Collection of articles covering safety and security of dams and civil structures

The U.S. Army Corps of Engineers has signed a memorandum agreement with the Southeastern Power Administration, Tennessee Valley Authority and Tennessee Valley Public Power Association, Inc., to perform a variety of work at Corps hydropower projects.

Blue Manchester LTD v North West Ground Rents LTD [2019] EWHC 142 (TCC) The High Court confirmed earlier this year that landlords must consider aesthetic appearance when assessing repairs as they may be obliged to reinstate original design features....

Title: Secondhand Smoke Blocks Artery Repair
Category: Health News
Created: 4/30/2008 2:00:00 AM
Last Editorial Review: 4/30/2008 12:00:00 AM

Title: What Is an Umbilical Hernia Repair Surgery?
Category: Procedures and Tests
Created: 4/13/2020 12:00:00 AM
Last Editorial Review: 4/13/2020 12:00:00 AM

ABSTRACT

Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks. How host immune responses are orchestrated after alphaviral infections and lead to musculoskeletal inflammation remains poorly understood. Here, we show that myositis induced by Ross River virus (RRV) infection is driven by CD11b^hi Ly6C^hi inflammatory monocytes and followed by the establishment of a CD11b^hi Ly6C^lo CX₃CR1⁺ macrophage population in the muscle upon recovery. Selective modulation of CD11b^hi Ly6C^hi monocyte migration to infected muscle using immune-modifying microparticles (IMP) reduced disease score, tissue damage, and inflammation and promoted the accumulation of CX₃CR1⁺ macrophages, enhancing recovery and resolution. Here, we detail the role of immune pathology, describing a poorly characterized muscle macrophage subset as part of the dynamics of alphavirus-induced myositis and tissue recovery and identify IMP as an effective immunomodulatory approach. Given the lack of specific treatments available for alphavirus-induced pathologies, this study highlights a therapeutic potential for simple immune modulation by IMP in infected individuals in the event of large alphavirus outbreaks.

IMPORTANCE Arthritogenic alphaviruses cause debilitating inflammatory disease, and current therapies are restricted to palliative approaches. Here, we show that following monocyte-driven muscle inflammation, tissue recovery is associated with the accumulation of CX₃CR1⁺ macrophages in the muscle. Modulating inflammatory monocyte infiltration using immune-modifying microparticles (IMP) reduced tissue damage and inflammation and enhanced the formation of tissue repair-associated CX₃CR1⁺ macrophages in the muscle. This shows that modulating key effectors of viral inflammation using microparticles can alter the outcome of disease by facilitating the accumulation of macrophage subsets associated with tissue repair.

Molecular radiotherapy using ¹⁷⁷Lu-DOTATATE is a most effective treatment for somatostatin receptor–expressing neuroendocrine tumors. Despite its frequent and successful use in the clinic, little or no radiobiologic considerations are made at the time of treatment planning or delivery. On positive uptake on octreotide-based PET/SPECT imaging, treatment is usually administered as a standard dose and number of cycles without adjustment for peptide uptake, dosimetry, or radiobiologic and DNA damage effects in the tumor. Here, we visualized and quantified the extent of DNA damage response after ¹⁷⁷Lu-DOTATATE therapy using SPECT imaging with ¹¹¹In-anti-H2AX-TAT. This work was a proof-of-principle study of this in vivo noninvasive biodosimeter with β-emitting therapeutic radiopharmaceuticals. Methods: Six cell lines were exposed to external-beam radiotherapy (EBRT) or ¹⁷⁷Lu-DOTATATE, after which the number of H2AX foci and the clonogenic survival were measured. Mice bearing CA20948 somatostatin receptor–positive tumor xenografts were treated with ¹⁷⁷Lu-DOTATATE or sham-treated and coinjected with ¹¹¹In-anti-H2AX-TAT, ¹¹¹In-IgG-TAT control, or vehicle. Results: Clonogenic survival after external-beam radiotherapy was cell-line–specific, indicating varying levels of intrinsic radiosensitivity. Regarding in vitro cell lines treated with ¹⁷⁷Lu-DOTATATE, clonogenic survival decreased and H2AX foci increased for cells expressing high levels of somatostatin receptor subtype 2. Ex vivo measurements revealed a partial correlation between ¹⁷⁷Lu-DOTATATE uptake and H2AX focus induction between different regions of CA20948 xenograft tumors, suggesting that different parts of the tumor may react differentially to ¹⁷⁷Lu-DOTATATE irradiation. Conclusion: ¹¹¹In-anti-H2AX-TAT allows monitoring of DNA damage after ¹⁷⁷Lu-DOTATATE therapy and reveals heterogeneous damage responses.

Prostate-specific membrane antigen (PSMA)–targeting α-radiation therapy (TAT) is an emerging treatment modality for metastatic castration-resistant prostate cancer. There is a subgroup of patients with poor response despite sufficient expression of PSMA in their tumors. The aim of this work was to characterize PSMA-TAT–nonresponding lesions by targeted next-generation sequencing. Methods: Of 60 patients treated with ²²⁵Ac-PSMA-617, we identified 10 patients who presented with a poor response despite sufficient tumor uptake in PSMA PET/CT. We were able to perform CT-guided biopsies with histologic validation of the nonresponding lesions in 7 of these nonresponding patients. Specimens were analyzed by targeted next-generation sequencing interrogating 37 DNA damage-repair–associated genes. Results: In the 7 tumor samples analyzed, we found a total of 15 whole-gene deletions, deleterious or presumably deleterious mutations affecting TP53 (n = 3), CHEK2 (n = 2), ATM (n = 2), and BRCA1, BRCA2, PALB2, MSH2, MSH6, NBN, FANCB, and PMS1 (n = 1 each). The average number of deleterious or presumably deleterious mutations was 2.2 (range, 0–6) per patient. In addition, several variants of unknown significance in ATM, BRCA1, MSH2, SLX4, ERCC, and various FANC genes were detected. Conclusion: Patients with resistance to PSMA-TAT despite PSMA positivity frequently harbor mutations in DNA damage-repair and checkpoint genes. Although the causal role of these alterations in the patient outcome remains to be determined, our findings encourage future studies combining PSMA-TAT and DNA damage-repair–targeting agents such as poly(ADP-ribose)-polymerase inhibitors.

Mismatch repair (MMR)–deficient tumors exhibit proteome-wide protein instability and aggregation.

You are preparing your home for sale? Don’t forget to make some small repairs since they can make a big difference both in terms of interest levels and offer prices for the home.

Whether for maintenance or augmentation, robots that can use tools on themselves are more independent and capable

https://www.ebay.com/itm/Microsoft-Xbox-One-X-1TB-Black-Console-as-is-for-repair-or-parts-only/264227168298

YMMV obviously--I ordered two of these a month ago and they have been running fine for me.  All I had to do was reinstall the newest system update and they have both been fine with no issues.  One system's issue noted was "freezes" and the other was "no video". 

It says he has only 2 in stock, but I bought two a while back and the listing has remained active for the entire time with stock available, so he probably leaves the number low to keep demand going. This is probably a bulk buyer who doesn't extensively troubleshoot the systems.  I am not affiliated with the seller.  Cosmetically, the systems are nice enough to trade in without taking a refurb fee when stores re-open for business.

Nintendo is no longer repairing the Wii video game console, which was released in 2006 and let players swing controllers to impact action on screen.

The competition and consumer watchdog has launched an inquiry into whether tractor manufacturers are failing farmers who want the right to repair their own machinery.

One year after releasing its plan to drag the NT budget out of structural deficit, the Labor Government says a third of its promises have been implemented in full. But some key measures are still in the works and the Opposition is demanding a better look at the books.

Queensland bicycle shops say they're having to turn customers away because of two-month delays on new stock, while overwhelming demand for repairs has them working 12-hour days.

A Chicago grand jury indicted the president and vice president of an Illinois refuse disposal container repair company for engaging in a conspiracy and scheme to defraud the city of Chicago on a contract for the repair of refuse carts. This is the first case to be brought in the Department’s ongoing antitrust investigation into the refuse cart repair industry.

A former president of an Illinois refuse disposal container repair company was sentenced today for his role in a conspiracy to commit mail and wire fraud in connection with bids on a contract for the repair of refuse carts for the city of Chicago.

A former vice president of an Illinois refuse disposal container repair company was sentenced today to serve 16 months in prison and to pay a $40,000 criminal fine for his role in a conspiracy to commit mail and wire fraud in connection with bids on a contract with the city of Chicago.

A settlement between the United States and the Jersey City, N.J. Municipal Utilities Authority (JCMUA) will resolve Clean Water Act violations by JCMUA for failing to properly operate and maintain its combined sewer system.

The Justice Department announced today that it reached a settlement with BAE Systems Ship Repair Inc., a leading provider of ship repair services, to settle allegations that its subsidiary, BAE Systems Southeast Shipyards Alabama LLC, engaged in a pattern or practice of discrimination by imposing unnecessary and additional documentary requirements on work-authorized non-U.S. citizens when establishing their eligibility to work in the United States.

The Justice Department’s Civil Division announced today that RMCN Credit Services Inc. (RMCN), of McKinney, Texas, and the Texas residents who own it, Doug and Julie Parker, have agreed to settle a federal court case charging them with falsely disputing negative information on consumers’ credit reports and collecting illegal upfront fees from customers

Temple University researchers discovered that boosting levels of a protein called Lin28 in injured spinal cords of mice prompts the regrowth of axons and repairs communication between the brain and body. They believe the discovery could be used to develop new treatments for both spinal cord and optic nerve injuries.

Free Geek is a non-profit reuse organization. Its mission: provide access to computers, the internet, education, and job skills to the local community.

A consumer product guide compiled along with iFixit shows which brands make it easy to fix our gadgets and which don't.

We’ve all ripped a pair of jeans, but we’re not all tailors. Nudie Jeans has a great solution.

From broken zippers to damaged USB cables, embrace your inner handyman with these quick DIY repairs.

Save your clothes with these easy fixes for common zipper problems.

It's a sign of quality when companies are willing to stand by the goods they sell.

Before buying new this holiday season, think repair - even if you are buying new!

The Right to Repair movement is rapidly growing – and it can't come soon enough.

It's to time to jump off the consumption train and embrace the art of repair.

Here is an interesting idea for a rug made of pieces of felt. We stumbled upon Julika Welge's Growing Carpet at this year's Designersblock at the London Design Festival, where the bright colours and the rich texture first

These days when your coffe machine breaks, it is usually cheaper and less hassle to just buy a new one. I was therefore pleasantly surprised about the repairability of my Presso coffee maker, which still keeps serving me off the grid!

Shorter post: They are " essentially, disposable. "

We should be able to fix the things we own, not be limited by manufacturers' unwillingness to provide access.

But it still only gets a 3 out of 10 from iFixit.

iFixit took them apart, but they can't put them together.

Keeping your bike in tip-top shape means regular maintenance, preventative measures, and the occasional on-the-road quick fix.

A new partnership with iFixit offers step-by-step instructions for fixing damaged gear.

Microsoft launched the Surface Laptop 3 back in October 2019. Since purchasing and using the new device, users have been reporting cracks appearing on the laptop screen, even without causing any physical damage to the device itself. While the reason is