ABSTRACTDespite global consensus on the importance of male involvement in family planning, disparities persist in low- and middle-income countries, where women continue to bear the responsibility for these initiatives. The Philippines, with a high fertility rate and unmet family planning needs, exemplifies this challenge. We present the experiences and lessons learned from implementing the no-scalpel vasectomy (NSV) program in Davao City, showcasing its potential for increasing male engagement in family planning decisions. Launched in 2008, the program aimed to address gender disparity by promoting NSV as a safe and effective contraceptive alternative to female-centric methods. Through the use of culturally sensitive information campaigns and couple-focused counseling, the program challenged traditional notions of masculinity and encouraged shared decision-making. Strong local government commitment and public-private partnerships played key roles in driving the program’s success. Results showed an average annual increase of 80% in NSV clients over the past 3 years compared to before the COVID-19 pandemic, underscoring its effectiveness. The program presents a compelling intervention model for similar initiatives, highlighting how overcoming cultural barriers, infrastructure limitations, and budgetary constraints through policy advocacy, strategic partnerships, and tailored approaches can significantly boost male involvement in family planning and improve reproductive health outcomes within communities.

The diagnosis of maturity-onset diabetes of the young (MODY), a monogenic form of diabetes mellitus caused by a mutation in a single gene, is often uncertain until genetic testing is performed. We report a 13-yr-old Korean boy who was initially diagnosed with type 2 diabetes (T2DM). MODY was suspected because of his nonobese body habitus and family history of multiple affected members. Targeted panel sequencing of all MODY-related genes was performed using the NextSeq 550Dx platform (Illumina). Sanger sequencing was performed using blood samples from the parents, siblings, and other relatives. A frameshift variant in the 3' region of the last exon of PDX1 was detected in the patient and his family members with diabetes. PP1_Moderate criterion was applied and this variant was confirmed to be the genetic cause of diabetes in the family and classified as likely pathogenic. The study highlights the importance of genetic testing for nonobese, early-onset diabetic patients with multiple affected family members. Increased awareness and aggressive genetic testing for MODY are needed.

Anorectal malformations (ARMs) constitute a group of congenital defects of the gastrointestinal and urogenital systems. They affect males and females, with an estimated worldwide prevalence of 1 in 5000 live births. These malformations are clinically heterogeneous and can be part of a syndromic presentation (syndromic ARM) or as a nonsyndromic entity (nonsyndromic ARM). Despite the well-recognized heritability of nonsyndromic ARM, the genetic etiology in most patients is unknown. In this study, we describe three siblings with diverse congenital anomalies of the genitourinary system, anemia, delayed milestones, and skeletal anomalies. Genome sequencing identified a novel, paternally inherited heterozygous Caudal type Homeobox 2 (CDX2) variant (c.722A > G (p.Glu241Gly)), that was present in all three affected siblings. The variant identified in this family is absent from population databases and predicted to be damaging by most in silico pathogenicity tools. So far, only two other reports implicate variants in CDX2 with ARMs. Remarkably, the individuals described in these studies had similar clinical phenotypes and genetic alterations in CDX2. CDX2 encodes a transcription factor and is considered the master regulator of gastrointestinal development. This variant maps to the homeobox domain of the encoded protein, which is critical for interaction with DNA targets. Our finding provides a potential molecular diagnosis for this family's condition and supports the role of CDX2 in anorectal anomalies. It also highlights the clinical heterogeneity and variable penetrance of ARM predisposition variants, another well-documented phenomenon. Finally, it underscores the diagnostic utility of genomic profiling of ARMs to identify the genetic etiology of these defects.

PURPOSE

Meeting scholarly activity requirements continues to be a challenge in many family medicine (FM) residency programs. Studies comprehensively describing FM resident scholarship have been limited. We sought to identify institutional factors associated with increased scholarly output and meeting requirements of the Accreditation Council for Graduate Medical Education (ACGME).

PURPOSE

Despite being key to better health outcomes for patients from racial and ethnic minority groups, the proportion of underrepresented in medicine (URiM) physicians remains low in the US health care system. This study linked a nationally representative sample of family physicians (FPs) with Medicaid claims data to explore the relative contributions to care of Medicaid populations by FP race and ethnicity.

PURPOSE

Currently, 40% of counties in the United States do not have an obstetrician or midwife, and in rural areas the likelihood of childbirth being attended to by a family medicine (FM) physician is increasing. We sought to characterize the effect of the FM presence on unit culture and a key perinatal quality metric in Iowa hospital intrapartum units.

Relatives of Lyle and Erik Menendez spoke in an interview Wednesday about their long-running fears that the brothers had been abused for years before they killed their parents.

After a press conference in which they’d called for the imprisoned siblings’ freedom, the family members told Chris Cuomo on NewsNation about how their suspicions only deepened as time passed.

“Over the years we really did know that there was abuse at gut-level. But as time goes on and we all talked to each other more and more, it validates the fears and the gut-level reactions that we had,” the brothers’ cousin Karen VanderMolen-Copley told Cuomo. “That solidified the knowledge that the sexual abuse actually did occur, because that’s not something you want to believe, and then once you talk to each other it becomes more and more obvious.”

Read more at The Daily Beast.

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Whoopi Goldberg told her co-hosts Tuesday on ABC's "The View" that she agrees with Vice President Kamala Harris voters who want to avoid family members who voted for President-elect Donald Trump during the holidays.

The post Whoopi Goldberg Endorses Harris Voters Avoiding Holidays with Trump-Supporting Family — ‘It Might Not Be the Time to Gather’ appeared first on Breitbart.

The show will premiere in January 2025

FOR the first time ever, LGBTI Australians seeking fertility and IVF treatment will be able to attend newly-opened centres designed especially for rainbow patients and their families.

The post The path to achieving family dreams appeared first on Star Observer.

Choosing to start a family is one of the biggest choices a couple can make. IVFAustralia charts the challenges and pitfalls for women couples making this important decision. The desire ...

The post Planning a family with donated sperm appeared first on Star Observer.

Rachelle and Kelly Swan bought their house in Spiritwood two years ago. They gave up their keys to the bank voluntarily in May, closing the door on the bat-infested house.  

The Opposition Leader, who has three young children, says all his election travel was declared and above board.

Bill White, VP of Real Estate Lending for NASA FCU, speaks to current housing market conditions, as well as the new Family Mortgage and other options from NASA FCU.

Hsu Ginseng - Succession Plan PR

Lifestyle Expert Shares Easy Tricks For Turkey Day!

The Park Family�s Infertility Story

Trust is critical, especially for a person with autism and their family. Meet the Vollmert family and get a sense of how they approach daily life and planning for a financially secure future with their autistic son, Scott. Learn more: http://u.nm.com/1AQBAsN

Anime airs Mondays through Thursdays at 7:30 p.m. EST

bHighlights:/bul class="group-list punch-points"li Refusal by patients or kin restricts ICU entry/li liGuidelines tackle the futility of

Nurse-Family Partnership Viral Facebook Campaign Gains More Than One Million Users in Only One Day

Family members of patients recently released from hospitals are at increased risk of contracting the dangerous Methicillin-resistant Staphylococcus aureus

The family members of Rajinikanth along with multifaceted talent Raghava Lawrence watched his latest movie Darbar in Rohini Silver Screens.

Mahendra Singh Dhoni, the former captain of the Indian cricket team, is currently enjoying a vacation with his family in Phuket, Thailand. Away from the cricketing world, Dhoni is taking some time off to relax. A picture shared on his daughter

निर्देशक- विजय कृष्ण आचर्याकलाकार- विक्की कौशल, मानुषी छिल्लर, कुमुद मिश्रा, मनोज पाहवा, यशपाल शर्मा, सादिया सिद्दीकी, अलका अमीन, सृष्टि दीक्षित और वेदांत सिन्हा "हमें कहां पता होता है कि हमारा जन्म कहां हुआ है, किस घर में, किस

In 2016, she introduced Zivame Studios, creating an omni-channel experience and expanding Zivame's presence into tier 2 and tier 3 cities across India.

Manchester : Manchester University Press, [2020]

Ithaca, NY : Cornell University Press, [2023]

Manchester : Manchester University Press, [2020]