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One of the main mechanisms of azole resistance of Aspergillus fumigatus is thought to be a reduction in the drug’s affinity for the target molecule, Cyp51A, due to its amino acid mutation(s). It is known that the azole resistance pattern is closely related to the mutation site(s) of the molecule. In this study, we tried to develop a simple and rapid detection method for cyp51A mutations using the endonuclease Surveyor nuclease. The Surveyor nuclease assay was verified using several azole-resistant strains of A. fumigatus that possess point mutations in Cyp51A. For validation of the Surveyor nuclease assay, blind tests were conducted using 48 strains of A. fumigatus (17 azole-resistant and 31 azole-susceptible strains). The Surveyor nuclease assay could rapidly detect cyp51A mutations with one primer set. Also, all the tested strains harboring different cyp51A single point mutations could be clearly distinguished from the wild type. The Surveyor nuclease assay is a simple method that can detect cyp51A mutations rapidly.

The semiannual OTC derivatives statistics provide data on notional amounts outstanding and gross market values for all types of over-the-counter derivatives contracts. They are reported by large dealers in 12 countries on a worldwide consolidated basis.

We document that corporate pension contributions respond to tax-based incentives using the 2017 Tax Cut & Jobs Act (TCJA) as a natural experiment. The TCJA cut the U.S. federal corporate tax rate, temporarily increasing contribution incentives for sponsors of defined-benefit retirement plans. We exploit cross-sectional variation in ex-ante exposure to these incentives.

Inflation pressure could be weak even after consumer demand for non-discretionary goods and services begins to grow as the economy gets back on its feet.

Gold and silver prices often move in tandem, but the gap between them widened by 31% January through April in line with a trend that began nine years ago.

Bank of Italy Working Papers by Giorgio Albareto, Andrea Cardillo, Andrea Hamaui and Giuseppe Marinelli

Bank of England Working Papers by Cristiano Cantore and Lukas Freund

Staying active and maintaining physical fitness has many benefits to all elements of wellness, including mental and emotional well-being that may be taxed during social distancing. At Penn State Mont Alto, the athletic department has been releasing weekly at-home workout and challenge videos that are accessible on our Facebook and Instagram pages to keep our student-athletes engaged.

Balancing finicky kid appetites with proper nutrition can be a challenge in the best of times. But now, with the majority of schools and day cares closed across Pennsylvania, many parents working from home, and schedules thrown in disarray, it may seem downright impossible. A Penn State nutritionist offers tips for feeding kids during stressful times.

Apple's higher-end 13-inch MacBook Pros are equipped to take advantage of 87W power adapters, though users won't see any charging speed benefits from the change.

Apple's latest iOS 13.5 beta release includes a new Health app feature that allows iPhone and Apple Watch users to automatically send Medical ID information to first responders.

Instead of every meeting attendee staring at a flat Zoom screen, Apple is looking to the future of video conferencing with Memoji-style avatars arranged in augmented reality around each meeting attendee.

Apple's Jeff Williams says that supply chains are running well and that the company is optimistic about the future for the economy both for itself and for America as a whole.

Wink customers will soon have to pay a monthly subscription fee to access any of the smart home hardware that they have purchased.

Qualcomm CEO Steve Mollenkopf in an interview on Thursday said the chipmaker's relationship with Apple has greatly improved since the two companies ended a bitter legal battle over patent licensing and royalties in 2019.

Amazon has reissued its popular Apple Watch deal, dropping the Series 5 Watches with Cellular to $399 after a $100 price cut. Multiple styles are on sale and in stock.

Eight years after it released tools to make what were then called iBooks, Apple has launched Apple Books for Authors, a new effort to get writers publishing on its platform.

OM Montenegro put on a two week Beach Outreach in the city of Bar.

Denver Newsroom, May 7, 2020 / 05:29 pm (CNA).- A Notre Dame sociologist is using data to challenge a Harvard Law professor’s assertions that homeschooling is “dangerous”, and detrimental to society.

The controversy stems from a recent paper by professor Elizabeth Bartholet in which she calls for a presumptive ban on homeschooling in the United States.

Bartholet, as quoted in a Harvard Magazine piece based on her paper, points to unspecified “surveys of homeschoolers” to assert that “up to 90 percent” of homeschooling families are “driven by conservative Christian beliefs, and seek to remove their children from mainstream culture.”

“Some” homeschooling parents are “‘extreme religious ideologues’ who question science and promote female subservience and white supremacy,” she writes.

David Sikkink, associate professor in the Department of Sociology at the University of Notre Dame, analyzed surveys of homeschooling families— including a 2016 government survey—  and found that these families are not overwhelmingly Christian nor religious, and are not as universally closed-off to the outside world as Bartholet asserts.

In the analysis Sikkink conducted, just 16% of homeschooling parents said they were homeschooling primarily for religious reasons. The number one reason homeschooling parents cited was a concern about school environment, such as safety, drugs, or negative peer pressure.

Eleven percent of parents reported homeschooling because their child has special needs.

While approximately half of the homeschooling parents surveyed mentioned religion as a factor in their decision to homeschool, Sikkink notes that the parents who cited religion as a reason were, on the whole, more highly educated than those parents who did not.

In terms of Bartholet’s assertion that some homeschooling parents “believe that women should be totally subservient to men and educated in ways that promote such subservience,” Sikkink’s analysis did not find evidence that religious households oppose higher education for girls.

Among the homeschooling families in the survey who use a religious curriculum, there was no difference in their self-reported educational expectations— i.e., what education level they expected their children to reach—  for their male children vs. their female children.

Several past studies have shown that homeschool students typically outperform their public and private school counterparts on things like standardized tests and college performance. A 2016 study from the National Council on Measurement in Education showed that, when adjusted for demographic factors, homeschool students were on par academically with their demographically-similar peers.

Moreover, the data Sikkink analyzed suggests that after family background and demographic controls are accounted for, about 64% of homeschoolers “completely agree” that they have much in life to be thankful for, compared to 53% of public schoolers.

On feelings of helplessness, or lack or goals or direction in life, homeschoolers do not substantially differ from their public school counterparts, the analysis suggests.

In the Arizona Law Review, Bartholet argues that while homeschool children may perform as well as their peers on standardized tests or in college, they are also often isolated from their peers and denied experiences and exposures that would make them more productive citizens.

Bartholet claims in her article that “a very large proportion of homeschooling parents are ideologically committed to isolating their children from the majority culture and indoctrinating them in views and values that are in serious conflict with that culture.”

“Isolated families,” she asserts, “constitute a significant part of the homeschooling world.”

In contrast, Sikkink’s analysis found that among the schooling groups surveyed, homeschooling families had the highest level of “community involvement” of all school sectors.

“Community involvement” activities included attending sporting events, attending concerts, going to the zoo or aquarium, going to a museum, going to a library, visiting a bookstore, or attending an event sponsored by a community, religious, or ethnic group.

Homeschooling graduates are almost identical to their public school counterparts in likelihood to vote in federal and local elections, Sikkink found.

Furthermore, the total number of volunteer and community service hours for homeschooling graduates is very similar to or slightly higher than public school graduates, the analysis found.

Bartholet asserts that some homeschoolers “engage in homeschooling to promote racist ideologies and avoid racial intermingling.”

In contrast: “The reality is that about 41% of homeschooled children are racial and ethnic minorities,” Sikkink writes.

“When asked about four closest friends, about 37% of young adult homeschoolers...mention someone of a different race or ethnicity—exactly the same as public schoolers.”

This diversity also extends to schooling practices— increasingly, Sikkink says, homeschooling adopts new forms, including “hybrids” that combine the benefits of home and institutional schooling.

“About 57 percent of homeschoolers are using some form of instruction outside the family,” Sikkink told CNA in an email.

“That includes using tutors, private or public schools, colleges or universities, or homeschooling coops. That percentage would be higher if we included those who reported obtaining curriculum from formal institutions, such as public schools.”

Moreover, about a third of homeschooling parents obtain their curriculum or books from a public school or school district.

“Altogether, 46% of homeschoolers have some pedagogical relationship with public schools,” Sikkink asserts.

Bartholet argues that homeschooling puts children at risk of abuse by their parents, while if children were in public schools, they would be among teachers who are mandatory reporters of any suspected abuse that may be taking place.

“The issue is, do we think that parents should have 24/7, essentially authoritarian control over their children from ages zero to 18? I think that’s dangerous,” Bartholet asserts in the Harvard Magazine piece.

“I think it’s always dangerous to put powerful people in charge of the powerless, and to give the powerful ones total authority.”

Sikkink says Bartholet’s image of a child confined to the home “24/7...from ages zero to 18” is not consistent with the data.

“When we look at the use of homeschooling for each year of the child's upbringing, we only find a small percentage that report that the child was homeschooled for all their years of schooling,” Sikkink told CNA in an email.

Many of these students are part-time public schoolers— about 25% of homeschoolers receive some instruction in public schools during their school-age careers, he wrote.

Homeschooling regulations vary widely by state. Sikkink told CNA he hopes future studies will examine the effects of state-level variation in regulation on homeschooling quality.

“The question of schooling oversight remains, of course, but it would be short-sighted not to keep homeschooling and other creative schooling options in the mix, including the hybrid models that cross sector boundaries,” Sikkink concludes.

 

Subsequent to the publication of this story, Sikkink told CNA he had revised his assessment of the percentage of homeschoolers using instruction outside the family, from 64% to 57%. The story has been updated to reflect that assessment.

2D design Despite the great popularity of spatial design programs and their unquestioned advantages, 2D design programs such as AutoCAD are still very popular and useful. One of such programs is DraftSight, which over the years has become very recognizable

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Structure System Solidworks The term structural system or structural frame in structural engineering refers to the load-resisting sub-system of a building or object that transfers loads through interconnected elements or members. In SOLIDWORKS 2020, the structure system feature is an advanced

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Learn how to use Cut Planes to slice and dice your geometry.

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This SOLIDWORKS tutorial is for a Wooden Canvas Teepee, the tutorial focuses on the use of Circular Patterns of part bodies and the use of 3D sketch for extrusions between guide points, and profile sweeps along a path. This is a fun tutorial that if you follow, you can create you own Teepee model, and apply a range of designs to with decals. The decal swatches seen in the video are available to download in the description below.

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This SOLIDWORKS Tutorial for a Insulated ceramic coffee cup focuses on the combine tool, and uses an assembly to create the layout of the final design before saving back into a part, and turned in to a functional coffee cup. Decals for the tutorial are available to download in the description.

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This is a SOLIDWORKS tutorial to create a pot of gold money jar. This tutorial demonstrates a range of modelling tools, but also highlights the use of the centreline sketch tool as a guide for sketches, new planes, and axis for pattern or move features. The decals and coin part for this design are available to download in the tutorials blog description.

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This SOLIDWORKS Tutorial for a Ceramic Cup Plaster Mold walks you through start to finish of the process of creating a model for a plaster mold and a 3 part cup mold. The tutorial focuses on copying bodies and combing them with each other to finish the tutorial with a 3 piece mold. The final ceramic cup is available to download in the description.

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A Special Purpose Machine, which is intended to perform a specific task, have a wide range of scope in the Industrial Applications like quantity packaging and bottle filling. It includes limit switches, sensors, logic controls where the process can be

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This is a SOLIDWORKS Tutorial for a drop out bowl mold. The mold is designed to create a slip cast ceramic bowl. The tutorial focuses on the combine tool, and the use of undercut analysis, which evaluates the design of the bowl for possible issues for molding. It is essential to test a model in this way before molding to avoid the model getting trapped in the mold.

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Being able to have an overview of changes to designs since initial release is an important aspect to time-efficient engineering. Making use of an automatically updated revision table helps with that.  What version are we using? Who has made these

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For this SOLIDWORKS tutorial, you can follow to create a Goldfish shaped Cat Treat Toy ready for 3D printing. The DXF files for this tutorial are available to download from the blog below. You can also download and 3D print this design yourself as the STL files are also available to download.

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In part 1 of this 2-part SOLIDWORKS Tutorial you will learn how to create the body of a Pinata. Part 2 of the tutorial involves shelling the model to turn it into a 2-part jar, and applying decals. The DXF file used in this tutorial are available to download from the blog description.

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CNA Staff, Apr 21, 2020 / 02:19 pm (CNA).- Indigenous rights groups are warning that many families in Bangladesh who have lost jobs and income because of the coronavirus pandemic are not yet receiving aid, and many are facing starvation.

A joint statement from three Bangladeshi indigenous rights groups warns that the vast majority of those living in rural areas are day laborers, and are now out of work.

Bangladesh, a low lying county situated just east of India, has 3,400 confirmed cases of COVID-19 and has recorded 110 deaths. Officials say actual numbers are likely higher due to a lack of testing kits.

Romen Kisku, a Catholic father of five and member of the Santal ethnic group, told UCA News that his family has received a small amount of food aid from a charity, but he worries it will not be enough to feed his 10-member family. He and his family live in the northern region of Dinajpur, and he said he hopes to find work in a neighboring region as a paddy farmer.

“Three men of our family are day laborers and our income pays for everything. Now we cannot go to work and government aid has not reached us. The minimal aid was too little for our family, so we have to go on starving if things don’t improve,” Kisku told UCA News.

Ethnic-minority Santal people live mostly in northwestern Bangladesh as well as parts of India and Nepal. About eight percent are Christian.

Bangladesh has a low percentage of Catholics— as low as 0.3% in some areas— and the Catholic aid group Caritas is struggling to raise funds for the poor.

“We have made an appeal to people in our parishes and areas, so they come up with whatever they can to assist those having hard times during this crisis. The suffering of people will intensify if the crisis lingers, so we need to help people any way possible,” Bishop Sebastian Tudu of Dinajpur told UCA News.

Though the government and charitable organizations are mobilizing to provide relief, the remoteness of the areas where many indigenous people live mean that in some areas, very few families have yet received government assistance.

Though Catholic Relief Services is active in providing aid in refugee camps in Bangladesh, a CRS spokesperson confirmed to CNA that CRS is not currently active in the Dinajpur region.

The branch of Caritas in the southeastern port city of Chittagong has taken two emergency cash handouts of 2,250 taka (US$27) and 1,547 taka to support 950 families on the hills, UCA News reported.

Bangladesh’s government started food relief and subsidized food sales at the end of March, aiming to support about 50 million poor and needy people across the country, UCA News reports.

Bangladesh imposed a nationwide lockdown March 26, with a restriction of no more than five people allowed to congregate in prayer in a mosque, the New York Post reported. Despite this, on April 18 a crowd of some 100,000 people gathered for a funeral in Brahmanbaria, in the eastern part of the country.

CNA Staff, Apr 27, 2020 / 11:30 am (CNA).- The number of Catholics in South Korea increased by less than 50,000 in 2019, continuing a trend of slowing growth after a peak following the 2014 apostolic visit by Pope Francis to the country. 

According to the Catholic Bishops' Conference of Korea, there are 5.91 million Catholics in South Korea’s 16 dioceses; an increase of 48,000 over to 2018’s total. Catholics make up 11% of the national population. 

Overall, the number of Catholics in the country increased by 0.8%, which is slightly lower than last year’s increase of 0.9%. In recent years, the Catholic population in South Korea has grown by an average of 1% each year. 

Like many countries, South Korea’s Catholic population is aging. About one in five South Korean Catholics are over the age of 65, and only 8.5% of Catholics are age 19 or under. A total of 14% of priests are over the age of 65.

South Korea’s flock saw the largest overall percentage increase in 2014, when it increased by 2.2%. Pope Francis visited the country in August of that year, the third visit by a pope to the country. Pope John Paul II visited South Korea in 1984 and again in 1989, when the country hosted the 44th International Eucharistic Congress.

These numbers come as South Korea is grappling with an outbreak of COVID-19, a disease which has seen much of its spread in the nation come from a single member of the Shincheonji Church of Jesus. About half of South Korea’s nearly 11,000 confirmed coronavirus infections stem from “Patient 31,” a member of that church who did not abide by isolation rules after coming down with COVID-19. 

The Catholic Bishops’ Association of Korea refers to Shincheonji Church of Jesus as a “pseudo-religious organization” and a “cult.” The church was founded in 1980 by a man who believes that he is the second coming of Jesus. 

In 2017, the conference created the "Korean Catholic Task Force on Newly-risen Religions” specifically to combat the growing popularity of the Shincheonji Church of Jesus. 

Another source of outbreak were 30 Catholic pilgrims who tested positive for the illness after returning to South Korea from a trip to the Holy Land. Korean Air Lines restricted travel to Israel after these infections were discovered.  

South Korea suspended the public celebration of Mass in late February, and re-opened churches--albeit with strict social distancing requirements--on April 26.

Amendments to the Price Increments of the 3-Year U.S. Treasury Note Futures Contract

Click here for the full text of the advisory

20-188

Allegations about Valeant’s practices and its own disclosures while under pressure cause one to wonder.

Caitlin (USA) is humbled that joining the OM team in Madagascar has encouraged them in their work to carry the name of Jesus to others.