also includes flexible dynamics processing options allowing the coverage of an impressively […]

The post Save 50% on Tokyo Dawn’s NOVA GE & SlickEQ M equalizer plugins appeared first on rekkerd.org.

According to an official statement, the government released a web link - www.qtoken.in - where people will be designated specific time for purchasing liquor after they fill personal details. The e-tokens will be sent on the mobile phones of the registered persons, it said.

Under the e-token system, customers are given specific time for purchasing alcohol so that there is no violation of social distancing norms by people queuing up outside liquor stores.