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Victoria the only Australian state with a stable AAA rating from both S&P and Moody’s




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Psychologists and professionals working with domestic violence victims trained at OSCE-supported events in Moldova on both banks

The OSCE Mission to Moldova held the final in a series of three training sessions for 12 psychologists and professionals working with domestic violence victims. The session took place on 27 June 2016 in Rybnitsa, a town on the left bank of the Dniester/Nistru River.

The event aimed to equip participants with essential skills in family counselling and post-traumatic stress rehabilitation. Participants studied means to identify family violence, various coaching techniques to use when working with families, as well as methods for handling trauma and post-traumatic stress among domestic violence victims.

In the past week, similar training events have been held in Chisinau and Tiraspol with the total participation of 50 professionals from Bender, Causeni, Chisinau, Comrat, Drochia, Rybnitsa and Tiraspol.

Participants in the training sessions included psychologists, teachers, medical professionals, lawyers and social workers, all of whom encounter cases of domestic violence in their work through Moldova’s referral system.

The training events were held as part of the Mission’s project to strengthen the capacity of those who provide crisis services to women and families on both banks of the Dniester/Nistru River. The project was developed following a country-wide assessment conducted in 2014 and 2015. The assessment identified a number of challenges in this field in Moldova, most notably the difficulties in accessing domestic violence services – including shelters and crisis centres – for those living in rural areas, and a lack of state resources. 

Related Stories




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OSCE Mission to Moldova strengthens professional skills and civic engagement among young people from both banks

The OSCE Mission to Moldova held a training event on essential debate techniques for 37 high-school students and 7 teachers from both banks of the Dniester/Nistru River on 1 to 3 July 2016 in Vadul-lui-Vodă, a town by the river. The event, which gathered students from Balti, Bender, Cahul, Ceadir-Lunga, Comrat, Parcani, Tiraspol and Vulcanesti, aimed to enhance youth engagement in civic processes at the local and national levels.

“This event has equipped me with skills that will be vital for both my professional and private life,” said Daria Bogdanova, a student from Tiraspol. “Engaging in debates is an excellent way to help us convey our thoughts more convincingly, search for compromise and exercise objectivity.”

The training event introduced students to the Karl Popper debate format that teaches students how to conduct and participate in academic debates, demonstrate leadership, make public speeches, co-operate in teams and apply critical thinking. The aim of the event was to develop students’ analytical and debate skills in order to strengthen their professional opportunities and civic engagement.

The students attending the training will apply their newly acquired knowledge and skills in a series of two debate tournaments to be held in the autumn. The training sessions and tournaments are organized as part of a one-year project implemented jointly by the OSCE Mission to Moldova and the Comrat-based NGO Piligrim-Demo that aims to actively engage young people, including those representing national minorities, in civic process at the local and national levels by developing their debate skills.

 

Related Stories




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ESPN to Exclusively Present 2025 MLB Opening Day Doubleheader Featuring Both World Series Champion Los Angeles Dodgers and American League Champion New York Yankees

The doubleheader begins on ESPN at 3 p.m. ET on Thursday, March 27 when Aaron Judge and the Yankees host Christian Yelich and the Milwaukee Brewers, who won the National League Central in 2024.




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Seven & i investor Artisan says it supports both offers for Japanese retailer

Artisan Partners, an investor in Japanese retail giant Seven & i Holdings, called on the company's special committee to consider a formal bidding process of competing takeover proposals to secure the highest offer. Seven & i received a buyout proposal from a member of its founding Ito family, it…




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Donald Trump meets Joe Biden in White House; both pledge smooth transition

In a brief meeting, the two leaders assured the nation of a peaceful transition of power on January 20, 2025.




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Biden meets Trump, both pledge smooth transition

In the meeting, the two leaders assured the nation of a peaceful transition of power on January 20 next year.




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Posten Bring meets “the high demand for more parcel lockers from both online stores and customers”

Posten Bring has rapidly rolled out Europe's longest network of parcel lockers, with 6,000 self-service parcel lockers at 2,000 locations across Norway.




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Trump and Biden both call for smooth transition in historic Oval Office meeting

President-elect Donald Trump was welcomed at the White House on Wednesday after declining to do the same for President Joe Biden after the 2020 election.





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Justin Martyr (100-167 A.D.), Philosopher, Apologist, and Martyr (1 June 167 A.D.) - Justin was born around 100 A.D. (both his birth and death dates are approximate) at Flavia Neapolis (ancient Shechem, modern Nablus) in Samaria (the middle portion of Isr

Justin became a Christian, but he continued to wear the cloak that was the characteristic uniform of the professional teacher of philosophy. His position was that pagan philosophy, especially Platonism, is not simply wrong, but is a partial grasp of the truth, and serves as "a schoolmaster to bring us to Christ." He engaged in debates and disputations with non-Christians of all varieties, pagans, Jews, and heretics. He opened a school of Christian philosophy and accepted students, first at Ephesus and then later at Rome. There he engaged the Cynic philosopher Crescens in debate, and soon after was arrested on the charge of practicing an anauthorized religion. (It is suggested that Crescens lost the debate and denounced Justin to the authorities out of spite.) He was tried before the Roman prefect Rusticus, refused to renounce Christianity, and was put to death by beheading along with six of his students, one of them a woman. A record of the trial, probably authentic, is preserved, known as The Acts of Justin the Martyr. ... Justin's works are found in the multi-volumed set called The Ante-nicene Fathers [Church leaders before the Council of Nicea in 325 A.D.], and in various other collections of early Christian writings.



  • Christian Church History Study
  • 1. 0 A.D. to 312 A.D. - Birth of Jesus and the early Church Age

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The Apostles' Creed - Sometimes titled Symbol of the Apostles, is an early statement of Christian belief, a creed or "symbol" - It is widely used by a number of Christian denominations for both liturgical and catechetical purposes, most visi

While the individual statements of belief that are included in the Apostles' Creed - even those not found in the Old Roman Symbol - are found in various writings by Irenaeus, Tertullian, Novatian, Marcellus, Rufinus, **Ambrose (about 337 A.D. - 397 A.D.), Augustine, Nicetus, and Eusebius Gallus, the earliest appearance of what we know as the Apostles' Creed was in the De singulis libris canonicis scarapsus ("Excerpt from Individual Canonical Books") of St. Priminius (Migne, Patrologia Latina 89, 1029 ff.), written between 710 A.D. and 714 A.D. This longer Creed seems to have arisen in what is now France and Spain. Charlemagne imposed it throughout his dominions, and it was finally accepted in Rome, where the Old Roman Creed or similar formulas had survived for centuries. -- {Note: The Christian Church historically has sought in large to be directed by the Gospels and the Apostolic Epistles of the New Testament - The Apostles' Creed is a classic and still currently relevant example of how true to form the Doctrines of the Church have remained in being faithful to the "common salvation" (Jude 1:3) as it was initially delivered to the Christian Church.}




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To both Republicans & Democrats

Somone please tell me what the HELL's wrong with all the people that
run this country!!!!!!

To both Republicans & Democrats

we're "broke" & can't help our own Seniors, Veterans, Orphans,
Homeless, Etc.???????????

In the last months we have provided aid to Haiti, Chile, Pakistan,
Lybia, Egypt and Turkey.. And now Japan Literally, BILLIONS of
DOLLARS!!!

Our retired seniors living on a 'fixed income' receive no aid nor do
they get any breaks while our government and religious organizations
pour Hundreds of Billions of $$$$$$'s and Tons of Food to Foreign
Countries!

We have hundreds of adoptable children who are shoved aside to make
room for the adoption of foreign orphans.

AMERICA: a country where we have homeless without shelter, children
going to bed hungry, elderly going without 'needed' meds, and mentally
ill without treatment-etc, etc.

YET......................
They have a 'Benefit' for the people of Haiti on 12 TV stations, ships
and planes lining up with food, water, tents clothes, bedding, doctors
and medical supplies.

Imagine if the *GOVERNMENT* gave 'US' the same support they give to
other countries.


Sad isn't it?




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The Small Business Guide to Virtual Assistants Both Human and Digital

Why Your Business Needs Virtual Assistants

If you are looking to de-clutter your business life so you can focus on serving your clients and customers, then virtual assistants are the perfect solution. They excel at the everyday tasks that keep your business up and running and can also handle the more complex tasks that you’re ready to hand off to someone else.

complete article




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One day, both her money and her husband are gone

There are bad dreams, there are nightmares and then there are situations like that of Joanne Sims.




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Tata Altroz CNG: Is it the best of both worlds?

The car is designed to switch easily between petrol and CNG modes, with extra safety modes




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Google Shopping Ads With Both Seller & Product Ratings

Google is showing both seller ratings and product ratings on a single Google Shopping Ad unit. It is a bit weird to see both ratings, and it can potentially be confusing to see different ratings for the same retailer but one is for the rating of the specific product and one is for the rating of the company selling that product, i.e the seller.

This was spotted by Hana Kobzová who posted about it on her PPC News site who wrote, "Google started showing both seller ratings and product ratings can appear together in Shopping ads. This help retailers to be more trustworthy, visible, and competitive."

Here is what it looks like:

There is a lot more detail on this over here but again, I am not sure I like this.

Forum discussion at X.




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To Judge Both the Living and the Dead

Fr. John Whiteford shares on the Sunday of the Last Judgment.




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Both Good and Pleasant

Fr. John Whiteford's sermon from October 13, 2024.




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The Prodigal Gets It Both Right and Wrong (Feb. 24, 2019)

Fr. Andrew Stephen Damick discusses the parable of the Prodigal Son, how he asks to return as a servant but is instead given sonship, expanding on this theme in terms of the ways in the spiritual life what we desire from God is often not what He is offering.




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This Feast Bothers Me

Fr. Theodore Paraskevopoulos describes the irony in the Palm Sunday story.




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Both Good and Bad Are Contagious




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It's Both/And!




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Both Sides of the Icons

Fr. Pat considers the case for iconoclasm, for the veneration of icons, and the settling of the issue.




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A Vocation Both Common and Special

There’s a sense in which The Vocation of Mary was the most special and the most common. In this homily given on the Feast of the Dormition in 2010, Fr. Pat considers these two vocations of our Lord's Mother.




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Demand generation vs lead generation: Do you need both?

Demand generation vs lead generation? Which should you use? You could be missing out on some qualified leads if you're not using both.

The post Demand generation vs lead generation: Do you need both? appeared first on Coaching and training to scale your copywriting business, plus programs for new copywriters, startups, and marketers.




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Interactive QuickTime: Developing and Evaluating Multimedia Learning Objects to Enhance Both Face-To-Face and Distance E-Learning Environments




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Teacher-student Relationship and SNS-mediated Communication: Perceptions of both role-players

Teacher-student relationships are vital for academic and social development of students, for teachers’ professional and personal development, and for having a supportive learning environment. In the digital age, these relationships can extend beyond bricks and mortar and beyond school hours. Specifically, these relationships are extended today while teachers and students communicate via social networking sites (SNS). This paper characterizes differences between teachers (N=160) and students (N=587) who are willing to connect with their students/teachers via Facebook and those who do not wish to connect. The quantitative research reported here within is based on data collection of personal characteristics, attitudes towards Facebook, and perceptions of teacher-student relationship. Findings suggest differences in characteristics of the two groups (willing to connect vs. not willing to connect) within both populations (teachers and students). Also, in both populations, those who were willing to connect, compared to those who were not willing to connect, present more positive attitudes towards using Facebook for teaching/learning and are more opposed to a banning policy of student-teacher SNS-based communication. We also found that students who were willing to connect showed a greater degree of closeness with their teachers compared to those who were not willing to connect. This study may assist policymakers when setting up regulations regarding teacher-student communication via social networking sites.




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No end in sight to Sudan war as both sides seek ‘decisive’ win

CAIRO: Sudan has seen a surge in extreme violence in recent weeks as the warring military and paramilitary push for a decisive victory, with no political solution in sight.

Fighting between the Sudanese army and the Rapid Support Forces (RSF) has intensified since late October, with reports of attacks on civilians including sexual violence against women and girls raising alarm.

The war that erupted in April 2023 has created what the UN calls the world’s worst displacement crises, with more than 11 million people forced from their homes.

It has put the country on the brink of famine, and sparked warnings of intensifying violence in a war that has already killed tens of thousands.

“Over the last two weeks, the situation in the country has been marked by some of the most extreme violence since the start of the conflict,“ according to Rosemary DiCarlo, UN Under-Secretary-General for Political and Peacebuilding Affairs.

“Let me stress that both warring parties bear responsibility for this violence,“ she said, adding that both sides “seem convinced they can prevail on the battlefield.”

Since October 20, at least 124 civilians have been killed in central Al-Jazira state and another 135,000 have fled to other states, according to the UN.

With global attention focused on other wars, chiefly in Ukraine and the Middle East, civilians in Sudan are paying a steep price for the escalation.

“All indicators so far show that both sides are committed to military solutions, with no genuine interest in political resolutions or even easing the suffering of civilians,“ according to Mohamed Osman of Human Rights Watch.

Amani al-Taweel, director of the Africa programme at the Al-Ahram Center for Political and Strategic Studies in Cairo, agreed.

“There is no political solution on the horizon,“ she told AFP, adding that both sides were seeking a “decisive military solution”.

Split

The war in Sudan has pitted army chief Abdel Fattah al-Burhan against his erstwhile ally Mohamed Hamdan Daglo, leader of the RSF.

The country is split into zones of control, with the army holding the north and east, and the government based in Port Sudan on the Red Sea coast.

The RSF controls much of the capital Khartoum, the Darfur region in the west and parts of Kordofan in the south, while the centre is split.

With no mandatory military conscription, the Sudanese army includes Islamist-leaning forces as well as other factions.

The RSF is primarily made up of tribal militias from Darfur’s Arab communities.

According to local reports, the army has about 120,000 troops while the RSF has 100,000.

On the battlefield, Sudan’s air force gives the military an advantage.

Rights groups have accused both sides of committing atrocities.

The UN population agency published on Tuesday horrific accounts of women and girls fleeing the violence, including one who said she was urged to kill herself with a knife rather than be raped.

‘Deadlock’

Successive rounds of talks have been held in Saudi Arabia, but the negotiations have yet to produce a ceasefire.

In August, the Sudanese military opted out of US-brokered negotiations in Switzerland and an African Union-led mediation has also stalled.

“The deadlock in peaceful channels, whether regionally or internationally, is exacerbating the violence,“ said Mahmud Zakaria, a professor of political science at Cairo University’s Faculty of African Postgraduate Studies.

Since October, the RSF escalated its attacks in Al-Jazira state, south of Khartoum, following what the military said was the defection of one of its commanders to the army.

Before the war, Al-Jazira was known as Sudan’s breadbasket, hosting Africa’s largest agricultural project, yielding 65 percent of the country’s cotton, according to Zakaria.

Proxy war?

Some areas have been scarred by conflict before.

Darfur saw a major war two decades ago, during which the then-government’s allies in the Janjaweed militia faced accusations of ethnic cleansing and genocide.

With roots in the Janjaweed, the RSF became a force in its own right in 2013.

Sudan’s conflict has increasingly drawn in regional powers, prompting the United States to urge all countries to stop arming rival generals.

Former Egyptian deputy foreign minister for African affairs Ali el-Hefny said progress will require global willpower.

Instead, foreign powers are “fuelling the violence, delaying Sudan’s return to stability”, he said.

The army has accused the United Arab Emirates of backing the RSF -- a charge it strongly denies.

In December, UN experts monitoring an arms embargo on Darfur described as “credible” allegations Abu Dhabi had funnelled weapons to Daglo’s forces on cargo planes.

The RSF has in turn alleged Egyptian support for the army, which Cairo has also denied.

Army chief Burhan has historically been close to Egyptian President Abdel Fattah al-Sisi, who pledged his “continued support” earlier this month.




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Airport chic: Fashion that lets you have both comfort and style

The trick to merging comfort and style is all about finding pieces that are both functional and fashionable.




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US election: Harris rattles Trump in fiery debate as both push for mantle of change

Harris criticised Trump’s legal woes, foreign policy, mostly on Ukraine, while Trump attacked her position on Israel




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Analog Equivalent Rights (18/21): Our analog parents had private conversations, both in public and at home

Privacy: Our parents, at least in the Western world, had a right to hold private conversations face-to-face, whether out in public or in the sanctity of their home. This is all but gone for our digital children.

Not long ago, it was the thing of horror books and movies that there would actually be widespread surveillance of what you said inside your own home. Our analog parents literally had this as scary stories worthy of Halloween, mixing the horror with the utter disbelief.

“There was of course no way of knowing whether you were being surveilled at any given moment. How often, or on what system, the Thought Police plugged in on any individual device was guesswork. It was even conceivable that they listened to everybody all the time. But at any rate they could listen to you whenever they wanted to. You had to live — did live, from habit that became instinct — in the assumption that every sound you made was overheard.” — from Nineteen Eighty-Four

In the West, we prided ourselves on not being the East — the Communist East, specifically — who regarded their own citizens as suspects: suspects who needed to be cleansed of bad thoughts and bad conversations, to the degree that ordinary homes were wiretapped for ordinary conversations.

There were microphones under every café table and in every residence. And even if there weren’t in the literal sense, just there and then, they could still be anywhere, so you had to live — did live, from habit that became instinct — in the assumption that every sound you made was overheard.

“Please speak loudly and clearly into the flower pot.” — a common not-joke about the Communist societies during the Cold War

Disregard phonecalls and other remote conversations for now, since we already know them to be wiretapped across most common platforms. Let’s look at conversations in a private home.

We now have Google Echo and Amazon Alexa. And while they might have intended to keep your conversations to themselves, out of the reach of authorities, Amazon has already handed over living room recordings to authorities. In this case, permission became a moot point because the suspect gave permission. In the next case, permission might not be there, and it might happen anyway.

Mobile phones are already listening, all the time. We know because when we say “Ok Google” to an Android phone, it wakes up and listens more intensely. This, at a very minimum, means it’s always listening for the words “Ok Google”. IPhones have a similar mechanism listening for “Hey Siri”. While nominally possible to turn off, it’s one of those things you can never be sure of. And we carry these governmental surveillance microphones with us everywhere we go.

If the Snowden documents showed us anything in the general sense, it was that if a certain form of surveillance is technically possible, it is already happening.

And even if Google and Apple aren’t already listening, the German police got the green light to break into phones and plant Bundestrojaner, the flower-pot equivalent of hidden microphones, anyway. You would think that Germany of all countries has in recent memory what a bad idea this is. It could — maybe even should — be assumed that the police forces of other countries have and are already using similar tools.

For our analog parents, the concept of a private conversations was as self-evident as oxygen in the air. Our digital children may never know what one feels like.

And so we live today — from what started as a habit that has already become instinct — in the assumption that every sound we make is overheard by authorities.




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Poll shows public jittery about the election, both parties equally so

The presidential election is right around the corner. This event has not put the nation in a very good mood.




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Who will buy Infowars? Both supporters and opponents of Alex Jones interested in bankruptcy auction

Conspiracy theorist Alex Jones' Infowars broadcasts could end next week as he faces a court-ordered auction of his company's assets to help pay the more than $1 billion defamation judgment he owes families of victims of the Sandy Hook Elementary School shooting.




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Traumatized by war, hundreds of Lebanon's children struggle with wounds both physical and emotional

Curled up in his father's lap, clinging to his chest, Hussein Mikdad cried his heart out. The 4-year-old kicked his doctor with his intact foot and pushed him away with the arm that was not in a cast. "My Dad! My Dad!" Hussein said. "Make him leave me alone!" With eyes tearing up in relief and pain, the father reassured his son and pulled him closer.




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Article Alert: How Aphia Can Serve Both the Taxonomic Community and the Field of Biodiversity Informatics

A new article published in the Journal of Marine Science and Engineering looks at how Aphia, the core platform that underpins the World Register of Marine Species (WoRMS),  can Serve the taxonomic community and the field of biodiversity informatics.

Abstract

The Aphia platform is an infrastructure designed to capture taxonomic and related data and information, and includes an online editing environment. The latter allows easy access to experts so they can update the content of the database in a timely fashion. Aphia is the core platform that underpins the World Register of Marine Species (WoRMS) and its more than 80 related global, regional and thematic species databases, but it also allows the storage of non-marine data. The content of Aphia can be consulted online, either by individual users or via machine-to-machine interactions. Aphia uses unique and stable identifiers for each available name in the database through the use of Life Science Identifiers (LSIDs). The system not only allows the storage of accepted and unaccepted names, but it also documents the relationships between names. This makes it a very powerful tool for taxonomic quality control, and also allows the linking of different pieces of information through scientific names, both within the Aphia platform and in relation to externally hosted databases. Through these LSIDs, Aphia has become an important player in the field of (marine) biodiversity informatics, allowing interactions between its own taxonomic data and e.g., biogeographic databases. Some applications in the field of biodiversity informatics encompass the coupling of species traits and taxonomy, as well as the creation of diverse, expert validated data products that can be used by policy makers, for example. Aphia also supplies (part of) its content to other data integrators and the infrastructure can be used to host orphan databases in danger of being lost.

Original Source: http://www.mdpi.com/2077-1312/3/4/1448/htm

 





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How Aphia—The Platform behind Several Online and Taxonomically Oriented Databases—Can Serve Both the Taxonomic Community and the Field of Biodiversity Informatics




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As both a full-time employee and a primary caregiver to one of my family members, I am worried about potentially exposing my family to COVID. Is there anything I can do? Elaine Varelas guides

Being a primary caregiver while working full time is a challenge in itself and even more so during the pandemic. Elaine Varelas guides on how to best keep your family members safe while maintaining your work responsibilities.

The post As both a full-time employee and a primary caregiver to one of my family members, I am worried about potentially exposing my family to COVID. Is there anything I can do? Elaine Varelas guides appeared first on Boston.com.




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Both Red Sox finalists denied Silver Slugger awards

Red Sox third baseman Rafael Devers and outfielder Jarren Duran were both finalists for AL Silver Slugger awards but neither won. Guardians' José Ramírez won for AL third basemen. Yankees sluggers Aaron Judge and Juan Soto as well as Orioles' Anthony Santander were the three AL outfield winners. BETTING: Check out our MA sports betting guide , where you can learn basic terminology, definitions and how to read odds for those interested in learning how to bet in Massachusetts. Duran, who was a finalist for the first time, led the majors in doubles with 48. He also tied with Arizona's Corbin Carroll for the major league lead in triples (14). He batted .285 with a .342 on-base percentage, .492 slugging




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Profit Margin Confidence and ABC’s Construction Backlog Indicator Both Fall in August

Associated Builders and Contractors reported Sept. 10 that its Construction Backlog Indicator fell to 8.2 months in August, according to an ABC member survey conducted from Aug. 20 to Sept. 5. The reading is down one month from August 2023.




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‘Super-Green’ Home Features Both Innovation and Artistry

For Thomas Marino, president of Advanced Technologies, Baton Rouge, La., “green” projects were nothing new. He had done projects that involved low-power, solar or other green elements. But when he ran into local attorney Joe Simmons at a trade show, the extremely environmentally conscious lawyer asked him to do the security and home automation for the custom home he was building. The home was new construction in a community of older homes and would feature as many green elements as possible, from the material in the countertops to the security and audio elements.




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SDM's 2015 Dealer of the Year combines both old and new ideas to pave the way for the future.

SDM’s 2015 Dealer of the Year combines both old and new ideas to pave the way for the future.




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Both workers and CEOs face mental health challenges: survey

Denver — Half of workers have experienced a mental health issue in the past year, results of a recent survey show.




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How to Develop Kids Foods and Beverages That are Both Appealing and Healthy

Parents care about health and wellness for their children, and their purchasing patterns drive innovation toward healthier children’s food and beverage products. We see growth in numerous categories in children’s products that are positioned as healthy and better-for-you, including dairy alternatives as well as new items in the sweet and savory bakery, and confectionery categories.  




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Fire crews on both U.S. coasts battle wildfires

Fire crews are battling small wildfires across the Northeast U.S. A blaze in New York and New Jersey killed a parks employee over the weekend and postponed Veterans Day plans. A quarter-inch of rain fell overnight from Sunday into Monday, giving a slight respite to firefighters. 




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FMI’ analyst view: ‘Ink Tranquillity: Both owners and consumers are paying attention to the food's safety and quality’

The low migration inks market size is projected to be worth US$ 1.4 billion in 2023. The market is likely to surpass US$ 2.8 billion by 2033. It is expected to showcase growth at an impressive CAGR of 6.9% during the forecast period.




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American infected with both COVID-19 and monkeypox at the same time

An American from California simultaneously contracted the coronavirus and monkeypox, reports NBC. Mitcho Thompson, from the town of Sebastopol, told the TV channel that he tested positive for COVID-19 at the end of June, and soon after noticed red spots on his back, legs, arms and neck. "The doctor was absolutely certain that I had monkeypox and that I had both," Thompson said.




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Top Security Aide: S. Korea-US Alliance Benefits Both Countries

[Politics] :
National security adviser Shin Won-sik said South Korea is no longer the sole beneficiary of the South Korea-U.S. alliance, pledging to defend the country’s core interests as a partner state that contributes to regional and global security and prosperity. In a keynote speech at the 2024 Global Dialogue ...

[more...]




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The ABC toxin complex from Yersinia entomophaga can package three different cytotoxic components expressed from distinct genetic loci in an unfolded state: the structures of both shell and cargo

Bacterial ABC toxin complexes (Tcs) comprise three core proteins: TcA, TcB and TcC. The TcA protein forms a pentameric assembly that attaches to the surface of target cells and penetrates the cell membrane. The TcB and TcC proteins assemble as a heterodimeric TcB–TcC subcomplex that makes a hollow shell. This TcB–TcC subcomplex self-cleaves and encapsulates within the shell a cytotoxic `cargo' encoded by the C-terminal region of the TcC protein. Here, we describe the structure of a previously uncharacterized TcC protein from Yersinia entomophaga, encoded by a gene at a distant genomic location from the genes encoding the rest of the toxin complex, in complex with the TcB protein. When encapsulated within the TcB–TcC shell, the C-terminal toxin adopts an unfolded and disordered state, with limited areas of local order stabilized by the chaperone-like inner surface of the shell. We also determined the structure of the toxin cargo alone and show that when not encapsulated within the shell, it adopts an ADP-ribosyltransferase fold most similar to the catalytic domain of the SpvB toxin from Salmonella typhimurium. Our structural analysis points to a likely mechanism whereby the toxin acts directly on actin, modifying it in a way that prevents normal polymerization.




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New Report Calls for Systemwide Reorientation to Account for Health Care and Support of Both Elders and Family Caregivers

The demand for family caregivers for adults who are 65 or older is increasing significantly, and family caregivers need more recognition, information, and support to fulfill their responsibilities and maintain their own health, financial security, and well-being, says a new report from the National Academies of Sciences, Engineering, and Medicine.