Customers are asked to do a mandatory battery check over safety concerns, and to reach out to Canyon if they are affected
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People in England will be able to get free varenicline tablets to help them quit cigarettes.

This is how disgusting Democrats are… the man who tried to murder Ronald Reagan in 1981 is now telling Democrats to stop asking him to assassinate Donald Trump. If you are a Democrat, you can’t be hated enough. Hinkley had to tell Democrats to stop with their negativity on social media, WAVY-TV reported. “I’m a […]

The post Would-Be Reagan Assassin John Hinkley Tells Leftists to Stop Asking Him to Murder Donald Trump appeared first on The Lid.

Philadelphia and other cities are quietly building installations like the “Urban Thinkscape” to layer on learning where families already spend time. On a tiny triangular lot in the city’s Belmont neighborhood, kids waiting with their parents for the No. 40 bus can also work on their executive functioning skills, playing a hopscotch variation designed to train their brains. In Chicago, a wooden game mounted on the wall of a laundromat teaches children, in two languages, how to find color patterns in a lineup of detergent bottle tops.

Sure, some airlines let you work in a free stopover. But Turkish Airlines goes one step further and offers up a free city tour on a stopover as short as six hours. Maybe getting into a shuttle bus and tooling around Istanbul after seven hours on an Airbus isn’t your cup of tea, but if […]

In a classic bit from an early Seinfeld, Jerry and Elaine are at the airport, trying to pick up the rental car that Jerry had reserved. As usual, things go poorly and get awkward fast:

Seinfeld - "Reservations"

JERRY: I don't understand...I made a reservation. Do you have my reservation?
AGENT: Yes, we do. Unfortunately, we ran out of cars.
JERRY: But, the reservation keeps the car here. That's why you have the reservation.
AGENT: I know why we have reservations.
JERRY: I don't think you do. If you did, I'd have a car. See, you know how to take the reservation--you just don't know how to hold the reservation. And, that's really the most important part of the reservation...the holding. Anybody can just TAKE them. [grabs chaotically at air]

And, how weirdly similar is that to our conflicted relationship with New Year's resolutions?

In Seinfeldspeak?

See, you know how to make the resolution, you just don't know how to keep the resolution. And, that's really the most important part of the resolution...the keeping. Anybody can just MAKE them!

Oversimplified? Probably.

But, ask yourself. Why this? And, why now? Or, why again?

Welcome to Resolvers Anonymous: I'm 'Merlin M.'

A few years ago, I shared a handful of stories on the failures that have led to my own cynicism about the usefulness of life-inverting resolutions. Because, yeah, I've historically been a big resolver.

Here's what I said when I first suggested favoring "Fresh Starts and Modest Changes" over reinventions:

Download MP3 of "Fresh Starts & Modest Changes"

Five years on, I think I probably feel even more strongly about this.

Partly because I've watched and read and heard the cyclical lamentations of folks who decided to use superficial totems (like new calendars) as an ad hoc coach and prime mover. And, partly because, in my capacity as a makebelieve productivity expert, I continue to see how self-defeating it is to pretend that past can ever be less than prologue--that we can each ignore yesterday's weather if we really wish hard enough for a sun-drenched day at the beach.

It simply doesn't work.

Companies that think they'll be Google for buying bagels. Writers who think they'll get published if they order a new pen. Obese people who think they'll become marathon runners if they pick up some new running shoes. And, regular old people with good hearts who continue to confuse new lives with new clothes.

Has this worked before? Can you look back on a proud legacy of successful New Year's resolutions that would suggest you're making serious progress by repeatedly making a list about fundamental life changes while slamming prosecco and wearing a pointy paper hat?

My bet is that most people who are seeing the kind of change and growth and improvement that sticks tend to avoid these sorts of dramatic, geometric attempts to leap blindly toward the mountain of perfection.

I'll go further and say that the repeated compulsion to resolve and resolve and resolve is actually a terrific marker that you're not really ready to change anything in a grownup and sustainable way. You probably just want another magic wand.

Otherwise you'd already be doing the things you've resolved to do. You'd already be living those changes. And, you'd already be seeing actual improvements rather than repeatedly making lists of all the ways you hope your annual hajj to the self-improvement genie will fix you.

Then, of course, we make things way worse by blaming everything on our pancakes.

Regarding "The First Pancake Problem"

Anyone who's ever made America's favorite round and flat breakfast food is familiar with the phenomenon of The First Pancake.

No matter how good a cook you are, and no matter how hard you try, the first pancake of the batch always sucks.

It comes out burnt or undercooked or weirdly shaped or just oddly inedible and aesthetically displeasing. Just ask your kids.

At least compared to your normal pancake--and definitely compared to the far superior second and subsequent pancakes that make the cut and get promoted to the pile destined for the breakfast table--the first one's always a disaster.

I'll leave it to the physicists and foodies in the gallery to develop a unified field theory on exactly why our pancake problem crops up with such unerring dependability. But I will share an orthogonal theory: you will be a way happier and more successful cook if you just accept that your first pancake is and always will be a universally flukey mess.

But, that shouldn't mean you never make another pancake.

So Loud. Then, So Quiet.

I offer all of this because today is January 7th, gang. And, for the past week, all over the web, legions of well-intentioned and seemingly strong-willed humans have been declaring their resolved intention to make this a year of more and better metaphorical pancakes.

And, like clockwork--usually around today or maybe tomorrow--a huge cohort of those cooks will begin to abandon their resolve and go back to thinking all their pancakes have to suck. Just because that first one failed.

And, as is the case every year, online and off, there won't be nearly as many breathless updates to properly bookend how poorly our annual ritual of aspirational change has fared. Which is instructive.

Not because new year's resolutions are a universally bad idea. And, not because Change is Bad. And, not because we should be embarrassed about occasionally falling short of our own (frequently unreasonable) aspirations.

I suspect we tout the resolution, but whisper the failure because we blame the cook. Or, worse, fingers point toward the pancake. Instead of just admitting that the resolution itself was simply unrealistic or fundamentally foreign.

And, that's a shame.

Remember, there's no "I" in "unreasonable"

Granted, I'm merely re-repeating a point I've struggled to make (to both others and myself) for years now. But, it will bear repeating every January in perpetuity.

Resist the urge to pin the fate of things you really care about to anything that's not truly yourself. The "yourself" who has a real life with complicated demands. The "yourself" who's going to face a hard slog trying to fold a new life out of a fresh calendar.

Calendars are just paper and staples. They can't make you care. And they can't help you spin around like Diana Prince, and instantly turn into Wonder Woman. Especially, if you're not already a hot and magical Amazon princess.

First, be reasonable. Don't set yourself up for failure by demanding things that you've never come close to achieving before. I realize this is antithetical to most self-improvement bullshit, but that's exactly the point. If you were already a viking, you wouldn't need to build a big boat. Start with where you are right now. Not with where you wish you'd been.

Also, accept that the first pancake will always suck. Hell, if you've never picked up a spatula before, be cool with the fact that your first hundred pancakes might suck. This is, as I've said, huge. Failure is the sound of beginning to suck a little less.

And, finally, also be clear about the sanity of the motivations underlying your expectations--step back to observe what's truly broken, derive a picture of incremental success that seems do-able, and really resolve to do whatever you can realistically do to actually get better. Rather than "something something I suddenly become all different."

At this point, you have logistical options for both execution and troubleshooting:

• Make a modest plan that you can envision actually doing without upending your real life;
• Build more sturdy scaffolding for sticking with whatever plan you've chosen;
• Make a practice of learning to not mind the duds--including those messed-up first pancakes;
• Or--seriously?--just accept that you never really cared that much about making breakfast in the first place. Care is not optional.

Otherwise, really, you'd never need to resolve to do anything. You'd already just be cooking a lot. Instead of being all mad and depressed about not cooking.

But, please. All I really ask of you. Don't blame the pancake. It's not really the pancake's fault.

Like me, the pancake just wants you to be happy. This and every other new year.

Stop codon read-through (SCR) is a process of continuation of translation beyond a stop codon. This phenomenon, which occurs only in certain mRNAs under specific conditions, leads to a longer isoform with properties different from that of the canonical isoform. MTCH2, which encodes a mitochondrial protein that regulates mitochondrial metabolism, was selected as a potential read-through candidate based on evolutionary conservation observed in the proximal region of its 3' UTR. Here, we demonstrate translational read-through across two evolutionarily conserved, in-frame stop codons of MTCH2 using luminescence- and fluorescence-based assays, and by analyzing ribosome-profiling and mass spectrometry (MS) data. This phenomenon generates two isoforms, MTCH2x and MTCH2xx (single- and double-SCR products, respectively), in addition to the canonical isoform MTCH2, from the same mRNA. Our experiments revealed that a cis-acting 12-nucleotide sequence in the proximal 3' UTR of MTCH2 is the necessary signal for SCR. Functional characterization showed that MTCH2 and MTCH2x were localized to mitochondria with a long t1/2 (>36 h). However, MTCH2xx was found predominantly in the cytoplasm. This mislocalization and its unique C terminus led to increased degradation, as shown by greatly reduced t1/2 (<1 h). MTCH2 read-through–deficient cells, generated using CRISPR-Cas9, showed increased MTCH2 expression and, consistent with this, decreased mitochondrial membrane potential. Thus, double-SCR of MTCH2 regulates its own expression levels contributing toward the maintenance of normal mitochondrial membrane potential.

Expert

A North Carolina woman made a stop for orange juice and ended up winning $250,000 from a scratch-off lottery ticket.

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The statewide email to teachers is just the latest chapter in a rocky relationship between Kentucky officials and teachers.

Thousands of North Carolina teachers will take leave on May 16 to protest at the state capitol, forcing some school districts to close.

Eliminating gifted programs all together is the wrong solution to fixing racial and economic imbalances, argues James R. Delisle.

Republican gubernatorial nominee Ron DeSantis is renewing a political trend that had fallen dormant: calling for the end of the use of the shared standards.

Christopher Gray | Smithsonian Magazine’s 2016 American Ingenuity Award Winner for Youth Achievement Christopher Gray is the founder and CEO of Scholly, the groundbreaking web and mobile app that matches current or future college students who need financial support with scholarships that can help them. Scholly has been downloaded 850,000 times and has connected college students with some $50 million in scholarships. Philadelphia-based Gray, an ABC “Shark Tank” winner and recipient of a $100,000 grant from philanthropist Steve Case’s Rise of the Rest competition, sees his digital platform as a 21st-century tool for helping countless young Americans achieve their college dreams without piling on crushing debt.

Yacouba Sawadogo, a farmer from Burkina Faso, has become a pioneer in the fight against desertification – succeeding where many international agencies have failed

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA

Oregon

Three national educational funders explain a new program that is highlighting innovative practices in schools around the country.

Allu Arjun, the star of Pushpa 2, will join Nandamuri Balakrishna on the iconic Telugu talk show ‘Unstoppable with NBK’. In this episode, airing November 15 on Aha, Arjun speaks about his acting inspirations, memorable co-stars, and personal insights shared by his mother. The episode will also preview Pushpa 2 and his historic National Award win.

Apple's App Store, iTunes Store and other media services unlawfully discriminate against European customers based on their place of residence, according to a European Commission statement on Tuesday. 

Attorney General Jennings announced Tuesday that the Delaware Department of Justice’s Investor Protection Unit is participating in a consolidated nationwide enforcement action to disrupt a fraudulent precious metals scheme that has solicited more than $180 million from seniors and other investors. The Delaware Department of Justice, the U.S. Commodity Futures Trading Commission, and 29 other […]

Legislation introduced in the Delaware House of Representatives Thursday would encourage competition, and protect consumers and business alike, by empowering the Attorney General to intervene against unfair business practices. Deceptive business practices have been illegal under Delaware’s Consumer Fraud Act, passed in 1965. However, Delaware is one of only six states that do not also […]

DOVER – More than 200 representatives from state and community agencies focused on assisting Delawareans navigate the challenging and sometimes harrowing experience of becoming gainfully employed will come together this week to further strategize on enhancing their collaborative efforts to serve their customers. The One-Stop Partner Convening provides an opportunity for front-line staff to continue […]

Workforce Development Improvement in Action WILMINGTON, DE – The 3rd Annual One-Stop System Convening, “All-in-to-Win”, is being held on Thursday, May 17th in the Del-ONE Conference Center at DelTech in Dover from 8:30- 3:00 p.m. The Convening provides an annual forum for front-line staff (involved in Delaware’s State Workforce Development System) to help further evolve […]

Lewes, Del. May 8, 2019 –The 4th Annual One-Stop System Convening, which brings together Delaware’s front line workforce staff, will be held on Tuesday, May 14th at the Dover Downs Conference Center from 8:30 am to 2:30 pm Staff, which helps Delaware job seekers and employers, are gathering to share ideas and streamline processes. This […]

A man was on Monday arrested for driving his car, a Mahindra Thar, on a railway track in Rajasthan's Jaipur. The man, said to be drunk, had taken his SUV on to railway tracks to shoot a reel for social media.

The $20 Merry Multiplier scratch-off ticket she chose turned out to be a $250,000 top prize winner.

Cadence_SPB_17.4-2019 + Matlab R2019a

请参考本文档中的步骤进行操作

1，打开BJT_AMP.opj

2，设置Matlab路径

3，打开BJT_AMP_SLPS.slx

4，打开后，设置PSpiceBlock，出现或CEFSimpleUI.exe停止工作

5，添加模块

6，相同

7，打开pspsim.slx

8，相同

9，打开C： Cadence Cadence_SPB_17.4-2019 tools bin

orCEFSimpleUI.exe和orCEFSimple.exe

10，相同

我想问一下如何解决，非常感谢！

I am running simulation in gui mode using Indago and every time there is UVM_ERROR occur simulation stops. I have to resume it manually. is there any way to disable this feature. 

Mazda is recalling CX-90 three-row crossover SUVs because of a software problem that could prevent the engine from restarting when the engine stop-start system is used. The CX-90 is available with mild-hybrid and plug-in hybrid powertrains, but this recall only involves 2024 mild-hybrid models, encompassing 38,926 vehicles in total. The mild...

"Dune: Prophecy" premieres November 17 at 9 p.m. ET on HBO and Max. Read Mashable's review.

TOUR products for Thailand with departure dates during the National Day holiday plus the Mid-Autumn festival have mostly sold out, major Chinese travel operators say, attributing the boom to a temporary

The Nigeria Civil Aviation Authority has warned flight crew members, especially pilots against working for multiple airlines concurrently with their approved privileges simulators and proficiency checks endorsed on their licence. The authority stated that such action posed a serious threat to safety and would be treated as a serious violation of the NCAA Regulations. This

The Defence Headquarters has said the new terrorist group, Lukarawa, has begun a recruitment process to bolster its fighting capabilities. It, however, said the military was aware of the group’s recruitment activities and working closely with other security agencies and the state government to halt the recruitment efforts. The DHQ had, last Thursday, confirmed the

At least two TV channels in a northern Afghan province stopped showing images of living beings during their broadcasts, journalists told AFP on Tuesday, in line with orders from morality police.

AniNation Festival brings top Israeli and global animated films to Jerusalem Cinematheque.

Co founder of Electronic Music Malta Edwin Balzan tells all in our Q&A

Lt. Col. Peter Lerner speaks to TML about the state of war after 400 days, including the UN Security Council 1701 Resolution and additions that would allow Israel to secure its borders.

Parliamentary representation by women in Pacific Island countries remains stubbornly low at 8.4 percent. Yet women leaders across the region have been meeting every year for the past four decades to discuss goals and drive action to address gender inequality and the most pressing development challenges in the Pacific. One of the critical issues discussed […]

The small community of Ribeira stands out in the Northeast, the poorest region of Brazil. There is no unemployment here. One in five inhabitants make a living directly or indirectly from the Arteza Cooperative of Tanners and Leather Artisans. “An idea has the power to transform your world,” said in a philosophical tone Ângelo Macio, […]

As climate change threatens the cryosphere — the frozen parts of the Earth — at an alarming rate putting almost a quarter of humanity at risk, Pakistan has advocated for coordinated regional efforts and international support to save the eco-system and build climate resilience, particularly across the Hindu Kush and Himalaya region.

The study ‘The State of the Cryosphere 2024’, released on Tuesday on the sidelines of COP29 in Baku, urged urgent action to control emissions to save glaciers, which are melting at a rapid pace due to global warming.

“Under a high emissions scenario…Hindu Kush Himalaya (HKH), may experience up to 80% of ice loss. With very low emissions however, up to 40% of glacier ice in the HKH region could be preserved,” it said, adding that projections in a few glacier regions even show slow re-growth beginning between 2100 and 2300, but only with very low emissions and essentially carbon neutrality by 2050.

Against this backdrop, the environment ministers from the HKH met on Tuesday at the Baku Olympics Stadium to come together to save the “third pole” and to keep global temperatures below 1.5 Celsius.

This gathering aimed to discuss the rapidly increasing climate risks and vulnerabilities in the region and beyond, while identifying areas for urgent collective actions, inevitable to addressing the pressing challenges and fulfilling the hopes of the quarter of humanity impacted by these changes, said a statement.

It stated that over the past decade, the rate of glacier melting in the HKH has accelerated by 65 per cent compared to the previous decade (2000-2010) and the trend is projected to continue.

“Over the last decade, the rate of glacier melting in the HKH has accelerated by 65% compared to the previous decade (2000- 2010), and the trend is projected to continue.”

Speaking at the event, Bhutan Prime Minister Tshering Tobgay said this was an opportune time for the region to unite to push for a new collective quantified role that would directly address the need of the countries which were most vulnerable to climate change.

Pakistan Prime Minister Adviser on Climate Change Romina Khurshid Alam said no country across the HKH region could tackle the climate crisis in isolation and besides regional unity, international response was essential.

She said Pakistan stood for regional partnership aiming to save the ecosystem and species, and build climate resilience. She argued for easy access to climate finance to ensure these countries could erect safeguards to protect themselves from climate change.

She said Pakistan was experiencing first-hand the impacts of climate change, increasing the risk of natural disasters in the form of GLOFs and threatening water security and agriculture as well as biodiversity.

Other speakers included delegates from China, Bangladesh, India, and Nepal. The event was organised by the Kingdom of Bhutan and the International Centre for Integrated Mountain Development.

Bleak state of Cryosphere

According to the State of Cryosphere 2024 report, if the current Nationally Determined Contributions (NDCs) are met, global temperatures will likely reach 2.3°C by 2100, leading to irreversible ice loss, significant sea-level rise, and severe impacts on coastal regions, mountain communities, and polar ecosystems.

In case of a high emissions scenario, the temperature may rise to 3-3.5°C, which will cause extreme damage, including rapid ice sheet loss, the disappearance of glaciers, and widespread permafrost thaw.

However, the 1.5°C temperature in line with the Paris Agreement can help stabilise the cryosphere and preserve part of glaciers but that cannot happen unless there is a drastic cut in emissions.

“This requires urgent action, however, with emergency-scale tightening of mitigation commitments and fossil fuel emissions declining 40% by 2030,” the report added.

In case there is no action to stop the melting of glaciers, “severe and potentially permanent changes to the water cycle, due to loss of snowpack and ice run-off during the warm summer growing season, will impact food, energy and water security.”

Produced as part of the 2024 Climate Change Media Partnership, a journalism fellowship organised by Internews’ Earth Journalism Network and the Stanley Centre for Peace and Security.

Header image: View of the landscape from Langtang, Nepal can be seen in this undated handout image. — Tika Gurung via Reuters

Published in Dawn, November 13th, 2024

Invasive cane toads have decimated native freshwater crocodile populations in northern Australia, as the predators don't know they should avoid the toxic amphibians

When worker ants are exposed to a pathogenic fungus, they build nests that are more compartmentalised to reduce the risk of an epidemic

In most vertebrates, a pattern of chemical marks on the genome is a reliable indicator of age, but in axolotls this clock seems to stop after the first four years of life

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