Imagine pulling up to a refueling station and filling your vehicle’s tank with liquid hydrogen, as safe and convenient to handle as gasoline or diesel, without the need for high-pressure tanks or cryogenic storage. This vision of a sustainable future could become a reality if a Calgary, Canada–based company, Ayrton Energy, can scale up its innovative method of hydrogen storage and distribution. Ayrton’s technology could make hydrogen a viable, one-to-one replacement for fossil fuels in existing infrastructure like pipelines, fuel tankers, rail cars, and trucks.

The company’s approach is to use liquid organic hydrogen carriers (LOHCs) to make it easier to transport and store hydrogen. The method chemically bonds hydrogen to carrier molecules, which absorb hydrogen molecules and make them more stable—kind of like hydrogenating cooking oil to produce margarine.

A researcher pours a sample of Ayrton’s LOHC fluid into a vial.Ayrton Energy

The approach would allow liquid hydrogen to be transported and stored in ambient conditions, rather than in the high-pressure, cryogenic tanks (to hold it at temperatures below -252 ºC) currently required for keeping hydrogen in liquid form. It would also be a big improvement on gaseous hydrogen, which is highly volatile and difficult to keep contained.

Founded in 2021, Ayrton is one of several companies across the globe developing LOHCs, including Japan’s Chiyoda and Mitsubishi, Germany’s Covalion, and China’s Hynertech. But toxicity, energy density, and input energy issues have limited LOHCs as contenders for making liquid hydrogen feasible. Ayrton says its formulation eliminates these trade-offs.

Safe, Efficient Hydrogen Fuel for Vehicles

Conventional LOHC technologies used by most of the aforementioned companies rely on substances such as toluene, which forms methylcyclohexane when hydrogenated. These carriers pose safety risks due to their flammability and volatility. Hydrogenious LOHC Technologies in Erlanger, Germany and other hydrogen fuel companies have shifted toward dibenzyltoluene, a more stable carrier that holds more hydrogen per unit volume than methylcyclohexane, though it requires higher temperatures (and thus more energy) to bind and release the hydrogen. Dibenzyltoluene hydrogenation occurs at between 3 and 10 megapascals (30 and 100 bar) and 200–300 ºC, compared with 10 MPa (100 bar), and just under 200 ºC for methylcyclohexane.

Ayrton’s proprietary oil-based hydrogen carrier not only captures and releases hydrogen with less input energy than is required for other LOHCs, but also stores more hydrogen than methylcyclohexane can—55 kilograms per cubic meter compared with methylcyclohexane’s 50 kg/m³. Dibenzyltoluene holds more hydrogen per unit volume (up to 65 kg/m³), but Ayrton’s approach to infusing the carrier with hydrogen atoms promises to cost less. Hydrogenation or dehydrogenation with Ayrton’s carrier fluid occurs at 0.1 megapascal (1 bar) and about 100 ºC, says founder and CEO Natasha Kostenuk. And as with the other LOHCs, after hydrogenation it can be transported and stored at ambient temperatures and pressures.

Judges described [Ayrton's approach] as a critical technology for the deployment of hydrogen at large scale.” —Katie Richardson, National Renewable Energy Lab

Ayrton’s LOHC fluid is as safe to handle as margarine, but it’s still a chemical, says Kostenuk. “I wouldn’t drink it. If you did, you wouldn’t feel very good. But it’s not lethal,” she says.

Kostenuk and fellow Ayrton cofounder Brandy Kinkead (who serves as the company’s chief technical officer) were originally trying to bring hydrogen generators to market to fill gaps in the electrical grid. “We were looking for fuel cells and hydrogen storage. Fuel cells were easy to find, but we couldn’t find a hydrogen storage method or medium that would be safe and easy to transport to fuel our vision of what we were trying to do with hydrogen generators,” Kostenuk says. During the search, they came across LOHC technology but weren’t satisfied with the trade-offs demanded by existing liquid hydrogen carriers. “We had the idea that we could do it better,” she says. The duo pivoted, adjusting their focus from hydrogen generators to hydrogen storage solutions.

“Everybody gets excited about hydrogen production and hydrogen end use, but they forget that you have to store and manage the hydrogen,” Kostenuk says. Incompatibility with current storage and distribution has been a barrier to adoption, she says. “We’re really excited about being able to reuse existing infrastructure that’s in place all over the world.” Ayrton’s hydrogenated liquid has fuel-cell-grade (99.999 percent) hydrogen purity, so there’s no advantage in using pure liquid hydrogen with its need for subzero temperatures, according to the company.

The main challenge the company faces is the set of issues that come along with any technology scaling up from pilot-stage production to commercial manufacturing, says Kostenuk. “A crucial part of that is aligning ourselves with the right manufacturing partners along the way,” she notes.

Asked about how Ayrton is dealing with some other challenges common to LOHCs, Kostenuk says Ayrton has managed to sidestep them. “We stayed away from materials that are expensive and hard to procure, which will help us avoid any supply chain issues,” she says. By performing the reactions at such low temperatures, Ayrton can get its carrier fluid to withstand 1,000 hydrogenation-dehydrogenation cycles before it no longer holds enough hydrogen to be useful. Conventional LOHCs are limited to a couple of hundred cycles before the high temperatures required for bonding and releasing the hydrogen breaks down the fluid and diminishes its storage capacity, Kostenuk says.

Breakthrough in Hydrogen Storage Technology

In acknowledgement of what Ayrton’s nontoxic, oil-based carrier fluid could mean for the energy and transportation sectors, the U.S. National Renewable Energy Lab (NREL) at its annual Industry Growth Forum in May named Ayrton an “outstanding early-stage venture.” A selection committee of more than 180 climate tech and cleantech investors and industry experts chose Ayrton from a pool of more than 200 initial applicants, says Katie Richardson, group manager of NREL’s Innovation and Entrepreneurship Center, which organized the forum. The committee based its decision on the company’s innovation, market positioning, business model, team, next steps for funding, technology, capital use, and quality of pitch presentation. “Judges described Ayrton’s approach as a critical technology for the deployment of hydrogen at large scale,” Richardson says.

As a next step toward enabling hydrogen to push gasoline and diesel aside, “we’re talking with hydrogen producers who are right now offering their customers cryogenic and compressed hydrogen,” says Kostenuk. “If they offered LOHC, it would enable them to deliver across longer distances, in larger volumes, in a multimodal way.” The company is also talking to some industrial site owners who could use the hydrogenated LOHC for buffer storage to hold onto some of the energy they’re getting from clean, intermittent sources like solar and wind. Another natural fit, she says, is energy service providers that are looking for a reliable method of seasonal storage beyond what batteries can offer. The goal is to eventually scale up enough to become the go-to alternative (or perhaps the standard) fuel for cars, trucks, trains, and ships.

Every invention begins with a problem—and the creative act of seeing a problem where others might just see unchangeable reality. For one 5-year-old, the problem was simple: She liked to have her tummy rubbed as she fell asleep. But her mom, exhausted from working two jobs, often fell asleep herself while putting her daughter to bed. “So [the girl] invented a teddy bear that would rub her belly for her,” explains Stephanie Couch, executive director of the Lemelson MIT Program. Its mission is to nurture the next generation of inventors and entrepreneurs.

Anyone can learn to be an inventor, Couch says, given the right resources and encouragement. “Invention doesn’t come from some innate genius, it’s not something that only really special people get to do,” she says. Her program creates invention-themed curricula for U.S. classrooms, ranging from kindergarten to community college.

We’re biased, but we hope that little girl grows up to be an engineer. By the time she comes of age, the act of invention may be something entirely new—reflecting the adoption of novel tools and the guiding forces of new social structures. Engineers, with their restless curiosity and determination to optimize the world around them, are continuously in the process of reinventing invention.

In this special issue, we bring you stories of people who are in the thick of that reinvention today. IEEE Spectrum is marking 60 years of publication this year, and we’re celebrating by highlighting both the creative act and the grindingly hard engineering work required to turn an idea into something world changing. In these pages, we take you behind the scenes of some awe-inspiring projects to reveal how technology is being made—and remade—in our time.

Inventors Are Everywhere

Invention has long been a democratic process. The economist B. Zorina Khan of Bowdoin College has noted that the U.S. Patent and Trademark Office has always endeavored to allow essentially anyone to try their hand at invention. From the beginning, the patent examiners didn’t care who the applicants were—anyone with a novel and useful idea who could pay the filing fee was officially an inventor.

This ethos continues today. It’s still possible for an individual to launch a tech startup from a garage or go on “Shark Tank” to score investors. The Swedish inventor Simone Giertz, for example, made a name for herself with YouTube videos showing off her hilariously bizarre contraptions, like an alarm clock with an arm that slapped her awake. The MIT innovation scholar Eric von Hippel has spotlighted today’s vital ecosystem of “user innovation,” in which inventors such as Giertz are motivated by their own needs and desires rather than ambitions of mass manufacturing.

But that route to invention gets you only so far, and the limits of what an individual can achieve have become starker over time. To tackle some of the biggest problems facing humanity today, inventors need a deep-pocketed government sponsor or corporate largess to muster the equipment and collective human brainpower required.

When we think about the challenges of scaling up, it’s helpful to remember Alexander Graham Bell and his collaborator Thomas Watson. “They invent this cool thing that allows them to talk between two rooms—so it’s a neat invention, but it’s basically a gadget,” says Eric Hintz, a historian of invention at the Smithsonian Institution. “To go from that to a transcontinental long-distance telephone system, they needed a lot more innovation on top of the original invention.” To scale their invention, Hintz says, Bell and his colleagues built the infrastructure that eventually evolved into Bell Labs, which became the standard-bearer for corporate R&D.

In this issue, we see engineers grappling with challenges of scale in modern problems. Consider the semiconductor technology supported by the U.S. CHIPS and Science Act, a policy initiative aimed at bolstering domestic chip production. Beyond funding manufacturing, it also provides US $11 billion for R&D, including three national centers where companies can test and pilot new technologies. As one startup tells the tale, this infrastructure will drastically speed up the lab-to-fab process.

And then there are atomic clocks, the epitome of precision timekeeping. When researchers decided to build a commercial version, they had to shift their perspective, taking a sprawling laboratory setup and reimagining it as a portable unit fit for mass production and the rigors of the real world. They had to stop optimizing for precision and instead choose the most robust laser, and the atom that would go along with it.

These technology efforts benefit from infrastructure, brainpower, and cutting-edge new tools. One tool that may become ubiquitous across industries is artificial intelligence—and it’s a tool that could further expand access to the invention arena.

What if you had a team of indefatigable assistants at your disposal, ready to scour the world’s technical literature for material that could spark an idea, or to iterate on a concept 100 times before breakfast? That’s the promise of today’s generative AI. The Swiss company Iprova is exploring whether its AI tools can automate “eureka” moments for its clients, corporations that are looking to beat their competitors to the next big idea. The serial entrepreneur Steve Blank similarly advises young startup founders to embrace AI’s potential to accelerate product development; he even imagines testing product ideas on digital twins of customers. Although it’s still early days, generative AI offers inventors tools that have never been available before.

Measuring an Invention’s Impact

If AI accelerates the discovery process, and many more patentable ideas come to light as a result, then what? As it is, more than a million patents are granted every year, and we struggle to identify the ones that will make a lasting impact. Bryan Kelly, an economist at the Yale School of Management, and his collaborators made an attempt to quantify the impact of patents by doing a technology-assisted deep dive into U.S. patent records dating back to 1840. Using natural language processing, they identified patents that introduced novel phrasing that was then repeated in subsequent patents—an indicator of radical breakthroughs. For example, Elias Howe Jr.’s 1846 patent for a sewing machine wasn’t closely related to anything that came before but quickly became the basis of future sewing-machine patents.

Another foundational patent was the one awarded to an English bricklayer in 1824 for the invention of Portland cement, which is still the key ingredient in most of the world’s concrete. As Ted C. Fishman describes in his fascinating inquiry into the state of concrete today, this seemingly stable industry is in upheaval because of its heavy carbon emissions. The AI boom is fueling a construction boom in data centers, and all those buildings require billions of tons of concrete. Fishman takes readers into labs and startups where researchers are experimenting with climate-friendly formulations of cement and concrete. Who knows which of those experiments will result in a patent that echoes down the ages?

Some engineers start their invention process by thinking about the impact they want to make on the world. The eminent Indian technologist Raghunath Anant Mashelkar, who has popularized the idea of “Gandhian engineering”, advises inventors to work backward from “what we want to achieve for the betterment of humanity,” and to create problem-solving technologies that are affordable, durable, and not only for the elite.

Durability matters: Invention isn’t just about creating something brand new. It’s also about coming up with clever ways to keep an existing thing going. Such is the case with the Hubble Space Telescope. Originally designed to last 15 years, it’s been in orbit for twice that long and has actually gotten better with age, because engineers designed the satellite to be fixable and upgradable in space.

For all the invention activity around the globe—the World Intellectual Property Organization says that 3.5 million applications for patents were filed in 2022—it may be harder to invent something useful than it used to be. Not because “everything that can be invented has been invented,” as in the apocryphal quote attributed to the unfortunate head of the U.S. patent office in 1889. Rather, because so much education and experience are required before an inventor can even understand all the dimensions of the door they’re trying to crack open, much less come up with a strategy for doing so. Ben Jones, an economist at Northwestern’s Kellogg School of Management, has shown that the average age of great technological innovators rose by about six years over the course of the 20th century. “Great innovation is less and less the provenance of the young,” Jones concluded.

Consider designing something as complex as a nuclear fusion reactor, as Tom Clynes describes in “An Off-the-Shelf Stellarator.” Fusion researchers have spent decades trying to crack the code of commercially viable fusion—it’s more akin to a calling than a career. If they succeed, they will unlock essentially limitless clean energy with no greenhouse gas emissions or meltdown danger. That’s the dream that the physicists in a lab in Princeton, N.J., are chasing. But before they even started, they first had to gain an intimate understanding of all the wrong ways to build a fusion reactor. Once the team was ready to proceed, what they created was an experimental reactor that accelerates the design-build-test cycle. With new AI tools and unprecedented computational power, they’re now searching for the best ways to create the magnetic fields that will confine the plasma within the reactor. Already, two startups have spun out of the Princeton lab, both seeking a path to commercial fusion.

The stellarator story and many other articles in this issue showcase how one innovation leads to the next, and how one invention can enable many more. The legendary Dean Kamen, best known for mechanical devices like the Segway and the prosthetic “Luke” arm, is now trying to push forward the squishy world of biological manufacturing. In an interview, Kamen explains how his nonprofit is working on the infrastructure—bioreactors, sensors, and controls—that will enable companies to explore the possibilities of growing replacement organs. You could say that he’s inventing the launchpad so others can invent the rockets.

Sometimes everyone in a research field knows where the breakthrough is needed, but that doesn’t make it any easier to achieve. Case in point: the quest for a household humanoid robot that can perform domestic chores, switching effortlessly from frying an egg to folding laundry. Roboticists need better learning software that will enable their bots to navigate the uncertainties of the real world, and they also need cheaper and lighter actuators. Major advances in these two areas would unleash a torrent of creativity and may finally bring robot butlers into our homes.

And maybe the future roboticists who make those breakthroughs will have cause to thank Marina Umaschi Bers, a technologist at Boston College who cocreated the ScratchJr programming language and the KIBO robotics kit to teach kids the basics of coding and robotics in entertaining ways. She sees engineering as a playground, a place for children to explore and create, to be goofy or grandiose. If today’s kindergartners learn to think of themselves as inventors, who knows what they’ll create tomorrow?

In physical books, yellowing pages are usually a sign of age. But brand-new users of Amazon’s Kindle Colorsofts, the tech giant’s first color e-reader, are already noticing yellow hues appearing at the bottoms of their displays.

Since the complaints began the trickle in, Amazon has reportedly suspended shipments and announced that it is working to fix the issue. (As of publication of this article, the US $280 Kindle had an average 2.6 star rating on Amazon.) It’s not yet clear what is causing the discoloration. But while the issue is new—and unexpected—the technology is not, says Jason Heikenfeld, an IEEE Fellow and engineering professor at the University of Cincinnati. The Kindle Colorsoft, which became available on 30 October, uses “a very old approach,” says Heikenfeld, who previously worked to develop the ultimate e-paper technology. “It was the first approach everybody tried.”

Amazon’s e-reader uses reflective display technology developed by E Ink, a company that started in the 1990s as an MIT Media Lab spin off before developing its now-dominant electronic paper displays. E Ink is used in Kindles, as well as top e-readers from Kobo, reMarkable, Onyx, and more. E Ink first introduced Kaleido—the basis of the Colorsoft’s display—five years ago, though the road to full-color e-paper started well before.

How E-Readers Work

Monochromatic Kindles work by applying voltages to electrodes in the screen that bring black or white pigment to the top of each pixel. Those pixels then reflect ambient light, creating a paper-like display. To create a full-color display, companies like E Ink added an array of filters just above the ink. This approach didn’t work well at first because the filters lost too much light, making the displays dark and low resolution. But with a few adjustments, Kaleido was ready for consumer products in 2019. (Other approaches—like adding colored pigments to the ink—have been developed, but these come with their own drawbacks, including a higher price tag.)

Given this design, it initially seemed to Heikenfeld that the issue would have stemmed from the software, which determines the voltages applied to each electrode. This aligned with reports from some users that the issue appeared after a software update.

But industry analyst Ming-Chi Kuo suggested in a post on X that the issue is due to the e-reader’s hardware. Amazon switched the optically clear adhesive (OCA) used in the Colorsoft to a material that may not be so optically clear. In its announcement of the Colorsoft, the company boasted “custom formulated coatings” that would enhance the color display as one of the new e-reader’s innovations.

In terms of resolving the issue, Kuo’s post also stated that “While component suppliers have developed several hardware solutions, Amazon seems to be leaning toward a software-based fix.” Heikenfeld is not sure how a software fix would work, apart from blacking out the bottom of the screen.

Amazon did not reply to IEEE Spectrum’s request for comment. In an email to IEEE Spectrum, E Ink stated, “While we cannot comment on any individual partner or product, we are committed to supporting our partners in understanding and addressing any issues that arise.”

The Future of E-Readers

It took a long time for color Kindles to arrive, and the future of reflective e-reader displays isn’t likely to improve much, according to Heikenfeld. “I used to work a lot in this field, and it just really slowed down at some point, because it’s a tough nut to crack,” Heikenfeld says.

There are inherent limitations and inefficiencies to working with filter-based color displays that rely on ambient light, and there’s no Moore’s Law for these displays. Instead, their improvement is asymptotic—and we may already be close to the limit. Meanwhile, displays that emit light, like LCD and OLED, continue to improve. “An iPad does a pretty damn good job with battery life now,” says Heikenfeld.

At the same time, he believes there will always be a place for reflective displays, which remain a more natural experience for our eyes. “We live in a world of reflective color,” Heikenfeld says.

This is story was updated on 12 November 2024 to correct that Jason Heikenfeld is an IEEE Fellow.

A super-hurricane is barreling toward Florida, gaining strength from a number of sources.

More blazes break out where wild land and urban areas overlap.

<a href="https://mtverify.com/" rel="nofollow ugc">먹튀검증</a> 전문가들이 꼼꼼하게 검증한 사이트만을 소개합니다. 안심하고 베팅하세요. 먹튀검증소: https://mtverify.com/

<a href="https://bluetechker.com/" rel="nofollow ugc">Blue Techker</a> naturally like your web site however you need to take a look at the spelling on several of your posts. A number of them are rife with spelling problems and I find it very bothersome to tell the truth on the other hand I will surely come again again.

Thank you for the auspicious writeup It in fact was a amusement account it Look advanced to more added agreeable from you By the way how could we communicate

helloI really like your writing so a lot share we keep up a correspondence extra approximately your post on AOL I need an expert in this house to unravel my problem May be that is you Taking a look ahead to see you

With no conclusive laboratory results, researchers are turning to other methods to find the elusive substance

We’ve all been there. You’ve gone to the store or scrolled through countless online sites, desperately searching for a graduation gift that’s unique, funny, and something your friend won’t toss in a drawer and forget about. Well, it turns out there’s a new trend catching fire, and it’s a fake college diploma. Yes, you heard […]

The post Why Fake College Diplomas Are the Latest Comedy Trend in Graduation Gifts appeared first on Chart Attack.

1. Security beefed up at Ram temple in Ayodhya after Pannun's threat message  The Times of India
2. Security beefed up around Ram Mandir in Ayodhya after Gurpatwant Pannun’s ‘threat’  Hindustan Times
3. Pannun Announces New Dates Of Temple Attacks In Canada, India Terms Threats ‘Terror Acts’: Intel Sources  News18
4. Khalistani terrorist Pannun warns of ‘shaking Ayodhya's foundations’  The Economic Times
5. Security beefed up in Ayodhya after Khalistan`s threat  Zee News

Register of Copyrights sides with industry's "market harm" argument for rereleased games.

It's a little rogue-lite, it's a bit '90s arcade, and it's surprisingly deep.

‘Idli Kadai,’ Dhanush’s fourth directorial project, has music scored by GV Prakash Kumar

From Juliette Binoche’s ‘A Thousand Times Good Night’ to Clint Eastwood’s ‘The Bridges of Madison County,’ here are some films that used photography as a lens to reveal the inner landscapes of the protagonist

The supporting cast ‘Thudarum’ includes Binu Pappu, Maniyanpilla Raju, Farhaan Faasil, and Thomas Mathew

A prolific figure in Tamil cinema, the versatile actor appeared in over 400 films across Tamil, Telugu, and Malayalam languages

‘Horizon Zero Dawn Remastered’ elevates a classic with breathtaking visuals, smooth performance, and a gripping narrative on PS5 and PC

The inaugural Red Lorry Film Festival in 2024 saw over 100 international films across various categories and languages

Playtonic Friends just announced that Victory Heat Rally from developer Skydevilpalm is coming to mobile through Crunchyroll and also on …

Continue reading "‘Victory Heat Rally’ From Skydevilpalm and Playtonic Friends Is Coming to PC and Crunchyroll for Mobile on October 3rd"

Action adventure game RWBY: Arrowfell from WayForward is now available on mobile through the Crunchyroll Game Vault. RWBY: Arrowfell, developed …

Continue reading "‘RWBY: Arrowfell’ Now Available on Mobile Through Crunchyroll Game Vault"

With some simple lifestyle changes, you can lower your risk of osteoporosis.

Actor recalled angry phone call with Murphy in which she claims he ‘ripped’ into her

Eat well With isolation comes the three Bs: boredom, bingeing, and (can’t be) bothered. The evil accomplice of all three is comfort eating. While snacks and treats are okay now ...

The post How to stay healthy during quarantine appeared first on Star Observer.

Moss Agate meaning revolves around growth, emotional healing, and nature's balance. Discover its grounding energy and how it fosters abundance and inner peace.

Apophyllite: Discover the healing powers of apophyllite crystals, known for enhancing clarity, intuition, and spiritual growth. Perfect for meditation and relaxation.

The Connecticut Democrat suddenly thinks Democrats need to listen to people outside their coalition.

Speaking with CBC News’s Eli Glasner, Cillian Murphy discusses ‘imploding emotionally’ in his role in Small Things Like These, his partnership with Matt Damon and Ben Affleck and how his experience on Oppenheimer influenced this film. CORRECTION: A previous version of this video interview includes reference to communities in Canada 'still finding bodies of Indigenous children in the ground' at 1:24. We have removed this portion of the interview. Searches at the sites of former residential schools using ground-penetrating radar have found evidence of possible unmarked graves.

Un avocat de Laval épinglé pour son compteur d’Hydro-Québec trafiqué qui lui a fait économiser près de 27 000$ d’électricité devra payer une amende.

SURFING legend Kelly Slater has revealed how miserable he was starring alongside Pamela Anderson on Baywatch.

Canada has launched a tourist drive but will tensions with China doom it to fail?

Seth Messingham from Hornsby North Public School and Zac “Nugget” Bovis from Berowra Public School represented North Sydney in the NSW PSSA Boy’s football State Carnival at Valentine Sports Park in Glenwood to secure a win North Sydney hasn’t seen since 1969.

Two exclusive conferences focusing on "Reference Material (RM) Producers" organized by National Accreditation Board for Testing and Calibration Laboratories (NABL) are scheduled to be held on January 10,

Joe Anderson, product and promotional marketing manager at Harland, explores the role of surface preparation in the application of hydrophilic and hydrophobic coatings.

Election polls are increasingly vulnerable to huge mistakes

This week, I’m rerunning some popular posts while we put the finishing touches on DCI’s new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors.

Last week, the Federal Trade Commission (FTC) released the redacted version of administrative complaint against the three largest pharmacy benefit managers (PBMs). The FTC rightly calls out how the gross-to-net bubble can raise patients’ out-of-pocket costs, while also acknowledging how rebates can reduce a plan's (but not the patient’s) costs. Apparently, the FTC believes that PBMs’ customers are pretty dumb, because PBMs are able to prevent plans from “appreciating” such healthcare financing dynamics.

Section V.E. of the complaint (starting on page 23) focuses on the PBMs’ alleged unlawful conduct related to preferring high-list/high-rebate insulin products over versions with lower list prices. I thought it would therefore be fun to take the Wayback Machine to November 2021, when I wrote about this specific topic.

Below, you can review my commentary about the warped incentives behind Viatris’ dual-pricing strategy for its interchangeable biosimilar of Lantus. Much of the FTC’s description of the drug channel aligns with my commentary. But before you fist pump too hard for Ms. Khan’s FTC, you should pause to reflect on the agency’s legal theories in light of plans’ revealed preferences.

---

The Food & Drug Administration (FDA) recently approved the first interchangeable biosimilar insulin product: the insulin glargine-yfgn injection from Viatris. Read the FDA’s press release.

Alas, I’m sad to report that the warped incentives baked into the U.S. drug channel will limit the impact of this impressive breakthrough.

Viatris is being forced to launch both a high-priced and a low-priced version of the biosimilar. However, only the high-list/high-rebate, branded version will be available on Express Scripts’ largest commercial formulary. Express Scripts will block both the branded reference product and the lower-priced, unbranded—but also interchangeable—version. Meanwhile, Prime Therapeutics will place both versions on its formularies, leaving the choice up to its plan sponsor clients.

Consequently, many commercial payers will adopt the more expensive product instead of the identical—but cheaper—version. As usual, patients will be the ultimate victims of our current drug pricing system.

Below, I explain the weird economics behind this decision, highlight the negative impact on patients, and speculate on what this all could mean for biosimilars’ future. Until plan sponsors break their addiction to rebates, today’s U.S. drug channel problems will remain.
Read more »

A new survey of plan sponsors sheds light on their satisfaction with transparency at large and small pharmacy benefit managers (PBMs).

As you will see, clients remain slightly more satisfied with the perceived transparency of smaller PBMs compared with the Big Three PBMs—CVS Caremark, Express Scripts, and Optum Rx.

However, plan sponsors are dissatisfied with transparency about how both large and small PBMs make money. Smaller PBMs have an edge, but it’s narrower than you might think.

Perhaps PBMs’ clients are unable or unwilling to negotiate better deals, write more effective contracts, and switch to more satisfying relationships. Or maybe they don’t mind the current system, despite the challenges for patients. Some argue that transparency could swoop down to solve this problem. Riddle me this: Should we watch what plan sponsors say, or what they do?

Read on to see what you think of my arguments below. Then, click here to share your thoughts with the Drug Channels community.
Read more »

Eeek! It's time for Drug Channels’ Halloween roundup of terrifying tales to share with your ghoulish fiends. This month’s tricks and treats:

• Spooky! Blue Shield of California frightens away the gross-to-net bubble with its Humira biosimilar strategy

• Vampiric! Prior authorization sinks its fangs into providers’ time

• Wicked! How the IRA will put a stake through specialty physician practices

• Eerie! Google’s monstrous AI podcasts leave me petrified

• Zoinks! Join the vampire hunters at Drug Channels Institute

Plus, Dr. Glaucomflecken tells us a frightening tale of copayments.

P.S. Stretch out your arms and join the ever-growing zombie horde who shamble after me on LinkedIn. You’ll find my ghostly rantings along with commentary from the undead hordes in the DCI community.
Read more »

If you’ve ever tried to get a bandage to stick to your elbow, you understand the difficulty in creating wearable devices that attach securely to the human body. Add digital electronic circuitry, and the problem becomes more complicated. Now include the need for the device to fix breaks and damage automatically—and let’s make it biodegradable while we’re at it—and many researchers would throw up their hands in surrender.

Fortunately, an international team led by researchers at Korea University Graduate School of Converging Science and Technology (KU-KIST) persevered, and has developed conductor materials that it claims are stretchable, self-healing, and biocompatible. Their project was described this month in the journal Science Advances.

The biodegradable conductor offers a new approach to patient monitoring and delivering treatments directly to the tissues and organs where they are needed. For example, a smart patch made of these materials could measure motion, temperature, and other biological data. The material could also be used to create sensor patches that can be implanted inside the body, and even mounted on the surface of internal organs. The biocompatible materials can be designed to degrade after a period of time, eliminating the need for an invasive procedure to remove the sensor later.

“This new technology is a glimpse at the future of remote healthcare,” says Robert Rose, CEO of Rose Strategic Partners, LLC. “Remote patient monitoring is an industry still in its early stages, but already we are seeing the promise of what is not only possible, but close on the horizon. Imagine a device implanted at a surgical site to monitor and report your internal healing progress. If it is damaged, the device can heal itself, and when the job is done, it simply dissolves. It sounds like science fiction, but it’s now science fact.”

Self-healing elastics

After being cut a ribbonlike film was able to heal itself in about 1 minute.Suk-Won Hwang

The system relies on two different layers of flexible material, both self-healing: one is for conduction and the other is an elastomer layer that serves as a substrate to support the sensors and circuitry needed to collect data. The conductor layer is based on a substance known by the acronym PEDOT:PSS, which is short for Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate. It’s a conductive polymer widely used in making flexible displays and touch panels, as well as wearable devices. To increase the polymer’s conductivity and self-healing properties, the research team used additives including polyethylene glycol and glycol, which helped increase conductivity as well as the material’s ability to automatically repair damage such as cuts or tears.

In order to conform to curved tissues and survive typical body motion, the substrate layer must be extremely flexible. The researchers based it on elastomers that can match the shape of curved tissues, such as skin or individual organs.

These two layers stick to each other, thanks to chemical bonds that can connect the polymer chains of the plastic films in each layer. Combined, these materials create a system that is flexible and stretchable. In testing, the researchers showed that the materials could survive stretching up to 500 percent.

The self-healing function arises from the material’s ability to reconnect to itself when cut or otherwise damaged. This self-healing feature is based on a chemical process called disulfide metathesis. In short, polymer molecules containing pairs of linked sulfur atoms, called disulfides, have the ability to reform themselves after being severed. The phenomenon arises from a chemical process called disulfide-disulfide shuffling reactions, in which disulfide bonds in the molecule break and then reform, not necessarily between the original partners. According to the KU-KIST researchers, after being cut, their material was able to recover conductivity in its circuits within about two minutes without any intervention. The material was also tested for bending, twisting, and its ability to function both in air and under water.

This approach offers many advantages over other flexible electronics designs. For example, silver nanowires and carbon nanotubes have been used as the basis for stretchable devices, but they can be brittle and lack the self-healing properties of the KU-KIST materials. Other materials such as liquid metals can self-heal, but they are typically difficult to handle and integrate into wearable circuitry.

As a demonstration, the team created a multifunction sensor that included humidity, temperature, and pressure sensors that was approximately 4.5 square centimeters. In spite of being cut in four separate locations, it was able to heal itself and continue to provide sensor readings.

Implant tested in a rat

To take the demonstration a step further, the researchers created a 1.8-cm² device that was attached to a rat’s bladder. The device was designed to wrap around the bladder and then adhere to itself, so no adhesives or sutures were required to attach the sensor onto the bladder. The team chose the bladder for their experiments because, under normal conditions, its size can change by 300 percent.

The device incorporated both electrodes and pressure sensors, which were able to detect changes in the bladder pressure. The electrodes could detect bladder voiding, through electromyography signals, as well as stimulate the bladder to induce urination. As with the initial demonstration, intentional damage to the device’s circuitry healed on its own, without intervention.

The biocompatible and biodegradable nature of the materials is important because it means that devices fabricated with them can be worn on the skin, as well as implanted within the body. The fact that the materials are biodegradable means that implants would not need a second surgical procedure to remove them. They could be left in place after serving their purpose, and they would be absorbed by the body.

According to Suk-Won Hwang, assistant professor at KU-KIST, a few hurdles remain on the path to commercialization. “We need to test the biocompatibility of some of the materials used in the conductor and substrate layers. While scalable production appears to be feasible, the high cost of disulfide derivatives might make the technology too expensive, aside from some special applications,” he says. “Biocompatibility testing and material synthesis optimization will take one to two years, at least.”

Three ways health plans can engage, connect with, and delight their pregnant members to nurture goodwill, earn long-term trust, and foster loyal relationships that last.

The post Pregnant and Empowered: Why Trust is the Latest Form of Member Engagement appeared first on MedCity News.

Hospitals across the U.S. have significantly restricted the use of pain medications containing narcotics. This shift comes amid […]

The post Pain Management in Crisis: Why Hospitals Are Limiting Pain Medications and What This Means for Patients appeared first on World of DTC Marketing.

The Centers for Medicare and Medicaid Services (CMS) recently announced a 2.9% cut to Medicare physician payments for […]

The post CMS Cuts Medicare Physician Payments: What It Means appeared first on World of DTC Marketing.

We’re seeing an alarming increase in the number of failed biotech companies. While the biotechnology industry holds enormous […]

The post Why Biotech Companies Fail: Lessons for CEOs appeared first on World of DTC Marketing.

NEW YORK – Moves by major US fast-food chains to temporarily scrub fresh onions off their menus on Oct 24, after the vegetable was named as the likely source of an E. coli outbreak at McDonald’s, laid bare the recurring nightmare for restaurants: Produce is a bigger problem for restaurants to keep free of contamination than beef. Onions are likely the culprit in the McDonald’s E. coli outbreak across the Midwest and some Western states that has sickened 49 people and killed one, the US Department of Agriculture said late on Oct 23. The company pulled the Quarter Pounder off its menu at one-fifth of its 14,000 US restaurants. In past years, beef patties dominated the dockets of food-borne-illness lawyers, before US federal health regulators cracked down on beef contamination after an E. coli outbreak linked to Jack in the Box burgers hospitalised more than 170 people across states and killed four. As a result, beef-related outbreaks became much rarer, experts say.

LONDON — The world's biggest food and beverage companies on average sell products in low-income countries that are less healthy than what they sell in high-income countries, according to a new report. Products sold by companies including Nestle, Pepsico and Unilever were assessed as part of a global index published by the Access to Nutrition Initiative (ATNI), its first since 2021. The non-profit group found that across 30 companies, the products sold in low-income countries scored lower on a star rating system developed in Australia and New Zealand than those sold in high-income countries. In the Health Star Rating system, products are ranked out of five on their healthiness, with five the best, and a score above 3.5 considered to be a healthier choice.

Jul 17, 2023

Apekshya Prasai, a political science doctoral candidate at the Massachusetts Institute of Technology, was recently named a 2023 Harry Frank Guggenheim Foundation Emerging Scholar.   The Emerging Scholars (nine in all) are doctoral candidates who are in the final year of writing dissertations on the nature of and responses to violence around the world.