Advice course for sufferers to begin in Erdington.

You might have heard people talk about IAB podcast stats, measurement guidelines, compliance, and certification. Here's what all of that means, and whether it even matters!

The post Do IAB-Certified Stats Matter for Your Podcast? first appeared on The Audacity to Podcast.

En los “temas de país”, panelistas analizaron la viabilidad y las implicaciones de las propuestas económicas que han planteado los candidatos a la Presidencia.

Panelistas analizaron el panorama de la diabetes en el país; los hábitos que permiten su complicación y los desafíos que enfrenta el sistema de salud

Panelistas advierten que el país debe transitar hacia proyectos de energía eólica y solar, pero manteniendo la confiabilidad que ofrece la generación hidráulica y térmica.

http://www.musicxray.com/xrays/2672410 bbyrne - GeorgiaBorn

DIABETES.

Diabetes infantil y lo que debe saber sobre ella.

La neuropatía diabética.

La actriz Sandra Beltrán mencionó que hace dos años comenzó a presentar síntomas que afectaron su calidad de vida.

Cada 14 de noviembre se desarrolla el Día Mundial de la Diabetes

En el programa 10AM de Caracol Radio, Clara López defendió la confiabilidad del sistema electoral venezolano. 

Among jazz trombonists with a sense of history, the name J.J. Johnson is spoken with an admiration that borders on reverence. Johnson was a pacesetter, a creative and articulate slideman and improviser who, either alone or with sometime partner Kai Winding, held the keys to the trombone kingdom from the early 1940s until his retirement more than half a century later... [ read more ]

En 6AM Hoy por Hoy, Juan Manuel Charry, abogado constitucionalista, analiza la decisión del presidente Gustavo Petro de abrir la puerta a una Asamblea Nacional Constituyente y las implicaciones que conyeba en la estructura constitucional del país.

En Caracol Radio estuvo la doctora Tatiana Villarreal, médica internista, aclarando porqué el gremio de la salud cuestiona el borrador tarifario del sistema

Varios alcaldes, entre ellos Alejandro Eder enviaron una carta al presidente Petro para pedir que retome los bombardeos y elimine las restricciones para enfrentar a los grupos armados

En el programa 10AM de Caracol Radio, Clara López defendió la confiabilidad del sistema electoral venezolano. 

Rodrigo Negrete, director de la ANLA, aseguró que una vez subsanen los problemas actuales, esta organización tomará una nueva decisión dentro de tres meses

“O s’abaixen els preus, o vaga de lloguers”. Aquesta és la consigna que han llançat les organitzacions en defensa de l’habitatge en els últims mesos. via Pocket

Mosaic has added 13 leading US environmental risk specialists to its team as the company drives a strategic buildout of business across the Americas A spokesperson said, “The expansion marks the next stage of rapid growth for Mosaic’s Environmental Liability division which the company launched as its seventh line of business less than two years […]

The Bermuda Diabetes Association, together with local partners, will introduce the Blue Circle Walk on October 28, a self-guided route in Hamilton designed to promote healthier lifestyles. A spokesperson said, “The Bermuda Diabetes Association with the support of the Corporation of Hamilton and many Hamilton businesses are launching a self guided walking route around the […]

The Bermuda Diabetes Association has launched the ‘LABELS’ campaign to “raise awareness around diabetes-related stigma.” A spokesperson said, “Ahead of National Diabetes Awareness Month [November], the Bermuda Diabetes Association has launched a campaign called LABELS to raise awareness around diabetes-related stigma. The campaign aims to #EndDiabetesStigma by spotlighting the harmful effects that a choice of […]

Modula 5 mg is a medication that contains Tadalafil, which is commonly used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). It works by increasing blood flow to the penis during sexual activity, which helps achieve and maintain an erection. For individuals with diabetes, Tadalafil can generally be used safely, but some factors should be considered when choosing the right formulation: Factors to Consider for Individuals with Diabetes: Impact on Blood Sugar: Tadalafil itself doesn’t directly affect blood sugar levels, but individuals with diabetes need to manage their overall health, including blood sugar levels, when using medications for ED. It’s important to monitor blood glucose levels regularly while on Tadalafil. Formulation of Modula 5 mg: Modula 5 mg is typically available in tablet form. The tablet formulation is suitable for people with diabetes, as it is not known to contain sugar or carbohydrates that could directly affect blood sugar. Oral tablets like Modula 5 mg are often preferred because they allow for controlled, consistent dosing. Side Effects: People with diabetes may be more prone to certain side effects, such as dizziness, headaches, or blurred vision. These side effects are more common in individuals who have other underlying conditions (such as cardiovascular issues) that may co-occur with diabetes. It's important to start with a lower dose, like 5 mg, and adjust based on tolerance and effectiveness, in consultation with a healthcare provider. Cardiovascular Health: Diabetes often comes with an increased risk of heart disease, which is also a concern when using medications like Tadalafil. It’s crucial to consult a healthcare provider to ensure that there are no contraindications with any existing heart conditions before starting MODULA 5 MG. Other Medications: People with diabetes may be on other medications to manage their condition, such as insulin or oral medications for blood sugar control. Tadalafil can interact with certain medications, especially nitrates (used for chest pain), leading to dangerous drops in blood pressure. Therefore, it is essential to ensure that Modula 5 mg doesn’t interact with any other ongoing treatments. Recommendation for People with Diabetes: Modula 5 mg (Tadalafil) in its tablet formulation is generally a suitable option for individuals with diabetes, provided they are managing their blood sugar levels effectively and have discussed the use of this medication with their healthcare provider. If there are concerns about side effects or interactions with other medications, starting with a lower dose or exploring other alternative treatments for ED may be recommended. Key Takeaways: Modula 5 mg (Tadalafil) is safe for most individuals with diabetes, but it's crucial to check for potential interactions with diabetes medications. Monitoring blood sugar and blood pressure regularly while using Tadalafil is essential for safety. Always consult a healthcare provider to ensure the medication is appropriate based on your medical history and current treatments. If you have specific concerns, such as interactions with your diabetes medications or heart conditions, consulting with your doctor is the best course of action before starting any treatment.

This month's nycdevops meetup speaker is Nathen Harvey of Google, who will give a talk titled "Introduction to Site Reliability Engineering".

The talk starts at 5pm sharp! (NY is in US/Eastern)

Please RSVP! See you there!

https://www.meetup.com/nycdevops/events/272956481/

(This is a virtual meetup. Everyone around the world is invited!)

“His mathematical legacy is enormous,” said John D’Angelo *76. “Joe was among the most friendly, popular and influential mathematicians of his generation.”

In a world overflowing with information, the ability to discern reliable sources has never been more critical. Many individuals resonate with a moment of uncertainty—perhaps it was a social media post that seemed too outrageous, or an article that didn’t quite align with the facts they knew. This is a common experience in today’s digital ... Read more

The post How to Distinguish Between Reliable and Unreliable Sources in the Digital Age appeared first on Star Two.

Texts classified according to guided reading levels (GRL) are ubiquitous in U.S. beginning reading classrooms. This study examined features of texts across three grade bands (kindergarten, early first grade, final first grade) and the 10 GRLs within these bands. The 510 texts came from three programs with different functions in beginning reading instruction: core, intervention, and content areas.

Ta Cong Son, Tran Manh Cuong, Le Quang Dung and Le Van Dung
Theor. Probability and Math. Statist. 111 (), 153-165.
Abstract, references and article information

Abdessamad Dehaj and Mohamed Guessous
Theor. Probability and Math. Statist. 111 (), 1-8.
Abstract, references and article information

Benjamin Jaye and Manasa N. Vempati
Proc. Amer. Math. Soc. 152 (), 5105-5116.
Abstract, references and article information

Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how the high risk variant (Arg-325), which is also a higher frequency (>50%) allele, is correlated with zinc transport activity. Here, we compared the activity of Arg-325 with that of a low risk ZnT8 variant (Trp-325). The Arg-325 variant was found to be more active than the Trp-325 form following induced expression in HEK293 cells. We further examined the functional consequences of changing lipid conditions to mimic the impact of lipid remodeling on ZnT8 activity during insulin granule biogenesis. Purified ZnT8 variants in proteoliposomes exhibited more than 4-fold functional tunability by the anionic phospholipids, lysophosphatidylcholine and cholesterol. Over a broad range of permissive lipid compositions, the Arg-325 variant consistently exhibited accelerated zinc transport kinetics versus the Trp-form. In agreement with the human genetic finding that rare loss-of-function mutations in ZnT8 are associated with reduced T2D risk, our results suggested that the common high risk Arg-325 variant is hyperactive, and thus may be targeted for inhibition to reduce T2D risk in the general populations.

Visual Abstract

Philipp Emanuel Geyer
Dec 17, 2020; 0:RA120.002359v1-mcp.RA120.002359
Research

Julia V Busik
Dec 23, 2020; 0:jlr.TR120000981v1-jlr.TR120000981
Thematic Reviews

Jenny E. Kanter
Dec 8, 2020; 0:jlr.ILR120001217v1-jlr.ILR120001217
Images in Lipid Research

In SAS Customer Intelligence Studio, you might notice that the user interface becomes unresponsive, as shown below: imgalt="SAS Customer Intelligence Studio UI becomes unresponsive" src="{fusion_66537

In SAS Customer Intelligence Studio, you can choose to create a new calculated variable in the Edit Value dialog box when you populate a treatment custom detail. Following creation of the new calculated

In SAS Customer Intelligence Studio,  when you add  Reply- node variable values in the Define Value dialog box, you might notice that two identically labeled data-grid variables are

Lipid metabolic abnormalities have emerged as potential risk factors for the development and progression of diabetic complications, including diabetic retinopathy (DR).  This review article provides an overview of the results of clinical trials evaluating the potential benefits of lipid lowering drugs, such as fibrates, omega 3 fatty acids, and statins, for the prevention and treatment of DR. Although several clinical trials demonstrated that treatment with fibrates leads to improvement of DR, there is a dissociation between the protective effects of fibrates in the retina, and the intended blood lipid classes, including plasma triglycerides, total cholesterol or HDL/LDL cholesterol ratio. Guided by these findings, plasma lipid and lipoprotein-independent mechanisms are addressed based on clinical, cell culture and animal model studies. Potential retinal-specific effects of fatty acids oxidation products, cholesterol, and ceramide, as well as lipid independent effects of PPAR alpha activation are summarized based on current literature. Overall, this review highlights promising potential of lipid-based treatment strategies further enhanced by the new knowledge of intra-retinal lipids and lipoproteins in DR.

The goal of clinical proteomics is to identify, quantify, and characterize proteins in body fluids or tissue to assist diagnosis, prognosis, and treatment of patients. In this way, it is similar to more mature omics technologies, such as genomics, that are increasingly applied in biomedicine. We argue that, similar to those fields, proteomics also faces ethical issues related to the kinds of information that is inherently obtained through sample measurement, although their acquisition was not the primary purpose. Specifically, we demonstrate the potential to identify individuals both by their characteristic, individual-specific protein levels and by variant peptides reporting on coding single nucleotide polymorphisms. Furthermore, it is in the nature of blood plasma proteomics profiling that it broadly reports on the health status of an individual – beyond the disease under investigation. Finally, we show that private and potentially sensitive information, such as ethnicity and pregnancy status, can increasingly be derived from proteomics data. Although this is potentially valuable not only to the individual, but also for biomedical research, it raises ethical questions similar to the incidental findings obtained through other omics technologies. We here introduce the necessity of - and argue for the desirability for - ethical and human rights-related issues to be discussed within the proteomics community. Those thoughts are more fully developed in our accompanying manuscript. Appreciation and discussion of ethical aspects of proteomic research will allow for deeper, better-informed, more diverse, and, most importantly, wiser guidelines for clinical proteomics.