A SURGE in bitcoin prices has seen the cryptocurrency market jump by over $13 billion overnight.

KEIR STARMER's secret weapon against Prime Minister Boris Johnson has been revealed by Professor Tim Bale who detailed what the Labour leader can succeed in.

THE EDITOR, Madam: In times of great challenge and hardship we must continue, as a people, to uphold the values and attitudes that make us truly Jamaican. It is a time for true patriotism and for us to reach down and pull up those among us with...

Intravenous access is difficult in some patients referred for ¹⁸F-FDG PET imaging. Extravasation at the injection site and accumulation in central catheters can lead to limited tumor ¹⁸F-FDG uptake, erroneous quantitation, and significant image artifacts. In this study, we compared the human biodistribution and dosimetry for ¹⁸F-FDG after oral and intravenous administrations sequentially in the same subjects to ascertain the dosimetry and potential suitability of orally administered ¹⁸F-FDG as an alternative to intravenous administration. We also compared our detailed intravenous ¹⁸F-FDG dosimetry with older dosimetry data. Methods: Nine healthy volunteers (6 male and 3 female; aged 19–32 y) underwent PET/CT imaging after oral and intravenous administration of ¹⁸F-FDG. Identical preparation and imaging protocols (except administration route) were used for oral and intravenous studies. During each imaging session, 9 whole-body PET scans were obtained at 5, 10, 20, 30, 40, 50, 60, 120, and 240 min after ¹⁸F-FDG administration (370 ± 16 MBq). Source organ contours drawn using CT were overlaid onto registered PET images to extract time–activity curves. Time-integrated activity coefficients derived from time–activity curves were given as input to OLINDA/EXM for dose calculations. Results: Blood uptake after orally administered ¹⁸F-FDG peaked at 45–50 min after ingestion. The oral-to-intravenous ratios of ¹⁸F-FDG uptake for major organs at 45 min were 1.07 ± 0.24 for blood, 0.94 ± 0.39 for heart wall, 0.47 ± 0.12 for brain, 1.25 ± 0.18 for liver, and 0.84 ± 0.24 for kidneys. The highest organ-absorbed doses (μGy/MBq) after oral ¹⁸F-FDG administration were observed for urinary bladder (75.9 ± 17.2), stomach (48.4 ± 14.3), and brain (29.4 ± 5.1), and the effective dose was significantly higher (20%) than after intravenous administration (P = 0.002). Conclusion: ¹⁸F-FDG has excellent bioavailability after oral administration, but peak organ activities occur later than after intravenous injection. These data suggest PET at 2 h after oral ¹⁸F-FDG administration should yield images that are comparable in biodistribution to conventional clinical images acquired 1 h after injection. Oral ¹⁸F-FDG is a palatable alternative to intravenous ¹⁸F-FDG when venous access is problematic.

Renza Scibilia
Jul 1, 2019; 37:302-303
Book Reviews

Results from a University of Iowa College of Dentistry study suggest that mild and moderate dental fluorosis is generally less noticeable over time, validating the beliefs of some supporters of community water fluoridation that there have been overestimates of fluorosis prevalence made by anti-fluoridation activists.

The ADA sent a letter to the U.S. Department of Health and Human Services April 17 asking the agency to “issue federal recognition that licensed dentists may administer point of service tests authorized by the Food and Drug Administration” during the COVID-19 pandemic.

Psychologists once conducted a simple experiment with far-reaching implications: They asked people to describe an instance in their lives when they had hurt someone and another instance when they had been hurt by someone else. The incidents that people described were similar whether they saw...

Thousands of teachers will head to the state capital on Wednesday to call for a nearly $10,000 raise over four years and an increase to per-pupil spending.

Teachers in Colorado forced at least one school district to close as they rallied at the capitol to call for more education funding.

Prediabetic state -- Prevention.

London : printed for J. Dodsley, 1782.

London : printed by W. Wilson, for E. Brewster, and George Sawbridge, at the Bible on Ludgate-Hill, neere Fleet-bridge, 1653.

BCBS Press release "Basel Committee and IOSCO announce deferral of final implementation phases of the margin requirements for non-centrally cleared derivatives", 3 April 2020

The evidence that culturally responsive teaching can fix the nation's schools for children of color is promising, but woefully incomplete, writes Heather C. Hill.

The comments come at a time when more foreign-born black people live in the United States than at any time in history—and many of the residents are children enrolled in the nation's K-12 public schools.

The Spanish side let a two-goal lead slip in their last Group B game, ten-man South Region recovering to win it in added time, substitute Sergei Sokolov the match winner.

The California district rolled out a culturally-specific program to support black male students, and the program has led to positive outcomes for students who had an opportunity to participate.

The California district rolled out a culturally-specific program to support black male students, and the program has led to positive outcomes for students who had an opportunity to participate.

Childhood obesity is already prevalent by preschool age, particularly among Latinos. Parents have tremendous influence on factors that contribute to childhood obesity (eg, diet, physical activity); thus, family plays a crucial role in pediatric obesity prevention.

This randomized controlled trial examined the effect of a behavioral intervention involving Latino-American parent–preschool-aged child dyads. The intervention resulted in reductions in absolute BMI across the 3-month study period, with patterns suggesting the largest effect for obese children. (Read the full article)

Background: This study summarizes drug resistance analyses in 4 recent phase 2b trials of the respiratory syncytial virus (RSV) fusion inhibitor presatovir in naturally infected adults.

Methods: Adult hematopoietic cell transplant (HCT) recipients, lung transplant recipients, or hospitalized patients with naturally acquired, laboratory-confirmed RSV infection were enrolled in 4 randomized, double-blind, placebo-controlled studies with study-specific presatovir dosing. Full-length RSV F sequences amplified from nasal swabs obtained at baseline and postbaseline were analyzed by population sequencing. Substitutions at RSV fusion inhibitor resistance-associated positions are reported.

Results: Genotypic analyses were performed on 233 presatovir-treated and 149 placebo-treated subjects. RSV F variant V127A was present in 8 subjects at baseline. Population sequencing detected treatment-emergent substitutions in 10/89 (11.2%) HCT recipients with upper and 6/29 (20.7%) with lower respiratory tract infection, 1/35 (2.9%) lung transplant recipients, and 1/80 (1.3%) hospitalized patients treated with presatovir; placebo-treated subjects had no emergent resistance-associated substitutions. Subjects with substitutions at resistance-associated positions had smaller decreases in viral load during treatment relative to those without, but similar clinical outcomes.

Conclusions: Subject population type and dosing regimen may have influenced RSV resistance development during presatovir treatment. Subjects with vs without genotypic resistance development had decreased virologic responses but comparable clinical outcomes.

Treatment of dogs naturally infected with Leishmania infantum using meglumine antimoniate (MA) encapsulated in conventional liposomes (LC) in association with allopurinol has been previously reported to promote marked reduction in the parasite burden in the main infection sites. Here, a new assay in naturally infected dogs was performed using a novel liposome formulation of MA consisting of a mixture of conventional and long-circulating (PEGylated) liposomes (LCP), with expected broader distribution among affected tissues of the mononuclear phagocyte system. Experimental groups of naturally infected dogs were as follows: LCP+Allop, receiving LCP intravenously as 2 cycles of 6 doses (6.5 mg Sb/kg/dose) at 4-day intervals, plus allopurinol at 30 mg/kg/12 h p.o. during 130 days; LC+Allop, receiving LC intravenously as 2 cycles of 6 doses (6.5 mg Sb/kg/dose), plus allopurinol during 130 days; Allop, treated with allopurinol only; non-treated control. Parasite loads were evaluated by quantitative PCR in liver, spleen and bone marrow and by immunohistochemistry in the ear skin, before, just after treatment and 4 months later. LCP+Allop and LC+Allop groups, but not the Allop group, showed significant suppression of the parasites in the liver, spleen and bone marrow 4 months after treatment, compared to the pre-treatment period or the control group. Only LCP+Allop group showed significantly lower parasite burden in the skin, in comparison to the control group. On the basis of clinical staging and parasitological evaluations, LCP formulation exhibited a more favorable therapeutic profile, when compared to LC one, being therefore promising for treatment of canine visceral leishmaniasis.

Equity markets have rallied Monday as countries eased coronavirus lockdown measures, but oil prices tumbled as a supply glut offset output cuts.

Jake Griggs, who will graduate Saturday with a 3.95 GPA with dual majors in management and political science, has been named Smeal’s spring 2020 management and organization student marshal.

In a shocking display of ignorance, pay for performance has become reformers' blitzkrieg. Both common sense and research are being ignored.

Interestingly, foreign portfolio investors (FPI), who were big sellers in March pulling out more than $8 billion, and have offloaded shares for most of April, turned buyers picking up some $50 million worth of stocks.

This is a gluten free and naturally sweetened banana bread in a mug.  It is super easy to fix and paleo, too! -- posted by francoroni

HONG KONG - Holdout anti-government protesters remained in control of a major arterial road in Hong Kong on Monday a day after organisers said two million people flooded the streets in a historic rebuke of the city's pro-Beijing leader.

In the lead-up to the Truth Matters conference in October, we will be focusing our attention on the sufficiency, authority, and clarity of Scripture. Of our previous blog series, none better embodies that emphasis than Frequently Abused Verses. The following entry from that series originally appeared on February 12, 2016. -ed.

All over the world, on any given day of the week, Jesus Christ’s body is repeatedly sacrificed. According to the Roman Catholic Church, that’s what happens every time they celebrate the Mass—their version of Communion, or the Lord’s Table.

In The Faith of Millions—a book certified by the Roman Catholic Church to be “free of doctrinal and moral error”—Catholic priest John O’Brien explains what happens during the Mass:

When the priest pronounces the tremendous words of consecration, he reaches up into the heavens, brings Christ down from His throne, and places Him upon our altar to be offered up again as the Victim for the sins of man. It is a power greater than that of monarchs and emperors: it is greater than that of saints and angels, greater than that of Seraphim and Cherubim. Indeed it is greater even than the power of the Virgin Mary. While the Blessed Virgin was the human agency by which Christ became incarnate a single time, the priest brings Christ down from heaven, and renders Him present on our altar as the eternal Victim for the sins of man—not once but a thousand times! The priest speaks and lo! Christ, the eternal and omnipotent God, bows His head in humble obedience to the priest’s command. ^[1] Rev. John A. O’Brien, The Faith of Millions, revised ed. (Huntington, IN: Our Sunday Visitor, Inc., 1974) 255–56.

The supposed ability to wield such supernatural power over almighty God is one of the priesthood’s most blasphemous acts. As O’Brien describes it, the priestly office is a position of immense, even ultimate power, as the priest yanks Christ out of His eternal kingdom and hurls Him once again onto the sacrificial altar.

The repeated sacrificial process is called transubstantiation, wherein the bread and wine transform into the literal body and blood of Christ. It may sound cannibalistic and creepy, but they argue that it’s what the Bible actually teaches:

So Jesus said to them, “Truly, truly, I say to you, unless you eat the flesh of the Son of Man and drink His blood, you have no life in yourselves. He who eats My flesh and drinks My blood has eternal life, and I will raise him up on the last day. For My flesh is true food, and My blood is true drink. He who eats My flesh and drinks My blood abides in Me, and I in him. (John 6:53­–56)

But is that really what Jesus meant by those graphic words? Was He truly prescribing the repeated and violent sacrifice of His physical body? Is that what Christ intended when He instituted Communion?

The simple answer is, No.

Linking Christ’s discourse in John 6 with the Lord’s Table is a significant leap. The events described in John 6 took place during His ministry in Galilee—it would be roughly a year before He and His disciples would meet in the Upper Room.

And even then, there are significant flaws with the Catholic interpretation. Apologist James McCarthy makes a salient point regarding Jesus’ physical body and the institution of the Lord’s Table. He notes that when Jesus referred to the bread, saying “This is my body” (Matthew 26:26), He was physically present with the disciples. McCarthy rightly observes: “Surely they would not have thought that Jesus’ body was both at the table and on the table.” ^[2] James G. McCarthy, The Gospel According to Rome (Eugene, OR: Harvest House, 1995) 135–36.

In his commentary on John’s gospel, John MacArthur compellingly refutes any connection between Jesus’ words in John 6:53­–56 and the celebration of the Lord’s Table:

It should be noted that the Roman Catholic Church appeals to this passage as a proof of the doctrine of transubstantiation—the false teaching that the body and blood of Christ are literally present in the bread and wine of the Mass. Catholic theologian Ludwig Ott writes, “The body and the blood of Christ together with His soul and His divinity and therefore the whole Christ are truly present in the Eucharist” (Fundamentals of Catholic Dogma [St. Louis: B. Herder, 1954], 382). It is a false foundation for a false doctrine, however, to suggest that Jesus was referring to the Eucharist (Communion or the Lord’s Table) here, since He used the word sarx (flesh). A different word, sōma (“body”), appears in the passages referring to Communion (Matthew 26:26; Mark 14:22; Luke 22:19; 1 Corinthians 10:16; 11:24, 27). Two additional considerations reinforce the fact that this passage does not refer to Communion: First, the Lord’s Table had not yet been instituted; therefore, the Jews would not have understood what Jesus was talking about if He were speaking of Communion. Second, Jesus said that anyone who partakes of His flesh has eternal life. If that was a reference to the Lord’s Table, it would mean that eternal life could be gained through taking Communion. That is clearly foreign to Scripture, however, which teaches that Communion is for those who are already believers (1 Corinthians 11:27–32) and that salvation is by faith alone (Ephesians 2:8–9). ^[3] John MacArthur, The MacArthur New Testament Commentary: John 1–11 (Chicago: Moody Press, 2006) 259–60.

And the disconnect between Scripture and the Catholic Mass runs far deeper than the nature of the elements. The author of Hebrews repeatedly states that Christ’s atoning sacrifice was a “once for all” event never to be repeated:

By this will we have been sanctified through the offering of the body of Jesus Christ once for all. Every priest stands daily ministering and offering time after time the same sacrifices, which can never take away sins; but He, having offered one sacrifice for sins for all time, sat down at the right hand of God, waiting from that time onward until His enemies be made a footstool for His feet. For by one offering He has perfected for all time those who are sanctified. (Hebrews 10:10­–14)

There is simply no way to harmonize the idea of Christ being repeatedly sacrificed when the New Testament clearly spells out the singularity and sufficiency of Christ’s perfect atoning sacrifice.

What’s clear is that no amount of contorting Scripture will create any endorsement of the Roman Catholic Mass. From every angle, it is biblically indefensible.

But that doesn’t give us an answer for what Jesus actually meant in John 6:53-56 regarding eating His flesh and drinking His blood. As with most interpretive challenges in Scripture, clarity is found in the surrounding context. And in this case, Christ’s statement makes a lot more sense when you read the whole chapter.

John 6 begins with Christ’s feeding of the five thousand (John 6:1–14). That miracle immediately won Him enormous popularity in a place where food was hard to come by. Jesus, knowing His kingdom is not of this world (John 18:36), had to go into isolation to avoid the masses from installing Him as king in Herod’s place (John 6:15). Instead of capitalizing on His popularity and ability to draw a large crowd, Jesus saw it as a hindrance to His larger mission.

But a free lunch is nothing to be sneezed at, especially among the poor, so the crowds continued to pursue Christ with hopes of more bounty. Jesus was acutely aware of their superficial faith and told them, “You seek Me, not because you saw signs, but because you ate of the loaves and were filled. Do not work for the food which perishes, but for the food which endures to eternal life” (John 6:26–27).

A lengthy dialogue then followed where Jesus continually urged the crowds to move beyond their temporal hunger and seek eternal sustenance. But His audience relentlessly pled with Him to prove His messiahship through a sign that involved food—hinting at the manna God provided the Israelites when they were wandering in the wilderness  (John 6:31).

Jesus contrasted that perishable “bread out of heaven” (John 6:31–32) with Himself, “I am the bread of life; he who comes to Me will not hunger, and he who believes in Me will never thirst” (John 6:35). In His immense patience with their unbelief, the Lord repeated that same point in an increasingly explicit manner:

I am the bread of life. Your fathers ate the manna in the wilderness, and they died. This is the bread which comes down out of heaven, so that one may eat of it and not die. I am the living bread that came down out of heaven; if anyone eats of this bread, he will live forever; and the bread also which I will give for the life of the world is My flesh. (John 6:48–51)

Jesus’ audience remained oblivious to what He was really talking about. That’s why He chose such provocative language as His discourse drew to a close. Dr. James White facetiously refers to Christ’s severe terminology and ghastly imagery in John 6:53-56 as “the beginning of the church shrinkage movement.” And with good reason; after Jesus spoke those words many of His disciples abandoned Him (John 6:66).

Their departure was by design. The Lord was determined to drive away followers who were nothing more than shallow hangers-on. Instead of capitalizing on His popularity, He saw it as a hindrance to His mission.

His message was clear: Temporal bread would only sustain them temporarily. They needed to eat eternal bread—flesh and blood—to live eternally. John MacArthur explains the significance of Christ’s metaphor in his sermon, I Am the Bread of Life:

If you want eternal life, eating is necessary. . . . You can’t just come and admire. You have to eat, which is to believe fully. But eating is in response to hunger. So, the people who eat are the people who are what? Hungry! What is hunger? It’s the aching of the heart of one who knows he’s empty. That’s the work of the Holy Spirit to make the heart hungry. That’s where the Father starts to draw. The hungry heart sees the bread. . . .

Eating is personal. It’s not a group event. You can all go out to dinner, but the food has to go in your mouth. Lots of people can do lots of things for you. They can come over and change the curtains, fix the room. People can do a lot of things to help you. You have to eat. You can’t do that by proxy. Eating is necessary. Eating is in response to hunger. Eating is personal and eating is transformational. If you don’t eat physically, you will die. If you eat, the food you take in transforms you, and that’s what Christ does.

The simple truth is our physical food cannot change our eternal destiny—not even the gruesome rituals of the Catholic Mass. Eating the body and blood of Christ was a necessary way for Him to express to an audience fixated on their physical hunger the need for all people to find salvation—to satisfy their spiritual hunger—through Him.

Stocks moved higher in Thursdays trading session; Retail sales fell for the third straight month; Houshold net worth hit a new record. Bobbi Rebell reports.

Since March 2016, the NIH Manuscript Submission (NIHMS) system has added support for researchers from the following federal agencies to deposit in PMC any manuscripts that fall under the agency’s public access policy:

• Assistant Secretary for Preparedness and Response (ASPR/HHS; intramural only at this time)
• Environmental Protection Agency (EPA; intramural only at this time)
• National Aeronautics and Space Administration (NASA; intramural/civil servants and grantees)

Manuscript deposit support for all Administration for Community Living (ACL/HHS) researchers will be available in NIHMS by October 2017 and for Department of Homeland Security researchers in early 2018.

Additionally, the Bill & Melinda Gates Foundation Open Access Policy now requires their grantees to make their published research results available in PMC immediately upon publication under a Creative Commons Attribution (CC-BY) license. Manuscript deposit support is not provided in NIHMS for Gates-funded researchers; rather the final published version of any Gates-funded article is to be deposited directly to PMC by the publisher or a funder-supported data provider without author involvement. More information on this open access policy is available on the Gates Foundation website.

PMC will continue to update the list of participating funding agencies at Public Access and PMC as support is implemented.

Microscopy and rapid diagnostic tests (RDTs) are the main diagnostic tools for malaria but fail to detect low-density parasitemias that are important for maintaining malaria transmission. To complement existing diagnostic methods, an isothermal reverse transcription-recombinase polymerase amplification and lateral flow assay (RT-RPA) was developed. We compared the performance with that of ultrasensitive reverse transcription-quantitative PCR (uRT-qPCR) using nucleic acid extracts from blood samples (n = 114) obtained after standardized controlled human malaria infection (CHMI) with Plasmodium falciparum sporozoites. As a preliminary investigation, we also sampled asymptomatic individuals (n = 28) in an area of malaria endemicity (Lambaréné, Gabon) to validate RT-RPA and assess its performance with unprocessed blood samples (dbRT-RPA). In 114 samples analyzed from CHMI trials, the positive percent agreement to uRT-qPCR was 90% (95% confidence interval [CI], 80 to 96). The negative percent agreement was 100% (95% CI, 92 to 100). The lower limit of detection was 64 parasites/ml. In Gabon, RT-RPA was 100% accurate with asymptomatic volunteers (n = 28), while simplified dbRT-RPA showed 89% accuracy. In a subgroup analysis, RT-RPA detected 9/10 RT-qPCR-positive samples, while loop-mediated isothermal amplification (LAMP) detected 2/10. RT-RPA is a reliable diagnostic test for asymptomatic low-density infections. It is particularly useful in settings where uRT-qPCR is difficult to implement.

PF06821497 has been identified as an orally available small-molecule enhancer of zeste homolog 2 inhibitor. The objectives of the present study were to characterize pharmacokinetic-pharmacodynamic-disease relationships of PF06821497 in xenograft mouse models with diffuse large B-cell lymphoma (Karpas422). An indirect-response model reasonably fit dose-dependent pharmacodynamic responses [histone H3 on lysine 27 (H3K27) me3 inhibition] with an unbound EC₅₀ of 76 nM, whereas a signal-transduction model sufficiently fit dose-dependent disease responses (tumor growth inhibition) with an unbound tumor stasis concentration (T_sc) of 168 nM. Thus, effective concentration for 70% of maximal effect (EC₇₀) for H3K27me3 inhibition was roughly comparable to T_sc, suggesting that 70% H3K27me3 inhibition could be required for tumor stasis. Consistently, an integrated pharmacokinetic-pharmacodynamic-disease model adequately describing tumor growth inhibition also suggested that ~70% H3K27me3 inhibition was associated with tumor stasis. Based on these results, we would propose that an EC₇₀ estimate for H3K27me3 inhibition corresponding to tumor stasis could be considered a minimum target efficacious concentration of PF06821497 in cancer patients.

You can donate at: virginmoneygiving.com/fund/FoodforLondonNOW

Data showed the domestic equity market gave up half the gains that it had amassed.

The star gave the Blinding Lights TikTok challenge a go while clad in fluorescent exercise gear

Sheffield United boss Chris Wilder has warned Manchester United to do the "morally correct" thing and allow Dean Henderson to see out the season with the Blades.