actors Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation By www.jneurosci.org Published On :: 2006-10-04 Holly OakleyOct 4, 2006; 26:10129-10140Neurobiology of Disease Full Article
actors AMR Multi-Stakeholder Partnership Platform - Creating a movement for change through engaging multiple actors and voices By www.fao.org Published On :: Wed, 18 Aug 2021 00:00:00 GMT The Tripartite organizations (FAO, OIE, WHO) invite partners to join public discussion on the establishment of the AMR Multi-Stakeholder Partnership Platform. Full Article
actors Grain, Oilseed Risk Factors By www.cmegroup.com Published On :: Wed, 20 Jan 2021 05:00:00 -0600 Macroeconomic risks for grains and oilseeds include China's growth and FX rates. Full Article [DO_NOT_USE] CME Research Soybean Product Research Article Agriculture Options FX Featured Article Corn Economic Reports Economic Events CME Group Both Erik Norland
actors In Major Push For Nuclear Power, India Asks States To Set Up Reactors By www.ndtv.com Published On :: Wed, 13 Nov 2024 04:49:16 +0530 India has ambitious plans to set up nuclear reactors across the country, especially in states where thermal power plants have either completed its life, or where access to coal is a challenge. Full Article
actors In Major Push For Nuclear Power, India Asks States To Set Up Reactors By www.ndtv.com Published On :: Wed, 13 Nov 2024 04:49:16 +0530 India has ambitious plans to set up nuclear reactors across the country, especially in states where thermal power plants have either completed its life, or where access to coal is a challenge. Full Article
actors Division of Small Business Announces Market Pressure Relief Fund Available for State Contractors By news.delaware.gov Published On :: Thu, 15 Jul 2021 20:07:01 +0000 Dover, Del. (July 15, 2021) – The Delaware Division of Small Business and Office of Management and Budget (OMB) announced today the launch of a Market Pressure Relief Fund designed to assist state contractors facing increased costs for construction materials due to the pandemic. The fund will provide adjustment reimbursements for non-transportation construction materials purchased […] Full Article Small Business DelBiz division of small business Relief Fund Small Biz State Contractors
actors Two American defense contractors sanctioned By www.shanghaidaily.com Published On :: Fri, 17 Feb 2023 00:01:00 +0800 THE Ministry of Commerce yesterday added two United States companies to the Unreliable Entity List over their involvement in arms sales to China’s Taiwan region. In a statement, the ministry said it Full Article World
actors 15-year-old aspiring actress is the first South African to attend the Universal Actors sessions in LA By www.iol.co.za Published On :: Thu, 07 Nov 2024 05:37:01 GMT Full Article
actors Sudan: Political Actors Condemn Further Airstrikes On Darfur By allafrica.com Published On :: Wed, 13 Nov 2024 05:04:33 GMT [Dabanga] Airstrikes killed dozens and injured others in Nyala and neighbouring Beleil in South Darfur and Mellit, El Koma, and Kabkabiya in North Darfur on Saturday and Sunday, according to a Radio Dabanga listener. Multiple political actors and groups have condemned the "random" air raids. Full Article Arms and Military Affairs Conflict Peace and Security East Africa Governance Legal and Judicial Affairs Sudan
actors Fusion reactors could create ingredients for a nuclear weapon in weeks By www.newscientist.com Published On :: Wed, 08 May 2024 09:00:29 +0100 Concern over the risks of enabling nuclear weapons development is usually focused on nuclear fission reactors, but the potential harm from more advanced fusion reactors has been underappreciated Full Article
actors Hybrid design could make nuclear fusion reactors more efficient By www.newscientist.com Published On :: Fri, 14 Jun 2024 17:19:26 +0100 Two types of fusion reactor called tokamaks and stellarators both have drawbacks – but a new design combining parts from both could offer the best of both worlds Full Article
actors Neighborhood Factors Could Raise Your Child's Odds for Asthma By www.medicinenet.com Published On :: Mon, 25 Jul 2022 00:00:00 PDT Title: Neighborhood Factors Could Raise Your Child's Odds for AsthmaCategory: Health NewsCreated: 7/25/2022 12:00:00 AMLast Editorial Review: 7/25/2022 12:00:00 AM Full Article
actors Impaired lung function and associated risk factors in children born prematurely: a systematic review and meta-analysis By err.ersjournals.com Published On :: 2024-10-09T00:15:15-07:00 Background Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function. Methods We searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus for relevant studies published on preterm cohorts born since 1990. Studies comparing forced expiratory volume in 1 s (FEV1) in preterm-born children aged ≥5 years to term-born controls or normative data were included. Study quality was assessed using the Newcastle–Ottawa Scale for cohort studies. Standardised mean differences in FEV1 and secondary spirometry outcomes per study were pooled using meta-analysis. The impact of different demographic and neonatal variables on studies’ FEV1 effect sizes was investigated by meta-regression analyses. Certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations framework. Results We identified 42 studies with unique cohorts including 4743 preterm children and 9843 controls. Median gestational age in the studies was 28.0 weeks and age at assessment ranged from 6.7 to 16.7 years. Preterm children had lower FEV1 than controls (–0.58 sd, 95% CI –0.69– –0.47 sd, p<0.001) resulting in a relative risk of 2.9 (95% CI 2.4–3.4) for abnormal outcome, with high certainty of evidence. FEV1 was significantly associated with gestational age, birthweight, bronchopulmonary dysplasia and invasive mechanical ventilation in univariate meta-regression analyses (R2=36–96%). Conclusion This systematic review shows robust evidence of impaired lung function in preterm-born children with a high certainty of evidence. Full Article
actors Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors [Metabolism, Transport, and Pharmacogenetics] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited. SIGNIFICANCE STATEMENT This study examined the disconnect between the in vitro synergy and in vivo efficacy of elimusertib/temozolomide combination therapy by exploring systemic and central nervous system (CNS) distributional pharmacokinetics. Results indicate that the lack of improvement in in vivo efficacy in glioblastoma (GBM) patient-derived xenograft (PDX) models could be attributed to inadequate exposure of pharmacologically active drug concentrations in the CNS. These observations can guide further exploration of elimusertib for the treatment of GBM or other CNS tumors. Full Article
actors Cyclic Aspiration in Mechanical Thrombectomy: Influencing Factors and Experimental Validation [RESEARCH] By www.ajnr.org Published On :: 2024-11-07T15:14:12-08:00 BACKGROUND AND PURPOSE: Mechanical thrombectomy is a fundamental intervention for acute ischemic stroke treatment. While conventional techniques are effective, cyclic aspiration (CyA) shows potential for better recanalization rates. We aim to investigate factors affecting CyA and compare them with static aspiration (StA). MATERIALS AND METHODS: StA setup consisted of an aspiration pump connected to pressure transducer. CyA was tested with 5 subsequent iterations: single solenoid valve with air plus saline (i1) or saline alone (i2) as aspiration medium; 2 solenoid valves with air plus saline (i3) as aspiration medium; complete air removal and saline feeding (i4); and pressurized saline feeding (i5). To assess the efficacy of clot ingestion, the pressure transducer was replaced with a distal aspiration catheter. Moderately stiff clot analogs (15 mm) were used to investigate the ingestion quantified as clot relative weight loss. Additionally, the aspiration flow rate was assessed for each setup. RESULTS: With CyA i1, the amplitude of the achieved negative pressure waves declined with increasing frequencies but progressively increased with each subsequent iteration, achieving a maximum amplitude of 81 kPa for i5 at 1 Hz. Relative clot weight loss was significantly higher with i5 at 5 Hz than with StA (100% versus 37.8%; P = .05). Aspiration flow rate was lower with CyA than with StA (i5 at 5 Hz: 199.8 mL/min versus StA: 311 mL/min; P < .01). CONCLUSIONS: CyA with the appropriate setup may represent an encouraging innovation in mechanical thrombectomy, offering a promising pathway for improving efficacy in clot ingestion and recanalization. The observed benefits warrant confirmation in a clinical setting. Full Article
actors New research to better understand the biological factors of suicidal behaviour By www.heraldscotland.com Published On :: Tue, 12 Nov 2024 06:30:00 +0000 New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour. Full Article
actors Marcus and Dom Voice Actors to Return for Gears of War: E-Day By www.vgchartz.com Published On :: Thu, 07 Nov 2024 20:52:58 GMT Publisher Xbox Game Studios and developer The Coalition have announced John DiMaggio, the voice actor for Marcus Fenix, and Carlos Ferro, the voice actor for Dom Santiago, will reprise their roles for the prequel Gears of War: E-Day. "On today's 18th anniversary of Gears of War, we're proud to share that John DiMaggio and Carlos Ferro are reprising their roles as the iconic voices of Marcus Fenix and Dominic Santiago in Gears of War: E-Day," announced the developer. Gears of War: E-Day is in development for the Xbox Series X|S, PC, and Xbox Game Pass. We are so back. ???????? On today's 18th anniversary of Gears of War, we're proud to share that John DiMaggio and @RealCarlosFerro are reprising their roles as the iconic voices of Marcus Fenix and Dominic Santiago in Gears of War: E-Day. pic.twitter.com/x9uaH9R0sR — Gears of War (@GearsofWar) November 7, 2024 A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.Full Article - https://www.vgchartz.com/article/463012/marcus-and-dom-voice-actors-to-return-for-gears-of-war-e-day/ Full Article Analysis Charts Industry
actors A Historical Mystery, Actors, & More By smartbitchestrashybooks.com Published On :: Thu, 07 Nov 2024 16:30:35 +0000 Full Article General Bitching... Ali hazelwood falon ballard Naina Kumar amanda quick
actors New Study Reveals Risk Factors for Sepsis-Related Deaths By www.medindia.net Published On :: Sepsis is a life-threatening condition that happens when the body's response to infections causes adverse effects on the tissues and organs. Dr. Finn E. Full Article
actors Bollywood actors who died by suicide and left us too soon By www.ibtimes.co.in Published On :: Fri, 03 Jul 2020 01:33:26 +0530 Let's take a look at Bollywood celebrities who chose the despicable act of suicide and left us too soon to their heavenly abode. Full Article
actors Degradation of norfloxacin by the synergistic effect of micro–nano bubbles and sodium hypochlorite: kinetics, influencing factors and pathways By pubs.rsc.org Published On :: Environ. Sci.: Processes Impacts, 2024, Advance ArticleDOI: 10.1039/D4EM00490F, PaperGuijuan Li, Yan Cheng, Mengyao Jing, Dan Zhang, Yufei Ma, Shengke YangThe degradation reaction process and influencing factors of norfloxacin in the sodium hypochlorite and micro–nano bubble composite system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Two Shakespearean Actors [Electronic book] / Richard Nelson. By encore.st-andrews.ac.uk Published On :: London : Faber & Faber (Plays), 1999. Full Article
actors Enhancement of essential cofactors for in vivo biocatalysis By pubs.rsc.org Published On :: Faraday Discuss., 2024, Accepted ManuscriptDOI: 10.1039/D4FD00013G, PaperPattarawan Intasian, Chalermroj Sutthaphirom, Oliver Bodeit , Duangthip Trisrivirat, Ninlapan Kimprasoot, Juthamas Jaroensuk, Barbara Bakker, Edda Klipp, Pimchai ChaiyenA scarcity of cofactors, necessary metabolites or substrates for in vivo enzymatic reactions are among the major barriers of product synthesis in metabolically engineered cells. This work compares our recently...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Metal–organic framework micro-nano reactors as armour of Escherichia coli for hydrogen production in air By pubs.rsc.org Published On :: Inorg. Chem. Front., 2024, 11,8070-8077DOI: 10.1039/D4QI02119C, Research ArticleYun Fan, Junyang Yan, Siyao Zhang, Ruifa Su, Baoli Zha, Weina ZhangThe MOF shell of an E. coli@ZIF-8 micro–nano reactor, used as armour for E. coli, not only protects the internal E. coli and improves its survival rate, but also delays the transport of oxygen to enable E. coli to produce hydrogen in air.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit By pubs.rsc.org Published On :: Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00891F, PaperYu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi LiThe DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Development and Simulation of Annular Flow Photoreactors: Integration of Light-Diffusing Fibers as optical diffusers with Laser Diodes By pubs.rsc.org Published On :: React. Chem. Eng., 2024, Accepted ManuscriptDOI: 10.1039/D4RE00400K, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sergio Carrillo De Hert, Rafael Lopez-Rodriguez, Michael Di Maso, Jonathan McMullen, Steven FergusonContinuous flow chemical photoreactors have emerged as a highly attractive platform, garnering considerable attention in both industry and academia. Utilizing thin channels, these reactors offer a promising solution for achieving...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Stable and permeable polyion complex vesicles designed as enzymatic nanoreactors By pubs.rsc.org Published On :: Soft Matter, 2024, Advance ArticleDOI: 10.1039/D4SM00216D, PaperYuting Wan, Yuening Qiu, Jin Zhou, Jinbo Liu, Martien A. Cohen Stuart, Yangfeng Peng, Junyou WangStable and permeable polyion complex vesicles designed as enzymatic nanoreactors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors PIX: TV actors Karan-Ankita's beautiful Greece holiday By www.rediff.com Published On :: Tue, 09 May 2017 09:15:49 +0530 Let us tour Greece with television actors Karan Patel and Ankita Bhargava. Full Article
actors TV Actors Vaibhavi Upadhyaya, Nitish Pandey No More By www.rediff.com Published On :: Wed, 24 May 2023 12:11:24 +0530 Vaibhavi rose to fame with Sarabhai vs Sarabhai while Nitish starred in Anupama. Full Article
actors Meet 2017's Highest Paid Actors In the World By www.rediff.com Published On :: Thu, 24 Aug 2017 23:02:32 +0530 The Khans and the Kumar make it to the list! Full Article Mark Wahlberg Daddy Paramount Pictures Kumar Andreas Baywatch
actors What are the effects of environmental factors on Co speciation at the magnetite surface? By pubs.rsc.org Published On :: Environ. Sci.: Nano, 2024, Advance ArticleDOI: 10.1039/D3EN00962A, PaperLaura Fablet, Fadi Choueikani, Mathieu Pédrot, Rémi MarsacMagnetite nanoparticles are abundant in the environment and are notably used for environmental applications due to their unique magnetic, adsorption and redox properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Chennai-based organisation invokes actors, celebrities to bring attention to climate change issues By www.thehindu.com Published On :: Mon, 19 Dec 2022 16:00:03 +0530 The organisation, Poovulagin Nanbargal, uses the birth dates and birth places of popular Tamil actors to highlight how climate change, such as increasing hot days, has affected the State over the decades Full Article Chennai
actors A review on instability factors of mono- and divalent metal ion batteries: from fundamentals to approaches By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, 12,30190-30248DOI: 10.1039/D4TA05386A, Review ArticleElmira Kohan, Roushan Khoshnavazi, Mir Ghasem Hosseini, Abdollah Salimi, Mehdi Salami-KalajahiDegradation phenomena in different components (cathode, anode, current collectors (CCs)) of mono- and divalent metal-based batteries affect their performance.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Mahindra unveils light weight compact tractors By www.thehindu.com Published On :: Tue, 15 Aug 2023 14:12:31 +0530 The new OJA range brings about a transformative shift in Light Weight Compact 4 wheel drive Tractor design and engineering, to deliver an edge innovation in tractor technology Full Article Industry
actors Bharat Small Reactors being readied, modification of 220 MW reactors under way, says Atomic Energy Commission’s Grover By www.thehindubusinessline.com Published On :: Sat, 17 Aug 2024 15:16:01 +0530 Modification minimal, change incremental, says RB Grover Full Article Economy
actors Small reactors could take off soon, says former AEC Chairman Kakodkar By www.thehindubusinessline.com Published On :: Mon, 02 Sep 2024 11:21:27 +0530 Kakodkar spoke about BSR development and a new type of fuel, ANEEL — a concoction of highly enriched uranium and thorium that is making waves in the nuclear energy sector Full Article Science
actors Study on the time-resolved detection performance of β-Ga2O3-based SBUV photodetectors: surface chemical analysis and the impacts of non-VO factors By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Advance ArticleDOI: 10.1039/D4TC03701D, PaperZeming Li, Rensheng Shen, Wancheng Li, Teng Jiao, Yuchun Chang, Hongwei Liang, Xiaochuan Xia, Baolin ZhangThe sub-intense component in the XPS O 1s spectra of β-Ga2O3 is not associated with oxygen vacancies, the intrinsic indirect bandgap and the surface traps contribute to the extension of the response and recovery times of β-Ga2O3-based PDs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Experimental factors influencing the bioaccessibility and the oxidative potential of transition metals from welding fumes By pubs.rsc.org Published On :: Environ. Sci.: Processes Impacts, 2024, Advance ArticleDOI: 10.1039/D3EM00546A, PaperManuella Ghanem, Laurent Y. Alleman, Davy Rousset, Esperanza Perdrix, Patrice CoddevilleExperimental conditions such as extraction methods and storage conditions induce biases on the measurement of the oxidative potential and the bioaccessibility of transition metals from welding fumes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
actors Taming the Factor Zoo: A Test of New Factors [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
actors Model-Free International Stochastic Discount Factors [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
actors How the Wealth Was Won: Factors Shares as Market Fundamentals [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
actors Foreign Currency Bank Funding and Global Factors [electronic journal]. By encore.st-andrews.ac.uk Published On :: International Monetary Fund Full Article
actors Factors that Fit the Time Series and Cross-Section of Stock Returns [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
actors Estimating Latent Asset-Pricing Factors [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
actors Currency Risk Factors in a Recursive Multicountry Economy [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
actors Currency Factors [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
actors Common Factors of Commodity Prices [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
actors Actors in the Child Development Process [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
actors Multiple factors remain a hurdle in setting up centralised sewer networks, Kerala govt. informs NGT By www.thehindu.com Published On :: Tue, 05 Nov 2024 00:57:20 +0530 Faecal sludge treatment plants proposed in a radius of 15 km on cluster basis in urban and rural local bodies Full Article Kerala
actors Inherited genetic factors may predict the pattern of X chromosome loss in older women By www.cancer.gov Published On :: Wed, 12 Jun 2024 12:00:00 +0000 An NCI study explores the causes and effects of a phenomenon known as mosaic loss of chromosome X, or mLOX, which may lead to several health conditions, including cancer. Full Article
