Eating should be a pleasure — and when you can take care of your health while taking care of your cravings, it’s doubly fulfilling. Here’s how to eat for your eyes.

TODAY WE PAUSE briefly to tip the cap to Mother Earth — or, more specifically, to the people plugging away at the day-to-day jobs of saving her life. People in the Northwest have a particular stake in Earth Day, a now-global event celebrating its 50th anniversary this month. The very first one was organized by […]

The Sutherlands hope that telling their story will help transgender parents be accepted to the point where, one day, "no-one bats an eyelid".

Queen Elizabeth wore a neon green outfit to her 90th birthday party. What could go wrong? Oh right, the internet...

Renza Scibilia
Jul 1, 2019; 37:302-303
Book Reviews

Psychologists once conducted a simple experiment with far-reaching implications: They asked people to describe an instance in their lives when they had hurt someone and another instance when they had been hurt by someone else. The incidents that people described were similar whether they saw...

Prediabetic state -- Prevention.

Background: This study summarizes drug resistance analyses in 4 recent phase 2b trials of the respiratory syncytial virus (RSV) fusion inhibitor presatovir in naturally infected adults.

Methods: Adult hematopoietic cell transplant (HCT) recipients, lung transplant recipients, or hospitalized patients with naturally acquired, laboratory-confirmed RSV infection were enrolled in 4 randomized, double-blind, placebo-controlled studies with study-specific presatovir dosing. Full-length RSV F sequences amplified from nasal swabs obtained at baseline and postbaseline were analyzed by population sequencing. Substitutions at RSV fusion inhibitor resistance-associated positions are reported.

Results: Genotypic analyses were performed on 233 presatovir-treated and 149 placebo-treated subjects. RSV F variant V127A was present in 8 subjects at baseline. Population sequencing detected treatment-emergent substitutions in 10/89 (11.2%) HCT recipients with upper and 6/29 (20.7%) with lower respiratory tract infection, 1/35 (2.9%) lung transplant recipients, and 1/80 (1.3%) hospitalized patients treated with presatovir; placebo-treated subjects had no emergent resistance-associated substitutions. Subjects with substitutions at resistance-associated positions had smaller decreases in viral load during treatment relative to those without, but similar clinical outcomes.

Conclusions: Subject population type and dosing regimen may have influenced RSV resistance development during presatovir treatment. Subjects with vs without genotypic resistance development had decreased virologic responses but comparable clinical outcomes.

Treatment of dogs naturally infected with Leishmania infantum using meglumine antimoniate (MA) encapsulated in conventional liposomes (LC) in association with allopurinol has been previously reported to promote marked reduction in the parasite burden in the main infection sites. Here, a new assay in naturally infected dogs was performed using a novel liposome formulation of MA consisting of a mixture of conventional and long-circulating (PEGylated) liposomes (LCP), with expected broader distribution among affected tissues of the mononuclear phagocyte system. Experimental groups of naturally infected dogs were as follows: LCP+Allop, receiving LCP intravenously as 2 cycles of 6 doses (6.5 mg Sb/kg/dose) at 4-day intervals, plus allopurinol at 30 mg/kg/12 h p.o. during 130 days; LC+Allop, receiving LC intravenously as 2 cycles of 6 doses (6.5 mg Sb/kg/dose), plus allopurinol during 130 days; Allop, treated with allopurinol only; non-treated control. Parasite loads were evaluated by quantitative PCR in liver, spleen and bone marrow and by immunohistochemistry in the ear skin, before, just after treatment and 4 months later. LCP+Allop and LC+Allop groups, but not the Allop group, showed significant suppression of the parasites in the liver, spleen and bone marrow 4 months after treatment, compared to the pre-treatment period or the control group. Only LCP+Allop group showed significantly lower parasite burden in the skin, in comparison to the control group. On the basis of clinical staging and parasitological evaluations, LCP formulation exhibited a more favorable therapeutic profile, when compared to LC one, being therefore promising for treatment of canine visceral leishmaniasis.

Jake Griggs, who will graduate Saturday with a 3.95 GPA with dual majors in management and political science, has been named Smeal’s spring 2020 management and organization student marshal.

This is a gluten free and naturally sweetened banana bread in a mug.  It is super easy to fix and paleo, too! -- posted by francoroni

Microscopy and rapid diagnostic tests (RDTs) are the main diagnostic tools for malaria but fail to detect low-density parasitemias that are important for maintaining malaria transmission. To complement existing diagnostic methods, an isothermal reverse transcription-recombinase polymerase amplification and lateral flow assay (RT-RPA) was developed. We compared the performance with that of ultrasensitive reverse transcription-quantitative PCR (uRT-qPCR) using nucleic acid extracts from blood samples (n = 114) obtained after standardized controlled human malaria infection (CHMI) with Plasmodium falciparum sporozoites. As a preliminary investigation, we also sampled asymptomatic individuals (n = 28) in an area of malaria endemicity (Lambaréné, Gabon) to validate RT-RPA and assess its performance with unprocessed blood samples (dbRT-RPA). In 114 samples analyzed from CHMI trials, the positive percent agreement to uRT-qPCR was 90% (95% confidence interval [CI], 80 to 96). The negative percent agreement was 100% (95% CI, 92 to 100). The lower limit of detection was 64 parasites/ml. In Gabon, RT-RPA was 100% accurate with asymptomatic volunteers (n = 28), while simplified dbRT-RPA showed 89% accuracy. In a subgroup analysis, RT-RPA detected 9/10 RT-qPCR-positive samples, while loop-mediated isothermal amplification (LAMP) detected 2/10. RT-RPA is a reliable diagnostic test for asymptomatic low-density infections. It is particularly useful in settings where uRT-qPCR is difficult to implement.

The star gave the Blinding Lights TikTok challenge a go while clad in fluorescent exercise gear

Don't let all this extra time at home get in the way of your long-cherished athletic goals. Here's how you can emerge from social distancing the proud champion of a sport you've just invented.

US Secretary of State Mike Pompeo claimed that there is evidence the COVID-19 coronavirus was created in a lab, despite US intelligence officials stating it probably occurred naturally.

In this tog-eat-tog world, the future of fashion—let alone that of green fashion—lies entirely in the industry's chameleon-like ability to reinvent itself. Take Italian outerwear company Allegri, for example. Although better known

Get rid of slugs (and snails) without the use of pesticides that harm beneficial creatures and pollute our waterways.

If it weren't for an added colorant, it would be grey or white like most of the other fish on display at the store.

Using traditional techniques and materials, this design adapts the age-old idea of evaporative cooling to create a low-energy, alternative air conditioner.

There is either a giant contradiction here in Ontario's Prince Edward County or I am missing something.

hello products are a solution to the struggle at the sink. This advertisement shows the frustrations moms and dads can face when it’s brush time and they need to negotiate with their kids to brush.

hello products are a solution to the struggle at the sink. This advertisement shows the frustrations moms and dads can face when it’s brush time and they need to negotiate with their kids to brush.

Anushka Sharma turns 32 today and the successful superstar and entrepreneur opened up about how she believed in herself right from when she started out as a model at a super young age of 15!

Her rise and rise in Bollywood is an inspiration to many given she made a huge mark in the industry despite being a total outsider with no industry connections! "Perseverance comes naturally to me. It's not something that you have to be hard on yourself for, it leads you. Honestly, life leads you! I can vouch for it! Life has lead me to where I am you know. Sometimes, you just put your head down and follow the road life takes you on," says Anushka.

The superstar, who is also the youngest woman producer of Bollywood having started Clean Slate Films when she was just 25, considers her father Colonel Ajay Kumar Sharma to be her greatest teacher. "I went to Army Public School in Bangalore and I have had some really good teachers there and I was very close to them and they have had a very lasting impression in my mind and my principal also. But my dad taught me some invaluable lessons," she says.

Anushka says, "He would drop me to school and he would have these conversations with me because the journey was little bit long. He would just tell me one thing and it has had such a lasting impression in my mind and in my personality and the way I deal with challenges in life. It's really been extremely special. The thing that he told me was no matter what situation you are in, no matter how bad the situation is, always do the right thing and pray to god that you know what is the right thing to do is at that moment."

The actress adds, "I think that's something that stuck with me cause I was so young and I really look up to my father. He is a very wise man and he has had a huge impression on my life. So, when he said that to me it really stuck with me."

Anushka says this advice helped her when she started out as a model at a very young age! "I started working when I was so young. It was important for me to know all this because at the age of 14-15, when you are taking decisions for yourself and your career, it's really hard. That's what's gave me clarity. That's what I did and I think that's something that has always stood out for me," she says.

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Actor Aasif Shaikh can give a comical twist to any scene because, as he says, comedy comes naturally to him. "Comedy comes naturally to me. Even if there is a serious scene with some hard-hitting dialogues, I can perform it in the most comical way," said the actor, who has a theatre background and years of experience in the entertainment industry.

He points out comedy is a very specialised genre. "It is very interesting and at the same time challenging as you have to keep updating your acts, so that they do not appear monotonous. I have been playing the role of Vibhuti in &TV's 'Bhabiji Ghar Par Hain' for five years and I keep on experimenting with my looks, dialogues, etc. to engage with the audience. This is how I raise the bar for myself," he shared.

Aasif follows international comedians and trends on social media to keep himself updated.

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Men who die of COVID-19 are losing, on average, 13 years of their lives, while women have 11 years cut off their life expectancy, according to a study carried out by Public Health Scotland.

One quarter of women surveyed confessed to having at least one beauty secret, while 23 per cent confided that nobody (even their friends) really knows the extent of their beautifying.

The Little Mix star, 27, revealed the nation's shutdown has given her time to embrace her natural locks as she shared a radiant selfie on Instagram on Tuesday.

Elaine Kalache, from Canberra, whose weight escalated after living off an unhealthy diet has shed more than half her body weight naturally after cutting out oils, sugar and fried foods.

Lubrication alters your mood by making it easier to penetrate. Every woman lubricates and the discharge increases when she is sexually excited. Dry vagina can make it difficult to have an intercourse. Moreover, it is painful and can cause infectious.

Online Resource

Hayden Library - RS380.S35 2019

Koul, Opender, author