Title: Drinking Before First Pregnancy Raises Risk of Breast Cancer: Study
Category: Health News
Created: 8/28/2013 4:35:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM

Title: Acupuncture Best for Hot Flashes in Breast Cancer Survivors: Study
Category: Health News
Created: 8/25/2015 12:00:00 AM
Last Editorial Review: 8/26/2015 12:00:00 AM

Title: Blood Test May One Day Predict Breast Cancer Relapse
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM

Title: Black Women at Raised Risk of Carrying Breast Cancer Genes
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: Bills Mount for Breast Cancer Survivors
Category: Health News
Created: 8/24/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

Title: Men Should be Included in Breast Cancer Clinical Trials: FDA
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Can Breast Cancer Be a Risk Factor for Opioid Use Among Older Patients?
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Exercise Could Help Fight 'Chemo Brain' in Breast Cancer Patients
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM

Title: How to Manage Menopause Symptoms After Breast Cancer
Category: Diseases and Conditions
Created: 7/7/2022 12:00:00 AM
Last Editorial Review: 7/7/2022 12:00:00 AM

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

The clinical impact of 16α-¹⁸F-fluoro-17β-estradiol (¹⁸F-FES) PET/CT on patient management has not been well investigated. The aim of this study was to assess the clinical impact of ¹⁸F-FES PET/CT on the management of patients with recurrent or metastatic breast cancer. Methods: Study subjects were identified retrospectively from a database of a prospective trial for postmarketing surveillance of ¹⁸F-FES between 2021 and 2023. Patients who were suspected or known to have recurrent or metastatic estrogen receptor–positive breast cancer based on a routine standard workup were included. Planned management before and actual management after ¹⁸F-FES PET/CT were assessed by 2 experienced medical oncologists via medical chart review. A 5-point questionnaire was provided to evaluate the value of ¹⁸F-FES PET/CT for management planning. The rate of intention-to-treat and interdisciplinary changes, and the impact of ¹⁸F-FES PET/CT according to PET/CT result or clinical indication, were examined. Results: Of the 344 included patients, 120 (35%) experienced a change in management after ¹⁸F-FES PET/CT. In 139 (40%) patients,¹⁸F-FES PET/CT supported the existing management decision without a change in management. Intention-to-treat and interdisciplinary changes accounted for 64% (77/120) and 68% (82/120) of all changes, respectively. A higher rate of change was observed when lesions were ¹⁸F-FES–negative (44% [36/81]) than ¹⁸F-FES–positive (30% [51/172]) or mixed ¹⁸F-FES–positive/negative (36% [33/91]). Regarding clinical indications, the highest rate of change was shown when evaluating the origins of metastasis of double primary cancers (64% [9/14]). Conclusion: ¹⁸F-FES PET/CT modified the management of recurrent or metastatic breast cancer, serving as an impactful imaging modality in clinical practice.

The Renaissance artist Michelangelo had carried out human dissections, which may have led him to include women with breast cancer in some of his pieces

To mark Breast Cancer Awareness Month, we speak to inspiring Singaporeans about their journey in battling and overcoming cancer.  Warda Ismail gets anxious about things easily, especially when it comes to her health.  So much so that her doctor once told her that she is a "borderline hypochondriac", she shared with AsiaOne in an interview.  For the uninitiated, hypochondria is a condition where a person is excessively and unduly worried about having a serious illness. To keep her mind at ease, the 44-year-old preschool educator has the habit of going for regular medical checkups.  Though she was vigilant, her worst nightmare came true — she was diagnosed with breast cancer on May 8 this year.  And in the midst of her recovery journey, she got more terrible news — her mother, who had been caring for her, was diagnosed with stage-three gall bladder cancer.  Despite the string of unfortunate events, Warda persevered and tried to have a more positive outlook on life and her health. 

Top Breast Cancer Surgeons Discuss Advanced Surgical Options

The Wheels Up Pink Plane is the first-ever pink Beechcraft King Air 350i. Proceeds benefit the Dubin Breast Center at Mount Sinai in New York City. Westchester County Airport, White Plains, NY

The Renaissance artist Michelangelo had carried out human dissections, which may have led him to include women with breast cancer in some of his pieces

Only 28% of American women are aware that eating a healthy medlinkdiet/medlink can reduce the risk of medlinkbreast cancer/medlink (!--ref1--).

Lecturers at the Faculty of Social and Communication Sciences of the University of the Basque Country/Euskal Herriko University (UPV/EHU) analyzed a playlist

About 40% of postmenopausal hormone-positive breast cancer cases may be linked to excess body fat, according to Spanish research published online in the

Black patients with bmedlinktriple-negative breast cancer/medlink (TNBC)/b received immunotherapy at significantly lower rates than white patients.

A team of researchers has uncovered nearly 200 potential breast carcinogens in food packaging materials such as plastics, paper, and cardboard, emphasizing

A groundbreaking medlinkAI/medlink technology could revolutionize breast cancer prevention and treatment. By identifying and analyzing damaged cells,

A recent study has found that prevalent treatments for medlinkbreast cancer/medlink, such as chemotherapy, radiation, and surgical interventions,

Researchers have created a groundbreaking in vitro model to study the spread of breast cancer to bone. Their research could lead to new tools that predict

Breast cancer can sometimes be asymptomatic, even when a lump is not present. Regular self-exams and screenings are crucial for early detection and improved outcomes.

Tissue stiffness in HER2-negative breast cancer, the most common type, can directly contribute to disease progression and metastasis, which can have serious consequences on patients.

Using a gene signature technique to customize chemotherapy for patients with early triple negative breast cancer may be a promising strategy to increase disease-free survival.

Drugs aimed at HER2-positive breast cancer may also help certain patients with bile duct cancer, as indicated by findings from a patient trial that will

While often perceived as a women's disease, breast cancer affects men as well. Stigma, however, can delay diagnosis and treatment, potentially worsening outcomes.

A newly developed model to study breast cancer metastasis offers a deeper understanding of how and why cancer spreads. (!--ref1--) Professor Eran

Breast cancer is the most common cancer worldwide and it is the second leading cause of death in women. It mainly occurs in middle-aged and older women.

Discover how Beata Halassy, a virologist, used oncolytic virotherapy to treat her breast cancer successfully.

British scientists claim to have developed a drug with the potential to 'vaccinate' those with a family history of bre

Medicaid expansion under the Affordable Care Act (ACA) is associated with better outcomes for patients with hormone receptor (HR)-negative, human epidermal

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors

Fewer women in India now suffer from cervical cancer - counted among the worst of killers. However, breast cancer cases have shot up alarmingly.

The coronavirus cases around the globe are at 2,995,757, with 207,022 deaths reported and 881,845 recoveries. The virus outbreak that began in 2019 continues to cause casualties, while health experts around the globe are extensively working on developing a vaccine and