Part mystery, part science fiction, this novel rests upon the alarming premise that time is more than a concept.

It’s not breaking news that law school graduates generally have difficulty working with clients, don’t understand the “big picture” of client matters, and aren’t well trained in negotiation. The problem for law students and law schools is exacerbated by the transition to the NextGen bar exam and a movement in various states to use alternative … Continue reading Two Short Articles Proposing Courses Teaching Preparation and Advocacy in Dispute Resolution →

Over the past two days, multiple dead birds were found along South Shore beaches, with officers from Department of Environment and Natural Resources collecting ”over 95 birds within several hours.” A Government spokesperson said, “The Department of Environment and Natural Resources [DENR] can advise that between the 5 -6th June 2022, the Bermuda Aquarium, Museum and Zoo received reports […]

Greenrock released a report from BVG Associates “to help progress offshore wind as a key potential element of a sustainable, low carbon energy system for Bermuda.” A spokesperson said, “Bermuda’s greenhouse gas emissions need to reduce 60% by 2030 to align with international efforts to limit global warming to 1.5 degrees centigrade. If warming exceeds […]

“A 60MW offshore wind farm could generate up to 40% of Bermuda’s electricity,” according to a new study released by Greenrock into Offshore Wind Feasibility. A spokesperson said, “After completing an independent review of work carried out to date a few months ago, Greenrock is pleased to announce the release of an Offshore Wind detailed […]

As part of the next steps for Bermuda’s Integrated Resource Plan [IRP], the Regulatory Authority [RA], is “exploring new sources of clean energy in the form of an offshore wind farm and is inviting the public to hear about the preliminary results prior to making a decision.” Nigel Burgess, Acting Chief Executive at the RA […]

The Regulatory Authority is reminding the public about two additional town hall events regarding the “potential of offshore wind farms for Bermuda.” A spokesperson said, “Following the success of its initial town hall meeting held in July 2023, regarding the potential of offshore wind farms for Bermuda, the Regulatory Authority is reminding the public about […]

Greenrock announced the release of the fourth study in our offshore wind feasibility study series – a Wind Speed and Annual Energy Production Analysis. A spokesperson said, “This study was commissioned to understand more accurately how much electricity could be generated by an offshore wind farm in Bermuda. “Key points from the study are as follows: […]

Carey Olsen has been named Offshore Law Firm of the Year at the Chambers High Net Worth Awards for the second year in a row. A spokesperson said, “The prestigious annual awards recognise national and international law firms which have demonstrated outstanding legal work and expertise, excellent client service and impressive strategic growth and innovation within the trusts […]

“Bermuda is now facing what can be considered a housing crisis,” Minister of Economy and Labour Jason Hayward said, adding that “various policies and interventions are needed at distinct levels relying on both public and private sector involvement to garner solutions.” Speaking in the House of Assembly today [Nov 10] the Minister said the ”Government will […]

A dead baby whale, either a Pygmy or Dwarf Sperm Whale, washed ashore on Sunday [July 21] in the east end. Patrick Talbot from the Department of Conservation said, “It was 4’ long, male and possibly a neonate (newborn) as it had no teeth yet. The animal was fairly fresh and in good condition. “A […]

[Updated] A dead whale washed up in the Devonshire Dock area this morning [Jan 23], with Aquarium staff responding to the area and removing the whale. According to people at the scene, the whale was seen floating close by the dock this morning before it was retrieved from the waters; Aquarium staff then removed the […]

Gabriella Cechini – representing Mercersburg Academy – finished second competing in Lehigh University’s Paul Short cross country run. Competing at the Lehigh University-Goodman campus in Bethlehem, Pennsylvania, Cechini clocked a personal best time of 18:29 over the 5k distance. Related Stories Armstrong Advances To Meet Of Champions Cechini Siblings Excel At 2024 Mid-Atlantic Prep Outerbridge […]

The Bermuda Underwater Exploration Institute announced the return of the Manhattan Short Film Festival, featuring Oscar-nominated shorts on September 26 and October 2. A spokesperson said, “The Bermuda Underwater Exploration Institute [BUEI] is excited to announce the return of the annual Manhattan Short Film Festival, screening this year’s Oscar-Nominated Short Films in our Tradewinds Auditorium […]

A 33-year-old woman was treated for non-life-threatening injuries after her motorcycle collided with debris on North Shore Road in Hamilton Parish, causing two hours of traffic diversions. A police spokesperson said, “At last check, a female rider hurt in a reported single vehicle Hamilton parish collision around 8:55am Monday, 30th September 2024, received treatment at […]

NASA is underfunding planetary exploration relative to recommendations made by the National Academies Decadal Survey report, resulting in mission delays and cancelations.

In the wake of the Grenfell Tower fire in London, where 79 people died or are presumed dead and many more were injured, serious concerns and questions around flammability of exterior cladding, the lack of fire sprinklers and the notion of “shelter in place,” among other subjects, have been brought to the forefront by the news media and the public at large. Jim Pauley, president and CEO of the National Fire Protection Association (NFPA), addressed these troubling fire safety issues in the upcoming edition of NFPA Journal, the association’s membership publication, which will be officially released next month.

YouTube is testing a new feature that will let creators use AI to “restyle” licensed songs for their shorts. The small group of creators with access can enter a prompt to change up different elements in a song, such as its mood or genre, and the expansion of YouTube’s Dream Track AI feature will…

The post Tips, Tricks, and Shortcuts for Unlocking Elden Ring’s Shadow of the Erdtree DLC appeared first on Xbox Wire.

Data from China's Zhurong rover has revealed what appears to be an ancient shoreline streaking through Mars' northern hemisphere.

Short breaks are among the most fundamental services for supporting families with disabled children. By providing breaks from caring and positive experiences for children and young people, they allow parent carers to focus on relationships with other children, or to have time to themselves or with their partner, leading to lower levels of psychological distress, higher levels of life satisfaction and better health. As a result, fewer parent carers reach ‘breaking point’ and fewer children require access to emergency provision or enter the looked after system. This report, commissioned by Every Disabled Child Matters, looks at the current provision of short breaks to families of disabled children in England.

As part of the implementation of the Equal Partners in Care (EPiC) Highland Carer’s Strategy 2014-2017 it was agreed to undertake a review of respite for Adult Carers of Adults (aged 16+). Independent consultants were commissioned by NHS Highland through Connecting Carers to undertake this work. There are four groups of people – totalling an estimated 200 people - with whom conversations have taken place during the review: Carers and staff from carer support organisations – more than 75 carers have given their views Health and social care workforce – we have met with just over 50 people who have given their views and shared our initial findings with more than 60 others Respite providers – we have met with staff from 15 organisations that are providers of respite Those staff responsible for overseeing the commissioning, planning and administration of respite.

In 2006 Mencap produced a comprehensive review of short break provision. Now, 10 years on, they are revisiting the support available for family carers to see whether recent policy initiatives and investment have delivered the much-needed change. A total of 264 family carers responded to their survey on short breaks provision and experiences of caring. They also sent Freedom of Information requests to all 152 local authorities in England that provide social care services. This report looks at short breaks provision in a climate of cuts to central and local government budgets. It examines the extent to which these cuts have impacted on the lives of people with a learning disability and their family carers. It also looks at the state of affairs for family carers of children and young people across the full spectrum of learning disability; from people with mild and moderate learning disabilities, to people with severe and profound disabilities.

The 10th international short break conference took place in Edinburgh from 13 to 15 September 2016. This conference report explores the barriers experienced in accessing short breaks and how these have been overcome.

Classic, buttery, whole wheat shortbread cookies. They're fragrant with rosewater, flecked with toasted nuts, and dried rose petals.

Continue reading Rose Shortbread Cookies on 101 Cookbooks

Mathilde Bédouet's 'Summer 96' qualified for the Oscars by winning the prestigious César Award, France's equivalent of the Academy Award.

The NFB film earned its Oscars qualification by winning the Helen Hill Award for animated short at the New Orleans Film Festival.

In this Oscar-qualified short, a group of friends go on a roadtrip as their car – and their country – falls apart.

Three-time Oscar nominee Torill Kove, who won the Academy Award for her short 'The Danish Poet,' is back in the Oscars race this year with a new film about her memories of growing up in Kenya.

Virgin Atlantic and British Airways have announced further suspension of routes

40% of AI data centers will face operational constraints due to power shortages by 2027 as AI drives unprecedented energy consumption, research firm Gartner said on Tuesday. Data center power requirements for AI-optimized servers are projected to reach 500 terawatt-hours annually by 2027, more than double 2023 levels, as companies rapidly expand facilities to handle large language model training and implementation. The surge in power demand will outpace utility providers' ability to expand capacity, Gartner analyst Bob Johnson said, leading to higher electricity costs that will cascade through the AI industry. Some operators are already seeking direct agreements with power producers to secure guaranteed supply.

Read more of this story at Slashdot.

velocityconf: RT @avleen: Ok folks, home stretch! We need 10 more people to record short #OpsSchool videos NEXT WEEK at @velocityconf. We can do it!...

If you are the type of person that likes to spoil a game from the off then Brighter Shores is… Continue reading Brighter Shores infinite money glitch – get cash rich with all the money you will ever need

The post Brighter Shores infinite money glitch – get cash rich with all the money you will ever need appeared first on ReadWrite.

Brighter Shores brings some of those classic MMORPG quests we know and love which take you on various twists and… Continue reading How to get the Fetid Flounder in Brighter Shores

The post How to get the Fetid Flounder in Brighter Shores appeared first on ReadWrite.

If you have ever accidentally hit that key below the escape key during a game and a large, scary text… Continue reading All console commands for Brighter Shores

The post All console commands for Brighter Shores appeared first on ReadWrite.

Since Brighter Shores is a game made by the original co-creator of Runescape, there are many comparisons between the two… Continue reading Brighter Shores Bank system explained and how to access

The post Brighter Shores Bank system explained and how to access appeared first on ReadWrite.

Three years ago, Chris Wallace walked away from Fox News over concerns that those at the “Fair and Balanced” network were beginning to, as he put it, “question the truth.” […]

The post CNN Host Reportedly Leaving Network After Short-Lived Stay: His Career Change Is Completely Absurd appeared first on The Western Journal.

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Madison T Wright
Nov 18, 2020; 0:RA120.002168v1-mcp.RA120.002168
Research

Gerhard Liebisch
Dec 1, 2020; 61:1539-1555
Special Report

A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for T3 and T4 hormones. Many characterized Tg gene mutations produce secretion-defective variants resulting in congenital hypothyroidism (CH). Tg processing and secretion is controlled by extensive interactions with chaperone, trafficking, and degradation factors comprising the secretory proteostasis network. While dependencies on individual proteostasis network components are known, the integration of proteostasis pathways mediating Tg protein quality control and the molecular basis of mutant Tg misprocessing remain poorly understood. We employ a multiplexed quantitative affinity purification–mass spectrometry approach to define the Tg proteostasis interactome and changes between WT and several CH-variants. Mutant Tg processing is associated with common imbalances in proteostasis engagement including increased chaperoning, oxidative folding, and engagement by targeting factors for ER-associated degradation (ERAD). Furthermore, we reveal mutation-specific changes in engagement with N-glycosylation components, suggesting distinct requirements for one Tg variant on dual engagement of both oligosaccharyltransferase complex isoforms for degradation. Modulating dysregulated proteostasis components and pathways may serve as a therapeutic strategy to restore Tg secretion and thyroid hormone biosynthesis.

Methods to shorten [¹⁸F]FDG Patlak PET imaging procedures ranging from 65–90 to 20–30 min after injection, using a population-averaged input function (PIF) scaled to patient-specific image-derived input function (IDIF) values, were recently evaluated. The aim of the present study was to explore the feasibility of ultrashort 10-min [¹⁸F]FDG Patlak imaging at 55–65 min after injection using a PIF combined with direct Patlak reconstructions to provide reliable quantitative accuracy of lung tumor uptake, compared with a full-duration 65-min acquisition using an IDIF. Methods: Patients underwent a 65-min dynamic PET acquisition on a long-axial-field-of-view (LAFOV) Biograph Vision Quadra PET/CT scanner. Subsequently, direct Patlak reconstructions and image-based (with reconstructed dynamic images) Patlak analyses were performed using both the IDIF (time to relative kinetic equilibrium between blood and tissue concentration (t*) = 30 min) and a scaled PIF at 30–60 min after injection. Next, direct Patlak reconstructions were performed on the system console using only the last 10 min of the acquisition, that is, from 55 to 65 min after injection, and a scaled PIF using maximum crystal ring difference settings of both 85 and 322. Tumor lesion and healthy-tissue uptake was quantified and compared between the differently obtained parametric images to assess quantitative accuracy. Results: Good agreement was obtained between direct- and image-based Patlak analyses using the IDIF (t* = 30 min) and scaled PIF at 30–60 min after injection, performed using the different approaches, with no more than 8.8% deviation in tumor influx rate value (K_i) (mean difference ranging from –0.0022 to 0.0018 mL/[min x g]). When direct Patlak reconstruction was performed on the system console, excellent agreement was found between the use of a scaled PIF at 30–60 min after injection versus 55–65 min after injection, with 2.4% deviation in tumor K_i (median difference, –0.0018 mL/[min x g]; range, –0.0047 to 0.0036 mL/[min x g]). For different maximum crystal ring difference settings using the scan time interval of 55–65 min after injection, only a 0.5% difference (median difference, 0.0000 mL/[min x g]; range, –0.0004 to 0.0013 mL/[min x g]) in tumor K_i was found. Conclusion: Ultrashort whole-body [¹⁸F]FDG Patlak imaging is feasible on an LAFOV Biograph Vision Quadra PET/CT system without loss of quantitative accuracy to assess lung tumor uptake compared with a full-duration 65-min acquisition. The ultrashort 10-min direct Patlak reconstruction with PIF allows for its implementation in clinical practice.

The movement toward open source AI made progress today when the Open Source Initiative released the first Open Source AI Definition (OSAID). While the OSAID provides one step forward, the […]

The post OSI Open AI Definition Stops Short of Requiring Open Data for LLMs appeared first on HPCwire.

The nation's depleted supply of IV solutions is recovering after a North Carolina facility recently resumed production after Hurricane Helene temporarily put it out of business.

Despite a $6,100 teacher pay raise this spring, school districts report that they're starting the new academic year with nearly 500 teaching vacancies.