Hisashi Kobayashi, whose steady leadership as dean guided Princeton's School of Engineering and Applied Science through a rapid expansion of programs and facilities in the late 1980s and early 1990s, died on March 9. He was 84.

DL Brasaemle
Nov 1, 1997; 38:2249-2263
Articles

Net Zero and Beyond: What Role for Bioenergy with Carbon Capture and Storage? 23 January 2020 — 8:30AM TO 10:00AM Anonymous (not verified) 6 January 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

In the context of the feasibility of reducing greenhouse gas emissions to net zero, policymakers are beginning to pay more attention to options for removing carbon dioxide from the atmosphere. A wide range of potential carbon dioxide removal (CDR) options are currently being discussed and modelled though the most prominent among them are bioenergy with carbon capture and storage (BECCS) and afforestation and reforestation.

There are many reasons to question the reliance on BECCS assumed in the models including the carbon balances achievable, its substantial needs for land, water and other inputs and technically and economically viable carbon capture and storage technologies.

This meeting will examine the potentials and challenges of BECCS in the context of other CDR and emissions abatement options. It will discuss the requisite policy and regulatory frameworks to minimize sustainability and socio-political risks of CDR approaches while also avoiding overshooting climate goals.

Attendance at this event is by invitation only.

Nonsmall cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. While mutations in Kras and overexpression of Myc are commonly found in patients, the role of altered lipid metabolism in lung cancer and its interplay with oncogenic Myc is poorly understood. Here we use a transgenic mouse model of Kras-driven lung adenocarcinoma with reversible activation of Myc combined with surface analysis lipid profiling of lung tumors and transcriptomics to study the effect of Myc activity on cholesterol homeostasis. Our findings reveal that the activation of Myc leads to the accumulation of cholesteryl esters (CEs) stored in lipid droplets. Subsequent Myc deactivation leads to further increases in CEs, in contrast to tumors in which Myc was never activated. Gene expression analysis linked cholesterol transport and storage pathways to Myc activity. Our results suggest that increased Myc activity is associated with increased cholesterol influx, reduced efflux, and accumulation of CE-rich lipid droplets in lung tumors. Targeting cholesterol homeostasis is proposed as a promising avenue to explore for novel treatments of lung cancer, with diagnostic and stratification potential in human NSCLC.

SAN JOSE, Calif., Oct. 16, 2024 — Supermicro, Inc. is launching a new optimized storage system for high performance AI training, inference and HPC workloads. This JBOF (Just a Bunch […]

The post Supermicro Introduces JBOF Storage Platform Powered by NVIDIA BlueField-3 for Scalable AI and HPC appeared first on HPCwire.

Oct. 24, 2024 — The San Diego Supercomputer Center (SDSC), part of the School of Computing, Information and Data Sciences at UC San Diego, has been leading the Open Storage Network (OSN) program for years, and along […]

The post SDSC Leads Expansion of Open Storage Network to More Campus Computing Sites appeared first on HPCwire.

SANTA CLARA, Calif., Aug. 13, 2024 — Pure Storage today announced that it joined Ultra Ethernet Consortium (UEC), a Linux Foundation initiative dedicated to building a complete, open, and accessible Ethernet-based […]

The post Pure Storage Embraces Next-Gen Networking for AI with Ultra Ethernet Consortium Membership appeared first on HPCwire.

What can be achieved using applications such as AI/ML, Deep Learning, and Big Data Analytics has been revolutionized by Magnum IO GPUDirect Storage’s capabilities. Agencies have invested in these solutions […]

The post Accelerating GPU Based Applications with NVIDIA Validated Magnum IO GPUDirect Storage and Pavilion appeared first on HPCwire.

MLCommons this week issued the results of its latest MLPerf Inference (v3.1) benchmark exercise. Nvidia was again the top performing accelerator, but Intel (Xeon CPU) and Habana (Gaudi1 and 2) […]

The post MLPerf Releases Latest Inference Results and New Storage Benchmark appeared first on HPCwire.

When storage is mentioned in an AI or Big Data analytics context, it is assumed to be a high-performance system. In practice, it may not be, and the user eventually […]

The post High-Performance Storage for AI and Analytics Panel appeared first on HPCwire.

The VDURA Data Platform is a next-generation data storage and management solution, purpose-built to meet the rigorous demands of Artificial Intelligence (AI) and High-Performance Computing (HPC). Leveraging a modern, shared-nothing […]

The post The VDURA Data Platform: Elevating Data Storage for AI and HPC appeared first on HPCwire.

SANTA CLARA, Calif. and MUNICH, Nov. 7, 2024 — Cerabyte, a pioneer of ceramic-based data storage solutions, today announced its participation at SuperComputing 2024 (SC24), taking place at the Georgia […]

The post Cerabyte Discusses Use Cases for Its Ceramic Data Storage Solution at SC24 appeared first on HPCwire.

BOISE, Idaho, Nov. 12, 2024 — Micron Technology, Inc. today announced it has begun qualification of the 6550 ION NVMe SSD with customers. The Micron 6550 ION is the world’s […]

The post Micron’s 6550 ION 60TB SSD Advances High-Capacity Storage for HPC and AI Workloads appeared first on HPCwire.

It is well established that holding information in working memory (WM) elicits sustained stimulus-specific patterns of neural activity. Nevertheless, here we provide evidence for a distinct class of neural activity that tracks the number of individuated items in working memory, independent of the type of visual features stored. We present two EEG studies of young adults of both sexes that provide robust evidence for a signal tracking the number of individuated representations in working memory, regardless of the specific feature values stored. In Study 1, subjects maintained either colors or orientations across separate blocks in a single session. We found near-perfect generalization of the load signal between these two conditions, despite being able to simultaneously decode which feature had been voluntarily stored. In Study 2, participants attended to two features with very distinct cortical representations: color and motion coherence. We again found evidence for a neural load signal that robustly generalized across these distinct visual features, even though cortically disparate regions process color and motion coherence. Moreover, representational similarity analysis provided converging evidence for a content-independent load signal, while simultaneously showing that unique variance in EEG activity tracked the specific features that were stored. We posit that this load signal reflects a content-independent "pointer" operation that binds objects to the current context while parallel but distinct neural signals represent the features that are stored for each item in memory.

Rome - The experience of farmers who manage agricultural heritage can help achieve the UN Decade of Ecosystem Restoration's main goals: support and scale-up efforts [...]

As the dams begin to come down, the National Park Service looks back at the region’s history and prepares for the welcome changes to the ecosystem

An international team of researchers led by Ida Djenontin, assistant professor of geography at Penn State, was recently awarded a $1.3 million grant from the U.S. National Science Foundation’s Dynamics of Integrated Socio-Environmental Systems program to investigate the socioecological outcomes of restoration in degraded woodlands ecosystems.

Realme is reportedly gearing up to unveil the Realme 14 Pro Lite in India as its model number, RAM, storage variants and colour options have surfaced online. The upcoming model is believed to be part of Realm's 14 series. The Realme 14 Pro Lite is said to come with up to 12GB of RAM and a maximum of 512GB of onboard storage. It could go official alongside the Realme 14 and Realme 14 Pro.

Tired of throwing rotten veggies? With these genius storage hacks, your produce will remain fresh for long!

FileJump's 2TB Cloud Storage Lifetime Subscription is a permanent solution for file storage, and it's on sale for £69.82 (reg. £366.34).

The Federal Energy Regulatory Commission has received two applications for preliminary permits for a pumped storage project at Lake Elsinore in California.

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Samantha Harvey has won the UK's top fiction prize for a novel that takes place over 24 hours on the International Space Station

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

Vision is initiated by capturing photons in highly specialized sensory cilia known as the photoreceptor outer segment. Because of its lipid and protein composition, the outer segments are prone to photo-oxidation, requiring photoreceptors to have robust antioxidant defenses and high metabolic synthesis rates to regenerate the outer segments every 10 days. Both processes required high levels of glucose uptake and utilization. Retinitis pigmentosa is a prevalent form of inherited retinal degeneration characterized by initial loss of low-light vision caused by the death of rod photoreceptors. In this disease, rods die as a direct effect of an inherited mutation. Following the loss of rods, cones eventually degenerate, resulting in complete blindness. The progression of vision loss in retinitis pigmentosa suggested that rod photoreceptors were necessary to maintain healthy cones. We identified a protein secreted by rods that functions to promote cone survival, and we named it rod-derived cone viability factor (RdCVF). RdCVF is encoded by an alternative splice product of the nucleoredoxin-like 1 (NXNL1) gene, and RdCVF was found to accelerate the uptake of glucose by cones. Without RdCVF, cones eventually die because of compromised glucose uptake and utilization. The NXNL1 gene also encodes for the thioredoxin RdCVFL, which reduces cysteines in photoreceptor proteins that are oxidized, providing a defense against radical oxygen species. We will review here the main steps of discovering this novel intercellular signaling currently under translation as a broad-spectrum treatment for retinitis pigmentosa.

Samantha Harvey has won the UK's top fiction prize for a novel that takes place over 24 hours on the International Space Station

Virginia Bioinformatics Institute Video Case Study

Hi there everyone.

This is such a challenging time.

Every day we're having to sit and watch in disbelief as people lie to our faces about COVID-19, how bad things are, and what to do about it. We watch in disbelief as nonviolent protesters are arrested and accused of violence — while the police use tear gas, rubber bullets, pepper spray, and batons against them. We watch in disbelief as white women pull guns on Black people after saying the actual words, "White people aren't racist… No one is racist." Our president lies so often, so willfully, childishly, self-centeredly, and so without compunction that FactCheck.org, a nonpartisan advocate for voters that aims to reduce the level of deception and confusion in U.S. politics, has a Donald Trump archive that is 107 pages long. And now I read that we've started executing federal prisoners again — despite what we all know about how flawed our criminal justice system is.

It can be hard to keep on top of how awful everything is.

I wanted to provide a few clarifying links, and recommend a book.

First, if you're feeling overwhelmed by the number of people in denial around you — and the capacity for people to lie to themselves and others about reality — I want you to know that you're not alone. Also, you're not crazy. Also, THERE IS AN OBJECTIVE REALITY. Keep hold of it. And if you don't know what cognitive dissonance is — this might be a good time to learn! A couple links —

• Cognitive dissonance is a huge factor in people, especially white people, denying the existence of structural racism and refusing to acknowledge our own investment in it. For just one example of how this plays out, check out "The psychological phenomenon that blinds Trump supporters to his racism," from the Washington Post a year ago.

• Cognitive dissonance is also playing a huge role these days in the pandemic. Check out "The Role of Cognitive Dissonance in the Pandemic," at The Atlantic.

Cognitive dissonance, when handled badly, is a killer. It makes people inexcusably ignorant, hurtful, and destructive. I find it helpful to learn about it, so at least I know what we're up against — and also so that I can be better equipped to watch for it in myself, because after all, I was socialized into this society too. Maybe you'll also find it helpful, especially now. When you're surrounded by people who are lying to themselves… It can be incredibly disorienting! And distressing, if these are people who profess to care about you. Learn about cognitive dissonance and shine some light through the bullshit around you.

Next, on the not unrelated topic of "The Letter" ("A Letter on Justice and Open Debate," published on July 7 at Harper Magazine and signed by 153 writers, artists, academics, and journalists). I really liked Hannah Giorgis's thoughts about The Letter, over at The Atlantic: "A Deeply Provincial View of Free Speech". Giorgis skewers The Letter's vagueness. She also reminds us of what free speech actually is, and what threats to free speech actually look like. An excerpt: "Any good-faith understanding of principles such as free speech and due process requires acknowledging some basic truths: Facing widespread criticism on Twitter, undergoing an internal workplace review, or having one’s book panned does not, in fact, erode one’s constitutional rights or endanger a liberal society." Yes!

Finally, I'm listening to a really great audiobook: Until We Reckon: Violence, Mass Incarceration, and a Road to Repair, by Danielle Sered. Sered is the director of Common Justice, which is a program in Brooklyn that provides a survivor-focused alternative to incarceration for violent crime. What I love about this book is that while I've been aware that our criminal justice system is broken — and that it's a lie that prisons keep anyone safe — I hadn't realized that there are workable alternatives already in play. Sered presents an alternative to incarceration that creates not just safety, but healing. The program is very survivor-focused. Survivors are deeply involved in decisions about how the people who harmed them are held accountable. And since most people who commit violent crime have also been victims of violent crime, the program helps those who've caused harm to heal too. The book is realistic about why people harm each other, and about how to change the system. It's a good introduction to the growing movement of restorative justice, and reading it makes me hopeful.

A heads up that Sered has a crystal clear grasp of what it's like to have PTSD and is searingly articulate about how it feels to want and need a person who harmed you to accept responsibility for what they did. If you are a survivor — of any kind of harm, not just violence — parts of this book may be gutting. I recommend taking breaks now and then.

Also, if you don't have time to read a book or if you can't access it right now while the libraries are in flux, I can recommend a recent podcast episode on the same topic. It's from the The Ezra Klein Show and it's the episode called: "A former prosecutor's case for prison abolition: Paul Butler on how our criminal justice system is broken — and how to fix it". I learned a LOT about how broken our criminal justice system is from that episode. I noticed that Ezra also has an even newer episode, an interview with sujatha baliga called "The transformative power of restorative justice." I haven't listened to that one yet, but it's on the same topic, so I'm guessing that's also an interesting and informative conversation.

Okay! So those are the things I wanted to share. Hang in there, everybody. I'll be writing another craft lesson blog post soon. Also, in Winterkeep news, I expect to have a cover (or several) to share with you soon! Be well, everyone.

IWMI and GWP partner with Bhutan’s Department of Water to advance efforts including mapping surface water bodies.

The post Cutting-edge mapping techniques are crucial for managing water storage in South Asia first appeared on International Water Management Institute (IWMI).

After holding a parallel assembly session, the BJP on Friday warned to form a parallel government in J&K to counter NC's dictatorial attitude.

Sony officially launched its highly anticipated PS5 Pro today, an enhanced version of the original PlayStation 5 (review), in select markets. Building on the power of the PS5, this upgraded console includes a more robust GPU, double the storage capacity, and

Durham : Duke University Press, [2023]

Manchester : Manchester University Press, [2019]

Cambridge, Mass. : Harvard University Press, 2011.

Leiden : SIdestone Press, [2017]