Tumor hypoxia, an integral biomarker to guide radiotherapy, can be imaged with ¹⁸F-fluoromisonidazole (¹⁸F-FMISO) hypoxia PET. One major obstacle to its broader application is the lack of standardized interpretation criteria. We sought to develop and validate practical interpretation criteria and a dedicated training protocol for nuclear medicine physicians to interpret ¹⁸F-FMISO hypoxia PET. Methods: We randomly selected 123 patients with human papillomavirus–positive oropharyngeal cancer enrolled in a phase II trial who underwent 123 ¹⁸F-FDG PET/CT and 134 ¹⁸F-FMISO PET/CT scans. Four independent nuclear medicine physicians with no ¹⁸F-FMISO experience read the scans. Interpretation by a fifth nuclear medicine physician with over 2 decades of ¹⁸F-FMISO experience was the reference standard. Performance was evaluated after initial instruction and subsequent dedicated training. Scans were considered positive for hypoxia by visual assessment if ¹⁸F-FMISO uptake was greater than floor-of-mouth uptake. Additionally, SUV_max was determined to evaluate whether quantitative assessment using tumor-to-background ratios could be helpful to define hypoxia positivity. Results: Visual assessment produced a mean sensitivity and specificity of 77.3% and 80.9%, with fair interreader agreement ( = 0.34), after initial instruction. After dedicated training, mean sensitivity and specificity improved to 97.6% and 86.9%, with almost perfect agreement ( = 0.86). Quantitative assessment with an estimated best SUV_max ratio threshold of more than 1.2 to define hypoxia positivity produced a mean sensitivity and specificity of 56.8% and 95.9%, respectively, with substantial interreader agreement ( = 0.66), after initial instruction. After dedicated training, mean sensitivity improved to 89.6% whereas mean specificity remained high at 95.3%, with near-perfect interreader agreement ( = 0.86). Conclusion: Nuclear medicine physicians without ¹⁸F-FMISO hypoxia PET reading experience demonstrate much improved interreader agreement with dedicated training using specific interpretation criteria.

A low-carbohydrate diet may help adults with type 2 diabetes gain better blood sugar control and make it possible to decrease diabetes medication, a new study suggests.

Michele Deodato
Oct 2, 2024; 44:e2308232024-e2308232024
BehavioralSystemsCognitive

Scientists converted the patient’s own cells into blood sugar-regulating cell clusters before injecting them back into her abdomen—and one year later, she still doesn't need insulin injections

Babies who were conceived and born during the period of rationing in the United Kingdom were less likely to develop certain diseases as adults, a new study finds

In a major update to the camera system, analyst Ming-Chi Kuo says the iPhone 18 Pro's wide angle lens will be upgraded to have a variable aperture.

Here's all you need to know about the two vendors that deal with the finest quality Rolex replica watches

DOVER, DE (MAY 9, 2022) – The Delaware Division of Public Health’s (DPH) Diabetes & Heart Disease Prevention & Control Program (DHDPC) and the Delaware Diabetes Coalition are co-sponsoring the 20th Annual Diabetes Wellness Expo on May 10, 2022, at the Delaware State Fairgrounds in Harrington, Delaware. The event is free to the public and will be […]

Hi,

I want to define a procedure that with @key, and I also want to restrict the variable's datatype, I tried with folloing but I received error in CIW

procedure(tt(handler @key str1 str2 "ssS")
  printf("handler: %L " handler)
)

tt('test)

The error is like: *Error* tt: argument for keyword ?str1 should be a symbol (type template = "ssS") at line 11 of file

Thanks,

James

Designers have long recognized the need to analyze the reliability of ICs. Two commonly used approaches for performing reliability analysis include calculating the change in device degradation and relying on safe operating checks in circuit simulators. 

With the advent of the ever-increasing use of ICs in mission-critical applications, the need for reliable reliability analysis has become of paramount importance. Over the years, you have been using reliability analysis in Virtuoso ADE Assembler and Virtuoso ADE Explorer to measure and review aging effects, such as device characteristic degradations, model parameter changes, self-heating effects, and so on.

Reliability analysis can be performed using two modes: Spectre native and RelXpert. The reliability analysis analyzes the effect of time on circuit performance drift and predicts the reliability of designs in terms of performance. In ADE Assembler, you can run the reliability simulation for fresh test (when time is zero), stress test (to generate degradation data), and aged test (at specific intervals, such as one year, three years, or 10 years). In the stress test, extreme environmental conditions are used to stress devices before aging analysis.

The following figure shows the reliability simulation flow.

The Reliability Options form has the following four tabs: 

• Basic: Enables you to specify analysis type, aging options, start and stop time of reliability simulation, and options related to device masking, degradation ratio, and lifetime calculation. 

• Modeling: Enables you to choose the modeling type you want to use during reliability simulation. 

• Degradation: Enables you to specify the options to print device and subcircuit degradation information into a .bt0 file. 

• Output: Enables you to specify the degradation reports to be generated and methods to filter degradation results in the reports.

While the Basic and the Output tabs are used by design engineers, the Modeling and the Degradation tabs are primarily used by model developers.

Reviewing degradation reports in text or XML formats can be a tiresome exercise because degradation data can be large and can contain a large number of instances due to advanced technology nodes and post-layout simulations. For you to work effectively and interactively with these reports, the new reliability report is based on the SQLite database, which adds the benefit of improved performance and capabilities of sorting and filtering reliability data using SQLite operators.

As they say, watching this in action might help you more than reading about it, so please take a look at our Training Bytes video channel, which offers many helpful videos on how to run Reliability Analysis in Virtuoso Studio.

All the related videos are linked together in a channel so that you can easily access and watch as many as you like.

Reliability Analysis in Virtuoso Studio

Want to Learn More?

For lab instructions and a downloadable design, enroll for the online training courses of your interest on

Reliability Analysis in Virtuoso Studio vIC23.1 (Online)

 Training is also available as "Blended" or "live" class.

Digital Badge Available

You can become Cadence Certified once you complete the course (s) and share your knowledge and certifications on social media channels. Go straight to the course exam at the Learning and Support Portal.

Note: Some of the above links are accessible only to Cadence customers who have a valid login ID for the Cadence Learning and Support Portal.

Do You Have Access to the Cadence Support Portal?

If not, follow the steps below to create your account.

• On the Cadence Support portal, select Register Now and provide the requested information on the Registration page.
• You will need an email address and host ID in order to sign up.
• If you need help with registration, contact support@cadence.com.

To stay up-to-date with the latest news and information about Cadence training and webinars, subscribe to the Cadence Training emails.

If you have questions about courses, schedules, online, public, or live onsite training, reach out to us at Cadence Training.

Related Resources

About Knowledge Booster Training Bytes

Knowledge Booster Training Bytes is an online journal that relays information about Cadence Training videos, online courses, and upcoming webinars that are available in the Learning section of the Cadence Learning and Support portal. This blog category brings you direct links to these videos, courses, and other related material on a regular basis.

Niyati Singh

On behalf of the Cadence Training team

Hello, I was wondering how can I create variable fields in the layout.

To start, I have a template for some type of designs, and I would like that one of the texts on the silkscreen changes accordingly to an external variable, like the folder name, or a text file in the same folder.

I was thinking something similar to a page frame that changes the date automatically. How can I generate that type of fields?

Hello everyone, 
I have a testbench for generating s2p files from a SP simulation that was working until few months ago. Today I have reopened (w/o making changes that I am aware of) and I get the error as shown below:

first I show the testbench settings:

notice how the s2p generation is disabled: the field "file" is left blank

in the corner I defined some parameters, "filename" is the word that is suppose to generate the name for the s2p. 

where the two variables are defined as follows

And now the output log:

spectre.out file gives the following error:


When clicking on the error message at "9", the input.scs file opens up and the line 9 gets highlighted in green



now, so far I understood that the problem seem to be related tom the "pathcds" variable, but I really don't understand what the error message here means, since I don't see any error in the input.scs file

by the way - if for instance I define the variable "filename" as shown below, then I get no errors:

thanks
Tommaso

I want to plot the inductance through formula L1=(imag(Z(1,1))/(2*pi*freq)), but the system tells me that the freq is unbound variable? What can I do?

Read through this blog to know more about the new Reliability Report view in Virtuoso ADE Assembler and Virtuoso ADE Explorer.(read more)

Title: Pomegranate Helps Diabetic Hearts
Category: Health News
Created: 8/30/2006 12:00:00 AM
Last Editorial Review: 8/30/2006 12:00:00 AM

Title: Gestational Diabetes Ups Child Obesity
Category: Health News
Created: 8/29/2007 12:00:00 AM
Last Editorial Review: 8/29/2007 12:00:00 AM

Title: 6 Deaths Reported From Diabetes Drug Byetta
Category: Health News
Created: 8/28/2008 12:00:00 AM
Last Editorial Review: 8/28/2008 12:00:00 AM

Title: Heart Risks the Same With 2 Diabetes Drugs: Study
Category: Health News
Created: 8/24/2010 6:10:00 PM
Last Editorial Review: 8/25/2010 12:00:00 AM

Title: Type 2 Diabetes May Have Link to Alzheimer's
Category: Health News
Created: 8/26/2010 10:43:00 AM
Last Editorial Review: 8/26/2010 10:43:52 AM

Title: Confusion Over Diabetes Types Adds to Patients' Woes
Category: Health News
Created: 8/29/2012 10:05:00 AM
Last Editorial Review: 8/29/2012 12:00:00 AM

Title: Health Tip: On the Go With Diabetes
Category: Health News
Created: 8/29/2012 8:05:00 AM
Last Editorial Review: 8/29/2012 12:00:00 AM

Title: Psoriasis Linked to Diabetes
Category: Health News
Created: 8/30/2012 11:00:00 AM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: In Diabetes, Any Protein in Urine May Signal Heart Risk
Category: Health News
Created: 8/30/2012 6:06:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Sleep Apnea Seen in Pregnant Women With Gestational Diabetes
Category: Health News
Created: 8/23/2013 12:35:00 PM
Last Editorial Review: 8/26/2013 12:00:00 AM

Title: Gene May Raise Diabetics' Chances of Heart Disease
Category: Health News
Created: 8/27/2013 4:35:00 PM
Last Editorial Review: 8/28/2013 12:00:00 AM

Title: Study May Explain Why Some Obese People Don't Get Diabetes
Category: Health News
Created: 8/27/2013 2:35:00 PM
Last Editorial Review: 8/28/2013 12:00:00 AM

Title: In Type 2 Diabetes, Gut May 'Taste' Sugar Differently
Category: Health News
Created: 8/28/2013 2:35:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM

Title: Whole Fruits Tied to Lower Diabetes Risk
Category: Health News
Created: 8/30/2013 9:35:00 AM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: Urine Test May Show Risk of Mental Decline in People With Type 2 Diabetes
Category: Health News
Created: 8/29/2013 5:36:00 PM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: Health Tip: Manage Stress to Keep Diabetes in Check
Category: Health News
Created: 8/25/2014 7:35:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM

Title: Exercise Best Bet Against Diabetes for College Graduates
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: How Reliable Are Medical Studies? Half of Findings Couldn't Be Replicated
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: Antibiotics Linked to Type 2 Diabetes Risk
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: Mouse Study Suggests Antibiotics in Kids Might Help Spur Type 1 Diabetes
Category: Health News
Created: 8/22/2016 12:00:00 AM
Last Editorial Review: 8/23/2016 12:00:00 AM

Title: Diabetes Drug May Help Kids With Autism Fight Unwanted Pounds
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM

Title: U.S. Deaths From Suicide, Drugs Surpass Diabetes
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM