A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine -- known as a neoantigen DNA vaccine -- for breast cancer patients.

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine -- known as a neoantigen DNA vaccine -- for breast cancer patients.

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.

Foods to eat that contain nutrients that may help to prevent breast cancer.

Breast cancer is leading cause of mortality among women compared to other types of cancers. Hence, early breast cancer diagnosis is crucial to the success of treatment. Various pathological and imaging tests are available for the diagnosis of breast cancer. However, it may introduce errors during detection and interpretation, leading to false-negative and false-positive results due to lack of pre-processing of it. To overcome this issue, we proposed a effective image pre-processing technique-based on Otsu's thresholding and single-seeded region growing (SSRG) to remove artefacts and segment the pectoral muscle from breast mammograms. To validate the proposed method, a publicly available MIAS dataset was utilised. The experimental finding showed that proposed technique improved 18% breast cancer detection accuracy compared to existing methods. The proposed methodology works efficiently for artefact removal and pectoral segmentation at different shapes and nonlinear patterns.

Breast cancer awareness: A contrast of its history in PakistanAn ode to breast cancer awareness:

As the month of October comes to an end with its sea of pink ribbons, it has reminded us once again of a critical issue that deserves more than just symbolic gestures: breast cancer awareness....

October is Breast Cancer Awareness Month. S-5! is donating $5,000 to two amazing charities to support breast cancer patients and their families. S-5! is asking people in the industry to join the company by purchasing its “Give Cancer the Boot” t-shirts.

Boston – Women who work the night shift as young adults may have an increased risk of breast cancer, according to a study of nurses conducted by the Channing Division of Network Medicine at Brigham and Women’s Hospital.

Kingston, Ontario – Women who have worked the night shift for 30 or more years may have an increased risk of breast cancer, according to a new study from Queen’s University.

San Francisco – A nonprofit organization has released a report identifying more than 20 occupations associated with an increased risk of breast cancer.

Childhood trauma can increase a breast cancer survivor's chance of experiencing more severe and longer-lasting treatment-related anxiety, depression and fatigue, as well as reduced cognitive function, years after cancer treatment has ended, according to a preliminary study led by Jamie Myers, Ph.D., FAAN, research associate professor at the University of Kansas School of Nursing.

Childhood trauma can increase a breast cancer survivor's chance of experiencing more severe and longer-lasting treatment-related anxiety, depression and fatigue, as well as reduced cognitive function, years after cancer treatment has ended, according to a preliminary study led by Jamie Myers, Ph.D., FAAN, research associate professor at the University of Kansas School of Nursing.

The coffee company launched an initiative to raise funds for firefighters diagnosed with breast cancer through its Fire Dept. Coffee Club and Fire Dept. Shirt Club.

Organizations like Unite for HER provide treatments associated with better quality of life and patient outcomes

Yiqun Han recognized for expertise in breast cancer research and treatment

MTI will hold its fifth annual "Teeing for Ta-Tas" charity golf tournament at Orlando's Rosen Shingle Creek Golf Resort to support AdventHealth breast cancer research on October 30, 2021, at 8:00 AM.

Special discounts available through October with local businesses

The race focuses on breast cancer survivors and families fighting the disease.

Breast cancer remains the most common invasive cancer diagnosed in women in the United States, accounting for about one in three new female cancers each ye

High-grade glioma (HGG), a type of aggressive brain cancer, accounts for the leading cause of cancer-related mortality for children and adolescents. 

Breast cancer remains the most common invasive cancer diagnosed in women in the United States, accounting for about one in three new female cancers each ye

CertainTeed will donate a percentage of its sales from each of its co-branded GlasRoc Sheathing boards to the Susan G. Komen organization from October 2024 to October 2025.

In addition to a $5,000 donation to advance breast cancer care, S-5! is holding a fundraising campaign to benefit two organizations: the Woody and Millie Ingram Guest House and the Careity Foundation.

See why the owner of Exterior Point Home Remodeling in New Jersey got the entire company involved in National Breast Cancer Awareness Month. 

Dana Laake and her special guest Dr. Véronique Desaulniers will discuss her book, Heal Breast Cancer Naturally: 7 Essential Steps to Beating Breast Cancer.

The post Heal breast cancer naturally, 7 essential steps to beating breast cancer first appeared on Federal News Network.

Dana Laake and her special guest Dr. Thomas Levy will discuss how silent oral infections are a major factor in most heart attacks and breast cancers.

The post Hidden Epidemic: Silent Oral Infections Cause Most Heart Attacks and Breast Cancers first appeared on Federal News Network.

Location: Electronic Resource- 

The Newsbabes -- those pink-clad broads of broadcasting -- are back again this year with their annual breast cancer fundraising, this year raising money for the Howard University Cancer Center. The event, in its fifth year, will be taking place June 27 from 7 to 9 p.m. at the Hamilton in downtown D.C. Tickets cost $75. The host committee consists of WJLA's Rebecca Cooper, NBC4's Angie Goff, CNN's Brianna Keilar and more.

The annual BF&M Breast Cancer Awareness Walk — which serves to help raise funds for the Bermuda Cancer and Health Centre — was held yesterday [Oct 16]. The charity previously noted that “for more than two decades, the BF&M Breast Cancer Awareness Walk has united our community in the fight against this deadly disease and […]

Tassel Bermuda has launched the “Adira” earring collection for Breast Cancer Awareness Month, with 15% of proceeds pledged to support the Bermuda Cancer and Health Centre. A spokesperson said, “Tassel Bermuda, the local polymer clay earring business, is proud to introduce its latest masterpiece, the “Adira” collection, a collaboration with the Bermuda Cancer and Health […]

Nightis a sculpture on the tomb of Giuliano de Medici, the Duke of Urbino, in the city of Florence. Michelangelo carved it between 1526 and 1531 and composed these lines to place in the mouth of this personification of the night:

Precious is sleep, better to be of stone,
while the oppression and the shame still last;
not seeing and not hearing, I am blest;
so do not wake me, hush! keep your voice down

In a 2000 letter to the New England Journal of Medicine, James J. Stark and Jonathan Katz Nelson argue that the model that Michelanglo used likely had advanced breast cancer. Her left breast has lumps indicative of a tumor in the nipple or the lymphatics beneath the nipple. As these shapes are not present in the other female breasts that Michelanglo composed, it's likely that this shape reflects, tragically, the model herself.

-via TYWKIWDBI

Jeannie Ambrose, one of about 1,000 affected patients, says the drug should be made available on the NHS

"This is really weird, maybe, but I had really heavy breasts. They were like 10 pounds when they removed them," Kathy Bates said on a podcast.

Visual Abstract

Visual Abstract

Understanding which patients with human epidermal growth factor receptor 2 (HER2)–negative or –low metastatic breast cancer (MBC) benefit from HER2-targeted strategies is urgently needed. We assessed the whole-body heterogeneity of HER2 expression on ⁸⁹Zr-trastuzumab PET (HER2 PET) and the diagnostic performance of HER2 PET in a large series of patients, including HER2-negative and -low MBC. Methods: In the IMPACT-MBC study, patients with newly diagnosed and nonrapidly progressive MBC of all subtypes were included. Metastasis HER2 status was determined by immunohistochemistry and in situ hybridization.⁸⁹Zr-trastuzumab uptake was quantified as SUV_max and SUV_mean. HER2 immunohistochemistry was related to the quantitative ⁸⁹Zr-trastuzumab uptake of all metastases and corresponding biopsied metastasis, uptake heterogeneity, and qualitative scan evaluation. A prediction algorithm for HER2 immunohistochemistry positivity based on uptake was developed. Results: In 200 patients, ⁸⁹Zr-trastuzumab uptake was quantified in 5,163 metastases, including 186 biopsied metastases. With increasing HER2 immunohistochemistry status, uptake was higher (geometric mean SUV_max of 7.0, 7.6, 7.3, and 17.4 for a HER2 immunohistochemistry score of 0, 1, 2, or 3+, respectively; P < 0.001). High uptake exceeding 14.6 (90th percentile) was observed in one third of patients with a HER2-negative or -low metastasis biopsy. The algorithm performed best when lesion site and size were incorporated (area under the curve, 0.86; 95% CI, 0.79–0.93). Conclusion: HER2 PET had good diagnostic performance in MBC, showing considerable whole-body HER2 heterogeneity and uptake above background in HER2-negative and -low MBC. This provides novel insights into HER2-negative and -low MBC compared with standard HER2 immunohistochemistry on a single biopsy.

The tumor marker cancer antigen 15-3 (CA 15-3) is that most commonly used to monitor metastatic breast cancer during active therapy and surveillance for disease recurrence after treatment. The association of CA 15-3 and ¹⁸F-FDG PET/CT findings can be considered complementary, since any significant rise may indicate the presence of disease and imaging is able to map the tumor sites. Although current guidelines do not recommend the routine performance of CA 15-3 in asymptomatic patients being followed up after definitive breast cancer treatment, most oncologists perform serial assessment of the tumor markers as part of routine follow-up of patients. The aim of this study was to evaluate the correlation between CA 15-3 levels and ¹⁸F-FDG PET/CT scan findings in patients with recurrent breast cancer. Methods: This was a cross-sectional study with data collected retrospectively. Patients being evaluated for breast cancer recurrence with ¹⁸F-FDG PET/CT imaging and CA 15-3 level were included. Evaluation of the association between CA 15-3 levels and ¹⁸F-FDG PET/CT scan findings was then done. Results: In total, 154 cases were included in this study; 62 patients had recurrence (positive) on the ¹⁸F-FDG PET/CT scans, whereas 92 patients had normal (negative) findings on follow-up ¹⁸F-FDG PET/CT scans. There was an association between CA 15-3 levels and the presence or absence of recurrence on ¹⁸F-FDG PET/CT scans, with 84.4% (27/32) of patients who had elevated CA 15-3 levels having disease recurrence on ¹⁸F-FDG PET/CT and 84.4% (27/32) of patients who had elevated CA 15-3 levels having disease recurrence on ¹⁸F-FDG PET/CT as well as a correlation with the burden of metastases. Most patients with disease recurrence on ¹⁸F-FDG PET/CT, however, had normal CA 15-3 levels. Conclusion: Higher CA 15-3 levels correlate with breast cancer recurrence on ¹⁸F-FDG PET/CT as well as with burden of metastasis. Notably, CA 15-3 levels within the reference range do not exclude breast cancer disease recurrence since more than half of patients with recurrence had normal CA 15-3 levels. ¹⁸F-FDG PET/CT should therefore be considered in patients with suspected breast cancer recurrence but normal CA 15-3 levels.

Though breast cancer mortality is declining overall, Asian American women and women under 50 have experienced an uptick in diagnoses of the disease

A new AI-powered, imaging-based technology that creates accurate three-dimensional models of tumors, veins and other soft tissue offers a promising new method to help surgeons operate on, and better treat, breast cancers. The technology, from Illinois-based startup SimBioSys, converts routine black-and-white MRI images into spatially accurate, volumetric images of a patient’s breasts. It then illuminates Read Article

Kathy Bates on not having reconstruction surgery after double mastectomy Kathy Bates revealed why she didn’t go for a reconstruction surgery after her double mastectomy and breast cancer diagnosis.In 2012, at age 64, the American Horror Story alum was diagnosed with breast cancer and...

The Renaissance artist Michelangelo had carried out human dissections, which may have led him to include women with breast cancer in some of his pieces

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