repair Watch Repair at Swiss Watch Gallery and Fine Jewelry By www.24-7pressrelease.com Published On :: Fri, 15 Mar 2024 08:00:00 GMT Trust your luxury timepiece repairs to the professionals at Swiss Watch Gallery and Fine Jewelry in Southern California. Full Article
repair Automotive Defense Specialists Announces Strong Internet Response to Recent Posts on Smog and Auto Repair Shop Needs in California By www.24-7pressrelease.com Published On :: Sun, 31 Mar 2024 08:00:00 GMT Automotive Defense Specialists is proud to announce a strong response to its recent information posts on legal issues for smog shops and auto repair technicians. The posts explain 'hot button' issues impacting California's hard-working smog and auto. Full Article
repair Automotive Defense Specialists Announces New Service for Bureau of Automotive Repair Compliance Issues By www.24-7pressrelease.com Published On :: Tue, 28 May 2024 08:00:00 GMT Automotive Defense Specialists is proud to announce a new service in support of comprehensive Bureau of Automotive Repair compliance. The SMOG community can prevent BAR citations, accusations, and suspensions with forethought. Full Article
repair Ron Gordon Watch Repair Announces Blog Post on Latest Advancements in OMEGA Speedmaster 38mm Collection By www.24-7pressrelease.com Published On :: Tue, 28 May 2024 08:00:00 GMT Ron Gordon Watch Repair, a leading OMEGA watch repair service in New York City, announces the newest additions to the OMEGA Speedmaster 38mm collection. Full Article
repair Ron Gordon Watch Repair Announces New Post on Revival of the Longines Pilot Majetek By www.24-7pressrelease.com Published On :: Wed, 31 Jul 2024 08:00:00 GMT In NYC? Need Rolex repair done right? Ron Gordon Watch Repair is your trusted choice. We offer expert service, genuine parts, & meticulous craftsmanship for your prized Rolex. Visit us today! Full Article
repair Ron Gordon Watch Repair Announces New Post on Rolex's Architectural Expansion in NYC By www.24-7pressrelease.com Published On :: Fri, 27 Sep 2024 08:00:00 GMT Explore Ron Gordon Watch Repair's blog on the new 30-story Rolex tower, a symbol of both innovation and heritage, mirroring the excellence of their watch repair services. Full Article
repair Hotchkiss Auto Repair Wins Best Auto Repair Shop in Denver By www.24-7pressrelease.com Published On :: Thu, 17 Aug 2023 08:00:00 GMT Overwhelming Neighborhood Support by Park Hill, Montclair, Hilltop, Lowry and Central Park Residents Result in Hotchkiss Auto Receiving the Best of Mile High Award Full Article
repair Sarasota AC Repair, Replacement and Installation Pros at ACS Home Services Donate Air Conditioner to Local Family By www.24-7pressrelease.com Published On :: Sun, 26 May 2024 08:00:00 GMT Sarasota AC Repair, replacement and installation contractors at ACS Home Services donated a brand new Air Conditioner to a local family worth $5000 Full Article
repair Vancouver Chimney Repair: Re-pointing for Long-lasting Structural Integrity By www.24-7pressrelease.com Published On :: Mon, 23 Sep 2024 08:00:00 GMT Re-pointing is an overlooked process in chimney repair and maintenance Full Article
repair [ENVS Lecture Series] A Rural Agrarian Reckoning: Multigenerational Farmers Seeking to Repair Soil, Agriculture, and Rural America Itself By events.tufts.edu Published On :: 21 Nov 2024 17:00:00 GMT Nov 21, 2024, 12pm EST Sydney Giacalone, doctoral candidate in anthropology at Brown University, researches multigenerational farmers and ranchers across the U.S. who are transitioning away from conventional practices towards environmentally and social repairing approaches. This experience often involves questioning past education and internalized ideologies and learning to collaborate with nonhuman life to repair degraded ecologies. Join Giacaloneto learn more about her research. Building: Curtis Hall Campus Location: Medford/Somerville campus City: Medford, MA 02155 Campus: Medford/Somerville campus Location Details: Curtis Hall Multipurpose Room (474 Boston Ave., Medford, MA) Wheelchair Accessible (for in-person events): Yes Open to Public: Yes Primary Audience(s): Alumni and Friends Event Type: Academic Date/Deadline, Lecture/Presentation/Seminar/Talk Event Sponsor Details: Environmental Studies Program Event Contact Name: Sinet Kroch Event Contact Email: sinet.kroch@tufts.edu RSVP Information: RSVP only needed for virtual attendants More info: tufts.zoom.us… Full Article 2024/11/21 (Thu)
repair Repair, Repurpose, Reimagine By www.npr.org Published On :: Fri, 20 May 2022 04:01:23 +0000 "Reduce, reuse, recycle." We've heard that for decades - but does it work? This hour, TED speakers reimagine the well-known slogan and reconsider how we think about what we consume and throw away. Guests include right-to-repair advocate Gay Gordon-Byrne, materials scientist Andrew Dent, technologist Jamie Beard and animal scientist Ermias Kebreab.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy Full Article
repair Repair, Repurpose, Reimagine (2022) By www.npr.org Published On :: Fri, 06 Jan 2023 05:10:00 +0000 Original broadcast date: Friday, May 20, 2022. "Reduce, reuse, recycle." We've heard that for decades - but does it work? This hour, TED speakers reimagine the well-known slogan and reconsider how we think about what we consume and throw away. Guests include right-to-repair advocate Gay Gordon-Byrne, materials scientist Andrew Dent, technologist Jamie Beard and animal scientist Ermias Kebreab.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy Full Article
repair Relationship Repair By www.npr.org Published On :: Fri, 06 Oct 2023 07:00:59 +0000 It's never too late to make things right—even when cracks form within our relationships with our families, our environment...or the inevitable. This hour, TED speakers offer healing solutions. Guests include clinical psychologist Becky Kennedy, death doula Alua Arthur and indigenous community leader and conservationist Valérie Courtois. TED Radio Hour+ subscribers now get access to bonus episodes, with more ideas from TED speakers and a behind the scenes look with our producers. A Plus subscription also lets you listen to regular episodes (like this one!) without sponsors. Sign-up at: plus.npr.org/tedLearn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy Full Article
repair The Future of Sustainability: Repair, repurpose, reimagine By www.npr.org Published On :: Fri, 17 May 2024 07:00:59 +0000 "Reduce, reuse, recycle." We've heard that for decades - but does it work? This hour, TED speakers reimagine the well-known slogan and reconsider how we think about what we consume and throw away. Guests include right-to-repair advocate Gay Gordon-Byrne, materials scientist Andrew Dent, technologist Jamie Beard and animal scientist Ermias Kebreab. Original broadcast date: May 20, 2022TED Radio Hour+ subscribers now get access to bonus episodes, with more ideas from TED speakers and a behind the scenes look with our producers. A Plus subscription also lets you listen to regular episodes (like this one!) without sponsors. Sign-up at plus.npr.org/ted.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy Full Article
repair How we repair and strengthen our most important relationships By www.npr.org Published On :: Fri, 23 Aug 2024 07:00:59 +0000 It's never too late to make things right—even when cracks form within our relationships with our families, our environment...or the inevitable. This hour, TED speakers offer healing solutions. Guests include clinical psychologist Becky Kennedy, death doula Alua Arthur and indigenous community leader and conservationist Valérie Courtois. Original broadcast date: October 6, 2023TED Radio Hour+ subscribers now get access to bonus episodes, with more ideas from TED speakers and a behind the scenes look with our producers. A Plus subscription also lets you listen to regular episodes (like this one!) without sponsors. Sign-up at: plus.npr.org/tedLearn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy Full Article
repair How to Build—and Repair—Trust at Work By hbr.org Published On :: In a world of hybrid offices and remote teams, trust among your work colleagues is more difficult than ever, but just as important. How do you build that trust, and how do you repair it when it breaks? Full Article
repair The Accuracy Nexus: 3D Scanning in Additive Manufacturing for Custom Car Builds and Mesh Repair Solutions By www.qualitymag.com Published On :: Fri, 23 Feb 2024 00:00:00 -0500 The integration of 3D scanning and additive manufacturing has opened new possibilities in metrology. Analyzing the technical intricacies of 3D laser scanning hardware and software reveals their pivotal role in shaping engineering's future. Full Article
repair Soaring to Success: How Laser Tracker Tech Enhances Maintenance, Repair and Overhaul Operations in the Aerospace Industry By www.qualitymag.com Published On :: Sun, 18 Aug 2024 00:00:00 -0400 Today, Maintenance, Repair, and Overhaul (MRO) operations are a significant sub-industry within manufacturing, valued at $656 billion and projected to exceed $800 billion by 2032. MRO involves maintaining machinery, equipment, and systems in optimal condition through repairs and overhauls to extend their operational life. Full Article
repair More Funding Available in Colorado for Low-Income Home Furnace Repair By www.achrnews.com Published On :: Mon, 02 Nov 2015 07:15:00 -0500 An additional $500,000 in funding is available this winter for low-income Coloradans who can't afford to repair their non-working home heating system, according to Energy Outreach Colorado (EOC). Full Article
repair HVAC Decisions: To Repair or Replace a Boiler By www.achrnews.com Published On :: Wed, 14 Dec 2022 07:00:00 -0500 Evaluating the age of the system and the urgency of the problem are two key ways to tell whether or not a boiler should be repaired or replaced. Full Article
repair Troubleshooting Puzzle: A Follow-Up on a Refrigeration System Repair By www.achrnews.com Published On :: Mon, 02 Sep 2019 04:00:00 -0400 In this month’s troubleshooting situation, you are responding to a customer’s complaint that their walk-in cooler “isn’t cooling enough.” Full Article
repair When to Repair or Replace an Evaporator Coil By www.achrnews.com Published On :: Wed, 12 Apr 2023 07:00:00 -0400 When faced with a leaky coil on a reach-in cooler, a decision needs to be made whether to repair or replace it. The final decision may come down to where the leak is located. Full Article
repair New Study Shows Homeowner ‘Repair Or Replace?’ Tipping Point By www.achrnews.com Published On :: Tue, 29 Oct 2024 02:00:00 -0400 People are still pinching pennies and choosing repairs, but there are ways for contractors to sell new equipment, even when it’s more expensive. Full Article
repair When Consumers Opt to Repair v. Replace By www.achrnews.com Published On :: Mon, 11 Nov 2024 17:00:00 -0500 Homeowners likely won’t choose to replace unless it’s cheaper than the repair. Full Article
repair The Time is Now for HVAC Contractors to Install and Repair All-Electric Heat Pumps By www.achrnews.com Published On :: Thu, 01 Aug 2024 14:00:00 -0400 All-electric options have come a long way since their inception, and there’s never been a better time to get on board. Full Article
repair Episode 379: Claire Le Goues on Automated Program Repair By traffic.libsyn.com Published On :: Tue, 03 Sep 2019 17:41:07 +0000 Felienne interviews Claire Le Goues about automatic program repair. Can programs repair themselves and what techniques are involved in that? Full Article
repair Murmurations: From Rupture to Repair By www.yesmagazine.org Published On :: Wed, 31 Jul 2024 19:09:21 +0000 Now more than ever, we must learn ways to make ourselves—and each other—whole in the aftermath of rupture. Full Article Empathy Health & Happiness Mental health Murmurations Forgiveness Repair Rupture Healing
repair Sail Repair with Wally Moran - Pt. 5 By feeds.thesailingchannel.tv Published On :: Wed, 21 Mar 2012 17:30:08 -0400 CLICK TO PLAY In this 5-part, 56 minute series, sailing writer, Contributing Editor to SAIL Magazine and charter skipper, Wally Moran tackles his first sail repair project using Sailrite's powerful yet easy to use Ultrafeed LSZ-1 sewing machine. In Part 5, Wally bends on the mainsail, reviews his repairs, and takes his boat out on the creek where he hoists the repaired main for inspection. 5-Part Series Available on Vimeo On Demand http://feeds.thesailingchannel.tv/~/557582082/0/thesailingchannel HD Download $9.99 | Streaming Rental $3.99 The series begins in the Sailrite booth at the U.S. Sailboat Show in Annapolis, MD. There, with the help of Sailrite's Matt Grant, Wally assess the repairs to a torn batten pocket and leechline on his mainsail. In realtime, we watch Matt make the batten pocket repair with the LSZ-1 sewing machine. In the next 3 episodes, Wally takes on the leechline repair, working outdoors at a local Annapolis marina. He uses the LSZ-1 and Sailrite's proven techniques to repair the leechline. Sailing Documentaries from $2.99. Brought to you by TheSailingChannel.TV Click the icon below to watch. Full Article sports sailing lifestyle outdoors
repair Sail Repair with Wally Moran - Pt. 5 By feeds.feedblitz.com Published On :: Wed, 21 Mar 2012 17:30:08 -0400 CLICK TO PLAY In this 5-part, 56 minute series, sailing writer, Contributing Editor to SAIL Magazine and charter skipper, Wally Moran tackles his first sail repair project using Sailrite's powerful yet easy to use Ultrafeed LSZ-1 sewing machine. In Part 5, Wally bends on the mainsail, reviews his repairs, and takes his boat out on the creek where he hoists the repaired main for inspection. 5-Part Series Available on Vimeo On Demand https://feeds.feedblitz.com/~/557582082/0/thesailingchannel HD Download $9.99 | Streaming Rental $3.99 The series begins in the Sailrite booth at the U.S. Sailboat Show in Annapolis, MD. There, with the help of Sailrite's Matt Grant, Wally assess the repairs to a torn batten pocket and leechline on his mainsail. In realtime, we watch Matt make the batten pocket repair with the LSZ-1 sewing machine. In the next 3 episodes, Wally takes on the leechline repair, working outdoors at a local Annapolis marina. He uses the LSZ-1 and Sailrite's proven techniques to repair the leechline. Sailing Documentaries from $2.99. Brought to you by TheSailingChannel.TV Click the icon below to watch. Full Article sports sailing lifestyle outdoors
repair Apple Now Sells iPhone 16 DIY Repair Parts And Tool Kits, Here's A Look At Pricing By hothardware.com Published On :: Mon, 11 Nov 2024 14:46:00 -0500 Nearly two months after launching its iPhone 16 lineup, which struggled for sales at launch and is still facing a measured rollout of Apple Intelligence, Apple has now added these devices to its self-repair program. It’s a continuation of the company’s efforts that began in 2022, which provides the tools and parts necessary for customers to Full Article
repair The Beoplay H100 Repairable Headphones Are Luxury Built for Longevity By design-milk.com Published On :: Wed, 30 Oct 2024 13:00:20 +0000 Bang & Olufsen's Beoplay H100 headphones come at a premium price, but they're built to last with a replaceable headband and ear cushions. Full Article Main Technology audio B&O Bang & Olufsen Bang and Olufsen headphone headphones wireless headphones
repair Case Study: Reliable, Cost-Effective Roof Repairs Needed for Beachside Condo Building By www.roofingcontractor.com Published On :: Tue, 16 Nov 2021 10:00:00 -0500 R/J Group Inc. shows how offering feasible repairs in place of total replacements not only saved the customer money, but led to additional work. Full Article
repair Roofing Assessment: To Repair, Restore or Replace? By www.roofingcontractor.com Published On :: Fri, 22 Sep 2023 00:00:00 -0400 Holcim Building Envelope offers advice on assessing a roof's condition for the most effective repair options. Full Article
repair Safety of repair, maintenance, minor alteration, and addition (RMAA) works : a new focus of construction safety By search.lib.uiowa.edu Published On :: Location: Engineering Library- TH3411.C38 2016 Full Article
repair All Hourly Unions Job At Boeing - Advance Composite Rework & Repair B 78806 By www.avjobs.com Published On :: Fri, 4 Aug 2023 06:05:03 -0400 All Hourly Unions Job At Boeing Advance Composite Rework & Repair B 78806 Full Article All Hourly Unions
repair First Class Air Repair, Groveland FL United States By www.avjobs.com Published On :: Thu, 3 Aug 2023 23:50:02 -0400 Request A Quote First Class Air Repair Leader In Aviation Maintenance For Many Of The Leading Commercial And Cargo Airlines Prov... Randol Cepeda, Qc Manager, Groveland, FL, United States Full Article First Class Air Repair
repair Issues of the Environment: Finding new ways to pay for road repairs and maintenance By www.wemu.org Published On :: Wed, 10 Jul 2024 06:10:49 -0400 The Michigan fuel tax is no longer sufficient to fund needed road repairs and maintenance. As more electric vehicles hit the streets, the tax will raise less money, but the need for road and bridge revenue will only increase. Conversations are underway about alternative possibilities. WEMU's David Fair talks about what that might look like with Denise Donohue, CEO of the County Road Association of Michigan. Full Article
repair Repairing the Roads of Refuge By www.amazingfacts.org Published On :: Tue, 13 Feb 2024 00:00:00 GMT Life is a road. Jesus said you are either on the broad way to destruction or the narrow road to life. Full Article Pastor Doug's Weekly Message
repair Repairing the Roads of Refuge By www.amazingfacts.org Published On :: Tue, 13 Feb 2024 00:00:00 GMT Life is a road. Jesus said you are either on the broad way to destruction or the narrow road to life. Full Article Pastor Doug's Weekly Message
repair Youth Library To Close Temporarily For Repairs By bernews.com Published On :: Wed, 21 Aug 2024 14:53:53 +0000 The Bermuda National Library’s Youth Library on Church Street in Hamilton will be temporarily closed for roof repairs and structural improvements from August 24th to October 14th. The Department of Libraries & Archives Director, Joanne Brangman, emphasised the importance of these structural repairs and improvements, stating, “These measures are necessary to enhance the library’s facilities […] Full Article All News #BermudaBooks
repair alterations and repairs By www.oglaf.com Published On :: Sun, 31 Jan 2021 00:00:00 +0000 Full Article
repair The G20 will survive but needs major repair By www.chathamhouse.org Published On :: Tue, 15 Nov 2022 11:57:21 +0000 The G20 will survive but needs major repair Expert comment NCapeling 15 November 2022 Russia’s attack on Ukraine is the biggest challenge to the existence of the G20 since its foundation. The leader-level version of the G20 was founded in 2008 to coordinate the international response to the global financial crisis across advanced and major emerging economies. At the outset it was judged a great success. The 2009 London Summit demonstrated a high degree of unity among the world’s largest economies on a comprehensive action plan to tackle the crisis. The group’s subsequent performance has disappointed. Particularly during the pandemic and the Donald Trump presidency in the US, the group made only a limited additional contribution to policies which national governments were pursuing in any case. The existing G20 approach for tackling debt distress in low-income countries, the ‘Common Framework’, is progressing far too slowly Nonetheless, its members continued to see it as an essential forum without which it would be even harder to tackle a growing list of global economic challenges. This faith was partly repaid when, following the election of the Joe Biden administration in the US, agreement was reached on the $650 billion special drawing rights (SDR) general allocation by the International Monetary Fund (IMF) in summer 2021. Impact of the war in Ukraine Following Russia’s attack on Ukraine earlier this year, leading western members of the group called for Russia to be suspended from the G20 as Russia’s action ran directly against the key principles of the rules-based international system on which the G20 was founded. Western countries also walked out of meetings of the G20 Finance Ministers’ and International Monetary and Financial Committee this spring rather than sit at the same table as Russian representatives. This contrasted with 2014 when Russia was suspended indefinitely from the G7 for its takeover of Crimea but no action was taken against it in the G20. However, China and India, supported by several other emerging economies declined to suspend Russia, creating a standoff which could have resulted in a rapid collapse of the G20, particularly as its informal structure means that, in contrast to the international financial institutions (IFIs), there are no legal principles or procedures to determine how to address such a situation. It appears the West has now concluded (rightly) that the G20 is too important as a forum for working with China and the other major emerging economies to be allowed to disappear. This is likely to be because there are no straightforward alternatives. The G7 is too narrow to fill the role and China is now highly unlikely to attend a future G7 Summit as a guest. The boards of the IFIs are not equipped to coordinate across institutions, which is a vital role of the G20, and the United Nations (UN) system does not offer the scope, speed, leader-level engagement, or flexibility of the G20. Moreover, as evidenced by the chair’s summary of the third G20 Finance Ministers’ and Central Bank Governors’ meeting in July, once the group gets past the dispute over how to handle Russia, there is a worthwhile agenda of issues which can be agreed on. Russia is unlikely to play a disruptive role as preserving its membership of the group will be its key objective, and it will not want to undermine support among other emerging economies As the 2022 president of the G20, Indonesia has been determined to produce a final communique for the leaders’ summit and it looks increasingly like this will be achieved, even though it was impossible to agree concluding statements for some earlier G20 ministerial meetings. The key will be to deal with the differences over Ukraine between the West and emerging economies with a short opening paragraph reflecting both views. This would then be followed by a consensus text on all the areas where the two groups do agree. Russia is unlikely to play a disruptive role as preserving its membership of the group will be its key objective, and it will not want to undermine support among other emerging economies by blocking issues that all agree on. However, even with a final communique achieved, returning to a fully functioning agenda setting, coordination, and decision-making role for G20 will be very challenging, particularly while the war in Ukraine continues. Tackling sovereign debt distress should be a top priority There are critically important issues on which G20 action is urgently needed. Top of the list is the acute problem of sovereign debt distress. Some 60 per cent of low-income countries are now judged to be in debt distress or at high risk of debt distress. But the existing G20 approach for tackling debt distress in low-income countries, the ‘Common Framework’, is progressing far too slowly, and there is no agreed mechanism for handling the growing list of emerging economies in debt distress. Without tackling debt distress, it is extremely hard to see how it will be possible to generate the vast flow of private sector climate finance necessary to help the developing world progress to net zero. And yet the G20 is one of the few forums in which a high-level approach to debt distress can be defined because China – along with the IFIs and the western-based private sector – is a key player in any solution. Urgent repairs needed However, there is a critical lack of trust among G20 participants which, although in part a reflection of the disagreements over handling Russia, is also about longer-term factors such as the growing geopolitical tensions between China and the US on trade and investment in high tech. An example of how this has played out was the action China and India took at the Rome G20 Summit in 2021 in blocking Italy’s efforts to establish a new ministerial task force designed to address the threat of future pandemics – a subject which all G20 countries agree is important. Full Article
repair Mycobacteria excise DNA damage in 12- or 13-nucleotide-long oligomers by prokaryotic-type dual incisions and performs transcription-coupled repair [Genomics and Proteomics] By www.jbc.org Published On :: 2020-12-11T00:06:21-08:00 In nucleotide excision repair, bulky DNA lesions such as UV-induced cyclobutane pyrimidine dimers are removed from the genome by concerted dual incisions bracketing the lesion, followed by gap filling and ligation. So far, two dual-incision patterns have been discovered: the prokaryotic type, which removes the damage in 11–13-nucleotide-long oligomers, and the eukaryotic type, which removes the damage in 24–32-nucleotide-long oligomers. However, a recent study reported that the UvrC protein of Mycobacterium tuberculosis removes damage in a manner analogous to yeast and humans in a 25-mer oligonucleotide arising from incisions at 15 nt from the 3´ end and 9 nt from the 5´ end flanking the damage. To test this model, we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping method developed in our laboratory to determine the repair pattern and genome-wide repair map of Mycobacterium smegmatis. We find that M. smegmatis, which possesses homologs of the Escherichia coli uvrA, uvrB, and uvrC genes, removes cyclobutane pyrimidine dimers from the genome in a manner identical to the prokaryotic pattern by incising 7 nt 5´ and 3 or 4 nt 3´ to the photoproduct, and performs transcription-coupled repair in a manner similar to E. coli. Full Article
repair Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination [Cell Biology] By www.jbc.org Published On :: 2020-12-18T00:06:18-08:00 Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products. A mismatch repair factor, MLH3 endonuclease, produces the majority of crossovers during meiotic HR, but it remains elusive whether mismatch repair factors promote HR in nonmeiotic cells. We disrupted genes encoding the MLH3 and PMS2 endonucleases in the human B cell line, TK6, generating null MLH3−/− and PMS2−/− mutant cells. We also inserted point mutations into the endonuclease motif of MLH3 and PMS2 genes, generating endonuclease death MLH3DN/DN and PMS2EK/EK cells. MLH3−/− and MLH3DN/DN cells showed a very similar phenotype, a 2.5-fold decrease in the frequency of heteroallelic HR-dependent repair of restriction enzyme–induced double-strand breaks. PMS2−/− and PMS2EK/EK cells showed a phenotype very similar to that of the MLH3 mutants. These data indicate that MLH3 and PMS2 promote HR as an endonuclease. The MLH3DN/DN and PMS2EK/EK mutations had an additive effect on the heteroallelic HR. MLH3DN/DN/PMS2EK/EK cells showed normal kinetics of γ-irradiation–induced Rad51 foci but a significant delay in the resolution of Rad51 foci and a 3-fold decrease in the number of cisplatin-induced sister chromatid exchanges. The ectopic expression of the Gen1 HJ re-solvase partially reversed the defective heteroallelic HR of MLH3DN/DN/PMS2EK/EK cells. Taken together, we propose that MLH3 and PMS2 promote HR as endonucleases, most likely by processing JMs in mammalian somatic cells. Full Article
repair Repairs to Tampa Bay Rays' Tropicana Field from Hurricane Milton put at $55.7 million By www.upi.com Published On :: Tue, 12 Nov 2024 17:27:58 -0500 It will cost $55.7 million to repair Tropicana Field, home to the MLB Tampa Bay Rays, in time for the 2026 home opener, St. Petersburg., Fla., city officials said Tuesday. Full Article
repair BRCA1 Promotes Repair of DNA Damage in Cochlear Hair Cells and Prevents Hearing Loss By www.jneurosci.org Published On :: 2024-10-16T09:30:18-07:00 Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss. Full Article
repair Mother of 4 asks for more transparency amid Norton Elementary repair extensions By www.cbc.ca Published On :: Sun, 10 Nov 2024 10:00:00 EST Families of Norton Elementary School won’t be seeing their kids return anytime soon. Repairs are going to take longer than expected and students are expected to be back in the school by the start of the next school year. Full Article News/Canada/New Brunswick
repair Apple starts supplying replacement parts for iPhone 16 repairs By appleinsider.com Published On :: Sun, 10 Nov 2024 19:13:03 +0000 Repair parts for the iPhone 16 lineup are now available to order in the US and other countries, including for those wanting to fix their iPhone for themselves.DIY repairs are well-suited to some, but can be labor-intensive and expensive.Following the release of the repair manuals for the iPhone 16 in September, it's now possible to acquire replacement parts for repairs from Apple directly. This is a continuation of a move starting in 2022 towards more user repairability of its products.Batteries, one of the most common replacement parts, sell for $99 for the iPhone 16 and iPhone 16 Plus, or $119 for the iPhone 16 Pro or Pro Max. Likewise, replacement camera assemblies cost $169 or $249, depending on the model. Continue Reading on AppleInsider | Discuss on our Forums Full Article
repair Repairing smiles in the Odessa province By www.om.org Published On :: Wed, 11 Jan 2017 01:05:54 +0000 A team of dentists and volunteers recently visited an orphanage in the Odessa province to fix 75 young smiles. Full Article
repair Antique 1948 Tucker automobile repaired by Penn College students garners honor By www.psu.edu Published On :: Tue, 22 Oct 2024 16:26:26 -0400 A 1948 Tucker repaired by students at Pennsylvania College of Technology earned honors at the recent Antique Automobile Club of America’s Eastern Division National Fall Meet in Hershey. The vehicle won the First Junior Award, meaning it was ranked the best among all cars judged for the first time in its class: limited production and prototype vehicles through 1998. Full Article