An investigational white button mushroom supplement shows promise in slowing and even preventing the spread of prostate cancer among men participating

Food as Medicine to Fight Prostate Cancer: White button mushroom supplement can keep prostate cancer at bay.

5 ways to naturally manage your high blood pressure.

Layn Natural Ingredient Corp, Ltd. introduces SustaNX, the newest ingredient in its Plantae™ PRESERVATION series of clean label, natural, polyphenol-rich antioxidant preservation solutions for food, beverage, flavor, fragrance, and pet food.

FFP’s new clean label antimicrobial ingredient, VegStable® Secure, helps brands naturally protect a variety of foods from pathogens and spoilage—with no compromise to functionality or taste.

Cancer-causing chemicals that occur naturally in foods are far more numerous in the human diet than synthetic carcinogens, yet both types are consumed at levels so low that they currently appear to pose little threat to human health, a committee of the National Research Council said in a report released today.

RW Garcia's high level of innovation has catalyzed an ever-expanding customer base for its gluten-free, non-GMO tortilla chips and crackers.

Plus- Wholesalers Can Enjoy a Retargeting Offer, Going On Now!

Spend a full day learning from Dr. Judy Morgan and come and engage with our local holistic community

Life as a designer can be very stressful and fill your life with stress and tension, you can treat without naturally and without damaging your health. When stress situations reach us, sometimes we feel so anxious that We try to reduce it on our own, such as self-medication, but in the long run, this can […]

The post 5 Ways to Reduce Stress Naturally appeared first on Snap2objects.

Dana Laake and her special guest Dr. Véronique Desaulniers will discuss her book, Heal Breast Cancer Naturally: 7 Essential Steps to Beating Breast Cancer.

The post Heal breast cancer naturally, 7 essential steps to beating breast cancer first appeared on Federal News Network.

Queen Elizabeth wore a neon green outfit to her 90th birthday party. What could go wrong? Oh right, the internet...

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.

Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium tuberculosis, has less than 1% of the catalytic efficiency of a typical natural CM and requires complex formation with 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase for high activity. To explore the full potential of MtCM for catalyzing its native reaction, we applied diverse iterative cycles of mutagenesis and selection, thereby raising kcat/Km 270-fold to 5 × 105 m−1s−1, which is even higher than for the complex. Moreover, the evolutionarily optimized autonomous MtCM, which had 11 of its 90 amino acids exchanged, was stabilized compared with its progenitor, as indicated by a 9 °C increase in melting temperature. The 1.5 Å crystal structure of the top-evolved MtCM variant reveals the molecular underpinnings of this activity boost. Some acquired residues (e.g. Pro52 and Asp55) are conserved in naturally efficient CMs, but most of them lie beyond the active site. Our evolutionary trajectories reached a plateau at the level of the best natural enzymes, suggesting that we have exhausted the potential of MtCM. Taken together, these findings show that the scaffold of MtCM, which naturally evolved for mediocrity to enable inter-enzyme allosteric regulation of the shikimate pathway, is inherently capable of high activity.

Title: Scientists Unravel Secrets of People Who Naturally Suppress HIV
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

hello products are a solution to the struggle at the sink. This advertisement shows the frustrations moms and dads can face when it�s brush time and they need to negotiate with their kids to brush.

Hypertension (high blood pressure) cases are on the rise. Practicing static isometric exercises (workouts that involve engaging muscles without movement)

The best way to go green could be to look back how we built and lived in the past. By SATHYA PRAKASH VARANASHI

Blossom Kochhar says if you can eat it, it can be used on your face.

Zero-waste apparel dyed with home-grown rhubarb and madder is the forte of Mridu Mehra Tiwari’s brand Kokūn, which just launched its Spring collection and a men’s range

I'm in Los Angeles at the moment. I advise you to look away now if the casual smugness of that opening sentence was too much to bear

Although relations between the United States and India have largely been cold or chilly since our independence, briefly in the early 1960s, there was a phase when Washington sensed the possibility of an entente. Ramachandra Guha recalls love and hate between the two nations before the age of George Bush.

Cancer-causing chemicals that occur naturally in foods are far more numerous in the human diet than synthetic carcinogens, yet both types are consumed at levels so low that they currently appear to pose little threat to human health, a committee of the National Research Council said in a report released today.

A fungus could offer an alternative to chemical pesticides for the control of biting midges that spread livestock diseases, including Bluetongue and African horse sickness, according to new research.

Old mining sites, such as quarries or pits, could provide refuges for endangered species, according to new research from the Czech Republic. Benefits are greater if the sites are allowed to recover naturally rather than being artificially restored with the use of topsoil, ground-levelling and seed planting.

I just had my 36-week checkup at the gynecologist and they told me that my baby is breech, meaning that if it doesn’t go head-down soon, I’m going to have t

These home remedies can help you tackle that pesky poison ivy rash the natural way.

After trying several methods to remove the label glue from the bottles, I finally found the winner.

Suffering from hot flashes, fatigue, insomnia or anxiety? Hormonal imbalance could be to blame — try these natural remedies to get things back on track.

Pesky insects can be a real pain during summer outdoor activities, but these simple remedies ease the aftermath of a bee sting.

Skip the abrasive chemicals in commercial teeth whiteners and reach for some pineapple instead. Here are several ways to naturally whiten your teeth.

Skip the harsh chemicals and try these nontoxic ways to clean your carpets.

The key to sparkling, streak-free window panes isn't chemicals, clean windows naturally with these tips.

Outdoor summer fun (or work) can lead to the most frustratingly stubborn clothing stains.

Drain flies, also known as sink moths or sewer flies, can be a huge nuisance. Here's how to get rid of drain flies naturally and without chemicals.

Non-chemical ways to make your sink and tub smell fresh.

There is no need to use harsh and poisonous sprays to get rid of wasps; there are plenty of ways to get rid of them naturally.

You don't need pesticides to get rid of these annoying insects.

Try these simple tips and bid goodbye to houseflies, those uninvited pests buzzing around your home.

Pink lakes are often salty and always cool, and they can be found in many spots around the world.

Rid your home of mild and mildew using non-toxic and affordable ingredients that eliminate any need for a scrub brush.

To moisten the air in your abode, grab some plants, put out some dishes of water, and get cooking. Here are some alternatives to an electric humidifier.

Mosquitoes are annoying, relentless and can pose a health risk for your family. Here are some effective ways to kill them and keep them away, the natural way.

Organic gardening brings benefits to both you and the plant

Banishing roaches from your home without toxic chemicals can be time-consuming, but the results will be well worth the effort.

Intestinal gas, flatulence, farting or breaking wind is a natural part of the digestive process. This odorless gas, although at times embarrassing, is the result of good digestion. Every day, our body produces one to three pints of gas that is ultimately passed. For some, gas is an ongoing problem. Discover alternative and natural healing methods in which you can reduce or eliminate the awkwardness of intestinal gas.

Revisit the type of Acne treatment remedies, which will help you fight acne naturally by avoiding your pores to get clogged.

Skin 2 Skin, plant-powered skincare announces the launch of its new Enzyme Renewal Mask. Made with papaya enzymes, pumpkin seed extract, avocado oil, and green tee extract, it exfoliates the skin while leaving it renewed, nourished and brightened.

Warm, dry weather conditions have led to additional growth on the Ikes Fire, which is now approximately 1,535 acres and 20% contained. Smoke settled into the Grand Canyon overnight as temperatures cooled but smoke may begin to lift as temperatures warm up throughout the day. https://www.nps.gov/grca/learn/news/ikes-fire-spreads-crews-secure-planning-area-20190815.htm

In one embodiment, a method for producing a naturally purified salt product such as magnesium sulfate heptahydrate, wherein the salt mixture is treated with a solution comprising magnesium chloride; the first slurry is separated to provide a second slurry, which is further separated to yield a first liquid stream; the first liquid stream is crystallized to provide the naturally purified salt product. In another embodiment, a high purity salt product is produced. In another embodiment, other products that are produced include naturally purified sodium chloride and magnesium chloride.